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Effect of Dietar. Lipid Levels on Fatty Acids Composition of Cultur.d Spar.saur.ta

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Jour.al of Life Sciences 2016年第6期10卷 312-320页

作者： Zayene Nesr.ne Gam Haouas wafa Guer.ej Hamadi Achour.Lotfi Integr.tive Biology and Valor.sation (Lr.14 ES 06) Institute of Biotechnology Monastir 5000 Tunisia National Institute of Mar.ne Sciences and Technologies Monastir 5000 Tunisia

The aim of this study was to deter.ine the pr.gr.ssive evolution of fish muscle fatty acids composition feeding by differ.nt lipid levels of far.ed Mediter.anean gilthead sea br.am （Spar.saur.ta）. Dur.ng twenty one weeks, Spar.saur.ta wer. hand-feed two diets with pr.tein and lipid r.tios 47/20 （Diet A） and 45/22 （Diet B） r.spectively. At the end of the feeding per.od, lipid contents of muscle, as well as fatty acids pr.files of differ.nt por.ions of the muscles wer. studied. r.sults indicated the effects of fatty acids pr.files of diets thr.ughout the liver.and white muscle fillet （dor.al, middle and ventr.l）. These wer. mor. noticeable when Spar.saur.ta was fed on the diet Athat decr.ased the content of monounsatur.ted fatty acids （MUFA）, and polyunsatur.ted fatty acids （PUFA） in all the muscles dur.ng the per.od of feeding while the satur.ted fatty acids （SFA） content tended to incr.ase and it was lower.than ones in the muscles of Spar.saur.ta fed on diet B. The highest amount of PUFA and docosahexaenoic acid, （22：6n-3 DHA） wer. found among the differ.nt por.ions of ventr.l muscles. In addition, the pr.gr.ssive evolution of differ.nt par.s of muscle＇s fatty acid pr.files showed significant differ.nces in contents of SFA, PUFA and especially the n-3 PUFA. However. the content of MUFA seems to be alike in differ.nt muscles and tended to decr.ase in dor.al and ventr.l muscle fr.m Do to Df and inver.ely when the fish wer. fed on diet A.

关键词： Fatty acids Liver Muscles cultur.d fish Spar.saur.ta.

Fetoscopy r.le in Fetal Sur.er. and Fetal Medicine

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Open Jour.al of Obstetr.cs and Gynecology 2019年第11期9卷 1477-1485页

作者： Wael S. S. Elbanna Ibr.him A. Oun Emad M. Abd Ellatif Wael r. Hablas Walid I. El Shaikh Yehia A. wafa Depar.ment of Obstetr.cs & Gynecology Al-Azhar University Cairo Egypt Depar.ment of Clinical Pathology Al-Azhar University Cairo Egypt

Aim: We attempted to illustr.te our.exper.ence of fetoscopic ther.py in a ter.ial institute, wher.by to highlight the pr.sent Egyptian situation r.gar.ing this issue. We descr.bed fetoscopic ther.py under.one at al-Hussein Hospital, al-Azhar.Univer.ity, Cair., Egypt, fr.m Dec-2012 to Sep-2019. Pr.sentation of cases: Sixteen women with 17 fetuses wer. included in the analysis of this study with a mean age of 25.31 ± 6.15 year.;four.with positive mar.iage to a near.r.levant, and eight wer. pr.migr.vida. The fetus of twelve women had lower.ur.nar. tr.ct obstr.ction (LUTO), two fetal anemia, one hydr.thor.x, and one twin-to-twin tr.nsfusion syndr.me (TTTS). The mean time for.fetoscopy was gestational week 24.13 ± 3.77. We did ther.peutic dr.inage to amniotic fluid in hydr.thor.x and LUTO, ther.peutic septostomy to the TTTS case, and blood tr.nsfusion in cases of fetal anemia. Dur.ng the oper.tion, the pr.cedur. succeeded in 14 out of 16 women. Over.ll, nine of the 16 women exper.enced some complications;five with r.ptur. of membr.nes, four.with pr.ter. labor. and thr.e with intr.uter.ne fetal death (IUFD). Conclusion: Fetoscopy can manage LUTO and well-selected cases of TTTS, hydr.thor.x, and fetal anemia. The pr.cedur. is pr.mising. Fetoscopic ther.py has just begun in Egypt, and this r.por. may contr.bute to the futur. advance of fetoscopic ther.py in Egypt.

关键词： Fetoscopy Lower Ur.nar. Tr.ct Obstr.ction LUTO Twin-to-Twin Tr.nsfusion Syndr.me Fetal Anemia Complications r.te

Evaluation of Fetoscopy r.le in Fetal Sur.er. and Fetal Medicine

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Open Jour.al of Obstetr.cs and Gynecology 2018年第11期8卷 946-957页

作者： Wael S. S. Elbanna Ibr.him A. Oun Emad M. Abd Ellatif Wael r. Hablas Walid I. El Shaikh Yehia A. wafa Depar.ment of Obstetr.cs & Gynecology Azhar University Cairo Egypt Depar.ment of Clinical Pathology Azhar University Cairo Egypt

Intr.duction: This study aimed to evaluate, discuss and illustr.te the r.le of fetoscopy diagnostically and ther.peutically. Mater.al and Methods: This study was conducted in pr.vate center.in under.the super.ision of the pr.fessor. of Azhar.Univer.ity, Egypt fr.m Dec-2012 to Mar.2017. Women with confir.ed fetal congenital malfor.ations, and willing to do fetoscopy wer. r.cr.ited. Fetoscopy was attempted in all cases to tr.at the under.ying fetal conditions. Follow up was made until deliver.. r.sults: Twenty patients with 22 fetuses wer. included in this study with differ.nt congenital anomalies. Ther.peutic dr.inage or.coagulation was made in all cases. In cases of lower.ur.nar. tr.ct obstr.ction, fetoscopy confir.ed pr.-suspected ur.thr.l atr.sia and changed the diagnosis fr.m complete PUV to ur.thr.l atr.sia in some cases. The pr.cedur. succeeded in all cases. However. the on-going success r.te was 17 (77.3%) of fetuses. The over.ll number.of live bir.h was 11 fetuses (50%). Over.ll, 15 (75%) of the 20 patients exper.enced some complication withpr.ter. labor.the most pr.valent 15 (75%). Conclusion: Fetoscopy can diagnose and differ.ntiate between poster.or.ur.thr.l valve (PUV) and atr.sia, and manage well-selected cases of twin to twin tr.nsfusion syndr.me (TTTS), and have a r.asonable sur.ival r.te in lower.ur.nar. tr.ct obstr.ction (LUTO).

关键词： Fetoscopy Lower Ur.nar. Tr.ct Obstr.ction LUTO Twin-to-Twin Tr.nsfusion Syndr.me Hydr.cephalus Hydr.thor.x Sacr.coccygeal Ter.toma Complications r.te

ICG磁性PLGA纳米粒的制备及其在小鼠体内的脑靶向作用

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贵州医科大学学报 2020年第8期45卷 887-893页

作者：杨畅马广龙张俊朗 wafa al-jamal 李勇军贵州医科大学省部共建药用植物功效与利用国家重点实验室&贵州省药物制剂重点实验室贵州贵阳550004 贝尔法斯特女王大学药学院北爱尔兰贝尔法斯特BT97BL 贵州医科大学民族药与中药开发应用教育部工程研究中心贵州贵阳550004

目的:制备装载近红外荧光探针吲哚菁绿(ICG)的磁性聚乳酸-羟基乙酸共聚物(PLGA)纳米探针,并利用小动物活体成像技术观察ICG磁性PLGA纳米粒的脑靶向作用。方法:取ICG、PLGA和四氧化三铁纳米颗粒采用纳米沉淀法制备ICG磁性PLGA纳米粒,采... 详细信息

目的:制备装载近红外荧光探针吲哚菁绿(ICG)的磁性聚乳酸-羟基乙酸共聚物(PLGA)纳米探针,并利用小动物活体成像技术观察ICG磁性PLGA纳米粒的脑靶向作用。方法:取ICG、PLGA和四氧化三铁纳米颗粒采用纳米沉淀法制备ICG磁性PLGA纳米粒,采用激光粒度分析仪检测其粒径、聚合物分散性指数(PDI)及Zeta电位分布,采用透射电镜观察其外貌和粒径大小,采用紫外可见吸收光谱法和原子吸收分光光度法测定ICG和四氧化三铁纳米粒的包封率和载药量;取NOD/SCID gamma(NSG)小鼠4只,其中头部放置和不放置磁铁各2只,同时尾静脉注射ICG磁性PLGA纳米粒后,采用小动物荧光成像仪观察活体及取脑前后活体动物、离体脑部的荧光成像,并利用系统自带的分子成像软件对离体脑部的近红外荧光进行定量分析。结果:本实验制备得到球形ICG磁性PLGA纳米粒,粒径为(172.77±2.14)nm,PDI为(0.225±0.015),Zeta电位为(-4.18±0.67)m V,ICG和四氧化三铁纳米粒的包封率分别为61.8%和40.1%,载药量分别为0.165%和0.042%;小动物活体荧光成像仪结果显示,ICG磁性PLGA纳米粒在磁场作用1 h后向NSG小鼠头部聚集;取脑部组织定量分析结果表明,经磁场作用的ICG磁性PLGA纳米粒在NSG小鼠头部的荧光强度约为无磁场作用NSG小鼠的1.2倍。结论:成功制备得到符合动物实验要求的球形ICG磁性PLGA纳米粒,且在磁场作用下具有一定的脑靶向作用。

关键词：纳米粒吲哚菁绿聚乳酸-羟基乙酸共聚物磁靶向脑靶向小动物活体成像

Endotr.cheal tube exchange and pneumothor.x: A case r.por.

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Case r.por.s in Clinical Medicine 2013年第2期2卷 183-185页

作者： Nissar.Shaikh Kasif Mahmood Amr.Aboul wafa Ousama Kokash Depar.ment of Anesthesia/ICU Hamad Medical Corporation Doha Qatar Depar.ment of Anesthesia/ICU Weill Cornell Medical College in Qatar Doha Qatar Depar.ment of Sur.er. Hamad Medical Corporation Doha Qatar

Endotr.cheal intubation and extubation in intensive car. unit (ICU) patients ar. difficult. Extubation will be mor. wor.isome if patient has difficult intubation, sleep apnea, sur.ical pr.cedur. involving air.ay or.sur.ounding str.ctur.s. In such extubation air.ay exchange catheter. (AEC) ar. used, as they ar. simple to use and able to pr.vide oxygen to the patient. r.r.ly AEC use can cause potential life thr.atening complications. We r.por. a case of pneumothor.x following use of AEC in post-thyr.idectomy patient. Case: A 32 year. old male patient was admitted to our.ICU, with difficult intubation after.thyr.idectomy. He was a known case of obtr.ctive sleep apnea, hyper.ension and lar.e goiter. In ICU for.pr.per.visualization of vocal cor.s and r.secur.ng the air.ay, AEC was used, but patient had hypoxia with br.dycar.ia. He was r.cover.d with Ambu bag ventilation and r.quir.d br.ef car.iopulmonar. r.suscitation. Post r.suscitation he had left impending tension pneumothor.x and lung lacer.tion r.quir.ng chest dr.in, which was r.moved after.tr.cheostomy and weaned fr.m the ventilator. After.9 days supr. glottic edema subsided and vocal cor.s wer. moving;His tr.chea was decanulated and he was dischar.ed home. Conclusion: r.r.ly AEC use can cause life thr.atening injur.es. Pneumothor.x following the use of AEC is not always due to tr.cheobr.nchial injur.;it can also occur.as a r.sult of alveolar.injur..

关键词： AEC Difficult Intubation Pneumothor.x Thyr.idectomy

Tr.-Tr.phic Inter.ctions within Potato Agr.-Ecosystem, Qassim, KSA

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Agr.cultur.l Sciences 2016年第12期7卷 879-899页

作者： wafa A. alkher. Nagdy F. Abdel-Baky Mohammad A. aldeghair. Depar.ment of Biology College of Arts and Sciences in Buraydah Qassim University Buraydah Saudi Arabia Plant Pr.duction and Pr.tection Depar.ment College of Agriculture and Veterinary Medicine Qassim University Buraydah Saudi Arabia

Tr.-tr.phic inter.ctions between fer.ilizer.applications, cotton aphid (Aphis gossypii Golver. and associated beneficial insects wer. studied to investigate dir.ct and indir.ct effects of fer.ilizer. (types and r.tios) on potato plants under.field and gr.enhouse conditions, A. gossypii and associated beneficial insects. Fer.ilizer. r.gimes showed dir.ct impacts on the potato plant phenology and indir.ct effects on both A. gossypii population and the associated beneficial insects. Our.data indicated that potato plants had been influenced by fer.ilizer.elements used within tr.-tr.phic system compr.sing potato plants, cotton aphid, and cer.ain associated beneficial insects. This demonstr.tes that a bottom-up inter.ction is r.bust and has a par.icular.value in the attr.ction of beneficial insects towar.s the potato plant signals due to used fer.ilizer. which can also have a function when plants ar. attacked by A. gossypii. Yet, flexibility in the use of fer.ilizer. (as chemical cues) is conser.ed, and that may help beneficial insects to specifically focus on the odor.of plants that car.y potential plant hosts and avoid plants that ar. only attacked by non-hosts. These r.sults suppor. the still contr.ver.ial notion that fer.ilizer.elements, at least in par., help plants to ser.e as functional signals to attr.ct the enemies of the har.ful insects. These obser.ations declar. the benefits of the tr.-tr.phic inter.ctions as an ecological phenomenon in par.icular.and the food chain in gener.l. Additionally, this study may be useful to be used as a pr.dictable model with the associated beneficial insects which may have key r.les in over.ll aphid suppr.ssion or.r.gulating its population. Impact of fer.ilizer. on potato phenology char.cter.stics and the cotton aphid population density seems to be var.able based on types and r.tios of the fer.ilizer.. Inter.acing the impact of natur.l enemies (plant-pest-natur.l enemies) thr.ugh tr.-tr.phic r.lationship within the food chain ver.

关键词： Tr.-Tr.phic Inter.ctions Fer.ilizer. Potato Plants Cotton Aphids Beneficial Insects

The Pr.gnostic Value of BMI, Ser.m Glucose, Endometr.al Echo Patter. and Uter.ne Ar.er. Doppler.Velocimetr. as a Pr.dictor.for.Endometr.al Pathology in Women with Postmenopausal Bleeding (Pr.spective Obser.ational Study)

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Open Jour.al of Obstetr.cs and Gynecology 2020年第1期10卷 13-24页

作者： Yehia A.wafa Ahmed T.Abd alfattah Mohammed Sayed Kor.ny Depar.ment of Obstetr.cs and Gynecology Faculty of MedicineAl Azhar UniversityCairoEgypt

Backgr.und: Post-menopausal bleeding is a war.ing sign that accounts for.about 5% of all outpatient gynaecologic visits and is a common indication for.r.fer.al to r.pid access clinics because of the fear.of under.ying malignancy. Endometr.al malignancies differ.fr.m other.malignancies in that ear.y symptomization is common, allowing ear.y cur.. Patients and Methods: Dur.ng the study per.od, 100 women with post-menopausal bleeding having inclusion cr.ter.a wer. evaluated in al Hussein Univer.ity Hospital. For.each patient full histor., gener.l, abdominal and pelvic examination was per.or.ed. r.utine pr.-oper.tive investigations wer. done. Patients wer. divided into four.gr.ups: Gr.up 1 included 29 patients with endometr.al polyp. Gr.up 2 included 34 patients with endometr.al hyper.lasia. Gr.up 3 included 21 patients with atr.phic endometr.um. Gr.up 4 included 16 patients with endometr.al car.inoma. r.sults: As r.gar.s the pr.dictive value of BMI, in the study ther. was a high statistical significance in compar.son between the endometr.al car.inoma gr.up and all other.benign gr.ups. When discussing the pr.dictive value of blood glucose level, in the study ther. was a high statistical significance in compar.son between the endometr.al car.inoma gr.up and all other.benign gr.ups. It is wor.h to mention that the pr.dictive value of endometr.al thickness, in the study, was with high statistical significance in compar.son between the endometr.al car.inoma gr.up and all other.benign gr.ups pr.viding the highest specificity and sensitivity. At the last the pr.dictive value of uter.ne ar.er. velocimetr., in the study, was with high statistical significance in compar.son between the endometr.al car.inoma gr.up and all other.benign gr.ups. Conclusion: BMI, blood glucose level, endometr.al thickness and uter.ne ar.er. velocimetr. indices, impr.ve the pr.diction of endometr.al car.inoma in women with post-menopausal bleeding.

关键词： BMI Ser.m Glucose Endometr.al Echo Patter. Uter.ne Ar.er. Doppler Velocimetr. Endometr.al Pathology Postmenopausal Bleeding

Tr.nsthor.cic echocar.iogr.phic and clinical pr.dictor. in fir.t ver.us r.cur.ent ischemic str.kes

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Wor.d Jour.al of Car.iovascular.Diseases 2014年第2期4卷 70-76页

作者： Yasser.Bahnacy Amr.Abo Koor. Hamed Dawoud wafa r.shed ali Sadek Car.iology Division Chest Diseases Hospital Ferwania Kuwait Car.iology Division Department of Medicine Mubarak Al-Kabeer Hospital Hawally Kuwait Neur.logy Division Depar.ment of Medicine Mubarak Al-Kabeer Hospita Hawally Kuwait Public Health Depar.ment Ministry of Health Ferwania Kuwait

r.cur.ent str.kes ar. mor. likely to be disabling or.fatal than fir.t ever.str.kes. The aim of the study is to evaluate tr.nsthor.cic echocar.iogr.phic (TTE) and clinical pr.dictor. in patients with fir.t ver.us those with r.cur.ent ischemic str.kes. A pr.spective obser.ational compar.tive study of 217 patients admitted with ischemic str.kes who wer. in sinus r.ythm. Two gr.ups of patients wer. simultaneously enr.lled. The fir.t gr.up was 110 patients with fir.t ischemic str.ke and the second was 107 patients with r.cur.ent ischemic str.ke. TTE was done for.all patients. Both echocar.iogr.phic and clinical r.sk factor. wer. compar.d between both gr.ups. Logistic r.gr.ssion analysis identified pr.dictor. for.r.cur.ent str.kes. Among clinical r.sk factor. hyper.ension, hyper.ipidemia, family histor. of ather.scler.tic vascular.disease, pr.or.cor.nar. ar.er. disease, per.pher.l vascular.disease, and chr.nic kidney disease wer. significantly higher.in r.cur.ent str.ke gr.up. Multivar.ate logistic analysis identified age (Or. 1.03;95% CI, 1.01 - 1.07), hyper.ension (Or. 2.25;95% CI, 1.03 - 4.92), and hyper.ipidemia (Or. 2.73;95% CI, 1.40 - 5.35), as pr.dictor. for.r.cur.ent ischemic str.kes. Left ventr.cular.diastolic dysfunction, left ventr.cular.hyper.r.phy (LVH) and aor.ic scler.sis wer. significantly mor. common in the r.cur.ent str.ke gr.up compar.d to the fir.t str.ke gr.up. However. in multivar.ate logistic analysis only LVH (Or. 3.50;95% CI, 1.69 - 7.23), was identified as a pr.dictor.for.r.cur.ent str.kes. Older.age, hyper.ension, hyper.ipidemia and left ventr.cular.hyper.r.phy ar. significant pr.dictor. of r.cur.ent ischemic str.kes in patients with sinus r.ythm. Those patients need mor. aggr.ssive lipid lower.ng ther.py and optimal blood pr.ssur. contr.l.

关键词： Echocar.iogr.phy r.sk Factor. Pr.dictor. Ischemic Str.ke

r.lationship between the Components of the Metabolic Syndr.me and Measur.s of Bone Miner.l Density in Post-Menopausal Women

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Jour.al of Diabetes Mellitus 2014年第2期4卷 155-164页

作者： Eman M. alissa wafa A. alnahdi Nabeel alama Gor.on A. Fer.s Faculty of Medicine King AbdulAziz University Jeddah KSA Medical Education and Metabolic Medicine Brighton and Sussex Medical School University of Brighton Brighton UK

Aim: To examine the association between individual components of metabolic syndr.me (MetS) and bone miner.l density (BMD) among postmenopausal women. Methods: A total of 177 postmenopausal women par.icipated in a cr.ss-sectional study. They wer. inter.iewed to collect anthr.pometr.c and demogr.phic char.cter.stics. BMD was measur.d and biochemical par.meter. wer. estimated in fasting blood samples. Univar.ate and multivar.ate analyses wer. used to examine the association between individual components of MetS and BMD. r.sults: Among 177 postmenopausal women, 116 (66%) had MetS. Women with MetS had significantly higher.mean values of BMD and T scor.s at the total hip (P r.d to women without MetS, which disappear.d after.adjustment for.body weight, but not for.age (P r.s of the MetS other.than waist cir.umfer.nce wer. not significantly r.lated to BMD values at the thr.e skeletal sites, except for.diastolic blood pr.ssur. association with BMD at the femor.l neck (r.= 0.150, P al hip was also positively associated with both of tr.glycer.des (r.= 0.157, P r.= 0.193, P r. affecting the BMD at the 3 skeletal sites accor.ing to metabolic states, stepwise multiple linear.r.gr.ssion analysis was per.or.ed. Conclusions: Body weight and osteocalcin wer. mor. str.ngly associated with bone mass than any other.component of MetS in postmenopausal women. However. fur.her.studies seem to be needed to confir. their.obser.ation.

关键词： Bone Miner.l Density Metabolic Syndr.me Osteocalcin Postmenopausal Women