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Effects of the inlet particle spatial distribution on the performance of a gas-solid cyclone separator

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Particuology 2024年第2期85卷 133-145页

作者： Yuge Yao Manxia Shang Xiwei ke Zhong Huang Tuo Zhou Junfu Lyu key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing100084China

The present study was aimed at the inlet particle spatial distribution of a gas-solid separator with high solid loading and investigated its effects on cyclone performance and the inner flow *** flow fields of a cyclone with different rectangular particle flow areas on the inlet surface were numerically simulated using a four-way coupling *** simulated results indicate that reducing the inlet particle flow area and lowing the inlet particle position can effectively reduce the scattered particles inside the cyclone separator and enhance the separation *** gathering the particles to the centerline can also weaken the particle *** particles near the roof account for the swirling particle ceiling *** inlet particle spatial distribution affects the pressure drop mainly by affecting the gas tangential velocity in the cylinder ***,compared to the hori-zontal particle distribution on the inlet surface,the vertical particle distribution has greater effects on cyclone performance.

关键词： Gas-solid cyclone Inlet particle spatial distribution Four-way coupling Separation efficiency Scattered particle

In situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen Huang Lining ke En Huang key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Scientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

In situ direct reprogramming technology can directly convert endogenous glial cells into functional neurons in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons in situ. In this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and investigated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ transdifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 transdifferentiation

Asymmetric two-dimensional diffraction grating via a vortex field in an inverted-Ytype atomic system

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Communications in Theoretical Physics 2024年第5期76卷 77-85页

作者： Duo Zhang ke wang Kunpeng Zhao Mei wang Zhaoyu Sun School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan 430023China

we propose a theoretical scheme to realize a two-dimensional(2D)diffraction grating in a four-level inverted-Y-type atomic system coupled by a standing-wave(Sw)field and a Laguerre-Gaussian(LG)vortex *** to asymmetric spatial modulation of the LG vortex field,the incident probe field can be lopsidedly diffracted into four domains and an asymmetric 2D electromagnetically induced grating is *** adjusting the detunings of the probe field and the LG vortex field,the intensities of the LG vortex field and the coherent Sw field,as well as the interaction length,the diffraction properties and efficiency,can be effectively *** addition,the effect of the azimuthal parameter on the Fraunhofer diffraction of the probe field is also *** asymmetric 2D diffraction grating scheme may provide a versatile platform for designing quantum devices that require asymmetric light transmission.

关键词： asymmetric diffraction grating standing-wave field Laguerre-Gaussian vortex field diffraction property

Open-vessel Synthesis of Poly-N-methoxyethylglycine

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Chemical Research in Chinese Universities 2024年第1期40卷 153-158页

作者： LIU Guojan MA ke CHEN Qi ZHANG Donghui LIU Runhui State key Laboratory of Bioreactor Engineering East China University of Science and TechnologyShanghai200237P.R.China key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismResearch Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237P.R.China School of Biotechnology East China University of Science and TechnologyShanghai200237P.R.China

Polypeptoids are widely used in biological applications owing to their diverse functions and proteolytic *** type of polypeptoids,poly-N-methoxyethylglycine(P-Nmeg),has been found to possess remarkable hydrophilicity and notable properties in terms of protein,cell,and bacterial ***,the currently known synthesis methods of P-Nmeg include solid-phase synthesis,which is time-consuming and difficult to scale up,and N-substituted N-carboxyanhydride(NNCA)ring-opening polymerization,whose monomers were difficult to *** this study,we used the chemical stable Nmeg N-phenoxycarbonyl(NPC)as the monomer,which was obtained without the use of highly toxic reactants,such as phosgene or phosphorus halide,to synthesize P-Nmeg under open-vessel *** adding BnNH_(2) as an initiator at 80℃,we can obtain controllable short chain length P-Nmeg with narrow dispersity.

关键词： Open-vessel Polypeptoid synthesis Poly-N-methoxyethylglycine Stable monomer Narrow dispersity

Exercise-induced adaptation of neurons in the vertebrate locomotor system

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Journal of Sport and Health Science 2024年第2期13卷 160-171页

作者： Yue Dai Yi Cheng Renkai Ge ke Chen Liming Yang key Lab of Adolescent Health Assessment and Exercise Intervention of Ministry of Education College of Physical Education and Health CareEast China Normal UniversityShanghai 200241China Shanghai key Laboratory of Multidimensional Information Processing School of Communication and Electronic EngineeringEast China Normal UniversityShanghai 200241China School of Physical Education and Health Care East China Jiaotong UniversityNanchang 330013China key Laboratory of High Confidence Software Technologies of Ministry of Education School of Computer SciencePeking UniversityBeijing 100871China

Vertebrate neurons are highly dynamic cells that undergo several alterations in their functioning and physiologies in adaptation to various external *** particular,how these neurons respond to physical exercise has long been an area of active *** of the vertebrate locomotor system’s adaptability suggest multiple mechanisms are involved in the regulation of neuronal activity and properties during *** this brief review,we highlight recent results and insights from the field with a focus on the following mechanisms:(a)alterations in neuronal excitability during acute exercise;(b)alterations in neuronal excitability after chronic exercise;(c)exercise-induced changes in neuronal membrane properties via modulation of ion channel activity;(d)exercise-enhanced dendritic plasticity;and(e)exercise-induced alterations in neuronal gene expression and protein *** hope is to update the community with a cellular and molecular understanding of the recent mechanisms underlying the adaptability of the vertebrate locomotor system in response to both acute and chronic physical exercise.

关键词： Dendritic plasticity Excitability Exercise Ion channel modulation Neuron adaptation

Visible and selective gel assembly via covalent click chemistry

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SmartMat 2024年第2期5卷 137-144页

作者： Yinglin Zheng Zhihai ke School of Science and Engineering The Chinese University of Hong KongShenzhenChina

This study marks the birth of visible and selective click covalent *** is achieved by amplifying orthogonal alkyne−azide click chemistry through interfacial multisite interactions between azide/alkyne functionalized polymer *** assembly of hydrogels via host−guest chemistry or noncovalent interactions such as electrostatic interactions has been *** macroscopic supramolecular assembly,here we report visible and selective“click”covalent assembly of hydrogels at the ***-like hydrogels modified with alkyne and azide groups,respectively,can click together via the formation of covalent *** concentration-dependent assembly and selective covalent assembly have been ***,macroscopic gel assembly clearly elucidates click preferences and component selectivity not observed in the solution reactions of competing monomers.

关键词： click chemistry hydrogel selective covalent assembly

Driver at 10 MJ and 1 shot/30 min for inertial confinement fusion at high gain:Efficient,compact,low-cost,low laser-plasma instabilities,beam color selectable from 2ω/3ω/4ω,applicable to multiple laser fusion schemes

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Matter and Radiation at Extremes 2024年第4期9卷 4-7页

作者：隋展蓝可 Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Instituteof Applied Physics and Computational Mathematics Beijing 100094China

The achievement of ignition at the National Ignition Facility(NIF)has prompted a global wave of further research on inertial fusion energy(IFE).However,IFE requires a target gain G of 30-100,and it is hard to achieve fusion at such high gain with the energy,configuration,and technical approach of the ***,we present a conceptual design for a next-generation laser driver that is applicable to multiple laser fusion schemes and provides 10 MJ,2-3 Pw at 3ω(or 2ω,in which case the energy and power can be higher),and one shot per 30 min,with the aim of achieving G>*** is also efficient,compact,and low in cost,and it has low susceptibility to laser-plasma instabilities.

关键词： applicable compact instabilities

Projecting wintertime Newly Formed Arctic Sea Ice through weighting CMIP6 Model Performance and Independence

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Advances in Atmospheric Sciences 2024年第8期41卷 1465-1482页

作者： Jiazhen ZHAO Shengping HE ke FAN Huijun wANG Fei LI key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044China Geophysical Institute University of Bergen and Bjerknes Centre for Climate ResearchBergen 5007Norway School of Atmospheric Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Nansen Environmental and Remote Sensing Center and Bjerknes Centre for Climate Research Bergen 5007Norway Nansen-Zhu International Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

Precipitous Arctic sea-ice decline and the corresponding increase in Arctic open-water areas in summer months give more space for sea-ice growth in the subsequent cold seasons. Compared to the decline of the entire Arctic multiyear sea ice,changes in newly formed sea ice indicate more thermodynamic and dynamic information on Arctic atmosphere–ocean–ice interaction and northern mid–high latitude atmospheric teleconnections. Here, we use a large multimodel ensemble from phase 6 of the Coupled Model Intercomparison Project(CMIP6) to investigate future changes in wintertime newly formed Arctic sea ice. The commonly used model-democracy approach that gives equal weight to each model essentially assumes that all models are independent and equally plausible, which contradicts with the fact that there are large interdependencies in the ensemble and discrepancies in models' performances in reproducing observations. Therefore, instead of using the arithmetic mean of well-performing models or all available models for projections like in previous studies, we employ a newly developed model weighting scheme that weights all models in the ensemble with consideration of their performance and independence to provide more reliable projections. Model democracy leads to evident bias and large intermodel spread in CMIP6 projections of newly formed Arctic sea ice. However, we show that both the bias and the intermodel spread can be effectively reduced by the weighting scheme. Projections from the weighted models indicate that wintertime newly formed Arctic sea ice is likely to increase dramatically until the middle of this century regardless of the emissions ***, it may decrease(or remain stable) if the Arctic warming crosses a threshold(or is extensively constrained).

关键词： wintertime newly formed Arctic sea ice model democracy model weighting scheme model performance model independence

Optimization of Fixture Number in Large Thin-walled Parts Assembly Based on IPSO

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 213-227页

作者： Changhui Liu Jing wang Ying Zheng ke Jin Jianbo Yu Jianfeng Liu School of Mechanical Engineering Tongji UniversityShanghai 201804China Shanghai Jiaotong University Shanghai 200240China Shanghai waigaoqiao Shipbuilding Co. Ltd.Shanghai 200137China

There are lots of researches on fixture layout optimization for large thin-walled *** researches focus on the positioning problem,i.e.,optimizing the positions of a constant number of ***,how to determine the number of fixtures is *** most cases,the number of fixtures located on large thin-walled parts is determined based on engineering experience,which leads to huge fixture number and extra ***,this paper constructs an optimization model to minimize the number of *** constraints are set in the optimization model to ensure that the part deformation is within the surface profile *** addition,the assembly gap between two parts is also *** conduct the optimization,this paper develops an improved particle swarm optimization(IPSO)algorithm by integrating the shrinkage factor and adaptive inertia *** the algorithm,particles are encoded according to the fixture *** dimension of the particle is assigned to a sub-region by constraining the optional position range of each fixture to improve the optimization ***,a case study on ship curved panel assembly is provided to prove that our method can optimize the number of fixtures while meeting the assembly quality *** research proposes a method to optimize the number of fixtures,which can reduce the number of fixtures and achieve deformation control at the same time.

关键词： Assembly quality Large thin-walled parts Fixture layout PSO FEM