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Chinese Journal of Oceanology and Limnology 1990年第2期8卷 135-149页

作者：纪明侯 M.Lahaye w.yaphe Institute of Oceanology. Academia Sinica Qingdao Department of Microbiology and Immunology McGill University Montreal Canada INRA-LBTG B. P. 527 44026 Nantes Cedex France Department of Microbiology and Immunology McGill University Montreal Canada

The 60% ethanolic extract from Gracilaria textorii (Rhbdophyta) was degraded with B- agarase, and certain charged (sulfated) and neutral oligosaccharides were separated by using DEAE Sephadex A 25 and Bio- gel P6 , P2 chromatographic techniques . Some of the charged oligomers were verified to be neoagarotetraose - 63- sulfate ( DP2 ). neoagarohexaose- 63 > 65 - disulfate ( DP3 ) and neoagarooctaose- 63, 65, 67-trisulfate (DP4) by using 13C-and ’H-NMR spectroscopy . One neutral oligomer was assumed to be a mixture of methylated neoagarotetraoses (DP2 ) by 1H-NMR spectroscopy .These oligomers assigned by their chemical shifts may be used as the model compounds for the structural investigation of the agar- type sulfated polysaccharides using the B- agarase degradation method .

关键词： oligomer neutral Gracilaria degraded verified RHODOPHYTA USING charged agarose reagent

STRUCTURAL STUDIES ON AGAR FRACTIONS EXTRACTED SEQUENTIALLY FROM CHINESE RED SEAwEEDS:GRACILARIA SJEOSTEDTII, G. TEXTORII AND G. SALICORNIA USING13C-NMR AND IR SPECTROSCOPY

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Journal of Oceanology and Limnology 1988年第2期6卷 87-103页

作者：纪明侯 M.Lahaye w.yaphe Institute of Occanology Academia Sinica Qingdao Dept of Microbiology & Immunology McGill University Montreal Canada CanadaM. Lahaye and w. yaphe(Dept of Microbiology & Immunology McGill University Montreal Canada)

The polysaccharides of three species of Chinese Gracilaria (Rhodophyta) were extracted by sequential solvent extraction and the chemical structures of the fractions obtained were investigated by using 13C-NMR and IR *** 13C-NMR spectra showed that the main extract, cold water fraction, from G. sjeostedtii consisted of repeating disaccharides of agarobiose and (1→3)-β-D-galactopyranosy 1-(1→4)-α-L-galactopyranose 6-sulfate, the latter being a precursor to agarobiose and converted to agarobiose after alkali modification. The component of the 60% ethanol fraction from G. textorii was composed mainly of agarose 6-sulfate, 6-O-methyl-agarose and some amount of agarose, whose structures remained unchanged after alkali treatment. The autoclave extract from G. salicornia revealed a complex structure composed of 6-0-methyl-agarose, 2-0-methyl-agarose, branched 4-0-methyl-L-galactose and agarose 4-sulfate, All the substiluents in these agaroses, were stable against alkali treatment. The alkali ex

关键词： NMR TEXTORII AND G C-NMR AND IR SPECTROSCOPY SALICORNIA USING STRUCTURAL STUDIES ON AGAR FRACTIONS EXTRACTED SEQUENTIALLY FROM CHINESE RED SEAwEEDS IR

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对三种红藻琼胶的化学与13C-NMR分析

海洋与湖沼 1986年第3期 185-195页

作者：纪明侯 M.Lahaye w.yaphe 中国科学院海洋研究所麦吉尔大学麦吉尔大学青岛蒙特利尔加拿大

用DEAE-Sephadex分级和13C-NMR方法研究了中国南方产凝花菜、易曲凹顶藻热带变种和坛紫菜三种经济红藻所含琼胶的结构特点。前两种红藻的琼胶主要由琼胶糖和6-OMe-琼胶糖组成,是优质的琼胶。坛紫菜多糖主要由琼胶糖和含高电荷的紫菜胶组... 详细信息

用DEAE-Sephadex分级和13C-NMR方法研究了中国南方产凝花菜、易曲凹顶藻热带变种和坛紫菜三种经济红藻所含琼胶的结构特点。前两种红藻的琼胶主要由琼胶糖和6-OMe-琼胶糖组成,是优质的琼胶。坛紫菜多糖主要由琼胶糖和含高电荷的紫菜胶组成,还含有微量6-OMe-琼胶糖,但坛紫菜经碱处理后的琼胶则是全由琼胶糖组成的真正琼胶。

关键词：琼胶酶凹顶藻坛紫菜碱处理级分紫菜琼胶紫菜胶凝花菜拟石花菜琼胶糖红藻

用13C-核磁共振和红外光谱法对三种卡拉胶原藻分步提取的卡拉胶级分的结构分析

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海洋与湖沼 1988年第3期 249-261页

作者：纪明侯 M.Lahaye w.yaphe 中国科学院海洋研究所麦吉尔大学麦吉尔大学青岛蒙特利尔加拿大

用13C-核磁共振(13C-NMR)和红外（IR）光谱分析了从三种卡拉胶原藻（鹿角沙菜、角叉菜、异枝麒麟菜）分步提取的主要卡拉胶级分的化学结构。13C-NMR谱图表明,所有主要级分由k-卡拉胶组成,除此之外,沙菜的冷水级分和角叉菜的40％乙醇级... 详细信息

用13C-核磁共振(13C-NMR)和红外（IR）光谱分析了从三种卡拉胶原藻（鹿角沙菜、角叉菜、异枝麒麟菜）分步提取的主要卡拉胶级分的化学结构。13C-NMR谱图表明,所有主要级分由k-卡拉胶组成,除此之外,沙菜的冷水级分和角叉菜的40％乙醇级分中还含有少量L-卡拉胶。IR谱图也表明,在1250;850和805cm-1有k-和L-卡拉胶所特有的吸收谱带。以1250,850和805cm-1对2920cm-1的吸收面积比值估算了硫酸基的相对含量。

关键词：卡拉胶二糖角叉菜胶双糖碳水化合物级分异枝麒麟菜分步提取吸收光谱法红外光谱法红外分光光度法核磁共振核自旋共振结构分析分析(力学)

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

关键词： braiding direction composite thin plate dynamic model large overall motion O313.7 three-dimensional (3D) braided composite

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Towards high-performance,efficient and sustainable material processing technologies for aerospace applications

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Chinese Journal of Aeronautics 2025年第1期38卷 1-2页

作者： Jun MA M.w.FU Stefania BRUSCHI Heng LI State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical and Industrial Engineering Norwegian University of Science and TechnologyTrondheim 7491Norway Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Department of Industrial Engineering University of PadovaPadova 35131Italy

The aerospace and aviation industry has long been at the forefront of materials and processing technologies,driven by its ongoing demand for lightweight,highly reliable,and durable *** manufacturing is a critical discipline that directly affects the performance,functionality,and safety of aircraft and aerospace *** meet the above-mentioned stringent requirements,advanced materials and cutting-edge processing technologies have evolved alongside aerospace innovations.

关键词： performance aviation mentioned

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy