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Functional self-assembling peptide nanofiber hydrogel for peripheral nerve regeneration

Regenerative Biomaterials 2017年第1期4卷 21-30页

作者： Xiaoli Wu Liumin He Wen Li Heng Li wai-man wong Seeram Ramakrishna Wutian Wu Department of Anatomy School of Biomedical ScienceLKS Faculty of MedicineThe University of Hong Kong21 Sassoon RoadHong Kong SARChina State Key Laboratory of Brain and Cognitive Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPokfulam21 Sassoon RoadHong Kong SARChina Joint Laboratory of Jinan University and the University of Hong Kong GHM Institute of CNS RegenerationJinan University601 Huangpu Avenue WestGuangzhou510632China Department of Mechanical Engineering Faculty of EngineeringCenter for Nanofibers and NanotechnologyNational University of Singapore117576SingaporeSingapore.

Peripheral nerves are fragile and easily damaged,usually resulting in nervous tissue loss,motor and sensory function *** in neuroscience and engineering have been significantly contributing to bridge the damage nerve and create permissive environment for axonal regrowth across *** have successfully designed two self-assembling peptides by modifying RADA 16-I with two functional motifs IKVAV and *** hydrogel formed when combing the two neutral solutions together,defined as RADA 16-Mix that overcomes the main drawback of RADA16-I associated with low *** the present study,we transplanted the RADA 16-Mix hydrogel into the transected rat sciatic nerve gap and effect on axonal regeneration was examined and compared with the traditional RADA16-I *** regenerated nerves were found to grow along the walls of the large cavities formed in the graft of RADA16-I hydrogel,while the nerves grew into the RADA 16-Mix hydrogel toward distal *** 16-Mix hydrogel induced more axons regeneration and Schwann cells immigration than RADA16-I hydrogel,resulting in better functional recovery as determined by the gait-stance duration percentage and the formation of new neuromuscular junction ***,our results indicated that the functional SAP RADA16-Mix nanofibrous hydrogel provided a better environment for peripheral nerve regeneration than RADA16-I hydrogel and could be potentially used in peripheral nerve injury repair.

关键词： Peripheral nerve regeneration self-assembling peptide IKVAV RGD nanofibrous hydrogel

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Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation

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World Journal of Gastroenterology 2005年第34期11卷 5362-5366页

作者： Annie OO Chan Cecilia Cheng wai Mo Hui Wayne HC Hu Nina YH wong KF Lam wai man wong Kam Chuen Lai Shiu Kum Lam Benjamin CY wong Department of Medicine the University of Hong Kong Hong Kong China Division of Social Science the Hong Kong University of Science and Technology Hong Kong China Department of Medicine the University of Hong Kong Hong Kong China Department of Statistics the University of Hong Kong Hong Kong China

AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 ***: Constipation was diagnosed by Rome Ⅱ *** ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were ***: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P＜0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology.

关键词： Constipation Anorectal physiology Coping mechanism

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Digital Rights management for a Chinese XML Text Centre

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现代图书情报技术 2002年第S1期 172-177页

作者： wai -man wong(The Open University of Hong Kong Library,Hong Kong,China)

The Electronic Text Centre of the OpenUniversity of Hong Kong(OUHK)has been in full operationsince early *** currently houses 7,300+electronictexts,including free electronic titles,electronic titlespurchased directly from the market,and about,1,000 locallyproduced electronic *** locally produced titles are notavailable in the market but require local digitization andnegotiation with publishers with regard to the right to use(RTU)them so as to meet the learning needs of the ***...

关键词： Text Digital Rights management for a Chinese XML Text Centre XML

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Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease

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World Journal of Gastroenterology 2006年第18期12卷 2923-2927页

作者： William Ng wai-man wong wai-Hong Chen Hung-Fat Tse Pui-Yin Lee Kam-Chuen Lai Sheung-wai Li Matthew Ng Kwok-Fai Lam Xi Cheng Chu-Pak Lau Division of Cardiology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Gastroenterology University Department of Medicine Queen Mary Hospital Hong Kong SAR China Division of Rehabilitation Medicine University Department of Medicine Queen Mary Hospital Hong Kong SAR China Department of Statistics and Actuarial Science University of Hong Kong Hong Kong SAR China

AIM： The use of low-dose aspirin to prevent cardiovascular disease events is well established. However, the incidence and predictors of upper gastrointestinal bleeding （UGIB） with its use are unknown. We studied prospectively the incidence and outcome of peptic ulceration in low-dose aspirin users. METHODS： A total of 991 patients with coronary artery disease （CAD） on low-dose aspirin were prospectively followed-up for two years for the occurrence and clinical features of first hospitalized episode of UGIB. RESULTS： UGIB had a bimodal presentation with 45% occurring within four months of aspirin initiation and had an overall prevalence of 1.5% per year. There was no UGIB-related death. Hypertension （OR = 4.6, 95%CI 1.5 - 14.7, P = 0.009）, history of peptic ulceration （OR = 3.1, 95%CI 1.1 - 9.0, P = 0.039）, tertiary education （OR = 3.08, 95%CI 1.1 - 9.0, P = 0.039） and higher lean body mass （P = 0.016） were independent factors associated with UGIB. Use of nitrate did not reduce UGIB. CONCLUSION： The incidence of UGIB in patients with CAD on long-term low-dose aspirin is low, but is accompanied with significant morbidity. With prolonged use of aspirin, UGIB continues to be a problem for those with risk factors and especially in patients with a history of peptic ulcers, in which UGIB tends to occur early after aspirin therapy.

关键词： Coronary artery disease, Aspidn Gastrointestinal bleeding

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Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?

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World Journal of Gastroenterology 2003年第6期9卷 1265-1269页

作者： Harry Hua-Xinag Xia Shiu Kum Lam wai man wong Wayne Hsing Cheng Hu Kam Chuen Lai Sau Hing wong Suet Yi Leung Siu Tsan Yuen Nicholas A.Wright Benjamin Chun-Yu wong Department of Medicine The University of Hong KongHong Kong SARChina Department of Pathology The University of Hong KongHong Kong SARChina Histopathology Unit London Research InstituteCancer ResearchUK

AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients ***-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.

关键词：胃溃疡幽门螺杆菌感染胃粘膜活组织检查

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Design, Synthesis, Photophysical Studies and Electrochemistry of Carbazole-, Oxadiazole-, and Oxadiazole-Triarylamine-Containing Rhenium(Ⅰ) Diimine Alkynyl Complexes

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Chinese Journal of Chemistry 2014年第10期32卷 1015-1021页

作者： wai-Kin Chung Keith man-Chung wong Vivian Wing-Wah Yam and Department of ChemistryThe University of Hong KongPokfulam RoadHong KongChina

A series of rhenium(I)diimine alkynyl complexes with various electron-and hole-transporting moieties has been synthesized and *** electronic absorption,emission and electrochemical properties have also been studied.

关键词： electrochemistry luminescence metal alkynyl rhenium(Ⅰ)diimine,UV/Vis spectroscopy

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A landscape of β-Ga_(2)O_(3) Schottky power diodes

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Journal of Semiconductors 2023年第9期44卷 47-56页

作者： man Hoi wong Department of Electronic and Computer Engineering Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

β-Ga_(2)O_(3) Schottky barrier diodes have undergone rapid progress in research and development for power electronic *** paper reviews state-of-the-art β-Ga_(2)O_(3) rectifier technologies,including advanced diode architectures that have enabled lower reverse leakage current via the reduced-surface-field *** device properties including onresistance,breakdown voltage,rectification ratio,dynamic switching,and nonideal effects are summarized for the different *** results on the high-temperature resilience of β-Ga_(2)O_(3) Schottky diodes,together with the enabling thermal packaging solutions,are also presented.

关键词： β-Ga_(2)O_(3) Schottky diodes power device edge termination nickel oxide

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SMA molecular line survey towards the massive star-forming region G10.6-0.4in W31complex

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Research in Astronomy and Astrophysics 2018年第11期18卷 29-42页

作者： wai-Ho wong Tao An Key Laboratory of Radio Astronomy Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China

Line surveys of complex molecules with millimeter and sub-millimeter telescopes are important for probing the physical and chemical environments of massive star forming regions(MSFRs).We present a molecular line survey with the Submillimeter Array(SMA) in the frequency ranges of 220.3–222.3 GHz and 230.3–232.3 GHz toward G10.6-0.4, the brightest star forming core in the W31 complex. Ninety-nine transitions from 22 molecular species and their isotopologues are identified. The moment 0 images of typical molecules show a compact core which is concentrated at the continuum peak position. Based on the local thermodynamic equilibrium assumption, the molecular line data are modeled. The rotational temperatures of those molecular species range from 96 to 178 K and their column densities range from 2.0×1014to 3.7×1017cm-2. The observational data suggest that all complex molecules are located in a warm environment. Chemical environments of the molecules are discussed. We compared molecular abundances and gas temperatures in G10.6-0.4 with those in other MSFRs, and found that gas temperatures and fractional abundances of specific molecules in G10.6-0.4 are similar to the typical MSFR W51 North, suggesting that there are similar physical and chemical environments in these two MSFRs.

关键词： stars: formation ISM: abundances ISM: individual objects: G10.6-0.4 ISM: molecules radio lines: ISM

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Interplay of laser power and pore characteristics in selective laser melting of ZK60 magnesium alloys:A study based on in-situ monitoring and image analysis

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Journal of Magnesium and Alloys 2024年第4期12卷 1346-1366页

作者： Weijie Xie Hau-Chung man Chi-wai Chan Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHong KongChina School of Mechanical and Aerospace Engineering Queen’s UniversityBelfast BT95AHUK Research Institute for Advanced manufacturing The Hong Kong Polytechnic UniversityHong KongChina

This study offers significant insights into the multi-physics phenomena of the SLM process and the subsequent porosity characteristics of ZK60 Magnesium(Mg)***-speed in-situ monitoring was employed to visualise process signals in real-time,elucidating the dynamics of melt pools and vapour plumes under varying laser power conditions specifically between 40 W and 60 *** morphological analysis was performed using Scanning-Electron Microscopy(SEM),demonstrating a critical correlation between laser power and pore *** laser power led to increased pore coverage,whereas a denser structure was observed at higher laser *** laser power influence on porosity was further confirmed via Optical Microscopy(OM)conducted on both top and cross-sectional surfaces of the *** increase in laser power resulted in a decrease in pore coverage and pore size,potentially leading to a denser printed part of Mg alloy.X-ray Computed Tomography(XCT)augmented these findings by providing a 3D volumetric representation of the sample internal structure,revealing an inverse relationship between laser power and overall pore *** laser power appeared to favour the formation of interconnected pores,while a reduction in interconnected pores and an increase in isolated pores were observed at higher *** interplay between melt pool size,vapour plume effects,and laser power was found to significantly influence the resulting porosity,indicating a need for effective management of these factors to optimise the SLM process of Mg alloys.

关键词： Selective laser melting(SLM) Magnesium(Mg)alloys Biodegradable implants Porosity In-situ monitoring

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Effect of Rorrico, extracted from group of Chinese medicines, on influenza A and H1N1 infections

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Journal of Traditional Chinese Medicine 2016年第6期36卷 701-705页

作者： Shiu Hon Chui Yee Hou wong Ming Yiu Fong Yee man Chiu Christopher wai Kei Lam State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and Health Macao University of Science and Technology Clinical Laboratory Diagnostix Medical Center Central

OBJECTIVE: To investigate the therapeutic and preventive effects of Rorrico on influenza, especially influenza A viral infection, including swine flu(H1N1)in ***: Eighty-nine subjects were recruited in Hong Kong and Macao, and divided into treatment group(TG) and prevention group(PG) based on their influenza A and swine flu symptoms. All subjects were prescribed Rorrico or placebo, and monitored by a Chinese medicine practitioner. Blood samples were collected before and after 7-day Rorrico or placebo treatment for laboratory ***: After treatment, there were some full recoveries and obvious relief of onset symptoms in the TG. Blood test results showed that Rorrico produced(a) no adverse effects on subjects' renal andliver functions, muscle enzyme and hematological status,(b) no up-regulation of pro-inflammatory cytokines tumour necrosis factor-a and interleukin-18 in both TG and PG,(c) mild yet statistically significant elevation of plasma mannose-binding lectin(MBL) in ***: Rorrico has no up-regulating effect on the participants' immune response, or, equally likely, the immuno-modulatory effects of Rorrico do not non-specifically or unnecessarily promote inflammation when not required. It is possible that oral administration of Rorrico can promote hepatic synthesis of MBL in healthy PG subjects, thereby conferring increased protection against infection.

关键词： Rorrico Influenza A Virus H1N1 Subtype Tumor necrosis factor-alpha Interleukin-18

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