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新时代大学生爱国主义教育的现实境遇与实践理路——基于《爱国主义教育法》实施视角

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高校辅导员学刊 2025年第1期17卷 15-19,95,96页

作者：丁露江西陶瓷工艺美术职业技术学院马克思主义学院江西景德镇333300

在“两个大局”背景下,西方强势的意识形态输出、国家经济社会发展的新矛盾新问题、碎片化和去中心化的“信息茧房”给新时代大学生爱国主义教育带来严峻挑战。《中华人民共和国爱国主义教育法》应运而生,为新时代大学生爱国主义教育的... 详细信息

在“两个大局”背景下,西方强势的意识形态输出、国家经济社会发展的新矛盾新问题、碎片化和去中心化的“信息茧房”给新时代大学生爱国主义教育带来严峻挑战。《中华人民共和国爱国主义教育法》应运而生,为新时代大学生爱国主义教育的现实境遇提供了规范——“教什么”、创新——“怎么教”、落实——“谁来教”的价值指向,同时通过尊法、学法、守法、用法、执法、护法的“六维”方式找到了涵养大学生爱国主义教育法治思维、规范大学生爱国主义教育法治行动、保障大学生爱国主义教育运行的实践理路。

关键词：《中华人民共和国爱国主义教育法》大学生爱国主义教育现实境遇实践理路

online Fault-Tolerant Tracking Control with Adaptive Critic for Nonaffine Nonlinear Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 215-227页

作者： ding wang Lingzhi Hu Xiaoli Li Junfei Qiao IEEE the School of Information Science and Technology Beijing Key Laboratory of Computational Intelligence and Intelligent SystemBeijing Laboratory of Smart Environmental Protection and Beijing Institute of Artificial Intelligence Beijing University of Technology

In this paper, a fault-tolerant-based online critic learning algorithm is developed to solve the optimal tracking control issue for nonaffine nonlinear systems with actuator ***, a novel augmented plant is constructed by fusing the system state and the reference trajectory, which aims to transform the optimal fault-tolerant tracking control design with actuator faults into the optimal regulation problem of the conventional nonlinear error system. Subsequently, in order to ensure the normal execution of the online learning algorithm, a stability criterion condition is created to obtain an initial admissible tracking policy. Then, the constructed model neural network(NN) is pretrained to recognize the system dynamics and calculate trajectory control. The critic and action NNs are constructed to output the approximate cost function and approximate tracking control,respectively. The Hamilton-Jacobi-Bellman equation of the error system is solved online through the action-critic framework. In theoretical analysis, it is proved that all concerned signals are uniformly ultimately bounded according to the Lyapunov *** tracking control law can approach the optimal tracking control within a finite approximation error. Finally, two experimental examples are conducted to indicate the effectiveness and superiority of the developed fault-tolerant tracking control scheme.

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A data-driven rolling optimization method for trajectory tracking error prediction of CNC machine tools

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Science China Technological Sciences 2025年第1期 274-289页

作者： Yinxin GUAN Jixiang YANG Shizhong TAN Han ding School of Mechanical Science and Engineering State Key Laboratory of Intelligent Manufacturing Equipment and TechnologyHuazhong University of Science and Technology

The dynamic performance of the feed-drive system in CNC machine tools directly influences the accuracy of machined parts. To enhance the motion control performance of CNC machine tools, a high-precision model of the feed-drive system is critical. However, current modeling methods for feed-drive systems seldom consider time-varying factors such as loads, wear, and lubrication. As a result, the model accuracy degrades when the system characteristics are affected by these time-varying factors. In this paper, a rolling optimization method with partial weights frozen is developed to realize quick iterative learning of a data-driven model for a feed drive system with time-varying characteristics using a small amount of ***, the long short-term memory fully connected(LSTM-FC) network is built and divided into feature extraction and output fitting parts based on their functions. Then, a weight freezing-based rolling optimization method is applied. The weights in the feature extraction part are frozen, which preserves the learned common knowledge and patterns by solidifying the way that high-dimensional features are extracted from the input. By adjusting the weights in the output fitting part, the extracted highdimensional features are remapped to the new data distribution changed by time-varying factors. Finally, the performance of the developed rolling optimization method is confirmed by experiments. The results show that the proposed rolling optimization method reduces the maximum prediction errors by 49.5% and the total training time by 96.3% compared with existing methods,which demonstrates that the proposed method can restore model accuracy when the system characteristics change due to timevarying factors, and significantly accelerate the optimization process by rolling optimization.

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AAV-mediated expression of p65shRNA and bone morphogenetic protein 4 synergistically enhances chondrocyte regeneration

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中国组织工程研究 2025年第17期29卷 3537-3547页

作者： Yu Yangyi Song Zhuoyue Lian Qiang ding Kang Li Guangheng Shenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration Division of Adult Joint Reconstruction and Sports MedicineDepartment of Orthopedic SurgeryShenzhen People’s Hospital(The Second Clinical Medical College Jinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020Guangdong ProvinceChina Department of orthopedics Zhengzhou Orthopedics HospitalZhengzhou 450000Henan ProvinceChina Department of orthopedics Shenzhen Pingle Orthopedics HospitalShenzhen 518000Guangdong ProvinceChina

BACKGRoUND:Adeno-associated virus(AAV)gene therapy has been proven to be reliable and safe for the treatment of osteoarthritis in recent ***,given the complexity of osteoarthritis pathogenesis,single gene manipulation for the treatment of osteoarthritis may not produce satisfactory *** studies have shown that nuclear factorκB could promote the inflammatory pathway in osteoarthritic chondrocytes,and bone morphogenetic protein 4(BMP4)could promote cartilage ***:To test whether combined application of AAV-p65shRNA and AAV-BMP4 will yield the synergistic effect on chondrocytes regeneration and osteoarthritis ***:Viral particles containing AAV-p65-shRNA and AAV-BMP4 were *** efficacy in inhibiting inflammation in chondrocytes and promoting chondrogenesis was assessed in vitro and in vivo by transfecting AAV-p65-shRNA or AAV-BMP4 into *** experiments were divided into five groups:PBS group;osteoarthritis group;AAV-BMP4 group;AAV-p65shRNA group;and BMP4-p65shRNA 1:1 *** were collected at 4,12,and 24 weeks *** staining,including safranin o and Alcian blue,was applied after collecting articular ***,the optimal ratio between the two types of transfected viral particles was further investigated to improve the chondrogenic potential of mixed cells in *** AND CoNCLUSIoN:The combined application of AAV-p65shRNA and AAV-BMP4 together showed a synergistic effect on cartilage regeneration and osteoarthritis *** cells transfected with AAV-p65shRNA and AAV-BMP4 at a 1:1 ratio produced the most extracellular matrix synthesis(Po results also revealed that the combination of the two viruses had the highest regenerative potential for osteoarthritic cartilage(Pwe also discovered that the combined therapy had the maximum effect when the two viruses were administered in equal *** either p65shRNA or BMP4

关键词： osteoarthritis adeno-associated virus bone morphogenetic protein 4 p65-short hairpin RNA gene therapy short hairpin RNA transforming growth factor-β1 extracellular matrix articular cartilage chondrocytes.

Ab initio modeling of the energy landscape for screw dislocations in body-centered cubic high-entropy alloys

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npj Computational Materials 2020年第1期6卷 754-764页

作者： Sheng Yin Jun ding Mark Asta Robert o.Ritchie Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

In traditional body-centered cubic(bcc)metals,the core properties of screw dislocations play a critical role in plastic deformation at low ***,much attention has been focused on refractory high-entropy alloys(RHEAs),which also possess bcc crystal ***,unlike face-centered cubic high-entropy alloys(HEAs),there have been far fewer investigations into bcc HEAs,specifically on the possible effects of chemical short-range order(SRo)in these multiple principal element alloys on dislocation ***,using density functional theory,we investigate the distribution of dislocation core properties in MoNbTaw RHEAs alloys,and how they are influenced by *** average values of the core energies in the RHEA are found to be larger than those in the corresponding pure constituent bcc metals,and are relatively insensitive to the degree of ***,the presence of SRo is shown to have a large effect on narrowing the distribution of dislocation core energies and decreasing the spatial heterogeneity of dislocation core energies in the *** is argued that the consequences of the mechanical behavior of HEAs is a change in the energy landscape of the dislocations,which would likely heterogeneously inhibit their motion.

关键词： alloys deformation cubic

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Shake-up Processes in the 3d Photoionization of Sr I and the Subsequent Auger Decay

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Chinese Physics Letters 2012年第6期29卷 114-117页

作者： ding Xiao-Bin DoNG Chen-Zhong Gerard o’Sullivan Key Laboratory of Atomic and Molecular Physics&Functional Materials of Gansu Province College of Physics and Electronic EngineeringNorthwest Normal UniversityLanzhou 730070 School of Physics University College DublinBelfieldDublin 4Ireland

The shake-up processes accompanied by 3d photoionization and subsequent Auger decay are studied using multiconfiguration Dirac-Fock *** is obtained with the experimental results for both the photoelectron and Auger electron *** energy and relative intensity of the 5s → 6s shake-up accompanied by the 3d photoionization process are identified quantitatively.

关键词： spectra methods subsequent

Microstructure change in Fe-based metallic glass and nanocrystalline alloy induced by liquid nitrogen treatment

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Journal of Materials Science & Technology 2021年第10期69卷 1-6页

作者： M.C.Ri D.w.ding Y.H.Sun w.H.wang Institute of Physics Chinese Academy of SciencesBeijing100190China Songshan Lake Materials Laboratory Dongguan523808China

The effects of acyclic liquid nitrogen(LN)treatment in a temperature range of-196℃to 50℃on the thermal and magnetic stability of Fe78Si9B13 and Fe73.5Si13.5B9Nb3Cu1 glassy ribbons have been *** intrinsic heterogeneities of the metallic glasses can be activated through cryogenic thermal cycling,making irreversible structural changes after the treatment and inducing rejuvenation to the *** microstructural changes of both Fe-based metallic glass(MG)and nanocrystalline alloy induced by LN treatment were *** experimental results show that the LN treatment could effectively rejuvenate the Fe-Si-B MGs and change their thermomechanical and magnetic *** on the partially-crystallinity and well-known magnetic constants,the increase of the energy at the order of 10m J/g and magnetic domain wall movement and rotation at the order of 5-6μm and 0.5°-0.8°are found for FINEMET-type amorphous alloy after LN *** is also found that LN treatment can contribute a little stored energy to the magnetic domain wall movement and magnetic domain rotation.

关键词： Metallic glasses Cryogenic thermal treatment Soft magnetic materials Rejuvenation Stored energy Domain wall

on the Application of PCA Technique to Fault Diagnosis

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Tsinghua Science and Technology 2010年第2期15卷 138-144页

作者： ding S ZHANG P ding E YIN S Naik A DENG P GUI w Institute for Automatic Control and Complex Systems (AKS) University of Duisburg-Essen 47057 Duisburg Germany Department of Physical Engineering University of Applied Sciences Gelsenkirchen 45877 Gelsenkirchen Germany School of Information Science and Engineering Central South University Changsha 410083 China

In this paper, we bdefly address the application of the standard principal component analysis （PCA） technique to fault detection and identification. Based on an analysis of the existing test statistic, we propose a new test statistic, which is similar to the Hawkin＇s T2 H statistic but without the numerical drawback. In comparison with the SPE index, the threshold setting associated with the new statistic is computationally simpler. our further study is dedicated to the analysis of fault sensitivity. we consider the off-set and scaling faults, and evaluate the test statistic by viewing its sensitivity to the faults. our final study focuses on identifying off-set and scaling faults. To this end, two algorithms are proposed. This paper also includes some critical remarks on the application of the PCA technique to fault diagnosis.

关键词： process monitoring fault diagnosis principal component analysis (PCA) multivariate analysis