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药物临床试验中严重不良事件案例收集及规范化干预对策设计探讨

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中国医药指南 2025年第1期23卷 141-144页

作者：李颖徐州医科大学第二附属医院药物临床试验机构江苏徐州221006

目的分析药物临床试验中严重不良事件(SAE)案例,并探讨、设计规范化干预对策方案。方法纳入徐州医科大学第二附属医院2017年5月至2023年12月上报的药物临床试验SAE报告58例,分析受试者基本情况以及SAE发生情况及原因。结果58例报告中男... 详细信息

目的分析药物临床试验中严重不良事件(SAE)案例,并探讨、设计规范化干预对策方案。方法纳入徐州医科大学第二附属医院2017年5月至2023年12月上报的药物临床试验SAE报告58例,分析受试者基本情况以及SAE发生情况及原因。结果58例报告中男性受试者SAE发生率高于女性(P<0.05),并且SAE发生率随年龄增加呈上升趋势;SAE在内分泌科发生率最高,占比34.48%;SAE导致住院发生率最高,占比67.24%;SAE中生物制品占比最高,为51.72%;SAE报告呈逐年递增趋势,其中大部分SAE可在15 d内上报,占比81.03%(47/58);多数(46.56%)SAE被判定与试验药物无关;SAE报告表填写不规范是出现频次最多的问题,占比65.00%。结论为确保药物临床试验的完整性和受试者生命健康,应加强SAE规范性干预对策,获知并上报SAE,对发生SAE的受试者进行相应的救治。

关键词：药物临床试验严重不良事件规范化干预对策

基于课程目标达成评价的教学改革策略研究——以学前教育专业“幼儿游戏”课程为例

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林区教学 2025年第1期 71-74页

作者：陈莹福建幼儿师范高等专科学校福州350000

基于学生中心、产出导向、持续改进的认证理念,以学前教育专业核心课程“幼儿游戏”为例,探索对接毕业要求的课程目标达成评价,并根据课程目标达成评价结果深挖学生课程学习的不足与需求,剖析典型问题,进而持续改进课程教学,对课程目标... 详细信息

基于学生中心、产出导向、持续改进的认证理念,以学前教育专业核心课程“幼儿游戏”为例,探索对接毕业要求的课程目标达成评价,并根据课程目标达成评价结果深挖学生课程学习的不足与需求,剖析典型问题,进而持续改进课程教学,对课程目标定位的合理性进行再审视,对课程教学内容的模块化进行再架构,对课程教学方法的适配度进行再优化,以期提升课程教学质量,促进学生专业能力的可持续发展与人才培养的质量提升。

关键词：幼儿游戏课程目标评价课程教学改革

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密闭空间微生物消杀方法研究进展

北京理工大学学报 2025年第1期45卷 87-104页

作者：戴荣继郭子沐张莹北京理工大学生命学院北京100081

空间站是一种在近地轨道长时间运行、可供多名航天员巡访、长期工作和生活的载人航天器,在密闭恒温恒湿的环境下,微生物的数量会快速增加,如果不加以控制,就会危害宇航员的身体健康,腐蚀或损坏航天器材,对航天安全产生不利的影响.通过... 详细信息

空间站是一种在近地轨道长时间运行、可供多名航天员巡访、长期工作和生活的载人航天器,在密闭恒温恒湿的环境下,微生物的数量会快速增加,如果不加以控制,就会危害宇航员的身体健康,腐蚀或损坏航天器材,对航天安全产生不利的影响.通过阐明空间微生物污染的主要来源与空间微生物污染对宇航员健康和设备安全方面造成的危害,综述了各种杀菌消毒方法如高温、辐射、环氧乙烷、臭氧、超临界流体、气体等离子体、光催化氧化、自清洁表面和诱导发光聚集等的作用原理、应用场景以及各方法可否应用于空间环境的优缺点,并且对适用于空间微生物污染防控的方法进行了评价.

关键词：空间生物学空间站消毒杀菌方法超临界流体气体等离子体光催化氧化自清洁表面聚集诱导发光

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Spraying Arginine at 5 Days before Harvest Delays Postharvest Broccoli Senescence via Nutrient Accumulation

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食品科学 2025年第1期46卷 131-141页

作者： SUN Yupeng CHEN ying SHANG Qingwen GUO Yanyin ZHANG Yuxiao WANG Yunqiao XUE Qingyue College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049China Zichuan District Agricultural and Rural Affairs Service Center Zibo 255049China

To determine the effects of preharvest arginine spraying on the nutritional level of broccoli and the mechanism of action of arginine in improving the storage quality of broccoli,arginine spraying(5 mmol/L)was conducted at 0,1,3,and 5 days before *** appearance,respiration rate,mass-loss rate,electrolyte leakage,glucosinolate,ascorbic acid,total phenol,total flavonoid,total sugar and sucrose contents,and sucrose phosphate synthase(SPS),invertase(INV),sucrose synthase synthesis(SSS)and cleavage(SSC)activities of broccoli samples were observed after 0,2,4,6,8,and 10 days of *** results showed that spraying arginine at 5 days preharvest(5-ARG)helped to inhibit broccoli respiration during storage,delay electrolyte leakage,and maintain broccoli ***,during the growth stage,total sugar accumulation was higher in the 5-ARG *** addition,during the storage period,sucrose synthesis was accelerated,while sucrose cleavage was inhibited,resulting in more sucrose retention in postharvest *** conclusion,5-ARG resulted in the accumulation of more nutrients during the growth process and effectively delayed the quality decline during storage,thereby prolonging the shelf life of ***,this study provides a theoretical basis for improving postharvest storage characteristics of broccoli through preharvest treatments.

关键词： arginine broccoli preharvest spraying nutrient accumulation storage quality postharvest senescence

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou Yuan-Yan Huang Ding-Yue Shang ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Control design of 60kW PEMFC generation system for residential applications

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第9期14卷 679-685页

作者： ying-ying ZHANG ying ZHANG Xi LI Guang-yi CAO Shandong Provincial Key Laboratory of Ocean Environment Monitoring Technology Institute of Oceanographic Instrumentation Shandong Academy of Sciences Control Science and Engineering Department Key Laboratory of the Ministry of Education for Image Processing and Intelligent Control Huazhong University of Science and Technology Fuel Cell Institute Department of Automation Shanghai Jiao Tong University

This paper presented a control design methodology for a proton exchange membrane fuel cell (PEMFC) generation system for residential applications. The dynamic behavior of the generation system is complex in such applications. A comprehensive control design is very important for achieving a steady system operation and efficiency. The control strategy for a 60 kW generation system was proposed and tested based on the system dynamic model. A two-variable single neuron proportional-integral (PI) decoupling controller was developed for anode pressure and humidity by adjusting the hydrogen flow and water injection. A similar controller was developed for cathode pressure and humidity by adjusting the exhaust flow and water injection. The desired oxygen excess ratio was kept by a feedback controller based on the load current. An optimal seeking controller was used to trace the unique optimal power point. Two negative feedback controllers were used to provide AC power and a suitable voltage for residential loads by a power conditioning unit. Control simulation tests showed that 60 kW PEMFC generation system responded well for computer-simulated step changes in the load power demand. This control methodology for a 60 kW PEMFC generation system would be a competitive solution for system level designs such as parameter design, performance analysis, and online optimization.

关键词： Proton exchange membrane fuel cell (PEMFC) Generation system Control strategy decoupling control Optimalseeking control

基于局部关系特征和注意力机制的交通事故预测方法

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北京理工大学学报 2025年第1期45卷 11-18页

作者：张亚辉李颖刘天恩燕山大学机械工程学院河北秦皇岛066004 北京理工大学机械与车辆学院北京100081

基于相机的事故预测方法主要是建立交通对象的全局关系,而缺乏对局部关系的考虑.为此,提出一种基于局部关系特征和注意力机制的预测模型,实现车载相机实时预测交通事故风险.该模型首先引入局部关系多图网络,捕捉车辆间的局部交互关系,... 详细信息

基于相机的事故预测方法主要是建立交通对象的全局关系,而缺乏对局部关系的考虑.为此,提出一种基于局部关系特征和注意力机制的预测模型,实现车载相机实时预测交通事故风险.该模型首先引入局部关系多图网络,捕捉车辆间的局部交互关系,解决交通对象的局部交互信息应用不充分的问题.其次利用动态空间注意力机制确定交通事故风险车辆.最后将门控循环网络和动态时间注意力机制联合,有效利用动态场景当前帧和历史帧间的时序信息.事故数据集的实验结果表明,该模型准确率达到73.78%,提前1.55s预测交通事故风险,同时单帧预测时间为1.65 ms,具有卓越的实时性.为交通事故风险预测提供一种有效的解决方案.

关键词：交通事故预测图神经网络注意力机制

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一种基于柱面镜聚焦系统的高灵敏度全谱光谱仪

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光谱学与光谱分析 2025年第1期45卷 222-230页

作者：陈吉文陈作儿赵迎北方工业大学电气与控制工程学院北京100144

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,... 详细信息

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,常使用光程短、系统精简的罗兰圆光学系统作为光谱仪的色散系统,并且在进行检测分析时,还需对设备腔体内部建立相对真空的环境进行实验,进而减小实验环境对真空紫外波段内各谱线强度的削弱作用。然而即使在该条件下,P和S这两种元素在真空紫外波段的谱线灵敏度仍然较弱。为此为了实现真空紫外波段范围内的高灵敏度,本研究在距离像面前30 mm处位置设计了一个柱面镜聚焦系统。其采用了材料为CaF_(2)、中心厚度为5 mm以及弧矢面曲率半径为22.06 mm的柱面镜作为核心部件。并利用仿真软件Zemax对设计的光学系统进行仿真与优化,以及从非序列模式下的辐射照度仿真结果可知,柱面镜聚焦系统在几乎不影响分辨率的情况下对各波长成像灵敏度有较大的提升。最后以中低合金钢为检测样品,使用电火花激发光源对样品中各元素在紫外波段内的各谱线进行激发,进而验证光谱仪的各项性能:通过一次拟合、参比拟合以及二次拟合,建立每个元素谱峰强度和实际含量之间的数学模型,并算得各元素的拟合优度R^(2)均在0.99以上;柱面镜聚焦系统显著提高了设备在真空紫外波段的灵敏度,响应提高了1倍以上。实验结果表明,柱面镜聚焦系统的设计方法对于提升罗兰圆色散系统的灵敏度具有一定的参考价值。

关键词：紫外光谱罗兰圆光学系统柱面镜灵敏度拟合优度

Separator Wettability Enhanced by Electrolyte Additive to Boost the Electrochemical Performance of Lithium Metal Batteries

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Nano-Micro Letters 2021年第12期13卷 434-436页

作者： ying Wang Department of Chemistry The Chinese University of Hong KongShatinN.T.Hong Kong SARPeople’s Republic of China

Lithium(Li)metal has been regarded as one of the most promising candidates to replace graphite anode due to its high theoretical specific capacity and the lowest electrochemical potential[1–3].However,the immoderate growth of Li dendrite during Li plating/stripping causes serious safety problem and poor performance that severely impedes the practical application of lithium metal batteries(LMBs)[4–6].

关键词： stripping replace lithium