检索结果-南通市图书馆

Journal of Iron and Steel Research International 2024年第1期31卷 3-23页

作者： Xue-cheng Peng Han-jie guo Xin-fang Zhang Yi-wa Luo Ye Sun Jing guo Rong-guang Yang Xiao-dan Zheng School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials University of Science and Technology Beijing(USTB)Beijing100083China Beijing Shougang gitane New MATERIALS Co. Ltd.Beijing102206China

Heat-resistant alloys with excellent mechanical properties are widely used in various fields,and further improvement in their properties is essential to meet the requirements in new-generation advanced supercritical boilers,nuclear reactors,superheaters,and other new materials *** effectively enhance the comprehensive performance of heat-resistant alloys,second-phase particle strengthening has been widely studied,and in the face of different service envi-ronments of advanced heat-resistant steels,the selection of suitable second-phase particles is essential to maximize the performance of these *** this end,three major types of reinforcing phases in heat-resistant alloys such as carbides,rare earth oxides,and intermetallic compounds are summarized.A comparative analysis of the precipitation behavior of the reinforcing phases with different types as well as the risks and means of controlling their use in service,is *** parameters for the application of various types of second-phase particles in heat-resistant alloys are provided to support the design and preparation of new ultrahigh-performance heat-resistant alloys.

关键词： Heat-resistant alloy Second-phase particle Carbide Rare earth oxide Intermetallic compound Strengthening

Supramolecular Manipulation of Intracellular Acidic Vesicles to Improve Cellular Self-Repair and Self-Defense

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CCS Chemistry 2024年第6期6卷 1487-1498页

作者： Ziyi wa.g chen Sun Yu Dong Yuan-Fu Ding chen Zhao Ian wa Ho Jiahong Lu Ruibing wa.g State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao 999078China

Lysosomes are the“cell stomach”that digests various species including macromolecules and pathogens for self-repair and self-defense upon fusion with endosomes,autophagosomes,and ***,artificially manipulating intracellular vesicles could potentially promote lysosome-mediated intracellular digestion for disease prevention and ***,a supramolecular strategy to efficiently tether and fuse acidic vesicles(i.e.,lysosomes,late endosomes,autolysosomes,and phagosomes)has been developed for the first time to enhance the digestion of cellular wastes and foreign matter,including pathogens.A linear polyethylene glycol(PEg)derivative dually tagged with morpholine(MOR)and adamantane(ADA)on the opposite side,namely,MOR-PEg-ADA,was designed to target intracellular acidic vesicles via MOR and to decorate their surfaces with ***,the addition of cucurbit[7]uril(CB[7])grafted hyaluronic acid(HA)induced supramolecular tethering and fusion of acidic vesicles via strong host-guest interactions between CB[7]of CB[7]-HA and ADA residing on the surface of acidic *** a proof-ofconcept,the overall cellular metabolism,including endogenous autophagy and the exogenous endocytosis and phagocytosis,was effectively upregulated,demonstrating that supramolecular regulation of the dynamics of intracellular acidic vesicles may promote the lysosome’s digestion to significantly improve cellular self-repair and self-defense.

关键词： supramolecular chemistry organelle regulation intracellular acidic vesicles lysosomes selfdefense self-repair

Added value of ratio of cross diameters of the appendix in ultrasound diagnosis of acute appendicitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastrointestinal Surgery 2024年第1期16卷 21-28页

作者： Feng-wa.gu Si-Ze Wu Department of Ultrasound The First Affiliated Hospital of Hainan Medical UniversityHaikou 570102Hainan ProvinceChina

BACKgROUND The maximum outer diameter(MOD)of the appendix is an essential parameter for diagnosing acute appendicitis,but there is space for improvement in ultrasound(US)diagnostic *** To investigate whether combining the ratio of the cross diameters(RATIO)of the appendix with MOD of the appendix can enhance the diagnostic performance of acute *** A retrospective study was conducted,and medical records of 233 patients with acute appendicitis and 112 patients with a normal appendix were *** MOD and RATIO of the appendix were calculated and tested for their diagnostic performance of acute appendicitis,both individually and in *** The RATIO for a normal appendix was 1.32±0.16,while for acute appendicitis it was 1.09±*** cut-off value for RATIO was determined to be≤*** area under the receiver operating characteristic curve(AUC)for diagnosing acute appendicitis using RATIO≤1.18 and MOD>6 mm was 0.870 and 0.652,*** was a significant difference in AUC between RATIO≤1.18 and MOD>6 mm(Pg the combination of RATIO≤1.18 and MOD>6 mm with MOD>6 mm alone,the combination showed increased specificity,positive predictive value(PPV),and ***,the sensitivity and negative predictive value *** Combining RATIO of the appendix≤1.18 and MOD>6 mm can significantly improve the specificity,PPV,and AUC in the US diagnosis of acute appendicitis.

关键词： Acute appendicitis Diameter Ratio Diagnosis Ultrasound

Active Cu and Fe Nanoparticles Codecorated Ruddlesden-Popper-Type Perovskite as Solid Oxide Electrolysis Cells Cathode for CO2 Splitting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第5期7卷 219-227页

作者： Dongliang Liu Hang Shang Chuan Zhou jie Miao Daxiang Xue Zeping chen Meijuan Fei Fengli Liang Qiang Niu Ran Ran Wei Zhou Zongping Shao State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Suzhou Laboratory School of Environmental Science and Engineering Nanjing Tech University Inner Mongolia Erdos Electric Power and Metallurgy group Co. Ltd. Jiangsu Province Key Laboratory of Aerospace Power System College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics wa School of Mines: Minerals Energy and Chemical Engineering (WASM-MECE) Curtin University

Solid oxide electrolysis cells （SOECs）, displaying high current density and energy efficiency, have been proven to be an effective technique to electrochemically reduce CO2into CO. However, the insufficiency of cathode activity and stability is a tricky problem to be addressed for SOECs. Hence, it is urgent to develop suitable cathode materials with excellent catalytic activity and stability for further practical application of SOECs. Herein, a reduced perovskite oxide, Pr0.35Sr0.6Fe0.7Cu0.2Mo0.1O3-δ（PSFCM0.35）, is developed as SOECs cathode to electrolyze CO2. After reduction in 10%H2/Ar, Cu and Fe nanoparticles are exsolved from the PSFCM0.35 lattice,resulting in a phase transformation from cubic perovskite to Ruddlesden–Popper （RP） perovskite with more oxygen vacancies. The exsolved metal nanoparticles are tightly attached to the perovskite substrate and afford more active sites to accelerate CO2adsorption and dissociation on the cathode surface. The significantly strengthened CO2adsorption capacity obtained after reduction is demonstrated by in situ Fourier transforminfrared（FT-IR） spectra. Symmetric cells with the reduced PSFCM0.35 （RPSFCM0.35）electrode exhibit a low polarization resistance of 0.43Ωcm2at850℃. Single electrolysis cells with the R-PSFCM0.35 cathode display an outstanding current density of 2947 mA cm-2at 850℃and 1.6 V. In addition, the catalytic stability of the R-PSFCM0.35 cathode is also proved by operating at 800℃with an applied constant current density of600 mA cm-2for 100 h.

关键词： cathode CO2 reduction nanoparticles decoration solid oxide electrolysis cells

Hormone-based pharmacotherapy for metabolic dysfunction-associated fatty liver disease

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Medical Review 2024年第2期4卷 158-168页

作者： Zara Siu wa Chui Yaqian Xue Aimin Xu State Key Laboratory of Pharmaceutical Biotechnology The University of Hong KongHong Kong SARChina Department of Medicine The University of Hong KongHong Kong SARChina School of Biomedical Sciences The University of Hong KongHong Kong SARChina State Key Laboratory of Pharmaceutical Biotechnology The University of Hong Kong999077Hong Kong SARChina Department of Medicine The University of Hong Kong999077Hong Kong SARChina Department of Pharmacology and Pharmacy The University of Hong Kong999077Hong Kong SARChina

Metabolic dysfunction-associated fatty liver disease(MAFLD)has reached epidemic proportions globally in parallel to the rising prevalence of *** its significant burden,there is no approved pharmacotherapy specifically tailored for this *** potential drug candidates for MAFLD have encountered setbacks in clinical trials,due to safety concerns or/and insufficient therapeutic ***,several investigational drugs that mimic the actions of endogenous metabolic hormones,including thyroid hormone receptorβ(THRβ)agonists,fibroblast growth factor 21(FgF21)analogues,and glucagon-like peptide-1 receptor agonists(gLP-1RAs),showed promising therapeutic efficacy and excellent safety *** them,resmetirom,a liver-targeted THRβ-selective agonist,has met the primary outcomes in alleviation of metabolic dysfunction-associated steatohepatitis(MASH),the advanced form of MAFLD,and liver fibrosis in phase-3 clinical *** hormone-based pharmacotherapies not only exhibit varied degrees of therapeutic efficacy in mitigating hepatic steatosis,inflammation and fibrosis,but also improve metabolic ***more,these three hormonal agonists/analogues act in a complementary manner to exert their pharmacological effects,suggesting their combined therapies may yield synergistic therapeutic *** in-depth studies on the intricate interplay among these metabolic hormones are imperative for the development of more efficacious combination therapies,enabling precision management of MAFLD and its associated comorbidities.

关键词： metabolic hormones metabolic dysfunctionassociated steatohepatitis(MASH) liver fibrosis biopharmaceutical development clinical trials

The mechanistic study on wa medicine Niang-Mu-Liang medicinal liquor mitigating diabetes mellitus erectile dysfunction in rats by inhibiting ferroptosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Medicine Discovery 2024年第10期8卷 1-5页

作者： Yu-Ming wa.g Rui Qian Xue-Hua Xie Yao chen Huan-Tian Cui Wei-Bo Wen jie Zhao graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China The First Affiliated Hospital Yunnan University of Chinese MedicineKunming 650500China

Background:This study aims to investigate the therapeutic effect of wa medicine Niang-Mu-Liang medicinal liquor(NML)on rats with diabetes mellitus erectile dysfunction(DMED)and its impact on the ferroptosis signaling ***:Thirty Sprague-Dawley rats were randomly divided into three groups:Control,DMED,and *** establishing the DMED model,treatments were administered for 8 *** the administration,apomorphine hydrochloride tests were conducted to measure the mass and organ index of testes and epididymides,sperm concentration and viability in each *** corpus cavernosum tissues were stained with hematoxylin and *** oxide and cyclic guanosine monophosphate levels in the penile corpus cavernosum tissues were determined using biochemical kits and enzyme-linked immunosorbent assay,while the expression of proteins related to the ferroptosis signaling pathway was measured by Western ***:Compared to the DMED group,the DMED rats treated with NML showed significantly increased erection frequency,testicular and epididymal mass and index,sperm count and viability,along with noticeable improvement in the pathological morphology of penile corpus *** content of nitric oxide and cyclic guanosine monophosphate,and the expression of ferritin heavy chain,ferritin light chain,and glutathione peroxidase 4 proteins in penile corpus cavernosum tissue were elevated,while the expression of transferrin and STEAP3 proteins was ***:NML can improve erectile function in DMED rats by inhibiting the ferroptosis signaling pathway.

关键词： Niang-Mu-Liang medicinal liquor diabetes mellitus erectile dysfunction nitric oxide/cyclic guanosine monophosphate ferroptosis

The earliest evidence for a microblade adaptation in the remote,high altitude regions of the Tibetan Plateau

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第5期67卷 1561-1573页

作者： Yingshuai JIN Xiaoling ZHANg Shejiang wa.g Junyi gE Wei HE wa DA Yunyao TAN Ziyi YANg Christopher MORgAN Xing gAO Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China University of the Chinese Academy of Sciences Beijing 100049China Cultural Relics Conservation Institute of the Xizang Autonomous Region Lhasa 850000China Nagqu Culture and Tourism Bureau Nagqu 852000China University of Nevada Reno 89557USA

Microblade assemblages are among the most common prehistoric archaeological materials found on the Tibetan Plateau(TP)and are thought to indicate large scale migration to and settlement of the *** microblade sites,however,have been systematically excavated,especially in the remotest,highest-elevation regions of the *** timing of the large-scale arrival,spread,and permanent settlement of people on the TP therefore remains *** this paper,we report on a recently excavated site,Locality 3 of the Nwya Devu Site(ND3),located at 4600 meters above sea level(masl),near the shore of Ngoin Lake,on the interior *** analyses reveal a fairly typical microblade technological orientation and two types of microblade cores:wedge-shaped and semi-conical,which are similar to those found throughout North *** Optically Stimulated Luminescence(OSL)dating and AMS^(14)C dating,the age of ND3 ranges from 11 to 10 *** date range indicates ND3 is the oldest microblade site yet recorded in the remote,high-elevation regions of the TP and thus provides important information about when and how hunter-gatherers using microblades began exploiting the higher altitudes of the *** together,studies at ND3 and throughout the TP suggest that a microblade adaptation is associated with the first prolonged human occupation of the plateau and that microblades played a significant role in mediating the risks and facilitating the mobility necessary to permanently inhabit the TP.

关键词： The interior of Tibetan Plateau Nwya Devu locality 3 Microblade Early Holocene High altitude adaption

Virus-Host Interactions Drive Contrasting Bacterial Diel Dynamics in the Ocean

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research 2024年第2期6卷 389-399页

作者： Xiaowei chen chen Hu Wei Wei Yunlan Yang Markus g.Weinbauer Hongbo Li Shiying Ren Ruije Ma YVibin Huang Tingwei Luo Nianzhi Jiao Rui Zhang State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesFujian Key Laboratory of Marine Carbon SequestrationXiamen UniversityXiamen 361102PR China College of the Environment and Ecology Xiamen UniversityXiamen 361102PR China Research Center for Environmental Ecology and Engineering School of Environmental Ecology and Biological EngineeringWuhan Institute of TechnologyWuhan 430205PR China Sorbonne Universités UPMCUniversitéParis 06CNRSLaboratoire d'Oceanographie de Villefranche(LOV)Villefranche-sur-Mer 06230France National Marine Environmental Monitoring Center Ministry of Ecological EnvironmentDalian 116023PR China Department of Ocean Sciences University of CaliforniaSanta CruzCAUSA NOAA/OAR Pacific Marine Environmental Laboratory SeattleWAUSA Institute for Advanced Study Shenzhen UniversityShenzhen 518055PR China

Marine organisms perform a sea of diel *** diel dynamics have been shown to be driven by light,energy resources,circadian rhythms,and the coordinated coupling of photoautotrophs and heterotrophic ***,we explore the diel fluctuation of viral production and decay and their impact on the total and active bacterial community in the coastal and open seawaters of the South China *** results showed that the night-production diel pattern of lytic viral production was concurrent with the lower viral decay at night,contributing to the accumulation of the viral population size during the night for surface *** diel variations in bacterial activity,community composition,and diversity were found highly affected by viral *** was revealed by the finding that bacterial community diversity was positively correlated to lytic viral production in the euphotic zone of the open ocean but was negatively related to lysogenic viral production in the coastal *** distinct but contrasting correlations suggest that viral life strategies can not only contribute to diversifying bacterial community but also potentially piggyback their host to dominate bacterial community,suggesting the tightly synchronized depth-dependent and habitat-specific diel patterns of virus-host *** further implies that viruses serve as an ecologically important driver of bacterial diel dynamics across the ocean,highlighting the viral roles in bacterial ecological and biogeochemical processes in the ocean.

关键词： coastal ocean Marine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

玉米野生种基因组研究进展及应用

生物技术通报 2024年第3期40卷 14-24页

作者：胡伊娃陈露浙江大学农业与生物技术学院作物科学研究所杭州310058

气候变化为粮食生产、生态系统的稳定性带来了重要的挑战。在极端气候变化下,发展适应性物种是作物遗传育种的重要目标之一。作为重要的作物之一,玉米在经历强烈的驯化瓶颈之后,已经丢失了大量的遗传多样性,特别是一些与生物和非生物胁... 详细信息

气候变化为粮食生产、生态系统的稳定性带来了重要的挑战。在极端气候变化下,发展适应性物种是作物遗传育种的重要目标之一。作为重要的作物之一,玉米在经历强烈的驯化瓶颈之后,已经丢失了大量的遗传多样性,特别是一些与生物和非生物胁迫相关的位点。在野生种和农家种中寻找玉米驯化过程中丢失的遗传多样性,并将其应用于现代遗传育种中,将为适应性新品种的创制提供新的契机。本文在对大刍草(玉米野生近亲)的发现及分类研究进行介绍之后,进一步总结了大刍草和玉米的性状与基因组差异,并综述了目前基于遗传学、群体遗传学、分子生物学等对大刍草和玉米之间差异遗传机理剖析的进展,多角度表明了大刍草在玉米遗传学研究中的重要性。最后,对未来气候变化下大刍草在玉米育种中的重要性提出了展望。

关键词：气候变化玉米适应性野生种

A near-zero quiescent power breeze wake-up anemometer based on a rolling-bearing triboelectric nanogenerator

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2024年第2期10卷 241-249页

作者： Xianpeng Fu Zhichao Jiang jie Cao Zefang Dong guoxu Liu Meiling Zhu Chi Zhang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing101400China School of Nanoscience and Engineering University of Chinese Academy of SciencesBeijing100049China Center on Nanoenergy Research Guangxi Colleges and Universities Key Laboratory of Blue Energy and Systems IntegrationSchool of Physical Science&TechnologyGuangxi UniversityNanning530004China Institute of Intelligent Flexible Mechatronics Jiangsu UniversityZhenjiang212013China College of Engineering Mathematics and Physical ScienceUniversity of ExeterExeterEX44QFUK

Wind sensors have always played an irreplaceable role in environmental information monitoring and are expected to operate with lower power consumption to extend service ***,we propose a breeze wake-up anemometer(B-wa)based on a rolling-bearing triboelectric nanogenerator(RB-TENg)with extremely low static *** B-wa consists of two RB-TENgs,a self-waking-up module(SWM),a signal processing module(SPM),and a wireless transmission *** two RB-TENgs are employed for system activation and wind-speed *** the ambient wind-speed exceeds 2 m/s,the wake TENg(W-TENg)and the SWM can wake up the system within 0.96 *** the same time,the SPM starts to calculate the signal frequency from the measured TENg(M-TENg)to monitor the wind speed with a sensitivity of 9.45 Hz/(m/s).After the wind stops,the SWM can switch off the B-wa within 0.52 s to decrease the system energy *** quiescent on-duty mode,the operating power of the B-wa is less than 30 nW,which can greatly extend the service lifetime of the *** integrating triboelectric devices and rolling bearings,this work has realized an ultralow quiescent power and self-waked-up wireless wind-speed monitoring system,which has foreseeable applications in remote weather monitoring,IoT nodes,and so on.

关键词： generator power service