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genes & Diseases 2023年第2期10卷 399-402页

作者： Yuening Sun xin Chen Siyan Liao Aochu Liu Huan Zhou Liling Jiang wa Ding wenjie Mei Jinbao Liu Xianping Shi guangzhou Municipal and guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseAffiliated Cancer Hospital of Guangzhou Medical University School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 510120China guangdong Province Engineering Technology Center for Molecular Probe and Biomedicine Imaging Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China

The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of ***(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to ***,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.

关键词： myeloid overcome resistance

Nutritional epigenetics education improves diet and attitude of parents of children with autism or attention deficit/hyperactivity disorder

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World Journal of Psychiatry 2024年第1期14卷 159-178页

作者： Renee J Dufault Katherine M Adler David O Carpenter Steven g gilbert Raquel A Crider College of graduate Health Studies A.T.Still UniversityKirksvilleMO 63501United States Department of Research Food Ingredient and Health Research InstituteNaalehuHI 96772United States Department of Health Sciences University of New HavenWest HavenCT 06516United States Institute for Health and the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Department of Research Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Department of Statistics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

BACKgROUND Unhealthy maternal diet leads to heavy metal exposures from the consumption of ultra-processed foods that may impact gene behavior across generations,creating conditions for the neurodevelopmental disorders known as autism and attention deficit/hyperactivity disorder(ADHD).Children with these disorders have difficulty metabolizing and excreting heavy metals from their bloodstream,and the severity of their symptoms correlates with the heavy metal levels measured in their *** may play a key role in helping parents reduce their ultra-processed food and dietary heavy metal intake by providing access to effective nutritional epigenetics *** To test the efficacy of nutritional epigenetics instruction in reducing parental ultra-processed food *** The study utilized a semi-randomized test and control group pretest-posttest pilot study design with participants recruited from parents having a learning-disabled child with autism or ***-two parents who met the inclusion criteria were randomly selected to serve in the test(n=11)or control(n=11)*** test group participated in the six-week online nutritional epigenetics tutorial,while the control group did *** efficacy of the nutritional epigenetics instruction was determined by measuring changes in parent diet and attitude using data derived from an online diet survey administered to the participants during the pre and post intervention *** intake scores were derived for both ultra-processed and whole/organic *** sample t-tests were conducted to determine any differences in mean diet scores within each *** There was a significant difference in the diet scores of the test group between the pre-and post-intervention *** parents in the test group significantly reduced their intake of ultra-processed foods with a preintervention diet score of 70(mean=5.385,SD=2.534)and a post-intervention diet score of 113(mean=8.692,SD=1.750)and the

关键词： Epigenomics Parenteral nutrition Autism Attention deficit/hyperactivity disorder Ultra-processed foods Heavy metals

捻转血矛线虫耐药虫株与敏感虫株circRNAs差异表达分析

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中国农业大学学报 2024年第2期29卷 122-130页

作者：寇慧林陈昕迪王腾宇高娃温海峰张艳敏于宇李峥刘春霞王文龙内蒙古农业大学兽医学院/农业农村部动物疾病临床诊疗技术重点实验室呼和浩特010010 河套学院医学系/内蒙古自治区蜱媒人畜共患传染病重点实验室内蒙古巴彦淖尔015000 内蒙古农业大学生命科学学院呼和浩特010010

为分析捻转血矛线虫伊维菌素敏感虫株与耐药虫株之间差异表达的circRNAs在调控耐药性中的作用,本研究以捻转血矛线虫敏感虫株和耐药虫株为研究对象,采用Illumina Hiseq 2000平台进行高通量测序及cDNA文库的构建,利用相关生物信息学软件... 详细信息

为分析捻转血矛线虫伊维菌素敏感虫株与耐药虫株之间差异表达的circRNAs在调控耐药性中的作用,本研究以捻转血矛线虫敏感虫株和耐药虫株为研究对象,采用Illumina Hiseq 2000平台进行高通量测序及cDNA文库的构建,利用相关生物信息学软件对测得的circRNAs进行差异性分析,同时对来源基因进行gO和KEgg pathway功能富集。运用TargetScan和Miranda软件预测关键circRNAs靶向的miRNAs,探究circRNAs-miRNAs的作用。随后又随机选取5个显著差异的circRNAs,进行RT-qPCR检测并与转录组测序结果进行一致性评定。结果显示:1)敏感虫株与耐药虫株共筛选出677个差异表达的circRNAs,其中47个显著差异,23个显著上调,24个显著下调。2)所有差异circRNAs的来源基因gO富集分析显示,共富集到生物过程336个、细胞组分59个和分子功能110个,主要与代谢过程、细胞膜结构和催化活性等相关,KEgg富集分析显示,富集到257条通路,主要与代谢(脂肪酸生物合成、甘油磷脂代谢和丙酸代谢)、胰高血糖素信号通路和AMPK信号通路等相关。3)circRNAs-miRNAs调控网络分析显示,627个差异circRNAs靶向结合187个miRNAs,组成了10602组调控关系。综上,本研究成功筛选了捻转血矛线虫伊维菌素敏感虫株和耐药虫株间差异表达的circRNAs,对所有差异circRNAs的来源基因进行功能注释和富集分析,并构建了部分显著差异circRNAs-miRNAs调控网络。本研究结果为捻转血矛线虫耐药性产生的分子机制研究提供了新思路。

关键词：捻转血矛线虫伊维菌素耐药性转录组 circRNAs 差异分析

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重组大肠杆菌全细胞转化苹果酸合成丙酮酸

中国食品学报 2024年第7期24卷 219-228页

作者：付声亮邹诗瑶高娃赵筱王金华王永泽工业发酵省部共建协同创新中心武汉430068 湖北省工业微生物重点实验室武汉430068 湖北工业大学生物工程与食品学院武汉430068

拟建立一条以苹果酸为原料,通过大肠杆菌全细胞转化获得丙酮酸的合成途径。以大肠杆菌BL21(DE3)为宿主,在pET28a上共表达内源的苹果酸酶(ME)和来自博伊丁假丝酵母(Candida boidinii)的醛糖还原酶(AR),并对细胞浓度、底物浓度、温度和pH... 详细信息

拟建立一条以苹果酸为原料,通过大肠杆菌全细胞转化获得丙酮酸的合成途径。以大肠杆菌BL21(DE3)为宿主,在pET28a上共表达内源的苹果酸酶(ME)和来自博伊丁假丝酵母(Candida boidinii)的醛糖还原酶(AR),并对细胞浓度、底物浓度、温度和pH值等催化关键因素进行研究。共表达后大肠杆菌苹果酸酶和博伊丁假丝酵母醛糖还原酶酶活分别为(2.8±0.21),(3.1±0.34)U/mL。适宜的催化条件为:细胞浓度OD600nm值为30,底物苹果酸质量浓度为30 g/L,木糖和苹果酸物质的量比为1.0,温度为40℃,反应体系pH值为7.8,丙酮酸产量最高可达23.16 g/L。本研究为生物法合成丙酮酸提供了一种新的方法。

关键词：丙酮酸全细胞催化苹果酸苹果酸酶醛糖还原酶

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离轴超构透镜设计与特性分析

中国光学（中英文） 2024年第1期17卷 52-60页

作者：胡金高娃赵尚男王灵杰叶昊坤张建萍张新中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049

本文提出了一种离轴超构透镜的设计方法,并分析了不同数值孔径、离轴角度等参数对于离轴超构透镜的光谱分辨率、聚焦效率以及仿真结果的影响。利用Lumerical软件分别仿真了参数为NA=0.408、α=13°;NA=0.180、α=13°及NA=0.408α=20°... 详细信息

本文提出了一种离轴超构透镜的设计方法,并分析了不同数值孔径、离轴角度等参数对于离轴超构透镜的光谱分辨率、聚焦效率以及仿真结果的影响。利用Lumerical软件分别仿真了参数为NA=0.408、α=13°;NA=0.180、α=13°及NA=0.408α=20°等多个离轴超构透镜。仿真结果表明:离轴角度与光谱分辨率大小成正相关,离轴角度越大,光谱分辨能力越强,但聚焦效率越低;数值孔径越小,相位分布的覆盖范围越小,会导致仿真聚焦位置与理论值偏差变大。设计者需要根据需求合理平衡数值孔径、离轴角度等参数,最终实现理想效果。本文得出的结论对离轴超构透镜的理论分析和实际应用中的参数设计具有重要参考价值。

关键词：超构透镜离轴超构透镜仿真分析

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wa, a new Antifungal Antibiotic from a Soil Fungus Strain 38

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Chinese Chemical Letters 1998年第6期9卷 539-540页

作者： Jun YANg Xiu Lan QI wen LI gang SHAO xin Sheng YAO S. KITANAKA(Department of Natural Medicinal Chemistry, Shenyang Pharmaceutical University, Shenyang 110015)(Department of Pharmacognosy, College of Pharmacy, Nihon University, Japan) Dept. of Natural Medicinal Chemistry Shenyang Pharmaceutical University Shenyang 110015 China Department of Pharmacognosy College of Pharmacy Nihon University Japan

A new antifungal antibiotics, wa, was isolated from the secondary metabolites of soil fungus strain 38, and its structure was elucidated as 4-(2-hydroxy-3-butynoxy)benzoic acid by means of the spectral data (H-1-and C... 详细信息

关键词： wa structure elucidation activity against P-oryzae

基于LSDYNA的井下套管水力切割仿真与实验研究

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机械设计与制造 2024年第6期400卷 282-286,293页

作者：付文颜廷俊朱庆利王文胜北京化工大学机电工程学院北京100029 中石化胜利石油工程有限公司井下作业公司山东东营257000

为弥补传统井下开窗方法的不足,磨料水射流技术逐渐被应用到此领域,基于实际井下应用,若开出(30×50)mm的孔,则可继续喷射地层,实现一次性开窗及破岩。磨料水射流技术开窗具有效率高、无毛刺、喷嘴结构简单的特点。这里利用LSDYNA软件... 详细信息

为弥补传统井下开窗方法的不足,磨料水射流技术逐渐被应用到此领域,基于实际井下应用,若开出(30×50)mm的孔,则可继续喷射地层,实现一次性开窗及破岩。磨料水射流技术开窗具有效率高、无毛刺、喷嘴结构简单的特点。这里利用LSDYNA软件模拟磨料水射流对套管壁的冲蚀与仿真,并分析了割缝中工件压力分布。采用第一次实验确定模拟模型,利用第二次实验进行模型的验证,用确定好的模拟模型对不同结构的喷嘴进行仿真,为研制可切割(30×50)mm孔的喷嘴提供依据,节省实验成本。

关键词：磨料水射流 LSDYNA 流固耦合

The use of Phanerochaete chrysosporium,Trichoderma harzianum and Trichoderma viride for biogas production

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Studies in Fungi 2020年第1期5卷 368-380页

作者： Mahmoud YA-g Awadalla OA Estafanous AN Etawy wa Tanta University Faculty of ScienceBotany and Microbiology DepartmentMycology Research Lab.Tanta 31527Egypt Agriculture Microbiology Department SoilWater and Environment Research InstituteAgriculture Research CenterCairoEgypt

The expanding cost of ordinary fuel in urban zones requires the investigation of other vitality *** exploitation of agricultural wastes for biogas production could protect our environment and can also solve emerging energy crises *** chrysosporium,Trichoderma virdie and Trichoderma harzianum were used to ferment rice straw and cattle dung for production of compost and *** yield was determined using displacement technique,using acidified water(1 N H_(2)SO_(4))to prevent solubilization of carbon dioxide contained in the *** results showed that the highest rate of biogas and methane were recorded with treated rice straw mixed with cattle dung where the amount of production from the total gas was 51.84 of biogas and 37.86 of methane per Liter(L)/Kilogram(Kg)of fermented ***,the results showed that the consumed biogas and methane related to volatile solids gave the highest amount with untreated rice straw(86.32 and 56.72 L/Kg respectively)followed by treated rice straw and untreated and treated mixtures of rice straw and cattle dung *** results also showed that the highest bacterial count was obtained from fungi treated rice straw mixed with cattle dung(125×10^(3)cells/g)followed by treated rice straw(32×10^(3)cells/g).This study confirms that ***,*** and *** significantly speed up the process of aerobic and anaerobic fermentation of rice straw in respect to biogas and methane production.

关键词： Aerobic fermentation Anaerobic fermentation Methane Rice straw

Sol-gel Template Synthesis and Photoluminescence Properties of (Pb_(0.5)Sr_(0.5))TiO_(3) Nanotube Arrays

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Chinese Physics Letters 2011年第7期28卷 278-281页

作者： JIANg Yan-Ping wa.g Yu CHAN Lai wa Helen TANg xin-gui ZHOU Yi-Chun Key Laboratory of Low-Dimensional Materials and Application Technology Xiangtan UniversityXiangtan 411105 Department of Applied Physics and Materials Research Centre Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Physics&Optoelectric Engineering and Guangzhou Higher Education Mega CenterGuangdong University of TechnologyGuangzhou 510006

Lead strontium titanate(Pb_(0.5)Sr_(0.5))TiO_(3)(PST)nanotube arrays are prepared by a sol-gel and spin-coating process using an anodic aluminium oxide *** structure and morphology of the as-prepared sample are characterized by x-ray diffraction,scanning electron microscopy and transmission electron *** results show that the as-prepared PST sample possesses a perovskite structure with a relatively uniform diameter of about 200 ***(PL)spectrum of the sample shows emission bands centered at about 2.87 eV at room temperature,which consists of three intense emission sub-bands at 3.02,2.87 and 2.76 eV,*** energy corresponding to the central PL peak is lower than the band-gap energy(3.2 eV)of PST bulk materials,which may originate from the size effect of the PST nanotube *** multi-peaks in the PL spectrum may be attributed to the radiative recombination of trapped electrons and holes in tail and gap states induced by local defect and oxygen *** Raman scattering spectrum of the PST nanotube arrays,which are obviously broadened in comparison with the bulk materials,show that their phonon modes are in agreement with those allowed in the tetragonal phase.

关键词： template perovskite bands

Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study

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Neural Regeneration Research 2024年第12期19卷 2773-2784页

作者： Hui Zhu James D.guest Sarah Dunlop Jia-xin Xie Sujuan gao Zhuojing Luo Joe E.Springer Wutian Wu Wise Young wai Sang Poon Song Liu Hongkun gao Tao Yu Dianchun wa.g Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei wa.g Yansheng Liu Kwok-Fai So Xiao-Ming Xu Kunming Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia Minderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Department of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA guangdong-HongKong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.M.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Department Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Research group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 *** combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locomotor training neurological recovery surgical intervention weightbearing walking training