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Advanced Optimized Anomaly Detection System for IoT Cyberattacks Using Artificial Intelligence

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Computers, Materials & Continua 2024年第2期78卷 1525-1545页

作者： Ali hamid Farea omar h.Alhazmi Kerem Kucuk Department of Computer Science Taibah UniversityMedina42315Saudi Arabia Department of Software Engineering Kocaeli UniversityKocaeli41001Turkey

While emerging technologies such as the Internet of Things(IoT)have many benefits,they also pose considerable security challenges that require innovative solutions,including those based on artificial intelligence(AI),given that these techniques are increasingly being used by malicious actors to compromise IoT *** an ample body of research focusing on conventional AI methods exists,there is a paucity of studies related to advanced statistical and optimization approaches aimed at enhancing security *** contribute to this nascent research stream,a novel AI-driven security system denoted as“AI2AI”is presented in this ***2AI employs AI techniques to enhance the performance and optimize security mechanisms within the IoT *** also introduce the Genetic Algorithm Anomaly Detection and Prevention Deep Neural Networks(GAADPSDNN)sys-tem that can be implemented to effectively identify,detect,and prevent cyberattacks targeting IoT ***,this system demonstrates adaptability to both federated and centralized learning environments,accommodating a wide array of IoT *** evaluation of the GAADPSDNN system using the recently complied WUSTL-IIoT and Edge-IIoT datasets underscores its *** an impressive overall accuracy of 98.18%on the Edge-IIoT dataset,the GAADPSDNN outperforms the standard deep neural network(DNN)classifier with 94.11%***,with the proposed enhancements,the accuracy of the unoptimized random forest classifier(80.89%)is improved to 93.51%,while the overall accuracy(98.18%)surpasses the results(93.91%,94.67%,94.94%,and 94.96%)achieved when alternative systems based on diverse optimization techniques and the same dataset are *** proposed optimization techniques increase the effectiveness of the anomaly detection system by efficiently achieving high accuracy and reducing the computational load on IoT devices through the adaptive selection of active features.

关键词： Internet of Things security anomaly detection and prevention system artificial intelligence optimization techniques

Understanding the Novel Approach of Nanoferroptosis for Cancer Therapy

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Nano-Micro Letters 2024年第9期16卷 501-556页

作者： Afsana Sheikh Prashant Kesharwani waleed h.Almalki Salem Salman Almujri Linxin Dai Zhe‑Sheng Chen Amirhossein Sahebkar Fei Gao Department of Pharmaceutics School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi 110062India Department of Pharmacology and Toxicology Faculty of PharmacyUmm Al-Qura UniversityMakkahSaudi Arabia Department of Pharmacology College of PharmacyKing Khalid University61421 Asir‑AbhaSaudi Arabia State Key Laboratory of Southwestern Chinese Medicine Resources Pharmacy SchoolChengdu University of Traditional Chinese MedicineChengdu 611130People’s Republic of China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityNew York 11439USA Biotechnology Research Center Pharmaceutical Technology InstituteMashhad University of Medical SciencesMashhadIran Applied Biomedical Research Center Mashhad University of Medical SciencesMashhadIran

As a new form of regulated cell death,ferroptosis has unraveled the unsolicited theory of intrinsic apoptosis resistance by cancer *** molecular mechanism of ferroptosis depends on the induction of oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage the structural integrity of *** to their high loading and structural tunability,nanocarriers can escort the delivery of ferro-therapeutics to the desired site through enhanced permeation or retention effect or by active *** review shed light on the necessity of iron in cancer cell growth and the fascinating features of ferroptosis in regulating the cell cycle and ***,we discussed the effect of ferroptosis-mediated therapy using nanoplatforms and their chemical basis in overcoming the barriers to cancer therapy.

关键词： Ferroptosis Nanoparticles Ferrotherapy Cancer Genes Nanotechnology Toxicity Reactive oxygen species

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Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.Tsirogiannis Evangelos Daskalakis Mohamed h.hassan Abdalla M.omar Paulo Bartolo EODh SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance hybrid composites Vehicle protection

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Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance:A visualization and bibliometric study

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World Journal of hepatology 2024年第6期16卷 951-965页

作者： Sa'ed h Zyoud omar E hegazi Samer O Alalalmeh Muna Shakhshir Faris Abushamma Shadi Khilfeh Samah W Al-Jabi Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Center An-Najah National University HospitalNablus 44839Palestine College of Pharmacy and health Sciences Ajman UniversityAjman 346United Arab Emirates Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Gastroenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a liver condition that is prevalent worldwide and associated with significant health risks and economic *** it has been linked to insulin resistance(IR),this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and *** To map the research landscape to underscore critical areas of focus,influential studies,and future directions of NAFLD and *** This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to *** search strategy used terms from the literature and medical subject headings,focusing on terms related to IR and *** software was used to visualize research trends,collaborations,and key thematic *** analysis examined publication type,annual research output,contributing countries and institutions,funding agencies,journal impact factors,citation patterns,and highly cited *** This analysis identified 23124 documents on NAFLD,revealing a significant increase in the number of publications between 1999 and *** search retrieved 715 papers on IR and NAFLD,including 573(80.14%)articles and 88(12.31%)*** most productive countries were China(n=134;18.74%),the United States(n=122;17.06%),Italy(n=97;13.57%),and Japan(n=41;5.73%).The leading institutions included the Universitàdegli Studi di Torino,Italy(n=29;4.06%),and the Consiglio Nazionale delle Ricerche,Italy(n=19;2.66%).The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States(n=48;6.71%),and the National Natural Science Foundation of China(n=37;5.17%).The most active journals in this field were hepatology(27 publications),the Journal of hepatology(17 publications),and the Journal of Clinical Endocrinology and Metabolism(13 publications).The main research hotspots were“therapeutic approaches for IR and NAFLD”and“inflamma

关键词： Nonalcoholic fatty liver disease Insulin resistance Bibliometric Visualization

Disparate outcomes in hispanic patients with metabolic dysfunctionassociated steatotic liver disease/steatohepatitis and type 2 diabetes: Large cohort study

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World Journal of Diabetes 2024年第5期15卷 886-897页

作者： Joseph Matthew Gosnell George Golovko Esteban Arroyave Akshata Moghe Michael L Kueht omar AbdulSaldarriaga Kevin h McKinney heather L Stevenson Monique R Ferguson Department of Pathology University of Texas Medical BranchGalvestonTX 77555United States Department of Pharmacology&Toxicology University of Texas Medical BranchGalvestonTX 77555United States Department of Medicine University of Texas Health Science Center at HoustonHoustonTX 77030United States Department of Surgery University of Texas Medical BranchGalvestonTX 77555United States Center for Tropical Diseases Department of Internal MedicineUniversity of Texas Medical BranchGalvestonTX 77555United States Department of Internal Medicine University of Texas Medical BranchGalvestonTX 77555United States

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASh)are a growing health burden across a significant portion of the global patient ***,these conditions seem to have disparate rates and outcomes between different ethnic *** combination of MASLD/MASh and type 2 diabetes increases the risk of hepatocellular carcinoma(hCC),and hispanic patients experience the greatest burden,particularly those in South *** To compare outcomes between hispanic and non-hispanic patients in the United States,while further focusing on the hispanic population within Southeast Texas to determine whether the documented disparity in outcomes is a function of geographical circumstance or if there is a more widespread reason that all clinicians must account for in prognostic *** This cohort analysis was conducted with data obtained from TriNetX,LLC(“TriNetX”),a global federated health research network that provides access to deidentified medical records from healthcare organizations *** cohort networks were used:University of Texas Medical Branch(UTMB)hospital and the United States national database collective to determine whether disparities were related to geographic regions,like Southeast *** This study findings revealed hispanics/Latinos have a statistically significant higher occurrence of hCC,type 2 diabetes mellitus,and liver fibrosis/cirrhosis in both the United States and the UTMB hispanic/Latino *** mortality in hispanics/Latinos was lower within the United States group and not statistically elevated in the UTMB *** This would appear to support that hispanic patients in Southeast Texas are not uniquely affected compared to the national hispanic population.

关键词： Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis hispanic Diabetes mellitus TriNetX Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Steatotic liver disease hepatocellular carcinoma

A novel saliva-based miRNA profile to diagnose and predict oral cancer

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International Journal of Oral Science 2024年第1期16卷 97-109页

作者： Jaikrishna Balakittnen Chameera Ekanayake Weeramange Daniel F.Wallace Pascal h.G.Duijf Alexandre S.Cristino Gunter hartel Roberto A.Barrero Touraj Taheri Liz Kenny Sarju Vasani Martin Batstone omar Breik Chamindie Punyadeera Saliva&Liquid Biopsy Translational Laboratory Griffith Institute for Drug DiscoveryGriffith UniversityNathanQLDAustralia Department of Medical Laboratory Sciences Faculty of Allied Health SciencesUniversity of JaffnaJaffnaSri Lanka Menzies health Institute Griffith UniversityGold CoastQLDAustralia School of Biomedical Sciences Faculty of HealthQueensland University of TechnologyBrisbaneQLDAustralia Centre for Cancer Biology Clinical and Health SciencesUniversity of South Australia&SA PathologyAdelaideSAAustralia Institute of Clinical Medicine Faculty of MedicineUniversity of OsloOsloNorway Department of Medical Genetics Oslo University HospitalOsloNorway Griffith Institute for Drug Discovery Griffith UniversityNathanQLDAustralia QIMR Berghofer Medical Research Institute Statistics UnitBrisbaneQLDAustralia School of Public health The University of QueenslandBrisbaneQLDAustralia School of Nursing Queensland University of TechnologyBrisbaneQLDAustralia eResearch Research InfrastructureAcademic DivisionQueensland University of TechnologyBrisbaneQLDAustralia Department of Anatomical Pathology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Faculty of Medicine The University of QueenslandBrisbaneQLDAustralia Royal Brisbane and Women’s hospital Cancer Care ServicesHerstonQLDAustralia Department of Otolaryngology Royal Brisbane and Women’s HospitalHerstonQLDAustralia Department of Oral and Maxillofacial Surgery Royal Brisbane and Women’s HospitalHerstonQLDAustralia

Oral cancer (OC) is the most common form of head and neck cancer. Despite the high incidence and unfavourable patient outcomes, currently, there are no biomarkers for the early detection of OC. This study aims to discover, develop, and validate a novel saliva-based microRNA signature for early diagnosis and prediction of OC risk in oral potentially malignant disorders (OPMD).The Cancer Genome Atlas (TCGA) miRNA sequencing data and small RNA sequencing data of saliva samples were used to discover differentially expressed miRNAs. Identified miRNAs were validated in saliva samples of OC (n=50), OPMD (n=52), and controls(n=60) using quantitative real-time PCR. Eight differentially expressed miRNAs (miR-7-5p, miR-10b-5p, miR-182-5p, miR-215-5p,miR-431-5p, miR-486-3p, miR-3614-5p, and miR-4707-3p) were identified in the discovery phase and were validated. The efficiency of our eight-miRNA signature to discriminate OC and controls was:area under curve (AUC):0.954, sensitivity:86%, specificity:90%,positive predictive value (PPV):87.8%and negative predictive value (NPV):88.5%whereas between OC and OPMD was:AUC:0.911,sensitivity:90%, specificity:82.7%, PPV:74.2%and NPV:89.6%. We have developed a risk probability score to predict the presence or risk of OC in OPMD patients. We established a salivary miRNA signature that can aid in diagnosing and predicting OC,revolutionising the management of patients with OPMD. Together, our results shed new light on the management of OC by salivary miRNAs to the clinical utility of using miRNAs derived from saliva samples.

关键词： specificity salivary diagnosis

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Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakhshwin Foziya W.Alhalabi Mohamad omar Barasheed Ahmed M.Bakhshwin Maha h.Jamal Mohammed A.Bazuhair Fatemah O.Kamel Rania M.Magadmi Zoheir A Damanhouri Samar M.Alsaggaf Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia hera General hospital MakkahSaudi Arabia Department of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:The Morris water maze test indicated an enhanced memory in the combination ***,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain *** inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were ***:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.

关键词： Alzheimer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

Diagnostic accuracy of ePOS score in predicting DNR labeling after ICU admission:A prospective observational study(ePOS-DNR)

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Journal of Intensive Medicine 2024年第2期4卷 216-221页

作者： omar E.Ramadan Ahmed F.Mady Mohammed A.Al-Odat Ahmed N.Balshi Ahmed W.Aletreby Taisy J.Stephen Sheena R.Diolaso Jennifer Q.Gano waleed Th.Aletreby Department of Critical Care King Saud Medical CityRiyadhSaudi Arabia Anesthesia Department Faculty of MedicineAin Shams UniversityCairoEgypt Anesthesia Department Faculty of MedicineTanta UniversityTantaEgypt Faculty of Medicine Alexandria UniversityAlexandriaEgypt Nursing Department King Saud Medical CityRiyadhSaudi Arabia

Background Resuscitation can sometimes be futile and making a do-not-resuscitate(DNR)decision is in the best interest of the *** electronic poor outcome screening(ePOS)score was developed to predict 6-month poor outcomes of critically ill *** explored the diagnostic accuracy of the ePOS score in predicting DNR decisions in the intensive care unit(ICU).Methods This study was conducted at the ICU of a tertiary referral hospital in Saudi Arabia between March and May ***,we calculated ePOS scores for all eligible consecutive admissions after 48 h in the ICU and recorded the DNR *** ability of the score to predict DNR was explored using logistic ***'s ideal cut-off value was calculated using the DeLong method,and different diagnostic accuracy measures were generated with corresponding 95%confidence intervals(CIs).Results We enrolled 857 patients,125 received a DNR order and 732 did *** average ePOS score of DNR and non-DNR patients was 28.2±10.7 and 15.2±9.7,*** score,as a predictor of DNR order,had an area under receiver operator characteristic(AUROC)curve of 81.8%(95%CI:79.0 to 84.3,P17 was associated with a sensitivity of 87.2(95%CI:80.0 to 92.5,Phis study,the ePOS score performed well as a diagnostic test for patients who will be labeled as DNR during their ICU stay.A cut-off score>17 may help guide clinical decisions to withhold or commence resuscitative measures.

关键词： Do-not-resuscitate(DNR) Resuscitation Intensive care unit(ICU) Diagnostic accuracy Sensitivity Specificity

Microalgae cultivation in photobioreactors: sustainable solutions for a greener future

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Green Chemical Engineering 2024年第4期5卷 418-439页

作者： Shaikh Abdur Razzak Khairul Bahar K.M.Oajedul Islam Abdul Khaleel haniffa Mohammed omar Faruque S.M.Zakir hossain Mohammad M.hossain Chemical Engineering Department King Fahd University of Petroleum and Minerals Center for Refining and Advanced Chemicals King Fahd University of Petroleum & Minerals Department of Chemical Engineering University of Bahrain

Microalgae cultivation in photobioreactors（PBRs） has emerged as a promising and sustainable approach to address various environmental and energy challenges, offering a multitude of benefits across diverse *** developments in microalgae cultivation in photobioreactors have contributed substantially to the development and optimization of sustainable bioprocesses. This review presents a comprehensive analysis of recent innovations and breakthroughs in the field of microalgae cultivation, with a specific focus on their application in photobioreactors, aimed at paving the way for a greener future. This study in-depth examines the advantages of microalgae cultivation in photobioreactors, concentrating on its effectiveness in wastewater treatment, CO2bioremediation, and the production of biofuels and high-value products. The review evaluates the effects of light,solar irradiation, temperature, nitrogen and phosphorus concentrations in culture media, CO2concentrations, and ph on microalgae growth performance, including specific growth and biomass productivity. The study also examines open systems like unstirred ponds, raceway ponds, and circular ponds and closed systems like horizontal tubular, vertical bubble-column, airlift, flat panel, and plastic-bag photobioreactors, comparing their pros and cons. To optimize microalgae cultivation, key factors in photobioreactor design, including photosynthetic efficiencies, light/dark（L/D） cycles, CO2concentrations, mass transfer, hydrodynamics behavior, and p h, are extensively investigated. In addition, the review outlines recent developments in large-scale photobioreactors and highlights the challenges and opportunities associated with photobioreactor scale-up and design parameter optimization, including genetic engineering and economic feasibility. This article is a vital resource for researchers, engineers, and industry professionals seeking sustainable bioprocesses and the application of microalgae-based technol

关键词： Microalgae biomass CO 2 biofixation Wastewater treatment Biofuel Photobioreactors