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Optimization of N18 Zirconium Alloy for Fuel Cladding of water Reactors

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Journal of materials Science & Technology 2012年第7期28卷 606-613页

作者： B.X. Zhou m. Y. Yao Z.K. Li X.m. wang J. zhoua C.S. Long Q. Liu B.F. Luan Laboratory for mierostructures Shanghai University Shanghai 200444 China Institute of materials Shanghai University Shaxighai 200072 China Northwest Institute for Non-ferrous metal Research Xian 721014 China Key Laboratory for Nuclear Fuel and materials Nuclear Power Institute of China Chengdu 610041 China College of material Science and Engineering Chongqing University Chongqing 400044 China

In order to optimize the microstructure and composition of N18 zirconium alloy （Zr-1Sn-0.35Nb-0.35Fe-0.1Cr, in mass fraction, %）, which was developed in China in 1990s, the effect of microstructure and composition variation on the corrosion resistance of the N18 alloy has been investigated. The autoclave corrosion tests were carried out in super heated steam at 400 ~C/10.3 mPa, in deionized water or lithiated water with 0.01 mol/L LiOH at 360 ~C/18.6 mPa. The exposure time lasted for 300-550 days according to the test temperature. The results show that the microstructure with a fine and uniform distribution of second phase particles （SPPs）, and the decrease of Sn content from 1% （in mass fraction, the same as follows） to 0.8% are of benefit to improving the corrosion resistance; It is detrimental to the corrosion resistance if no Cr addition. The addition of Nb content with upper limit （0.35%） is beneficial to improving the corrosion resistance. The addition of Cu less than 0.1% shows no remarkable influence upon the corrosion resistance for N18 alloy. Comparing the corrosion resistance of the optimized N18 with other commercial zirconium alloys, such as Zircaloy-4, ZIRLO, E635 and Ell0, the former shows superior corrosion resistance in all autoclave testing conditions mentioned above. Although the data of the corrosion resistance as fuel cladding for high burn-up has not been obtained yet, it is believed that the optimized N18 alloy is promising for the candidate of fuel cladding materials as high burn-up fuel assemblies. Based on the theory that the microstructural evolution of oxide layer during corrosion process will affect the corrosion resistance of zirconium alloys, the improvement of corrosion resistance of the N18 alloy by obtaining the microstructure with nano-size and uniform distribution of SPPs, and by decreasing the content of Sn and maintaining the content of Cr is discussed.

关键词： Zirconium alloys Corrosion resistance Composition variation microstructure

Implementing an innovated liver ex-situ machine perfusion technology:The 2018 Joint International Congress of ILTS,ELITA and LICAGE

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 283-285页

作者： Jun-Jun Jia Jian-Hui Li Hai-Yang Xie Lin zhoua Shu-Sen Zheng Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Combined multi-Organ Transplantation Ministry of Public HealthFirst Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

The 2018 Joint International Congress of ILTS,ELITA and LICAGE were held in Lisbon,Portugal on may 23–26,*** exciting and innovative program brought together 1144 experts in liver transplantation(LT)such as surgeons,physicians or basic scientists from 61 *** presentations included 110 invited speakers,181 oral presentations,and 545 *** editorial highlights some of the most innovative and impactful presentations in

关键词： NmP wIT DCD Implementing an innovated liver ex-situ machine perfusion technology:The 2018 Joint International Congress of ILTS,ELITA and LICAGE

Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3680-3696页

作者： Yunkun Li Xiaoding Shen Haitao Ding Yuxin Zhang Dayi Pan Liping Su Yahui wu Zaixiang Fang Jie zhoua Qiyong Gong Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and molecular Imaging Key Laboratory of Sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China

Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune ***,we constructed a PEGylated dendritic epirubicin(Epi)prodrug(Epi-P4D)to regulate the metabolism of cancer-associated fibroblasts(CAFs),thus enhancing Epi penetration into both multicellular tumor spheroids(mTSs)and tumor tissues in mouse colon cancer(CT26),mouse breast cancer(4T1)and human breast cancer(mDA-mB-231)*** cytotoxicity against CT26 mTSs and remarkable antitumor efficacy of Epi-P4D were ascribed to reduced fibronectin,α-SmA,and collagen ***,thinning of the tumor tissue stroma and efficient eradication of tumor cells promoted the immunogenic cell death effect for dendritic cell(DC)maturation and subsequent immune activation,including elevating the CD4^(+)T cell population,reducing CD4^(+)and CD8^(+)T cell hyperactivation and exhaustion,and amplifying the natural killer(NK)cell proportion and effectively activating *** a result,this dendritic nanomedicine thinned the stroma of tumor tissues to enhance drug penetration and facilitate immune cell infiltration for elevated antitumor efficacy.

关键词： Dendritic prodrug Enhanced penetration metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution

Nanoparticle drug delivery system for the treatment of brain tumors:Breaching the blood–brain barrier

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2786-2789页

作者： Qiyu Tang Guo Zhao Hong Fang Yale Jiang Peiwen ma Jiawei zhoua Dongyan Liu Shujun Xing Gaoquan Li Nian Liu Huiyu Chen Shuhang wang Ning Li Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Chongqing Upgra Biotechnology Co. Ltd.Chongqing 401331China

To the Editor:malignant brain tumors represent a substantial morbidity and mortality burden globally,with 308,102 new cases and 251,329 cancer-related deaths in *** tumors encompass primary tumors originating in the brain and brain metastases(Bm)that have been spread from cancer lesions of other ***,Bm are the most prevalent intracranial malignant tumor affecting approximately 20%-40%of cancer patients2.

关键词： Nanoparticle Drug delivery system Blood-brain barrier Tumor Glioma

Effect of Tm-Er concentration ratio on the photoluminescence of Er-Tm:Al2O3 thin films fabricated by pulsed laser deposition

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Progress in Natural Science:materials International 2008年第6期18卷 661-664页

作者： Bo zhoua,Zhisong Xiaoa,*,Anping Huang a,Lu Yan a,Fang Zhu a,Jinliang wang a,Penggang Yin b,Hao wang c aDepartment of Physics,School of Science,Beihang University,Beijing 100083,China bSchool of materials Science and Engineering,Beihang University,Beijing 100083,China cFaculty of Physics and Electronics,Hubei University,wuhan 430062,China Department of Physics School of Science Beihang University Beijing 100083 China School of materials Science and Engineering Beihang University Beijing 100083 China Faculty of Physics and Electronics Hubei University Wuhan 430062 China

Er-Tm codoped amorphous aluminum oxide(a-Al2O3)thin films have been prepared by an alternative pulsed laser *** phase structure and the surface of the deposited thin films were characterized by the X-ray diraction(XRD)and scanning electron microscopy(SEm),*** photoluminescence(PL)in the region of 350-900 nm was observed when pumped at 325 nm,and the PL performance has been improved by modifying the Tm3 +*** the increasing of[Tm]/[Er]concentra-tion ratio,the intensity of emission of 382 nm and 500 nm bands was improved eectively while that of 765 nm band increased *** results suggest that the resonant energy transfer and cross relaxation between Tm3 +and Er 3+play an important role in the evolution of the luminescent response.

关键词： Tm Er Concentration Photoluminescence Energy transfer

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非政府组织、员工责任信念与人力资源优势

系统管理学报 2018年第6期27卷 1125-1132页

作者：冉戎聂军周洲耿玉玉重庆大学公共管理学院重庆400030 重庆大学中国公共服务评测与研究中心重庆400030

在企业社会责任背景下,以员工效用最大化为目标,分析了NGO参与CSR建设对企业人力资源影响的机理和原理。企业参与CSR建设有助于构建企业的人力资源竞争优势,从而提高企业的竞争优势,NGO参与企业社会责任建设后可以增强这种竞争优势。具... 详细信息

在企业社会责任背景下,以员工效用最大化为目标,分析了NGO参与CSR建设对企业人力资源影响的机理和原理。企业参与CSR建设有助于构建企业的人力资源竞争优势,从而提高企业的竞争优势,NGO参与企业社会责任建设后可以增强这种竞争优势。具体而言:①履行CSR的企业可以以较低的工资水平吸引到高努力程度和高责任观念的员工;②企业履行社会责任时,若能与NGO紧密合作,将能够强化员工的社会责任观念,具体体现为员工自愿承担更高的减排成本和工作努力程度的提高;③企业在履行社会责任时,若能与NGOs紧密合作,将增加具有社会责任观念的劳动力产生"绿色集聚效应"的可能性,同时会向着履行社会责任的绿色企业集聚在劳动力市场竞争中对不履行社会责任的企业产生"挤出效应"的概率。

关键词：企业社会责任减排成本意识水平系数挤出效应聚集效应

含苯并噻二唑的吩噻嗪染料分子的设计合成及其在染料敏化太阳能电池中的应用

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化学学报 2018年第3期76卷 215-223页

作者：潘彬朱义州邱昌娟王冰郑健禺南开大学化学学院元素有机化学国家重点实验室天津300071 天津化学化工协同创新中心天津300071

设计合成了三种含苯并噻二唑的吩噻嗪类有机染料光敏剂JY50~JY52,在对其光物理和电化学性质进行研究的基础上,使用三种染料对纳米TiO_2电极进行敏化制备太阳能电池器件,并系统研究了其光电转化效率及电荷传输阻抗等光伏特性.研究结果表... 详细信息

设计合成了三种含苯并噻二唑的吩噻嗪类有机染料光敏剂JY50~JY52,在对其光物理和电化学性质进行研究的基础上,使用三种染料对纳米TiO_2电极进行敏化制备太阳能电池器件,并系统研究了其光电转化效率及电荷传输阻抗等光伏特性.研究结果表明,在染料分子中引入共轭基团有助于其摩尔吸光系数的提升,从而提升光电流.两个长烷基链的引入能够有效地抑制染料分子激发态电子在TiO_2光阳极表面的电子复合,从而提升其电子注入效率.其中,在Am 1.5(100 m w·cm^(-2))的模拟光强下,基于碘电解质的染料JY51电池器件获得了7.61%的光电转化效率.

关键词：吩噻嗪苯并噻二唑有机染料染料敏化太阳能电池光电转化效率

Room temperature ferromagnetism in typical ferroelectric BaTiO3 film

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Room temperature ferromagnetism in typical ferroelectric BaT...

Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells

第18届国际真空大会

作者： Denglu Houa,1, Zhenzhen zhoua,2, Xiaojuan Yeb, Qian Zhanga, Li maa, Congmian Zhena aCollege of Physics Science and Information Engineering, Hebei Normal University, Shijiazhuang 050016, China bNanjing National Laboratory of microstructures, Nanjing University, Nanjing 210093, China

Room temperature ferromagnetism was observed in BaTiO3 （BTO） film which was prepared by pulsed laser deposition and rapid thermal annealing on a low-resistive n-Si substrate. Fe or Cu ions as acceptor dopants （substituting for Ti4+） generally result in the formation of oxygen vacancies in BTO. However, when the BTO films were implanted with Fe ions at 1×1015 cm-2 dose or Cu ions at 5×1016 cm-2 dose by metal vapor vacuum arc technology, they exhibited diamagnetic behavior at room temperature, and the implantation of Ti ions decreased the magnetization of BTO films. The implantation of transition metal ions appears to reduce the magnetization of BTO film, at least at low dose. Structural studies indicated that BTO and Fe, Cu or Ti-implanted BTO films showed a single phase character. The ferromagnetism in BTO film stems from cation defects on Ti sites as in the case of ZnO thin films [mukes Kapilashrami, Jun Xu, Valter Strm, K. V. Rao, and Lyubov Belova, Appl. Phys. Lett. 95, 033104（2009）;Nguyen Hoa Hong, Joe Sakai, and Virginie Brizé, J. Phys.: Condens. matter 19, 036219（2007）], because there is no magnetic impurities present in the BTO film. The BTO film showed obvious ferroelectric performance at the same time. Our results demonstrate that the room temperature ferromagnetism and ferroelectricity can coexisted in the BTO film, which makes it a kind of promising single-phase multiferroic material.

关键词： ferromagnetism multiferroic ferroelectricity BaTiO3 film

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Effect of nicotinamide mononucleotide on insulin secretion a...