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Medications in type-2 diabetics and their association with liver fibrosis

World Journal of Gastroenterology 2020年第23期26卷 3249-3259页

作者： mohamed Tausif Siddiqui Hina Amin Rajat Garg Pravallika Chadalavada wael Al-Yaman Rocio Lopez Amandeep Singh Department of Gastroenterology Hepatology and NutritionDigestive Diseases and Surgery InstituteCleveland ClinicClevelandOH 44195United States Department of Hospital Medicine Cleveland ClinicOH 44195United States Department of Quantitative Health Sciences Cleveland ClinicOH 44195United States

BACKGROUND The prevalence of nonalcoholic fatty liver disease(NAFLD) is significantly rising worldwide. Type-2 diabetes(T2D) is a major risk factor for NAFLD *** To assess the association of commonly used medications to advanced fibrosis(AF) in patients with biopsy-proven NAFLD and *** We used the International Classification of Disease 9 th Revision Clinical Modification coding system to identify patients with T2D and included patients who underwent liver biopsy for suspected NAFLD between January 1, 2000 to December 31, 2015. We compared demographics, clinical characteristics, and differences in pattern of medication use in patients who had biopsy-proven AF to those without it. A univariate and multivariate analysis was performed to assess the association of different classes of medication with the presence of *** A total of 1183 patients were included in the final analysis, out of which 32%(n =381) had AF on liver biopsy. Mean age of entire cohort was 52 years and majority were females(65%) and Caucasians(85%). Among patients with AF, 51% were on oral hypoglycemics, 30% were on insulin, 66% were on antihypertensives and 27% were on lipid lowering agents for the median duration of 19 mo, 10 mo, 26 mo, and 24 mo respectively. Medications associated with decreased risk of AF included metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin while the use of furosemide and spironolactone were associated with higher prevalence of *** In our cohort of T2D with biopsy proven NAFLD, the patients who were receiving metformin, liraglutide, lisinopril, hydrochlorothiazide, atorvastatin and simvastatin were less likely to have AF on biopsy, while patients who were receiving furosemide and spironolactone had a higher likelihood of having AF when they underwent liver biopsy. Future studies are needed to confirm these findings and to establish measures for prevention of NAFLD progression in patients with T2D.

关键词： Diabetes medications Anti-lipid medications Antihypertensive medication Fatty liver Advanced fibrosis

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Climate change and epidemiology of human parasitoses in Saudi Arabia:A review

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Journal of Coastal Life Medicine 2016年第7期4卷 580-588页

作者： wael mohamed Lotfy Souad mohamed Alsaqabi Parasitology Department Medical Research InstituteAlexandria UniversityAlexandriaEgypt Biology Department Faculty of ScienceQassim UniversityUnizahSaudi Arabia

Climate change is an emerging global *** has hazardous effects that vary across different geographic regions and *** is anticipated to have significant effects in Saudi *** present work reviews the future of human parasitoses in Saudi Arabia in response to the expected climate *** key projections are increased precipitations,flash floods,unstable temperatures,sea-level rise and shoreline *** environmental changes could strongly influence the epidemiology of fly-borne,mosquito-borne,snail-borne and water-borne human parasitoses in the country.

关键词： Global warming Kingdom of Saudi Arabia Parasites Fly-borne Mosquito-borne Snail-borne Water-borne Infection

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Second-line panitumumab as a triweekly dose for patients with wild-type KRAS exon 2 metastatic colorectal cancer:a single-institution experience

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Cancer Biology & Medicine 2016年第1期13卷 136-141页

作者： mohamed A.Daoud Engy M.Aboelnaga wael M.mohamed Department of Radiation Oncology Mansoura Faculty of Medicine King Abdullah Medical City

Objective: Panitumumab administered as monotherapy in colorectal cancer(CRC) has shown response and disease stabilization rates of approximately 30%. The current study aimed to evaluate the progression-free survival(PFS) and overall survival(OS) of patients with metastatic colorectal cancer(mCRC) treated with panitumumab every 3 weeks as a second line ***: This study is a retrospective analysis of 18 patients, aged more than 18 years, with wild-type KRAS exon 2 mCRC treated with panitumumab as a second-line single agent after progression on first-line ***: The median number of courses received was 10(range, 4-29), and the median duration of treatment was 30 weeks(range,12-96 weeks). After a median follow-up period of 13 months, the median PFS was 6 months(range, 4.3-7.7 months) and the median OS was 11 months(range, 7.4-14.5 months). The median PFS was 4 months for patients with < grade 2 skin toxicity and 6months(range, 4.5-7.5 months) for patients with ≥ grade 2 skin rash(P=0.05). The median OS was 9 months(range, 6.4-11.5months) and 14 months(range, 11.6-16.3 months) for the two groups of patients(P=0.002).Conclusions: Panitumumab given every 3 weeks is effective and well tolerated in patients with advanced CRC that progressed after standard chemotherapy.

关键词： Metastatic colorectal carcinoma panitumumab second-line KRAS

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Molecular detection of monocyte chemotactic protein-1 polymorphism in spontaneous bacterial peritonitis patients

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World Journal of Gastroenterology 2014年第33期20卷 11793-11799页

作者： Maysa Kamal Salama Dina Sabry mohamed AS Al-Ghussein Rasha Ahmed Sayed AbdAllah Fatma.mohamed Taha wael Fathy Miriam Safwat Wadie Mona Nabih Amr Abul-Fotouh Tarneem Darwish Medical Biochemistry and Molecular Biology Department Faculty of Medicine Cairo University Cairo11562 Egypt Biochemistry Department Faculty of Pharmacy Al-Azhar University Gaza 1277 Palestine Tropical Medicine Department Faculty of Medicine Cairo University Cairo11562 Egypt Internal Medicine Department Faculty of Medicine Cairo University Cairo 11562 Egypt Tropical Medicine Department Faculty of Medicine Bny Swif University Bny Swif 62511 Egypt Biomedical Informatics and Biostatistics Department Faculty of Medicine Cairo University Cairo 11562 Egypt

AIM: To investigate the association of the functional monocyte chemotactic protein-1 (MCP-1) promoter polymorphism (A-2518G) with spontaneous bacterial peritonitis (SBP).

关键词： Monocyte chemotactic protein-1 Genotype Spontaneous bacterial peritonitis Liver cirrhosis As-cites Gene expression Interleukin-10

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An Automatic Deep Neural Network Model for Fingerprint Classification

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Intelligent Automation & Soft Computing 2023年第5期36卷 2007-2023页

作者： Amira Tarek Mahmoud wael AAwad Gamal Behery mohamed Abouhawwash Mehedi Masud Hanan Aljuaid Ahmed Ismail Ebada Department of Computer Science Faculty of SciencePort Said UniversityPort SaidEgypt Department of Computer Science Faculty of Computers and Artificial IntelligenceDamietta UniversityNew DamiettaEgypt Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)College of EngineeringMichigan State UniversityEast LansingMI 48824USA Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Computer Sciences Department College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman University(PNU)P.O.Box 84428Riyadh11671Saudi Arabia Department of Information Systems Faculty of Computers and Artificial IntelligenceDamietta UniversityNew DamiettaEgypt

The accuracy ofﬁngerprint recognition model is extremely important due to its usage in forensic and securityﬁ***ﬁngerprint recognition system has particular network architecture whereas many other networks achieve higher *** solve this problem in a uniﬁed model,this paper proposes a model that can automatically specify ***,it is called an automatic deep neural net-work(ADNN).Our algorithm can specify the appropriate architecture of the neur-al network used and some signiﬁcant parameters of this *** parameters are the number ofﬁlters,epochs,and *** guarantees the high-est accuracy by updating itself until achieving 99%accuracy then it stops and out-puts the ***,this paper proposes an end-to-end methodology for recognizing a person’s identity from the inputﬁngerprint image based on a resi-dual convolutional neural *** is a complete system and is fully automated whether in the features extraction stage or the classiﬁcation *** goal is to automate thisﬁngerprint recognition system because the more automatic the sys-tem is,the more time and effort it *** model also allows users to react by inputting the initial values of these ***,the model updates itself until itﬁnds the optimal values for the parameters and achieves the best *** advantage of our algorithm is that it can recognize people from their thumb and otherﬁngers and its ability to recognize distorted *** algo-rithm achieved 99.75%accuracy on the publicﬁngerprint dataset(SOCOFing).This is the best accuracy compared with other models.

关键词： Automatic system ﬁngerprint classiﬁcation residual networks deep learning

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A Novel Deep Learning-Based Model for Classification of Wheat Gene Expression

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Computer Systems Science & Engineering 2024年第2期48卷 273-285页

作者： Amr Ismail WalidHamdy Aya MAl-Zoghby wael AAwad Ahmed Ismail Ebada Yunyoung Nam Byeong-Gwon Kang mohamed Abouhawwash Faculty of Science Port Said UniversityPort SaidEgypt Modern Academy for Computer Science and Management Technology Cairo11742Egypt Faculty of Computers and Artificial Intelligence Damietta UniversityNew DamiettaEgypt Department of ICT Convergence Soonchunhyang UniversityAsan31538South Korea Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Deep learning(DL)plays a critical role in processing and converting data into knowledge and *** technologies have been applied in a variety of applications,including image,video,and genome sequence *** deep learning the most widely utilized architecture is Convolutional Neural Networks(CNN)are taught discriminatory traits in a supervised *** comparison to other classic neural networks,CNN makes use of a limited number of artificial neurons,therefore it is ideal for the recognition and processing of wheat gene *** is an essential crop of cereals for people around the *** Genotypes identification has an impact on the possible development of many countries in the agricultural *** quantitative genetics prediction of genetic values is a central *** is an allohexaploid(AABBDD)with three distinct *** sizes of the wheat genome are quite large compared to many other kinds and the availability of a diversity of genetic knowledge and normal structure at breeding lines of wheat,Therefore,genome sequence approaches based on techniques of Artificial Intelligence(AI)are *** paper focuses on using the Wheat genome sequence will assist wheat producers in making better use of their genetic resources and managing genetic variation in their breeding program,as well as propose a novel model based on deep learning for offering a fundamental overview of genomic prediction theory and current *** this paper,the hyperparameters of the network are optimized in the CNN to decrease the requirement for manual search and enhance network performance using a new proposed model built on an optimization algorithm and Convolutional Neural Networks(CNN).

关键词： Gene expression convolutional neural network optimization algorithm genomic prediction wheat

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Hierarchical TiO_2/ZnO Nanostructure as Novel Non-precious Electrocatalyst for Ethanol Electrooxidation

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Journal of Materials Science & Technology 2015年第1期31卷 97-105页

作者： Gehan M.K.Tolba Nasser A.M.Barakat A.M.Bastaweesy E.A.Ashour wael Abdelmoez mohamed H.El-Newehy Salem S.Al-Deyab Hak Yong Kim Organic Materials and Fiber Engineering Department Chonbuk National University Chemical Engineering Department Faculty of EngineeringMinia University BioNanosystem Department Chonbuk National University Department of Chemistry College of ScienceKing Saud University

Metal oxides have a higher chemical stability in comparison to metals,so they can be utilized as electrocatalysts if the activity could be *** the composition,the morphology of the nanostructures has a considerable impact on the electrocatalytic *** this work,zinc oxide nano branches-attached titanium dioxide nanofibers were investigated as an economic and stable catalyst for ethanol electrooxidation in the alkaline *** introduced material has been synthesized by electrospinning process followed by hydrothermal ***,electrospinning of colloidal solution consisting of titanium isopropoxide,poly（vinyl acetate） and zinc nanoparticles was performed to produce nanofibers embedding solid *** order to produce TiO2nanofibers containing ZnO nanoparticles,the obtained electrospun nanofiber mats were calcined in air at 600 °*** formed ZnO nanoparticles were exploited as seeds to outgrow ZnO branches around the TiO2nanofibers using the hydrothermal technique at sub-critical water conditions in the presence of zinc nitrate and bis-hexamethylene *** morphology of the final product,as well as the electrochemical measurements indicated that zinc nanoparticles content in the original electrospun nanofibers has a significant influence on the electrocatalytic activity as the best performance was observed with the nanofibers synthesized from electrospun solution containing 0.1 g Zn,and the corresponding current density was 37 mA/***,this study paves a way to titanium dioxide to be exploited to synthesize effective and stable metal oxide-based electrocatalysts.

关键词： Direct ethanol fuel cells Electrospinning Nanofibe

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The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

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Journal of Behavioral and Brain Science 2019年第8期9卷 313-324页

作者： mohamed Saad Maha Bilal wael Gabr Aymen Abd Elnaby Neurology Department Mansoura University Mansoura Egypt Radiology Department Mansoura University Mansoura Egypt Internal Medicine Department Tiabah University Madina KSA

Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients. Objectives: To correlate MS related CI to cortical brain lesions using brain magnetic resonance imaging (MRI). Materials and Methods: Cognitive impairment was detected using mini mental state examination (MMSE);Neurological examination and brain MRI were performed for all patients. Correlation was calculated between disease cortical burden detected by MRI and CI. Results: Fifty-three patients with proven MS were scanned by brain MRI;69.8% of them had cognitive impairment diagnosed with MMSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS). Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predict subsequent development of MS-related CI.

关键词： Multiple Sclerosis Cognitive Impairment MRI Cortical Brain Lesion MS Related CI

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Validity of QRS Configuration and Myeloperoxidase Level as Determinants of CAD Severity and Prognosis in Patients with STEMI

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World Journal of Cardiovascular Diseases 2021年第1期11卷 82-97页

作者： wael Ali Khalil mohamed Abdou Abdelhamed Ahmed S. Eldamanhory Cardiology Department Faculty of Medicine Zagazig University Zagazig Egypt

Background: Terminal QRS distortion and fragmentation (fQRS) with elevated myeloperoxidase (MPO) were linked to poor cardiovascular outcomes in acute coronary syndrome. We aimed to investigate these parameters in early prediction of coronary artery disease severity based on SYNTAX score and in-hospital adverse events in STEMI patients. Methods: A total of 215 patients with first STEMI admitted for primary PCI were included in the study. They were divided according to the admission ECG into group I with QRS distortion or fQRS, group II with combined QRS distortion and fQRS, and group III without QRS distortion or fQRS. Myeloperoxidase and troponin I levels, ST resolution ratio, left ventricular EF%, and severity of coronary artery lesions using SYNTAX risk score were measured. Results: MPO level, SYNTAX score, and in-hospital mortality were higher in group I and II and were higher in group II compared to group I. By regression analysis, QRS distortion, fQRS, and MPO > 412 ng/ml were independent predictors of both CAD severity and in-hospital mortality. DM was an independent predictor of CAD severity (OR: 2.851, P 0.012) while high SYNTAX score was an independent predictor of in-hospital mortality (OR: 6.113, P 0.001). Adding MPO level to any QRS configuration pattern increased predictive value for the detection of CAD severity that was more evident in the combined QRS distortion and fragmentation. Conclusion: Terminal QRS distortion, fragmentation, or combined QRS distortion and fragmentation have a significant value in predicting in-hospital adverse events and CAD severity

关键词： QRS Distortion QRS Fragmentation Myeloperoxidase Level SYNTAX Score ST-Elevation Myocardial Infarction

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Clinical efficacy of direct-acting antiviral therapy for recurrent hepatitis C virus infection after liver transplantation in patients with hepatocellular carcinoma

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World Journal of Hepatology 2020年第9期12卷 628-640页

作者： mohamed Saleh Ismail Manal Hassan Saira Aijaz Khaderi wael Ahmed Yousry Maha Mohsen Kamal El-Din mohamed mohamed Bahaa El-Din Osama Aboelfotoh El Sayed Ahmed Omar Kaseb John Alan Goss FasihaKanwal Prasun Kumar Jalal Division of Gastroenterology Baylor College of MedicineHoustonTX 77030United States Department of Internal medicine Gastroenterology and HepatologyAin Shams UniversityCairo 11566Egypt Department of Surgery Division of Abdominal TransplantationBaylor College of MedicineHoustonTX 77030United States Department of Epidemiology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Surgery Ain Shams UniversityCairo 11566Egypt Department of Gastrointestinal Medical Oncology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

BACKGROUND Recurrent hepatitis C virus(HCV)infection of transplanted liver allografts is universal in patients with detectable HCV viremia at the time of ***-acting antiviral(DAA)therapy has been adopted as the standard of care for recurrent HCV infection in the post-transplant ***,there are insufficient data regarding its efficacy in liver transplant(LT)recipients with a history of hepatocellular carcinoma(HCC),and the risk of HCC recurrence after DAA therapy is *** of DAA treatment failure and HCC recurrence in LT *** A total of 106 LT recipients given DAAs for recurrent HCV infection from 2015 to 2019 were identified(68 with and 38 without HCC).Descriptive statistics and logistic regression models were used to estimate the multivariate odds ratios and respective 95%confidence intervals for predictors of treatment failure and HCC *** Six patients(6%)experienced DAA therapy failure post-LT and 100(94%)had a sustained virologic response at follow-up week 12.A high alanine transaminase level>35 U/L at treatment week 4 was a significant predictor of treatment *** to pre-LT DAA therapy is a predictor of post-LT HCC recurrence,P=*** relapse post-LT was also associated with post-transplantation HCC recurrence,P=*** DAAs are effective and safe in the treatment of recurrent HCV infection in LT recipients with history of *** to pre-and post-LT DAA therapy is associated with post-transplantation HCC recurrence.

关键词： Direct-acting antiviral Liver transplant Hepatocellular carcinoma Recurrence

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