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Open Journal of Applied Sciences 2021年第4期10卷 395-413页

作者： Bashair al-Ahmadi Anwar Saleh wafa al-shammakh Department of Mathematics Faculty of Science University of Jeddah Jeddah Saudi Arabia

A graphical index is a numeric value corresponding to a graph which is structurally invariant and in molecular graph theory these invariants are known as topological indices. In the field of Chemical and Medical Sciences, the topological indices are used to study the chemical, biological, medical and pharmaceutical features of drugs. With reference to the previous deadly diseases, the COVID-19 pandemic has considered to be the biggest life threatening issue that modern medicines have ever tackled. COVID-19 is immedicable and even the existing treatments are only helping the certain group of sufferers. Scientists have tested available antiviral agents and got a favorable impact on recovering from pandemic. Some of these antiviral agents are remdesivir, chloroquine, hydroxychloroquine, theaflavin and dexamethasone. Keeping in view of the importance of topological indices in the study of pharmaceutical and chemical drugs, in this paper, we calculate the Mdn-Polynomial, some downhill Zagreb topological indices and some downhill Zagreb polynomials of some of the anti viral agents remdesivir, chloroquine, hydroxychloroquine, theaflavin and dexamethasone. The results thus obtained may be useful for the finding new medicine and vaccine for the treatment of COVID-19.

关键词： COVID-19 Remdesivir Chloroquine Hydroxychloroquine Theaflavin Dexamethasone Mdn-Polynomial Downhill Zagreb Polynomial

On the Uphill Domination Polynomial of Graphs

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Journal of Applied Mathematics and Physics 2020年第6期8卷 1168-1179页

作者： Thekra alsalomy Anwar Saleh Najat Muthana wafa al shammakh Department of Mathematics Faculty of Science University of Jeddah Jeddah Saudi Arabia

A path π = [v1, v2, …, vk] in a graph G = (V, E) is an uphill path if deg(vi) ≤ deg(vi+1) for every 1 ≤ i ≤ k. A subset S ⊆ V(G) is an uphill dominating set if every vertex vi ∈ V(G) lies on an uphill path originating from some vertex in S. The uphill domination number of G is denoted by γup(G) and is the minimum cardinality of the uphill dominating set of G. In this paper, we introduce the uphill domination polynomial of a graph G. The uphill domination polynomial of a graph G of n vertices is the polynomial alt="" />, where up(G, i) is the number of uphill dominating sets of size i in G, and γup(G) is the uphill domination number of G, we compute the uphill domination polynomial and its roots for some families of standard graphs. also, UP(G, x) for some graph operations is obtained.

关键词： Domination Uphill Domination Uphill Domination Polynomial

In vivo study of pomegranate(Punica granatum) peel extract efficacy against Giardia lamblia in infected experimental mice

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 59-63页

作者： wafa Abdullah al-Megrin Department of Biology Faculty of SciencePrincess Nourah Bint Abdul Rahman UniversityRiyadhSaudi Arabia

Objective: To investigate the efficacy of pomegranate(Punica granatum) peel extract as an alternative treatment on the white laboratory mice against ***: Experimental animals were divided into five groups, including Group A:control(infected untreated), Group B: infected and fed with pectin 7 days before infection, Group C: infected and fed with pectin starting from 7th day of infection,Group D: infected and fed with pomegranate peel extract 7 days before infection, and Group E: infected and fed with pomegranate peel extract starting from 7th day of ***: Results from this study revealed that the prevention rate in the experimental groups reached approximately 50% by the 10 th day of using pomegranate peel ***, stool cyst counts of groups showed a significant reduction in the shedding of cysts approximately 75.6% by day 20 post-infection. ELISA test showed a reduction in Giardia antigen in the stools of the experimental groups which received pomegranate peel extract. The cure rate of these groups was approximately 97.4% by 28 th day of ***: Our present findings indicated that the pomegranate peel extract proved to be valuable in prevention and treatment of Giardia lamblia infection. Further studies are required to determine the effective dose of pomegranate peel extract against Giardia lamblia infection.

关键词： Pomegranate Giardia lamblia Swiss albino mice Saudi Arabia

Numerical Solutions for Quadratic Integro-Differential Equations of Fractional Orders

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Open Journal of Applied Sciences 2017年第4期7卷 157-170页

作者： Fatheah alhendi wafa shammakh Hind al-Badrani Department of Mathematics King Abdulaziz University Jeddah Saudi Arabia Taibah University Madinah Saudi Arabia

In this article, variational iteration method (VIM) and homotopy perturbation method (HPM) solve the nonlinear initial value problems of first-order fractional quadratic integro-differential equations (FQIDEs). We use the Caputo sense in this article to describe the fractional derivatives. The solutions of the problems are derived by infinite convergent series, and the results show that both methods are most convenient and effective.

关键词： Fractional Quadratic Integro-Differential Equations Variational Iteration Method Homotopy Perturbation Method

The engineering of doxorubicin-loaded liposome-quantum dot hybrids for cancer theranostics

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Chinese Physics B 2014年第8期23卷 125-128页

作者：田博文 wafa' T. al-Jamal Kostas Kostarelos Nanomedicine Laboratory UCL School of Pharmacy University College London Laboratory of Biophysics and Surface Analysis School of Pharmacy University of Nottingham School of Pharmacy University of East Anglia Nanomedicine Laboratory Faculty of Medical & Human Sciences University of Manchester

Many studies have recently attempted to develop multifunctional nanoconstructs by integrating the superior fluores- cence properties of quantum dots （QD） with therapeutic capabilities into a single vesicle for cancer theranostics. Liposome- quantum dot （L-QD） hybrid vesicles have shown promising potential for the construction of multifunctional nanoconstructs for cancer imaging and therapy. To fulfil such a potential, we report here the further functionalization of L-QD hybrid vesi- cles with therapeutic capabilities by loading anticancer drug doxorubicin （Dox） into their aqueous core. L-QD hybrid vesi- cles are first engineered by the incorporation of TOPO-capped, CdSe/ZnS QD into the lipid bilayers of DSPC：Chol：DSPE- PEG2000, followed by Dox loading using the pH-gradient technique. The loading efficiency of Dox into L-QD hybrid vesicles is achieved up to 97%, comparable to liposome control. all these evidences prove that the incorporation of QD into the lipid bilayer does not affect Dox loading through the lipid membrane of liposomes using the pH-gradient technique. Moreover, the release study shows that Dox release profile can be modulated simply by changing lipid composition. In conclusion, the Dox-loaded L-QD hybrid vesicles presented here constitute a promising multifunctional nanoconstruct capable of transporting combinations of therapeutic and diagnostic modalities.

关键词： nanomedicine theranostic multimodality nanotechnology

Air/CO2 cooling garment: Description and benefits of use for subjects exposed to a hot and humid climate during physical activities

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International Journal of Mining Science and Technology 2019年第6期29卷 899-903页

作者： Chady al Sayed Ludwig Vinches Olivier Dupuy wafa Douzi Benoit Dugue Stephane Halle Department of Mechanical Engineering ecole de Technologie SuperieureMontreal H3C 1K3Canada Laboratory MOVE Faculty of Sports SciencesUniversity of PoitiersPoitiers 86073France

The severity of the hot and humid conditions to which miners are exposed increases as the depth of the work site *** can cause heat stress that can greatly affect the health and safety of *** resolve this,a cooling garment has been developed that uses an atmospheric discharge of liquid CO2 to create a cool microclimate with an average temperature of 12.5(±0.4)℃ beneath the *** evaluate the garment's cooling efficiency,19 male subjects participated in an experimental *** two modes,cooling on and off,were *** physiological differences were found between the two modes after minute 27(pal body temperature(maximum difference of 0.33℃).It was found that the modes also affected the subjects'*** ON-mode was associated with better well-being and thermal comfort,and reduced humidity *** of exertion were lower in the ON-mode condition from minute *** findings provide strong evidence of the ability of this cooling garment to reduce heat stress in hot and humid conditions similar to those encountered in deep mines.

关键词： Cooling garment Deep mining Hot and humid Liquid CO2 expansion Physiological measurements Perceptual responses

Reservoir quality evaluation of the Narimba Formation in Bass Basin,Australia:Implications from petrophysical analysis,sedimentological features,capillary pressure and wetting fluid saturation

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Energy Geoscience 2024年第1期5卷 37-53页

作者： wafa Abdul Qader al-Ojaili Mohamed Ragab Shalaby Wilfried Bauer Department of Applied Geosciences German University of Technology in OmanOman Geology Department Faculty of ScienceUniversity of Brunei DarussalamBrunei Darussalam Geology Department Faculty of SciencesTanta UniversityTanta31527Egypt

The evaluation of reservoir quality was accomplished on the Late Paleocene to Early Eocene Narimba Formation in Bass Basin,*** study involved combination methods such as petrophysical analysis,petrography and sedimentological studies,reservoir quality and fluid flow units from derivative parameters,and capillary pressure and wetting fluid saturation *** and diagenetic features are affecting the reservoir ***,compaction,and presence of clay minerals such as kaolinite are found to reduce the quality while dissolution and secondary porosity are noticed to improve *** is believed that the Narimba Formation is a potential reservoir with a wide range of porosity and *** ranges from 3.1%to 25.4%with a mean of 15.84%,while permeability ranges between 0.01 mD and 510 mD,with a mean of 31.05 *** on the heterogenous lithology,the formation has been categorized into five groups based on permeability *** I showed an excellent to good quality reservoir with coarse *** impacts of both textural and diagenetic features improve the reservoir and producing higher reservoir quality index(RQI)and flow zone indicators(FZI)as well as mostly mega *** non-wetting fluid migration has the higher possibility to flow in the formation while displacement pressure recorded as *** II showed a fair quality reservoir with lower petrophysical properties in macro *** irreducible water saturation is increasing while the textural and digenetic properties are still enhancing the reservoir *** III reflects lower quality reservoir with mostly macro pores and higher displacement *** may indicate smaller grain size and increasing amount of cement and clay *** IV,and V are interpreted as a poor-quality reservoir that has lower RQI and *** textural and digenetic features are negatively affecting the reservoir and are leading to smaller pore size and pore throat radii(r35)

关键词： Narimba formation Petrophysics Reservoir quality Capillary pressure Wetting fluid saturation

Comparison of perceived pain and patients’ satisfaction with traditional local anesthesia and single tooth anesthesia: A randomized clinical trial

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World Journal of Clinical Cases 2019年第19期7卷 2986-2994页

作者： Mohammad I al-Obaida Mehdiya Haider Rawan Hashim wafa alGheriri Sree Lalita Celur Samar A al-Saleh Ebtissam M al-Madi Department of Restorative Dental Sciences College of DentistryKing Saud UniversityRiyadh 11527Saudi Arabia College of Dentistry Princess Nourah bint AbdulRahman UniversityRiyadh 11671Saudi Arabia Department of Basic Dental Sciences College of DentistryPrincess Nourah bint AbdulRahman UniversityRiyadh13414Saudi Arabia Department of Prosthetic Dental Sciences College of DentistryKing Saud UniversityRiyadh 11527Saudi Arabia

BACKGROUND Contemporary innovations in the area of local anesthesia have attempted to provide an absolutely pain free experience for *** the introduction of Computer-Controlled Local Anesthetic Delivery Systems to dentistry,many studies have compared its efficacy and safety to conventional ***,very few studies have compared single tooth anesthesia(STA)and traditional local *** To compare pain rating,changes in blood pressure,and heart rate during the local anesthetic *** secondary objectives were to measure the patients’level of satisfaction and the differences in anesthetic efficiency between the STA system and traditional local *** A randomized controlled trial was conducted and a total of 80 patients with dental restorative needs were enrolled for the *** patients were evaluated for their general physical status and oral clinical findings before *** regarding perceived pain,changes in heart rate and blood pressure,and patients’satisfaction was collected using an electronic data form and was analyzed using paired and unpaired *** No significant difference was noted in perceived pain(P=0.59)and systolic blood pressure(P=0.09)during anesthetic injection using both traditional and STA *** patients had a significantly higher heart rate during anesthesia,although a statistically significant difference was noted among the traditional anesthesia and the STA groups even before *** the restorative procedure,less pain was perceived by STA patients on the Wong-Baker FACES pain scale,which was statistically significant(Palyses of post-procedure patient responses showed that STA patients had a significantly better treatment experience and preferred to have the same method of injection in the future(P=0.04).CONCLUSION STA system can provide less painful and more comfortable restorative treatment procedures in comparison to the traditional infil

关键词： Local anesthesia Single tooth anesthesia Pain experience Patient satisfaction Pulse rate Heart beat Wong-Baker FACES pain scale

Comparing the efficiency of artificial neural networks in sEMG-based simultaneous and continuous estimation of hand kinematics

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Digital Communications and Networks 2022年第2期8卷 162-173页

作者： wafa Batayneh Enas Abdulhay Mohammad alothman Jordan University of Science and Technology Mechanical Engineering DepartmentIrbid22110 Jordan Jordan University of Science and Technology Biomedical Engineering DepartmentIrbid22110 Jordan

Surface Electromyography(sEMG)plays a key role in many applications such as control of Human-Machine Interfaces(HMI)and neuromusculoskeletal *** has strongly nonlinear relations to joint kinematics and reflects the subjects’intention in moving their *** relations have been traditionally examined by either integrated biomechanics and multi-body dynamics or gesture-based classification ***,these methods have drawbacks that limit their *** from them,joint kinematics can be continuously reconstructed from sEMG via estimation approaches,for instance,the Artificial Neural Networks(ANNs).The Comparison of different ANNs used in different studies is difficult,and in many cases,*** current study focuses on fairly evaluating four types of ANN over the same dataset and conditions in proportional and simultaneous estimation of 15 hand joint angles from 10 sEMG *** presented ANNs are Feedforward,Cascade-Forward,Radial Basis Function(RBFNN),and Generalized Regression(GRNN).Each ANN is applied to its special parametric *** the methods efficiently solved the regression problem of the complex multi-input multi-output *** RBFNN has the best performance over the others with a 79.80%mean correlation coefficient over all joints,and its accuracy reaches as high as 92.67%in some ***,the highest accuracy over individual joints is 93.46%,which is achieved via the *** good accuracy suggests that the proposed approaches can be used as alternatives to the previously adopted ones and can be employed effectively to synchronously control multi-degrees of freedom HMI and for general multi-joint kinematics estimation purposes.

关键词： Surface electromyography Kinematics estimation Artificial neural networks

Circle-criterion Based Nonlinear Observer Design for Sensorless Induction Motor Control

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International Journal of Automation and computing 2014年第6期11卷 598-604页

作者： wafa Bourbia Farid Berrezzek Bachir Bensaker University Badji Mokhtar Department of Electrotechnic BP.12 Annaba 23000 Algeria University Med Cherif Messadia Souk Ahras 41000 Algeria Laboratory of Electromechanical Systems University Badji Mokhtar BP.12 Annaba 23000 Algeria

This paper deals with the design of a nonlinear observer for sensorless induction motor control. Based upon the circle criterion approach, a nonlinear observer is designed to estimate pertinent but unmeasurable state variables of the considered induction machine for sensorless control purpose. The observer gain matrices are computed as a solution of linear matrix inequalities(LMI) that ensure the stability conditions of the state observer error dynamics in the sense of Lyapunov concepts. Measured and estimated state variables can be exploited to perform a state feedback control of the machine system. The simulation results are presented to illustrate the effectiveness of the proposed approach for nonlinear observer design.

关键词： Nonlinear observer circle-criterion Lyapunov stability linear matrix inequalties (LMI) induction motor