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Decoding molecular mechanisms:brain aging and Alzheimer's disease

Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali Syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem xueyi wang Ran wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

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High Power Density EV Integrated Fast Battery Chargers Based on the General Torque Cancelation Law for Three-Phase Motors

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 756-766页

作者： Yanxiong Lei Guiping Du Tuhuan Li Wenjie Ma xueyi wang School of Electric Power South China University of TechnologyGuangzhou 510641China

Integrated battery chargers are highly effective for saving costs and improving the power density of on-board chargers in electric vehicles (EVs), However, achieving torque elimination of the commonly used three-phase (3p) motors during the fast-charging process is challenging. In this paper, the general torque cancelation law applied in 3p permanent magnet synchronous motors (PMSMs) and induction motors (IMs) is derived to design high power density integrated fast battery chargers. Two novel integrated systems with fast-charging and vehicle-to-grid (V2G) capabilities are proposed based on this law. The main advantages of the proposed systems are: (1) Two filter inductors are constituted by the stator windings while charging, and only one external inductor and several contactors are supplemented to the motor-drive circuit. Therefore, the proposed integrated systems possess high power density;(2) The 3p open-winding (OW) motor is employed, with no need to modify the propulsion system or redesign the interior structure of the motor;(3) Employing an individual controller for each phase of the inner current loop control, the proposed systems realize unity power factors and low current harmonics in the fast-charging and V2G mode. Simulation and experimental results verify the feasibility of the proposed topologies and control strategies.

关键词： Electric vehicles(EVs) fast charging integrated battery charger 3p PMSM/IM torque cancelation

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Simulation of mode conversion at the magnetopause

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Chinese Science Bulletin 2012年第12期57卷 1375-1383页

作者： LIN Yu JOHNSON Jay wang xueyi LU QuanMing Physics Department Auburn University Auburn 36849 USA Department of Geophysics and Planetary Science University of Science and Technology of China Hefei 230026 China princeton Plasma Physics Laboratory Princeton University Princeton 08543 USA

Two-dimensional(2-D)and three-dimensional(3-D)hybrid simulations are carried out for mode conversion from fast mode compressional wave to kinetic Alfvn waves(KAWs)at the inhomogeneous magnetopause *** cases in which the incident fast wave propagates in the xz plane,with the magnetopause normal along x and the background magnetic field pointing along z,the 2-D (xz)simulation shows that KAWs with large wave number kxρi～1 are generated near the Alfve′n resonance surface,whereρi is the ion Larmor *** nonlinear wave properties are manifest in the mode conversion *** of the driver frequency are *** a result of nonlinear wave interaction,the mode conversion region and its spectral width are *** the 3-D simulation,after this first stage of the mode conversion to KAWs with large kx,a subsequent generation of KAW modes of finite ky is observed in the later stage,through a nonlinear parametric decay *** the nonlinear cascade to ky can lead to massive transport at the magnetopause,the simulation results provide an effective transport mechanism at the plasma boundaries in space as well as laboratory plasmas.

关键词：模拟模式磁层顶等离子体边界模式转换非线性波非线性参数波动力学混合模拟

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A pH Self-Monitoring Heterogeneous Multicompartmental Proteinosome with Spatiotemporal Regulation of Insulin Transportation

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Chinese Journal of Chemistry 2021年第12期39卷 3386-3392页

作者： Ping Wen xueyi wang Haixu Chen Dietmar Appelhans Xiaoman Liu Lei wang Xin Huang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of Technology(HIT)HarbinHeilongjiang 150001China Dongguan Hospital of Southern Medical University Southern Medical UniversityDongguanGuangdong 523059China Leibniz-lnstitut fur Polymerforschung Dresden e.V. Hohe Strafe 6Dresden 01069Germany

Inspired by the intricate eukaryotic cell structure,the spontaneously assembling multicompartments capable of spatiotemporally regulated biomacromolecules transportation is still a ***,a heterogeneous proteinosome-based multicompartment was designed and constructed by combining aqueous two-phase system and Pickering emulsion *** loading PEGylated insulin with boronic acid group into the multicompartment and glucose oxidase(GOx)into the innermost microgel domain,a short-or long-term transportation pathway of the loaded insulin was constructed by responding to the concentration of ***,the diminution of dynamic boronic ester bonding,the hindrance of polyethylene oxide micro-chamber,electrostatic interaction and the swelling behavior of hydrogel triggered by GOx/glucose reaction resulted in spatiotemporally controlled multi-pathway transportation mode with the releasing of insulin loaded inside the innermost microgel at high concentration of glucose(10 mg·mL^(-1)).Specially,by incorporating rhodamine B and fluorescein labelled BSA into the multicompartment,the release procedure of the loaded insulin can be monitored by the fluorescence ***,a multimode microcompartment is constructed which is then expected to provide a promising platform for further therapeutic protein,gene and drug delivery,as well as towards the design of complicated cell biomimetics.

关键词： Multicompartment Vesicles Sensors Spatiotemporal regulation Drug delivery

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Global hybrid simulations of soft X-ray emissions in the Earth’s magnetosheath

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Earth and Planetary Physics 2024年第1期8卷 47-58页

作者： Jin Guo TianRan Sun San Lu QuanMing Lu Yu Lin xueyi wang Chi wang RongSheng wang Kai Huang School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Comparative Planetology/CAS Key Lab of Geospace Environment University of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center of Astronautical Science and Technology Harbin 150001China National Space Science Center Chinese Academy of SciencesBeijing 100190China Physics Department Auburn UniversityAuburnALUSA

Earth’s magnetopause is a thin boundary separating the shocked solar wind plasma from the magnetospheric plasmas,and it is also the boundary of the solar wind energy transport to the *** X-ray imaging allows investigation of the large-scale magnetopause by providing a two-dimensional(2-D)global view from a *** performing 3-D global hybrid-particle-in-cell(hybrid-PIC)simulations,we obtain soft X-ray images of Earth’s magnetopause under different solar wind conditions,such as different plasma densities and directions of the southward interplanetary magnetic *** all cases,magnetic reconnection occurs at low latitude *** soft X-ray images observed by a hypothetical satellite are shown,with all of the following identified:the boundary of the magnetopause,the cusps,and the *** X-ray emissivity in the magnetosheath is characterized by large amplitude fluctuations(up to 160%);however,the maximum line-of-sight-integrated X-ray intensity matches the tangent directions of the magnetopause well,indicating that these fluctuations have limited impact on identifying the magnetopause boundary in the X-ray ***,the magnetopause boundary can be identified using multiple viewing *** also find that solar wind conditions have little effect on the magnetopause *** Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will provide X-ray images of the magnetopause for the first time,and our global hybrid-PIC simulation results can help better understand the 2-D X-ray images of the magnetopause from a 3-D perspective,with particle kinetic effects considered.

关键词： magnetopause X-ray emissivity X-ray imaging SMILE global hybrid-PIC simulation

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Synthesis of Diamond Films on Stainless Steel Substrates

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Chinese Physics Letters 1994年第3期11卷 181-184页

作者： ZHAN Rujuan CHEN Jifong ZHU Xiaodong JIANG Xicheng wang xueyi WU Hao Department of Modern Physics Structure Research LaboratoryUniversity of Science and Technology of ChinaHefei 230026

The continuous diamond films have been deposited on the stainless steel substrate using the hot cathode dc discharge plasma chemical vapor deposition *** characteristics of diamond film are reported and the pretreatme... 详细信息

关键词： steel Diamond stainless

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ASYMBOOST-BASED FISHER LINEAR CLASSIFIER FOR FACE RECOGNITION

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Journal of Electronics(China) 2008年第3期25卷 352-357页

作者： wang Xianji Ye xueyi Li Bin Li Xin Zhuang Zhenquan MOE-Microsofl Key Laboratory of Multimedia Computing and Communication University of Science and Technology of China Hefei 230025 China

When using AdaBoost to select discriminant features from some feature space (e.g. Gabor feature space) for face recognition, cascade structure is usually adopted to leverage the asymmetry in the distribution of positive and negative samples. Each node in the cascade structure is a classifier trained by AdaBoost with an asymmetric learning goal of high recognition rate but only moderate low false positive rate. One limitation of AdaBoost arises in the context of skewed example distribution and cascade classifiers: AdaBoost minimizes the classification error, which is not guaranteed to achieve the asymmetric node learning goal. In this paper, we propose to use the asymmetric AdaBoost (Asym- Boost) as a mechanism to address the asymmetric node learning goal. Moreover, the two parts of the selecting features and forming ensemble classifiers are decoupled, both of which occur simultaneously in AsymBoost and AdaBoost. Fisher Linear Discriminant Analysis (FLDA) is used on the selected fea- tures to learn a linear discriminant function that maximizes the separability of data among the different classes, which we think can improve the recognition performance. The proposed algorithm is dem- onstrated with face recognition using a Gabor based representation on the FERET database. Ex- perimental results show that the proposed algorithm yields better recognition performance than AdaBoost itself.

关键词： AsymBoost AdaBoost Gabor feature Face recognition

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Liposome-coated CaO_(2)nanoblockers for enhanced checkpoint blockade therapy by inhibiting PD-L1 de novo biosynthesis

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Nano Research 2023年第5期16卷 7227-7236页

作者： Ruijun Che Dandan Han Fei wang Huifang Liu Miao Fan Hongyu Yan Tingshan Xiao Zhaoshuo wang Xiaohan Zhou xueyi wang Kaihan Zhang Caiwen Ou Jinchao Zhang Zhenhua Li College of Chemistry&Environmental Science Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of EducationChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding 071002China Affiliated Dongguan Hospital Southern Medical UniversityDongguan 523059China Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation Guangzhou 510515China College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding 071002China Department of Chemistry the University of ManchesterManchester M139PLUK

The blocking of the immune checkpoint pathway with antibodies,especially targeting to programmed death-1/programmed death ligand-1(PD-1/PD-L1)pathway,was currently a widely used treatment strategy in clinical ***,the shortcomings of PD-L1 antibodies were constantly exposed with the deepening of its research and their therapeutic effect was limited by the translocation and redistribution of intracellular ***,we proposed to improve immune checkpoint blockade therapy by using liposomes-coated CaO_(2)(CaO_(2)@Lipo)nanoparticles to inhibit the de novo biosynthesis of ***_(2)@Lipo would produce oxygen and reduce hypoxia-inducible factor-1α(HIF-1α)level,which then downregulated the expression of *** in vitro and in vivo results have confirmed CaO_(2)@Lipo promoted the degradation of HIF-1αand then downregulated the expression of PD-L1 in cancer cells for avoiding immune ***,to mimicking the clinical protocol of anti-PD-L1 antibodies+chemo-drugs,CaO_(2)@Lipo was combined with doxorubicin(DOX)to investigate the tumor inhibition *** found CaO_(2)@Lipo enhanced DOX-induced immunogenic cell death(ICD)effect,which then promoted the infiltration of T cells,strengthened the blocking effect,thus provided an effective means to overcome the traditional immune checkpoint blockade treatment.

关键词： immune checkpoint blockade therapy oxygen-producing hypoxia-inducible factor-1α(HIF-1α) programmed death ligand-1(PD-L1)redistribution immunogenic cell death

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Metallogenic mechanisms of super-large Cu and Au deposits in the Dexing region and simulating experiments

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Chinese Journal Of Geochemistry 2010年第1期29卷 1-14页

作者： WU xueyi and wang Zijiang The State Key Laboratory of Ore Deposit Geochemistry,Institute of Geochemistry,Chinese Academy of Sciences,Guiyang 55002,China The State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang 55002 China

Based on the results of previous studies and under the direction of the theory of "ore deposit genesis",the authors made use of high temperature and high pressure experimental facilities and conditions at the Tectono-geochemistry Research Room under the State Key Laboratory of Ore Deposit Geochemistry,Institute of Geochemistry,Chinese Academy of Sciences,and put the focus on the multi-source of tectonically controlling ore-forming materials,the characteristics of multi-stage and multi-episode hydrothermal activities and mineralization and the characteristics of multi-genesis and multi-ore deposition so as to shed light on the metallogenic mechanisms of super-large Cu and Au *** addition simulating experiments were made on multi-stage and multi-episode tectonic activities and rock and ore deformation,multi-stage and multi-episode tectonic activities and mobilization and migration of ore-forming materials,and multi-stage and multi-episode tectonic activities and superimposition and enrichment of ore-forming *** experimental results showed that under the action of multi-stage and multi-episode tectonic stress the deformation and fragmentation of not only rocks and ores have been intensified,and but also the ore-forming materials originally disbursed in the rocks and ores have been mobilized and migrated and superimposed and *** experimental results also provided the scientific experimental data and grounds for deep-going research on the rules of metallogenesis and geneses of super-large ore deposits in the Dexing region,Jiangxi Province.

关键词：成矿机制模拟实验德兴地区金矿床超大型构造地球化学成矿物质来源国家重点实验室

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Ectopic expression of poplar gene PsnERF138 in tobacco confers salt stress tolerance and growth advantages

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Forestry Research 2021年第1期1卷 118-126页

作者： Lin Liu Zihan Cheng Wenjing Yao xueyi wang Fenglin Jia Boru Zhou Tingbo Jiang State Key Laboratory of Tree Genetics and Breeding Northeast Forestry University51 Hexing RoadHarbin 150040China Co-Innovation Center for Sustainable Forestry in Southern China/Bamboo Research Institute Nanjing Forestry University159 Longpan RoadNanjing 210037China

The AP2/ERF family is one of the largest plant-specific transcription factors and plays a vital role in plant growth and stress *** this study,PsnERF138 was cloned from Populus alba×Populus glandulosa and transformed into tobacco using the Agrobacterium-mediated transformation ***138 was localized in the nucleus through subcellular localization assay in *** normal conditions,the root lengths of PsnERF138 transgenic lines were much longer than those of wild *** salt stress,the transgenic tobacco lines over-expressing PsnERF138 showed a significant increase in seed germination rate,plant height,and root length,compared to control *** addition,the transgenic tobacco lines displayed some advantages at the physiological level,such as higher superoxide dismutase(SOD)activity,peroxidase(POD)activity,proline content,and lower malondialdehyde(MDA)content,as compared to those in the control *** staining also showed that the transgenic tobacco lines had lower reactive oxygen species(ROS)accumulation,compared to control plants under salt *** combined results indicate that poplar PsnERF138 plays a contributing role in augmenting salt tolerance and conferring multiple growth advantages as being overexpressed in tobacco.

关键词： stress tobacco content

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