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Intensive care unit adaptations in the COVID-19 pandemic:Lessons learned

World Journal of Virology 2022年第6期11卷 394-398页

作者： Anwar Khedr David Rokser Jeanine Borge Hannah Rushing Greta Zoesch wade johnson Han-Yin Wang April Lanz Brian N Bartlett Jessica Poehler Salim Surani Syed A Khan Department of Medicine BronxCare Health SystemBronxNY 10457United States Department of Critical Care Medicine Mayo Health SystemMankatoMN 56001United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Administration Mayo Clinic Health SystemMankatoMN 56001United States Hospital Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Emergency Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine Texas A&M UniversityHealth Science CenterCollege StationTX 77843United States

The coronavirus disease 2019 pandemic had deleterious effects on the healthcare systems around the *** increase intensive care units(ICUs)bed capacities,multiple adaptations had to be made to increase surge *** this editorial,we demonstrate the changes made by an ICU of a midwest community hospital in the United *** changes included moving patients that used to be managed in the ICU to progressive care units,such as patients requiring noninvasive ventilation and high flow nasal cannula,ST-elevation myocardial infarction patients,and post-neurosurgery ***,newer tactics were applied to the processes of assessing oxygen supply and demand,patient care rounds,and post-ICU monitoring.

关键词： COVID-19 Pandemics Oxygen Intensive care units ST elevation myocardial infarction Nasal cannula

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The evolution of copulation frequency and the mechanisms of reproduction in male Anolis lizards

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Current Zoology 2014年第6期60卷 768-777页

作者： Michele A. johnson Mafia Veronica LOPEZ Tara K. WHITTLE Bonnie K. KIRCHER Alisa K. DILL Divina VARGHESE Juli wade Trinity University Department of Biology One Trinity Place San Antonio Texas 78212 USA Michigan State University Departments of Psychology and Zoology East Lansing Michigan 48824 USA

The evolution of many morphological structures is associated with the behavioral context of their use, particularly for structures involved in copulation. Yet, few studies have considered evolutionary relationships among the integrated suite of structures associated with male reproduction. In this study, we examined nine species of lizards in the genus Anolis to determine whether larger copulatory morphologies and higher potential for copulatory muscle performance evolved in association with higher copulation rates. In 10--12 adult males of each species, we measured the size of the hemipenes and related muscles, the seminiferous tubules in the testes, and the renal sex segments in the kidneys, and we assessed the fiber type composition of the muscles associated with copulation. In a series of pbylogenetically-informed analyses, we used field behavioral data to determine whether observed rates of copulation were associated with these *** found that species with larger hemipenes had larger fibers in the RPM （the retractor penis magnus, a muscle that controls hemipenis movement）, and that the evolution of larg- er hemipenes and RPM fibers is associated with the evolution of higher rates of copulatory behavior. However, the sizes of the seminiferous tubules and renal sex segments, and the muscle fiber composition of the RPM, were not associated with copulation rates. Further, body size was not associated with the size of any of the reproductive structures investigated. The results of this study suggest that peripheral morphologies involved in the transfer of ejaculate may be more evolutionarily labile than internal structures involved in ejaculate production.

关键词： Anolis Copulation Hemipenes Lizards Reproduction Reptiles

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An Alzheimer's Disease-Relevant Presenilin-1 Mutation Augments Amyloid-Beta-Induced Oligodendrocyte Dysfunction

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神经损伤与功能重建 2011年第2期6卷 128-141页

作者： MAYA K.DESAI BRENDAN J.GUERCIO wade C.NARROW WILLIAM J.BOWERS Department of Pharmacology and Physiology University of Rochester School of Medicine and DentistryRochesterNew York Center for Neural Development and Disease University of Rochester School of Medicine and DentistryRochesterNew York Department of Microbiology and Immunology University of Rochester School of Medicine and DentistryRochesterNew York Department of Neurology University of Rochester School of Medicine and DentistryRochesterNew York

研究表明,家族性阿尔茨海默病(FAD)患者处于无症状或临床前阶段时,脑白质即出现病理改变。此种改变在髓鞘破坏及阿尔茨海默病(AD)病理生理中的作用有待进一步研究阐明。笔者前期研究证实,三重转基因AD小鼠(人淀粉前体蛋白基因的Swedish... 详细信息

研究表明,家族性阿尔茨海默病(FAD)患者处于无症状或临床前阶段时,脑白质即出现病理改变。此种改变在髓鞘破坏及阿尔茨海默病(AD)病理生理中的作用有待进一步研究阐明。笔者前期研究证实,三重转基因AD小鼠(人淀粉前体蛋白基因的Swedish突变,早老素-1 M146V(PS1M146V)敲入突变及tauP301L突变)表现出类似FAD患者的髓鞘破坏,Aβ1-42促进了白质病变。本研究离体实验证实,PS1M146V变异导致小鼠少突胶质前体细胞在分化过程中易出现类似Aβ1-42诱导的变化。PS1M146V的表达损伤少突胶质前体细胞的功能并影响髓鞘碱性蛋白的分布,暴露于Aβ1-42加重此影响。由PS1M146V及Aβ1-42导致的髓鞘破坏及髓鞘碱性蛋白在亚细胞结构中的误定位可被TWS119(糖原合成激酶(GSK)-3β抑制剂)抑制,提示GSK-3β激酶活动在此病理过程中有重要作用。综上所述,本研究有助于增加对AD早期无症状阶段,由PS1M146V及Aβ1-42导致少突胶质细胞功能异常及髓鞘损伤的机制的理解,并提供了针对少突胶质细胞预防AD相关白质病变的新的治疗靶点。

关键词：阿尔茨海默病白质髓磷脂少突胶质细胞髓鞘碱性蛋白淀粉β样蛋白早老素-1 3重转基因AD

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