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Effects of mRNA, Protein Expression and Activity for Myocardial SOD2 by a Single Bout of or Long-Term Strenuous Endurance Exercise in Rats

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chinese Medicine 2014年第4期5卷 251-258页

作者： simao Xu Weichun Liu Minhua Li Department of Physical Education Guangxi Normal University Guilin China

Objective: To explore the effects of myocardial SOD2 by strenuous endurance exercise. Methods: 27 grown male SD rats were randomly divided into control group (c), a single bout of strenuous endurance exercise group (E1) and seventh-week strenuous endurance exercise group (E2). Real-time PcR was used to observe the changes of mRNA expression for myocardial SOD2. Western bolt was used to observe the changes of SOD2 protein expression. In addition, SOD2, T-SOD and SOD1 activity changes were observed. Results: Myocardial SOD2 expression level at mRNA and protein of Group E1, E2 was significantly higher than that in group c, and SOD2 and T-SOD activity in group E2 were significantly higher than those in group c. Those changes were more obvious in group E2. conclusions: Strenuous endurance exercise can improve level of myocardial SOD2 expression at mRNA and protein, and enhance the activity for SOD2, thus increasing the activity for T-SOD. Effect of long-term strenuous endurance exercise was better than a single bout of one.

关键词： SOD2 Strenuous Endurance Exercise Myocardia

Notification Oriented Paradigm(NOP)and Imperative Paradigm:A comparative Study

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Journal of Software Engineering and Applications 2012年第6期5卷 402-416页

作者： Jean M.simao cesar A.Tacla Paulo c.Stadzisz Roni F.Banaszewski Graduate School in Electrical Engineering&Industrial computer Science(cPGEI) Federal University of Technology of Paraná(UTFPR)CuritibaBrazil Graduate School of Applied computing(PPGcA) Federal University of Technology of Paraná(UTFPR)CuritibaBrazil.

This paper presents a new programming paradigm named Notification Oriented Paradigm (NOP) and analyses performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which allows better performance, causal-knowledge organization, and entity decoupling than standard solutions based upon current paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions thanks to the concept of high-level programming. However, they are considered slower to execute and lesser flexible to program than IP. Anyway, both paradigms present similar drawbacks like causal-evaluation redundancies and strongly coupled entities, which decrease software performance and processing distribution feasibility. These problems exist due to an orientation to monolithic inference mechanism based upon sequential evaluation by means of searches over passive computational entities. NOP proposes another manner to structure software and make its inferences, which is based upon small, smart, and decoupled collaborative entities whose interaction happen by means of precise notifications. This paper discusses NOP as a paradigm and presents certain comparison of NOP against IP. Actually, performance is evaluated by means of IP and NOP programs with respect to a same application, which allow demonstrating NOP superiority.

关键词： Notification Oriented Paradigm Notification Oriented Inference NOP and IP comparison

Environmental Forensic Investigation in the Residential Neighborhood Volta Grande IV,Volta Redonda,RJ,Brazil,Using TPH and PAHs Analyses in Soil Samples

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Journal of Environmental Protection 2019年第7期10卷 972-991页

作者： Jose c.R.Gouvea Jr. Fernando simao e Silva Reginaldo A.Bertolo Tiago R.Moura Stephen Emsbo-Mattingly cEPAS—Groundwater Research center University of Sao PauloIGc-USPSao PauloBrazil NewFields Rio de JaneiroBrazil NewFields RocklandMassachusettsUSA

This article presents the results of a forensic investigation concerning the origin of hydrocarbons detected in the subsurface soil of the residential neighborhood Volta Grande IV, Volta Redonda, RJ, Brazil. Previous investigations identified several areas with concentrations of volatile organic compounds (VOcs) and polycyclic aromatic hydrocarbons (PAHs) above the Brazilian regulatory standards of cONAMA 420/2009 within the study area. concern was raised that these hydrocarbons might be derived from local steel mill wastes. This forensic investigation determined that the VOcs in the residential soil are associated with gasoline and possibly diesel fuel oil releases into the subsurface soils that are not associated with the steel mill waste. The PAHs in residential subsurface soil generally fell below background concentrations and are likely associated with regional soot. The PAHs in the three samples with concentrations above background (out of a total of thirty-six samples) exhibit compositional features similar to coal byproducts, such as tar and coke, possibly attributable to the steel mill operation. This work discusses the geoforensic data and chemical signatures that support these findings.

关键词： Environmental Forensic Investigation Hydrocarbons Fingerprinting Polycyclic Aromatic Hydrocarbons

Derivation Method for Determining Sorbitol in Fruit Trees

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American Journal of Plant Sciences 2014年第23期5卷 3457-3463页

作者： Regina celia Faria simao canesin William Deodato Isique Salatier Buzetti Juliana Aparecida de Souza University of Sao Paulo State(UNESP) Ilha Solteira CampusIlha SolteiraBrazil

The goal of this study is to describe a methodology for the analysis of D-sorbitol using benzyl alcohol as derivatizing agent and liquid chromatography equipped with a diode-array detector (HPLc-DAD). The study was performed at the University of São Paulo State (UNESP), Ilha Solteira campus, Brazil. The axillary buds of fruit trees were collected from the UNESP Teaching and Research Farm. Benzyl alcohol was used as derivatizing agent to extract D-sorbitol from the buds. Next, the D-sorbitol underwent solid phase extraction (SPE) using c18 cartridges and was then analyzed by liquid chromatography (HPLc-DAD). The HPLc-DAD derivatization method proposed showed excellent chromatography resolution and high accuracy in the separation of D-sorbitol (derivatized) for the axillary buds of avocado, black mulberry, Japanese pear and peach and also enabled eliminating the use of hazardous derivatizing agents.

关键词： Benzyl Alcohol Polyols HPLc-DAD

运动经PKc-Nrf2途径调节肝HO-1表达及抗氧化能力的研究

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广西师范大学学报（自然科学版） 2017年第1期35卷 113-118页

作者：李国峰许思毛广西师范大学体育学院广西桂林541006

为探讨规律耐力运动通过PKc-Nrf2途径提高大鼠肝血红素加氧酶-1(HO-1)表达及抗氧化能力(T-AOc)的效应,将24只成年雄性SD大鼠随机分为安静对照组(A)、运动组(B)与白屈菜赤碱运动组(c)。B、c组进行8周较大强度的持续耐力跑,但c组在每次运... 详细信息

为探讨规律耐力运动通过PKc-Nrf2途径提高大鼠肝血红素加氧酶-1(HO-1)表达及抗氧化能力(T-AOc)的效应,将24只成年雄性SD大鼠随机分为安静对照组(A)、运动组(B)与白屈菜赤碱运动组(c)。B、c组进行8周较大强度的持续耐力跑,但c组在每次运动前进行PKc抑制剂即白屈菜赤碱(cHE)处理。实验中观察各组肝细胞膜PKc及肝细胞总PKc的活性水平,Western Blotting观察肝细胞核Nrf2及肝细胞HO-1的蛋白表达水平,以及观察肝细胞HO-1活性和T-AOc水平,结果发现:与A组相比,B组肝细胞膜PKc及肝细胞总PKc的活性显著升高、细胞膜PKc活性/肝细胞总PKc活性的值显著升高(Pc等均显著升高(Pc组中被明显遏制。综上可见,较大强度的规律耐力运动可经过PKc-Nrf2途径,诱导肝细胞HO-1蛋白表达而提高肝脏抗氧化能力。

关键词：耐力运动肝脏蛋白激酶c 核因子E2相关因子2 血红素加氧酶

Notification Oriented and Object Oriented Paradigms comparison via Sale System

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Journal of Software Engineering and Applications 2012年第9期5卷 695-710页

作者： Jean M.simao Danillo L.Belmonte Adriano F.Ronszcka Robson R.Linhares Glauber Z.Valenca Roni F.Banaszewski Joao A.Fabro cesar A.Tacla Paulo c.Stadzisz Márcio V.Batista Graduate School in Electrical Engineering&Industrial computer Science(cPGEI) Federal University of Technology-ParanáCu-ritibaBrazil Graduate School of Applied computing(PPGcA) Federal University of Technology-ParanáCuritibaBrazil

This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow causal-knowledge organization and decoupling better than standard solutions based upon current paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and lesser flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease software performance and processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based on sequential evaluation searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based on small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. This paper presents a quantitative comparison between two equivalent implementations of a sale system, one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in c++ and other developed according to the principles of NOP based on a NOP framework in c++. The results showed that NOP implementation obtained quite equivalent results with respect to OOP implementation. This happened because the NOP framework uses considerable expensive data-structures over c++. Thus, it is necessary a new compiler to NOP in order to actually use its potentiality.

关键词： Notification Oriented Paradigm Notification Oriented Inference NOP and OOP comparison

A Game comparative Study:Object-Oriented Paradigm and Notification-Oriented Paradigm

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Journal of Software Engineering and Applications 2012年第9期5卷 722-736页

作者： Jean M.simao Danillo L.Belmonte Glauber Z.Valenca Márcio V.Batista Robson R.Linhares Roni F.Banaszewski Joao A.Fabro cesar A.Tacla Paulo c.Stadzisz Adriano F.Ronszcka Graduate School in Electrical Engineering&Industrial computer Science(cPGEI) Federal University of Technology-ParanáCu-ritibaBrazil Graduate School of Applied computing(PPGcA) Federal University of Technology-ParanáCuritibaBrazil

This paper presents a new programming paradigm named Notification-Oriented Paradigm (NOP) and analyses the performance aspects of NOP programs by means of an experiment. NOP provides a new manner to conceive, structure, and execute software, which would allow better performance, causal-knowledge organization, and decoupling than standard solutions based upon usual paradigms. These paradigms are essentially Imperative Paradigm (IP) and Declarative Paradigm (DP). In short, DP solutions are considered easier to use than IP solutions due to the concept of high-level programming. However, they are considered slower in execution and less flexible in development. Anyway, both paradigms present similar drawbacks such as redundant causal-evaluation and strongly coupled entities, which decrease the software performance and the processing distribution feasibility. These problems exist due to an orientation to a monolithic inference mechanism based upon sequential evaluation by searching on passive computational entities. NOP proposes another way to structure software and make its inferences, which is based upon small, collaborative, and decoupled computational entities whose interaction happens through precise notifications. In this context, this paper presents a quantitative comparison between two equivalent implementations of a computer game simulator (Pacman simulator), one developed according to the principles of Object-Oriented Paradigm (OOP/IP) in c++ and other developed according to the principles of NOP. The results obtained from the experiments demonstrate, however, a quite lower performance of NOP implementation. This happened because NOP applications are still developed using a framework based on c++. Besides, the paper shows that optimizations in the NOP framework improve NOP program performance, thereby evidencing the necessity of developing a NOP language/compiler.

关键词： Notification Oriented Paradigm Notification Oriented Inference NOP and OOP comparison

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核热火箭反应堆燃料对比分析

载人航天 2018年第6期24卷 784-795页

作者：王三丙马元郭斯茂谢奇林中国工程物理研究院核物理与化学研究所四川绵阳621900 中国航天科技集团公司第六研究院十一所陕西西安710100

针对核热推进反应堆核燃料的制备与考核问题,回顾了美国与苏联/俄罗斯在核热推进方面的研究,通过各种耐高温核燃料的热物性比较,给出了潜在可行的核燃料类型,并对未来最有潜力的钨基金属陶瓷燃料(cERMET燃料)与(U、Zr)c固溶体燃料进行... 详细信息

针对核热推进反应堆核燃料的制备与考核问题,回顾了美国与苏联/俄罗斯在核热推进方面的研究,通过各种耐高温核燃料的热物性比较,给出了潜在可行的核燃料类型,并对未来最有潜力的钨基金属陶瓷燃料(cERMET燃料)与(U、Zr)c固溶体燃料进行了热物性参数、氢腐蚀考核等性能参数的研究对比分析。可为未来核热推进反应堆设计提供参考。

关键词：核热推进核燃料热物性热膨胀系数氢腐蚀

狗肝菜多糖对二甲基亚硝胺诱导的肝纤维化大鼠TGF-β1/Smads信号通路的影响

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中药药理与临床 2016年第6期32卷 113-117页

作者：高雅张可兰黄思茂曹后康张可锋桂林医学院桂林541004 甘肃省中医院兰州730050

目的:以二甲基亚硝胺(DMN)诱导的大鼠肝纤维化为模型,研究狗肝菜多糖对DMN诱导的肝纤维化大鼠TGF-β1/Smads信号通路的影响。方法:将96只大鼠随机分为对照组、模型组、狗肝菜多糖(300 mg/kg,200 mg/kg,100 mg/kg)组和秋水仙碱组(0.12 mg... 详细信息

目的:以二甲基亚硝胺(DMN)诱导的大鼠肝纤维化为模型,研究狗肝菜多糖对DMN诱导的肝纤维化大鼠TGF-β1/Smads信号通路的影响。方法:将96只大鼠随机分为对照组、模型组、狗肝菜多糖(300 mg/kg,200 mg/kg,100 mg/kg)组和秋水仙碱组(0.12 mg/kg)。除对照组以外,其余各组大鼠均腹腔注射0.5%DMN溶液(1.5 ml/kg),隔天1次,在首次注射DMN同时,各组大鼠灌胃给予相应的药物,而正常组和模型组灌胃给予相应体积的生理盐水溶液,每天给药1次,连续5周,5周末眼球取血,脱臼致死,收取肝脏。生化法检测血清中碱性磷酸酶(ALP)、谷氨酰氨基转移酶(GGT)水平;酶联免疫法检测(ELISA)血清中透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PcⅢ)和Ⅳ型胶原(Ⅳ-c)含量。苏木精-伊红染色(HE染色)进行肝组织病理学检查;蛋白质印迹法(Western blot)检测肝组织a-平滑肌肌动蛋白(a-SMA)、转化生长因子β1(TGF-β1)和Smad2/3/7的蛋白表达情况。结果:与模型组比较,经狗肝菜多糖(300 mg/kg,200 mg/kg,100 mg/kg)组干预后,血清中ALP、GGT、HA、LN、PcⅢ和Ⅳ-c水平显著降低;肝组织中a-SMA、TGF-β1、Smad2/3的蛋白表达被抑制,而Smad7的表达得到促进;病理切片显示肝纤维化大鼠肝组织炎症坏死程度和肝纤维化病变程度较模型组明显减轻。结论:狗肝菜多糖具有抗DMN诱导的大鼠肝纤维化的作用,其机制与TGF-β1/Smads信号通路相关因子的表达有关。

关键词：狗肝菜多糖肝纤维化 TGF-β1/Smads 信号通路