检索结果-南通市图书馆

The Rewards of Fundamental Atomic Spectrometry Research

光谱学与光谱分析 2000年第2期20卷 156-159页

作者： walter slavin bonaire technologies ridgefield,ct 06877 usa bonaire technologies Ridgefield CT 06877 United States

Atomic spectrometry research is the life blood of the atomic spectrometry instrument *** instrument designer can be expected to innovate in the execution of instrumentation and should be expected to be the expert in optical,electronic and software *** new technology has required too long a period of gestation to be compatible with commercial time scales and *** in the past decade,the pressure from stockholders for increased return on investments has put increasingly strong pressure on management to reduce expenses and focus increasingly on projects that guarantee a fast *** pressure falls particularly heavily on the larger companies;the same companies that a decade or more ago were the ones that brought the more far reaching and expensive new concepts to market. Fundamental research in atomic spectrometry has been accomplished in the past several decades mostly in the academic environment and in research institutions that are Federally *** of the Federally funded research institutions have been forced to alter their missions to more tangible and immediate goals,and many have also seen severe financial reductions.

关键词： The Rewards of Fundamental Atomic Spectrometry Research

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Elevated blood pressure: Our family's fault?The genetics of essential hypertension

引用

World Journal of Cardiology 2014年第5期6卷 327-337页

作者： Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P slavin The John A. Burns School of Medicine University of Hawaii Honolulu HI 96813 United States Hawaii Community Genetics Honolulu HI96814 United States

AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of ***: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS ***: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using phar

关键词： Essential hypertension Epigenomics Genome-wide association study Genes MicroRNAs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：