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increased excitatory amino acid transporter 2 levels in basolateral amygdala astrocytes mediate chronic stress–induced anxiety-like behavior

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Neural Regeneration Research 2025年第6期20卷 1721-1734页

作者： Xirong Xu Shoumin Xuan Shuai Chen Dan Liu Qian Xiao Jie tu Shenzhen Key Laboratory of Neuroimmunomodulation for Neurological Diseases Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina CAS Key Laboratory of Brain Connectome and Manipulation Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Brain Connectome and Behavior the Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina University of Chinese of Academy of Sciences BeijingChina Faculty of Life and Health Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong ProvinceChina

The conventional perception of astrocytes as mere supportive cells within the brain has recently been called into question by empirical evidence, which has revealed their active involvement in regulating brain function and encoding behaviors associated with ***, astrocytes in the basolateral amygdala have been found to play a role in the modulation of anxiety-like behaviors triggered by chronic stress. Nevertheless, the precise molecular mechanisms by which basolateral amygdala astrocytes regulate chronic stress–induced anxiety-like behaviors remain to be fully elucidated. in this study, we found that in a mouse model of anxiety triggered by unpredictable chronic mild stress, the expression of excitatory amino acid transporter 2 was upregulated in the basolateral amygdala. interestingly, our findings indicate that the targeted knockdown of excitatory amino acid transporter 2 specifically within the basolateral amygdala astrocytes was able to rescue the anxiety-like behavior in mice subjected to stress. Furthermore, we found that the overexpression of excitatory amino acid transporter 2 in the basolateral amygdala, whether achieved through intracranial administration of excitatory amino acid transporter 2agonists or through injection of excitatory amino acid transporter 2-overexpressing viruses with GfaABC1D promoters, evoked anxiety-like behavior in mice. Our single-nucleus RNA sequencing analysis further confirmed that chronic stress induced an upregulation of excitatory amino acid transporter 2 specifically in astrocytes in the basolateral amygdala. Moreover, through in vivo calcium signal recordings, we found that the frequency of calcium activity in the basolateral amygdala of mice subjected to chronic stress was higher compared with normal *** knocking down the expression of excitatory amino acid transporter 2 in the basolateral amygdala, the frequency of calcium activity was not significantly increased, and anxiety-like behavior was ob

关键词： anxiety astrocytes basolateral amygdala behavior dihydrokainic acid excitatory amino acid transporter 2 fiber photometry glutamate LDN-212320 transporter

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High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun wang Shuai wang Yan Li Libo Chen Handong Jiao Zhijing Yu Jiguo tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research institute for intelligent wearable Systems The Hong Kong Polytechnic University institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (LiMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** LiMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and Li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of LiMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of LiMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable LiMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Semiconductor doping

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MiL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng Huang Mudong tu Hua Li Yong Peng wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MiL-53 modified with ultra-low rhodium（Rh@NiFe-MiL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MiL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MiL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： X ray photoelectron spectroscopy

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Extramedullary plasmacytoma with the uvula as first affected site:A case report

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world Journal of Clinical Oncology 2025年第1期16卷 53-58页

作者： Jing Yang Hui Peng Sheng-Ke tu Min Li Kui Song Department of Hematology The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Jishou UniversityJishou 416000Hunan ProvinceChina

BACKGROUND Extramedullary plasmacytoma(EMP)represents one of the rarer forms of plasma cell malignancies,capable of impacting a variety of tissues and organs throughout the *** majority of EMP cases are predominantly found in the head and neck region,especially within the laryngopharynx,as well as in the gastrointestinal *** there have been documented instances of oropharyngeal involvement in EMP cases in the academic literature,it is important to note that EMP specifically affecting the uvula is exceedingly ***,it is noteworthy that over 60% of epithelial carcinomas in the upper respiratory tract and oropharynx tend to metastasize to the cervical lymph nodes,indicating a propensity for regional spread in these types of *** this context,we present a rare case of extramedullary plasmacytoma where the uvula served as the initially affected *** case emphasizes the need for heightened awareness among clinicians regarding such unusual comorbidities,as early recognition and diagnosis can significantly influence patient management and treatment *** addition,a review of the relevant literature is included to further educate and inform healthcare professionals about this rare presentation,ultimately aiming to enhance clinical understanding and improve patient care in similar *** SUMMARY A 51-year-old man was admitted to our hospital because of a slowly enlarging neck mass.A physical examination revealed a palpable left lymph node,and magnetic resonance imaging(MRi)of the oropharynx and the neck showed a soft tissue mass in the oropharynx and enlargement of multiple lymph nodes in the *** soft tissue mass was diagnosed as plasmacytoma by immunohistochemical *** immunoglobulins and bone marrow biopsy showed normal ***,we diagnosed that as EMP of the *** four cycles of adjuvant chemotherapy dominated by bortezomib,MRi reexamination showed a significant reduction of the mass

关键词： Extramedullary plasmacytoma Plasmacytoma Uvula Multiple myeloma Case report

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De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期 174-180页

作者： Fan-Xiao Meng Xing-Yu wang Ka Lu Ju-Song Yang Fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. Furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

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[Evaluation of the toxicity of perfluorooctanoic acid toward human colorectal cancer cells using multi-dimensional approaches]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 96-103页

作者： Rui-Jia Zhang Ying-Shi Lin Lan-Yin tu Zi-Tong Chen wei-wei Zhang Tian-Gang Luan Bao-wei Chen School of Life and Health Sciences Hainan University Haikou 570228 China. School of Life Sciences Sun Yat-sen University Guangzhou 510275 China. School of Artificial intelligence Sun Yat-sen University Zhuhai 519082 China. Guangzhou Center for Disease Control and Prevention Guangzhou 510440 China. School of Marine Sciences Sun Yat-sen University Zhuhai 519082 China.

while human exposure to perfluorooctanoic acid (PFOA) can lead to ulcerative colitis, the molecular mechanisms responsible for PFOA-induced intestinal toxicity are unclear. Herein, we examined the toxicity of PFOA toward human colorectal cancer cells (HCT116) from three dimensions: the cytotoxic phenotype, cell respiration, and transcription levels of metabolism-related genes. Formazan was used to assess how PFOA exposure affects HCT116-cell relative viability, after which the mitochondrial respiratory activities of these cells were determined by analyzing extracellular flux. The quantitative real-time polymerase chain reaction (qPCR) method was used to detect metabolism-related gene expression levels. The cytotoxicity assay revealed that the HCT116 showed significantly inhibited relative activities compared to those of the control when exposed to 300 μmol/L PFOA for 48 h (with most cells retained at the G0/G1 stage. in contrast, the mitochondrial respiratory activities of the HCT116 were promoted by concentrations of PFOA as low as 50 μmol/L. Two genes related to cellular metabolism (dipeptidase 1 () and sphingosine kinase 1 ()) were found to be related to the PFOA-promoted formation of ulcerative colitis using our self-developed Metabolic Gene and Pathway Query software and Comparative Toxicogenomics Database (CTD). The qPCR studies revealed that and expression levels were enhanced by 8-10 times in HCT116 exposed to 300 μmol/L PFOA relative to the control, whereas this trend was not observed for HCT116 exposed to 50 μmol/L PFOA. Collectively, these results suggest that the respiratory activity of cellular mitochondria may serve as an index for determining the interference effects associated with PFOA and that metabolic pathways mediated by and may be involved in the development of PFOA-induced ulcerative colitis. Future studies should investigate the relationships between changes in metabolism-related genes ( and ) and the mitochondrial respiratory act

关键词： Metabolic Gene and Pathway Query software human colorectal enterotoxicity metabolic disorder perfluorooctanoic acid (PFOA)

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Comeld^TM Joints: A Novel Technique for Bonding Composites and Metal

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稀有金属材料与工程 2009年第A03期38卷 134-141页

作者： tu w Guild F J Hogg P J Queen Mary University of London imperial College London South Kensington Campus University of Manchester PO Box 88

Current and future structural applications for composite laminates frequently involve design solutions combining composite laminates and metal; the materials must be joined. Two conventional means of joining are available mechanical joining and adhesive bonding. Both methods have critical disadvantages. A novel surface treatment for metals developed at Twi, Surfi-Sculpt, leads to the formation of surface protrusions on metal surfaces. These protrusions are typically 1.0 mm high and 0.6 mm in diameter. The surface modified metal can be bonded with composite laminates to form a Comeld～TM joint. These joints can be described as a combination of mechanical fastening and adhesive bonding. This paper describes our current work using finite element modelling to optimize the protrusions in respect to their geometry and distribution. The simulations require multi-scale modelling techniques to transfer results between the global model of the whole joint and the unit cell models containing a protrusion. Results from the simulations show critical effects on stress distributions arising from changing protrusion geometry. These joints show significant advantages over conventional adhesive joining technologies and their application would allow improved performance for combinations of metal and composite laminates.

关键词：复合材料金属表面处理技术物理性能

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柳江盆地髫髻山组凝灰岩地球化学与熔体包裹体水含量特征

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岩矿测试 2025年第1期44卷 88-101页

作者：赵汇珍陈勇涂聪冯艳伟中国石油大学(华东)深层油气全国重点实验室山东青岛266580 中国石油大学(华东)地球科学与技术学院山东青岛266580 中国科学技术大学地球和空间科学学院安徽合肥230026

水作为岩浆体系中最主要的挥发组分,对岩浆的形成和演化有重要的影响,柳江盆地髫髻山组岩浆岩是燕山期火山活动的重要产物,尽管前人对其地球化学特征进行了大量研究,但关于柳江盆地燕山期岩浆中的水含量仍不清楚。熔体包裹体记录了原始... 详细信息

水作为岩浆体系中最主要的挥发组分,对岩浆的形成和演化有重要的影响,柳江盆地髫髻山组岩浆岩是燕山期火山活动的重要产物,尽管前人对其地球化学特征进行了大量研究,但关于柳江盆地燕山期岩浆中的水含量仍不清楚。熔体包裹体记录了原始岩浆信息,是获取岩浆水含量特征的最直接样品。本文基于全岩地球化学分析,利用标准样品建立了显微激光拉曼光谱定量熔体包裹体水含量的标定曲线,并对柳江盆地髫髻山组下部流纹质岩屑-晶屑凝灰岩中石英斑晶内的原生熔体包裹体进行了水含量定量分析。结果表明:髫髻山组下部凝灰岩样品具有富Si、Al、大离子亲石元素富集、高场强元素亏损、轻稀土富集、重稀土亏损、负Eu异常、Sr含量低等特点;熔体包裹体中水含量的定量分析结果为0.99%~4.98%,平均水含量为2.62%,与前人统计的酸性岩浆水含量基本一致。地球化学特征和熔体包裹体水含量分析结果共同揭示了研究区髫髻山期早期为富水酸性岩浆。结合髫髻山期样品的熔体包裹体水含量测定结果及其早期的大规模火山喷发背景,本文认为岩浆中高含水量增强了岩浆系统的喷发动力,是诱发研究区髫髻山期早期大规模火山爆发的有利因素之一。

关键词：柳江盆地髫髻山组凝灰岩熔体包裹体水含量显微激光拉曼光谱法

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Extension of the High-Order Space-Time Discontinuous Galerkin Cell Vertex Scheme to Solve Time Dependent Diffusion Equations

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Communications in Computational Physics 2012年第5期11卷 1503-1524页

作者： Shuangzhang tu Gordon w.Skelton Qing Pang Department of Computer Engineering Jackson State UniversityJacksonMS 39217USA

in this paper,the high-order space-time discontinuous Galerkin cell vertex scheme(DG-CVS)developed by the authors for hyperbolic conservation laws is extended for time dependent diffusion *** the extension,the treatment of the diffusive flux is exactly the same as that for the advective *** to the Riemannsolver-free and reconstruction-free features of DG-CVS,both the advective flux and the diffusive flux are evaluated using continuous information across the cell *** a result,the resulting formulation with diffusive fluxes present is still consistent and does not need any extra ad hoc techniques to cure the common“variational crime”problem when traditional DG methods are applied to diffusion *** this reason,DG-CVS is conceptually simpler than other existing DG-typed *** numerical tests demonstrate that the convergence order based on the L_(2)-norm is optimal,i.e.O(h^(p+1))for the solution and O(h^(p))for the solution gradients,when the basis polynomials are of odd *** even-degree polynomials,the convergence order is sub-optimal for the solution and optimal for the solution *** same odd-even behaviour can also be seen in some other DG-typed methods.

关键词： High-order method space-time method discontinuous Galerkin(DG)method cellvertex scheme(CVS) diffusion equations

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A Compact High Order Space-Time Method for Conservation Laws

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Communications in Computational Physics 2011年第2期9卷 441-480页

作者： Shuangzhang tu Gordon w.Skelton Qing Pang Department of Computer Engineering Jackson State UniversityJacksonMS 39217USA

This paper presents a novel high-order space-time method for hyperbolic conservation *** important concepts,the staggered space-time mesh of the space-time conservation element/solution element(CE/SE)method and the local discontinuous basis functions of the space-time discontinuous Galerkin(DG)finite element method,are the two key ingredients of the new *** staggered spacetime mesh is constructed using the cell-vertex structure of the underlying spatial *** universal definitions of CEs and SEs are independent of the underlying spatial mesh and thus suitable for arbitrarily unstructured *** solution within each physical time step is updated alternately at the cell level and the vertex *** this solution updating strategy and the DG ingredient,the new scheme here is termed as the discontinuous Galerkin cell-vertex scheme(DG-CVS).The high order of accuracy is achieved by employing high-order Taylor polynomials as the basis functions inside each *** present DG-CVS exhibits many advantageous features such as Riemann-solver-free,high-order accuracy,point-implicitness,compactness,and ease of handling boundary *** numerical tests including the scalar advection equations and compressible Euler equations will demonstrate the performance of the new method.

关键词： High order method space-time method cell-vertex scheme(CVS) conservation laws

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