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Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index:A Mendelian Randomization Study

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Phenomics 2022年第6期2卷 430-437页

作者： Hui Zhang Meng Hao Zixin Hu Yi Li Xiaoxi Hu Xiaoyan Jiang Zuyun Liu xuehui Sun Xiaofeng wa.g Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 200433China Fudan University-the People’s Hospital of Rugao Joint Research Institute of Longevity and Ageing Rugao 226599JiangsuChina Key Laboratory of Arrhythmias of the Ministry of Education of China Tongji University School of MedicineShanghai 200092China Center for Clinical Big Data and Analytics Second Affiliated Hospital and Department of Big Data in Health ScienceSchool of Public HealthZhejiang University School of MedicineHangzhou 310030ZhejiangChina

Owing to the susceptibility of conventional observational studies to confounding factors and reverse causation,the causal association between cardiac function and frailty is *** aimed to investigate whether cardiac function has causal effects on *** this study,a two-sample Mendelian randomization(MR)study was conducted using genetic variants associated with cardiac function assessed by magnetic resonance imaging phenotypes as instrumental *** variants asso-ciated with cardiac function by magnetic resonance imaging(including seven cardiac function phenotypes)and the frailty index(FI)were obtained from two large genome-wide association *** estimates from each genetic instrument were combined using inverse variance weighted(IVW),weighted median,and MR‒Egger regression *** found that the increase in genetically determined stroke volume(beta-0.13,95%CI-0.16 to-0.10,p=1.39E-6),rather than other cardiac phenotypes,was associated with lower FI in MR analysis of IVW after Bonferroni *** analyses examining potential bias caused by pleiotropy or reverse causality revealed similar findings(e.g.,intercept[SE],-0.008[0.011],p=0.47 by MR‒Egger intercept test).The leave-one-out analysis indicated that the association was not driven by single nucleotide *** evidence of heterogeneity was found among the genetic variants(e.g.,MR‒Egger:Q statistic=14.4,p=0.156).In conclusion,we provided evidence that improved cardiac function could contribute to reducing *** findings support the hypothesis that enhancing cardiac function could be an effective prevention strategy for frailty.

关键词： Cardiac function Frailty Mendelian randomization genetics

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基于氢氧化钙为中和剂的大肠杆菌丁二酸发酵

中国调味品 2024年第10期49卷 9-13页

作者：陈思宇孙瑞雪包晨鹏王金华高娃王永泽湖北工业大学生物工程与食品学院武汉430068 湖北工业大学发酵工程教育部重点实验室武汉430068 湖北工业大学工业发酵省部共建协同创新中心武汉430068

氢氧化钙因其价格相对低廉且与其配套的有机酸分离纯化工艺成熟,常作为中和剂应用于有机酸发酵中。但在丁二酸发酵中,因其不能提供丁二酸合成所必需的二氧化碳,存在发酵产量低的问题。文章建立并优化了以氢氧化钙为中和剂结合二氧化碳... 详细信息

氢氧化钙因其价格相对低廉且与其配套的有机酸分离纯化工艺成熟,常作为中和剂应用于有机酸发酵中。但在丁二酸发酵中,因其不能提供丁二酸合成所必需的二氧化碳,存在发酵产量低的问题。文章建立并优化了以氢氧化钙为中和剂结合二氧化碳脉冲补料发酵生产丁二酸的方法。发酵初期不添加中和剂,pH值自然下降至5.7时,立即流加23%氢氧化钙溶液使pH值升至7.5,然后停止添加中和剂,通入0.2 m^(3)/(m^(3)·min)二氧化碳气体至pH值降至6.5时停止通气使发酵液自然发酵,当pH值下降至5.7时,再循环上述操作。使用该方法时,发酵产量为88.47 g/L,糖酸转化率为96.03%,平均生产强度为2.21 g/(L·h),相较于以氢氧化钙为中和剂不补入或者连续通入二氧化碳的方式,糖酸转化率分别提高了298%和95%。该方法为解决使用氢氧化钙作中和剂发酵丁二酸产量低的问题提供了新思路,也为利用现有有机酸分离设备大规模生产丁二酸打下了良好基础。

关键词：大肠杆菌丁二酸氢氧化钙二氧化碳中和剂

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Endoscopic surgery for intraventricular hemorrhage:A comparative study and single center surgical experience

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World Journal of Clinical Cases 2022年第16期10卷 5208-5216页

作者： Feng-Bo wa.g Xiao-wa Yuan Jin-Xiao Li Ming Zhang Zhao-Hui Xiang Department of Neurosurgery Xinyi People's HospitalXinyi 221400Jiangsu ProvinceChina

BACKgROUND Intraventricular hemorrhage is a neurosurgical emergency,and a dangerous condition associated with high morbidity and ***,hematoma evacuation is generally executed by external intracranial drainage(EVD)or surgical ***,endoscopic evacuation is emerging as a good alternative because it brings relatively less invasion and ***,successful endoscopic evacuation requires skilled manipulation of endoscopic devices and the evidence supporting its efficacy differs in different *** To improve the technique usage and provide more evidence of endoscopic evacuation efficacy,we summarize our surgical experience and compared the outcomes of the endoscopic evacuation with EVD using real-world *** We retrospectively studied 96 consecutive patients with intraventricular hemorrhage who underwent either endoscopic surgery(n=43)or non-endoscopic surgery(n=53)for hemorrhage evacuation between November 2013 and September 2019 in our ***’conditions prior to and after the operation were evaluated and analyzed to assess the efficacy of the *** consciousness status improvement and perioperative in-hospital parameters in the two types of operation groups were assessed and *** Patients in the endoscopic and non-endoscopic groups presented with a similar state of consciousness,with a comparable glasgow Coma Scale(gCS)*** average operation time of the endoscopic group was longer than that of the nonendoscopic group(median 2.42 h vs 1.08 h,Pgh the endoscopic group was older and had a baseline graeb score that indicated more severe hemorrhage than the non-endoscopic group(graeb median:Endoscopic group=9 vs non-endoscopic group=8,P=0.023),the clearance rate of hematoma was as high as 60.5%.Both the endoscopic and non-endoscopic groups showed an improved gCS index after ***,this improvement was more marked in patients in the endoscopic group(median improvement of g

关键词： Ventriculoscope Intraventricular hemorrhage Minimal invasion Ventricular irrigation fluid Endoscopic evacuation Efficacy

MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1

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Chinese Medical Journal 2014年第8期127卷 1410-1416页

作者： Li Yang Huang Qiming Shi xuehui Jin Xiang Shen Li Xu Xiaolin Wei Wenbin Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Key Laboratory of Ophthalmology and Visual Science Beijing 100730 China Department of Cell Biology Peking University Health Science Center Peking University Stem Cell Research Center Beijing 100191 China

Background MicroRNAs （miRNAs） contribute to tumorigenesis by acting as either oncogenes or tumor suppressor genes. In this study, we investigated the role of miR-145 in the pathogenesis of uveal melanoma. Methods Expression profiles of miRNAs in uveal melanoma were performed using Agilent miRNA array. Quantitative real-time polymerase chain reaction was used to screen the expression levels of miR-145 in normal uveal tissue, uveal melanoma tissue, and uveal melanoma cell lines. Lenti-virus expression system was used to construct MUM-2B and OCM-1 cell lines with stable overexpression of miR-145. Cell proliferation, cell cycle, and cell apoptosis of these miR-145 overexpression cell lines were examined by MTT assay and flow cytometry respectively. The target genes of miR-145 were predicted by bioinformatics and confirmed using a luciferase reporter assay. The expression of insulin-like growth factor-1 receptor （IgF-1R）, insulin receptor substrate-1 （IRS-1） proteins was determined by Western blotting analysis. IRS- 1 was knocked down in OCM-1 cells. TUNEL, BrdU, and flow cytometry assay were performed in IRS-1 knocked down OCM-1 cell lines to analyze its function. Results Forty-seven miRNAs were up regulated in uveal melanoma and 61 were down regulated, miR-145 expression was significantly lower in uveal melanoma sample and the cell lines were compared with normal uveal sample. Overexpression of miR-145 suppressed cell proliferation by blocking the g1 phase entering S phase in uveal melanoma cells, and promoted uveal melanoma cell apoptosis. IRS-1 was identified as a potential target of miR-145 by dual luciferase reporter assay. Knocking down of IRS-1 had similar effect as overexpression of miR-145. Conclusion miR-145 might act as a tumor suppressor in uveal melanoma, and downregulation of the target IRS-1 might be a potential mechanism.

关键词： uveal melanoma microRNA array miR-145 insulin receptor substrate-1

Effects of Low-Intensity Ultrasound on Cell Proliferation and Reproductivity

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Transactions of Tianjin University 2016年第2期22卷 125-131页

作者：杨春梅蒋学慧杜康蔡启亮 Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments School of Precision Instrument and Opto-Electronics Engineering Tianjin University Department of Urology Tianjin Institute of Urology The Second Hospital of Tianjin Medical University

Ultrasound has been widely used in clinics. Cellular responses to low-intensity ultrasound are parameter-dependent. Proper parameter setting is vital to its exact use. To get guidelines for parameter setting, lowintensity ultrasound stimulation on the proliferation and reproductivity of Hep g2 and 3T3 cells in vitro was examined with a 1.06 MHz-generator by changing the parameters(including intensity, pulse repetition frequency and duty cycle)in a wide range. Cell viability and reproductivity at different time after sonication were measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and colony formation assay to indicate timerelated proliferation. The results illustrate that ultrasound irradiation at 0.4—0.8 W/cm^2 and high pulse repetition frequency(100 Hz)can facilitate cell proliferation, while above 0.8 W/cm^2 would resist it. The extent of resistance closely correlated with duty cycle and pulse repetition frequency. Resistance effect at low pulse repetition frequency(1 Hz)is greater than that at high pulse repetition frequency(100 Hz)and not time-related. The influence of high pulse repetition frequency is time-accumulated, indicating cellular process involved. These findings would provide valuable guidelines for the application of low-intensity ultrasound in stem cell transformation and tissue engineering.

关键词： low-intensity ultrasound cell viability cell morphology cell proliferation cell reproductivity

植物生长调节剂对长挺秀高粱农艺性状和产量的影响

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农药科学与管理 2024年第6期45卷 48-53,59页

作者：周江明张国顺张路生韩小伟卜令豪王红霞何川田雪慧滨州市农业科学院山东滨州256600 滨州市农技推广中心山东滨州256600 滨州市滨城区农技推广中心山东滨州256600

为筛选出有效降低“长挺秀”高粱株高、提高其抗倒伏能力及产量的植物生长调节剂及最佳施用量,选用4种植物生长调节剂进行田间试验。结果表明,“长挺秀”高粱3~4叶期叶面喷施胺鲜·乙烯利、甲哌鎓、多效唑和矮壮素均能不同程度地矮化植... 详细信息

为筛选出有效降低“长挺秀”高粱株高、提高其抗倒伏能力及产量的植物生长调节剂及最佳施用量,选用4种植物生长调节剂进行田间试验。结果表明,“长挺秀”高粱3~4叶期叶面喷施胺鲜·乙烯利、甲哌鎓、多效唑和矮壮素均能不同程度地矮化植株,增加茎粗,提高抗倒伏能力,达到增产效果,其中30%胺鲜·乙烯利可溶性液剂最佳施用量为450 g/hm^(2),250 g/L甲哌鎓水剂最佳施用量为1 500 g/hm^(2),50%矮壮素水剂最佳施用量为900 g/hm^(2),15%多效唑可湿性粉剂最佳施用量为405 g/hm^(2)。此结果可为“长挺秀”高粱优质高产栽培与植物生长调节剂的登记应用提供技术支撑。

关键词：植物生长调节剂 “长挺秀”高粱抗倒伏产量

SELECTIVE COPPER REMOVAL FROM CUPRIFEROUS gOLD CONCENTRATE

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中国有色金属学会会刊：英文版 1995年第1期5卷 36-41页

作者： Deng Tong(Institute of Chemical Metallurgy, Academia Sinica, Beijing 100080) Muir David(School of MPS , Murdoch University, wa 6150, Australia) ACAD SINICA INST CHEM METBEIJING 100080PEOPLES R CHINA MURDOCH UNIV SCH MATH & PHYS SCIMURDOCHWA 6150AUSTRALIA

ＳＥＬＥＣＴＩＶＥＣＯＰＰＥＲＲＥＭＯＶＡＬＦＲＯＭＣＵＰＲＩＦＥＲＯＵＳＧＯＬＤＣＯＮＣＥＮＴＲＡＴＥＤｅｎｇ；Ｔｏｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＭｅｔａｌｌｕｒｇｙ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂ... 详细信息

ＳＥＬＥＣＴＩＶＥＣＯＰＰＥＲＲＥＭＯＶＡＬＦＲＯＭＣＵＰＲＩＦＥＲＯＵＳＧＯＬＤＣＯＮＣＥＮＴＲＡＴＥＤｅｎｇ；Ｔｏｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＣｈｅｍｉｃａｌＭｅｔａｌｌｕｒｇｙ，ＡｃａｄｅｍｉａＳｉｎｉｃａ，Ｂｅｉｊｉｎｇ１０００８０）Ｍｕｉｒ...

关键词： copper selective leaching cupriferous gold concentate

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热处理对镍基合金g3耐蚀性能的影响

稀有金属材料与工程 2012年第3期41卷 482-485页

作者：田伟谢发勤赵雪会西北工业大学陕西西安710072 中国石油集团石油管工程技术研究院陕西西安710065

针对国产商用镍基耐蚀合金g3,采用TEM、SEM等方法研究固溶时效对合金微观组织及析出相的影响;进而利用高温高压釜的挂片试验,分析组织变化以及析出相对材料在H2S/CO2共存的井下水中耐蚀性能的影响。结果表明,该镍基合金的固溶温度应低于... 详细信息

针对国产商用镍基耐蚀合金g3,采用TEM、SEM等方法研究固溶时效对合金微观组织及析出相的影响;进而利用高温高压釜的挂片试验,分析组织变化以及析出相对材料在H2S/CO2共存的井下水中耐蚀性能的影响。结果表明,该镍基合金的固溶温度应低于1150℃,以避免合金晶粒过大。随时效温度的提高,晶界析出的M23C6碳化物增多,并在晶内形成M6C片状碳化物。析出相的形成导致镍基合金的点蚀加剧,由于碳化铬在晶界上析出而导致的贫铬是引发点蚀的主要原因。

关键词：镍基耐蚀合金固溶处理析出相腐蚀

Stabilization of MYC g-quadruplex DNA by ruthenium(II)complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation

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genes & Diseases 2023年第2期10卷 399-402页

作者： Yuening Sun Xin Chen Siyan Liao Aochu Liu Huan Zhou Liling Jiang wa Ding Wenjie Mei Jinbao Liu Xianping Shi guangzhou Municipal and guangdong Provincial Key Laboratory of Protein Modification and Degradation State Key Laboratory of Respiratory DiseaseAffiliated Cancer Hospital of Guangzhou Medical University School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouGuangdong 510120China guangdong Province Engineering Technology Center for Molecular Probe and Biomedicine Imaging Guangdong Pharmaceutical UniversityGuangzhouGuangdong 510006China

The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of ***(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to ***,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance.

关键词： myeloid overcome resistance