Background: Identification of risk factors for the development of hepatocellul ar carcinoma (HCC) is important for HCC surveillance in chronic hepatitis B viru s (HBV) infection. Our aim was to study the independent r...
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Background: Identification of risk factors for the development of hepatocellul ar carcinoma (HCC) is important for HCC surveillance in chronic hepatitis B viru s (HBV) infection. Our aim was to study the independent risk factors and effect of HBV genotypes on HCC development in a prospective longitudinal cohort of chro nic hepatitis B patients. Patients and methods: Chronic hepatitis B patients rec ruited since 1997 were prospectively followed up for the development of HCC. HCC was diagnosed by a combination of αfetoprotein, imaging, and histology. Liver cirrhosis was defined as ultrasonic features of cirrhosis together with hyperspl enism, ascites, varices, and/or encephalopathy. Results: In total, 426 patients were followed up for 1664 person years; median 225 (range 12-295) weeks. Forty nine (11%) patients had underlying clinical liver cirrhosis. A total of 242 (57 %) and 179 (42%) patients had HBV genotypes C and B, respectively. Twenty five patients developed HCC in a median follow up of 121 (range 14-236) weeks. The overall incidence of HCC was 1502 cases per 100 000 person years. On multivariat e analysis, clinical liver cirrhosis and HBV genotype C infection were independe ntly associated with HCC development,with an adjusted relative risk of 10.24 (95 %confidence interval (CI) 4.39-23.89; p hosis.
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