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Investigation on reversible pump turbine flow structures and associated pressure field characteristics under different guide vane openings

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Science China(Technological Sciences) 2019年第11期62卷 2052-2074页

作者： BINAMA Maxime SU wenTao cai weiHua LI FengChen wEI Xianzhu MUHIRwA Alex GONG Ruzhi wEKESA David w School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Energy and power Shenyang Institute of Engineering Shenyang 110136China School of Energy and power Engineering Northeast Electric Power UniversityJilin 132012China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China State Key Laboratory of Hydropower Equipment Harbin Institute of Large Electric MachineryHarbin 150040China

The use of reversible pump turbines(RpT) within pumped storage power plants goes with prolonged periods of off-design operating conditions, which leads to the onset of operating mode-dependent instabilities. In order to decrease the gravity of RpT flow instabilities and associated damages or even completely eliminate them, a deep understanding of its onset and development mechanism is needed. In line with this, the present study seeks to numerically investigate the onset and development mechanism of RpT unsteady flow structures as well as the evolutional characteristics of associated pressure pulsations throughout the RpT complete flow passage, under off-design conditions for three GVOs namely 17, 21, and 25 mm. The study results showed that low torque operating conditions and associated vaneless space back flow structures were the trigger of flow unsteadiness onset within the RpT vaneless space, the instabilities which grew to cause the S-shape characteristics appearance. Moreover, the runner flow unsteadiness was found to decrease with the GVO increase. On the other hand, the GVO increase worsened the pressure pulsation levels within RpT flow zones, where pressure pulsations within the vaneless space and flow zones in its vicinities were found to be the most sensitive to GVO changes.

关键词： reversible pump-turbine flow unsteadiness pressure pulsation guide vane opening numerical simulation

prognostic role of the stromal cell derived factor-1 in patients with hepatitis B virus-related acute-on-chronic liver failure

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world Journal of Clinical Cases 2024年第19期12卷 3845-3853页

作者： Li zhang Jian-Yu wang cai-Yan zhao Chuan Shen Mei-Ru Chen zhi-Ying Tian Department of Gastroenterology Hengshui People's HospitalHengshui 053000Hebei ProvinceChina Department of Neurology Hengshui People's HospitalHengshui 053000Hebei ProvinceChina Department of Infection The Third Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Stromal cell derived factor-1(SDF-1)plays a pivotal role in the recruitment of stem cells to injured ***,the changes of SDF-l in patients with hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF)have yet to be *** To study the SDF-1 changes in patients with HBV-related *** 30 patients with HBV-related ACLF,27 patients with chronic hepatitis B and 20 healthy individuals are involved in our *** SDF-l mRNA expression in liver tissue was detected by quantitative real-time polymerase chain *** staining was performed to illustrate the expression of SDFl,CXC receptor 4(CXCR4)and *** serum SDF-l concentrations were also detected by enzyme-linked immunosorbent *** The expression of SDF-1 mRNA from ACLF patients was remarkably higher than that from other patients(both ppression of SDF-l,CXCR4 and Ki67 from ACLF were the highest among the three groups(all ppatients were significantly lower than that in other patients(both ppatients,the serum SDF-1 Levels were positively correlated with serum total bilirubin and international normalized *** addition,the serum SDF-l levels in survival were significantly lower compared with the non-survivals(ppredicting 28-d mortality was 0.722(pprovides the SDF-1 changes in patients with HBV-related *** SDF-1 Level at admission may serve as a promising prognostic marker for predicting short-term prognosis.

关键词： Stromal cell derived factor-1 CXC receptor 4 Acute-on-chronic liver failure Hepatitis B prognosis

Synthesis and Crystal Structure of Lanthanide Heteropolymolybdate Complex(NH_(4))_(11)Gd[Gd_(4)Mo_(29)O_(100)(H_(2)O)_(23)]·25.75H_(2)O

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Chinese Journal of Structural Chemistry 2000年第6期19卷 432-439页

作者： HUANG Jin-Feng wANG Shi-Ming lin Shen cai Xiu-zhen lin Xiang Department of Chemistry Fujian Normal UniversityFuzhou350007 Fujian Institute of Research on the Structure of Matter the Chinese Academy of SciencesFuzhouFujian 350002

The title complex crystallizes in the triclinic system, space group p1 with a=16.9568(5), b=18.8631(6), c=24.1640(8), α=100.110(1), β=92\^330(1), γ=113.368(1)°, V=7602.54(4)~3, D_c=3.002 g/cm^3, F(000)=5893, M_r=6245.25, μ(Mo Kα)=5.010mm^-1, z=2 and final R=0.0722 and wR=0\^1960 for 16015 observed reflections with I≥2σ(I). The Gd(Ⅲ) ion is coordinated by nine oxygen atoms, forming a distorted mono-capped square antiprism, while the Mo(Ⅵ) ions have their different coordination numbers such as 4,5 and 6 with different configurations such as tetrahedron, square pyramid and octahedron, respectively.

关键词： crystal structure gadolinium complex heteropolymolybdate

Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles

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Journal of zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第11期12卷 875-883页

作者： Jin-xing lin Yu-dong JIA cai-qiao zHANG Key Laboratory of Animal Epidemic Etiology ＆ Immunological prevention of the Ministry of Agriculture Department of Veterinary Medicine College of Animal Sciences Zhejiang University Hangzhou 310058 China

The development of ovarian follicular cells is controlled by multiple circulating and local hormones and factors, including follicle-stimulating hormone （FSH） and epidermal growth factor （EGF）. In this study, the stagespecific effect of EGF on FSH-induced proliferation of granulosa cells was evaluated in the ovarian follicles of egg-laying chickens. Results showed that EGF and its receptor （EGFR） mRNAs displayed a high expression in granulosa cells from the prehierarchical follicles, including the large white follicle （LwF） and small yellow follicle （SYF）, and thereafter the expression decreased markedly to the stage of the largest preovulatory follicle. SYF represents a turning point of EGF/EGFR mRNA expression during follicle selection. Subsequently the granulosa cells from SYF were cultured to reveal the mediation of EGF in FSH action. Cell proliferation was remarkably increased by treatment with either EGF or FSH （0.1-100 ng/ml）. This result was confirmed by elevated proliferating cell nuclear antigen （pCNA） expression and decreased cell apoptosis. Furthermore, EGF-induced cell proliferation was accompanied by increased mRNA expressions of EGFR, FSH receptor, and the cell cycle-regulating genes （cyclins D1 and El, cyclin-dependent kinases 2 and 6） as well as decreased expression of luteinizing hormone receptor mRNA. However, the EGF or FSH-elicited effect was reversed by simultaneous treatment with an EGFR inhibitor AG1478. In conclusion, EGF and EGFR expressions manifested stage-specific changes during follicular development and EGF mediated FSH-induced cell proliferation and retarded cell differentiation in the prehierarchical follicles. These expressions thus stimulated follicular growth before selection in the egg-laying chicken.

关键词： Epidermal growth factor Follicle-stimulating hormone Granulosa cell proliferation Chicken

老年2型糖尿病患者抑郁和焦虑与脑小血管病相关性分析

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中华老年医学杂志 2024年第8期43卷 1000-1006页

作者：黄辛炜黄逸欢黄银琼林化松蔡驰李柯陆惠吴晓鸿林夏鸿中山大学附属第七医院内分泌科深圳518000 中山大学附属第七医院老年医学科深圳518000 福建医科大学附属第二医院内分泌科泉州362000 福建医科大学附属第二医院放射影像学科泉州362000

目的本研究主要探究老年2型糖尿病(T2DM)患者中焦虑和抑郁与脑小血管病(CSVD)之间的相关性, 并就焦虑与抑郁的影响因素进行分析。方法回顾性分析2020年7月至2021年12月在福建医科大学第二附属医院内分泌科住院的101例老年T2DM住院患者... 详细信息

目的本研究主要探究老年2型糖尿病(T2DM)患者中焦虑和抑郁与脑小血管病(CSVD)之间的相关性, 并就焦虑与抑郁的影响因素进行分析。方法回顾性分析2020年7月至2021年12月在福建医科大学第二附属医院内分泌科住院的101例老年T2DM住院患者的临床资料, 收集各项临床特征、实验室检验和检查数据。采用汉密尔顿抑郁量表和汉密尔顿焦虑量表进行评估, 焦虑的分界值为14分, 抑郁的分界值为8分。使用3.0T磁共振扫描仪进行脑部扫描, 扫描序列包括T1wI序列、T2wI序列、3D-FLAIR序列、SwI序列。根据Staals提出的CSVD的MRI总负荷评分标准, 分别对CSVD的MRI影像学改变, 即腔隙灶(LIs)、脑微出血(CMBs)、血管周围间隙(pVSs)、白质高信号(wMHs)进行分析并负荷评分, 负荷评分≥1分定义为CSVD组。依据以上标准将入选患者分为有无抑郁组、有无焦虑组, 分别对各自两组之间的临床特征、生化检验数据和CSVD的MRI影像学改变特征进行单因素分析, 然后采用Spearman相关分析法分析老年T2DM伴焦虑、抑郁的相关因素, 运用二元Logistic分析对老年T2DM合并抑郁、焦虑的危险因素进行分析。结果与无抑郁组相比, 老年T2DM伴抑郁组患者年龄更大, 女性更多, 且wMHs和DwMHs的发生率更高(pwMHs和DwMHs的发生率更高(ppearman相关性分析显示, 年龄(r=0.224, p=0.024)、wMHs(r=0.231, p=0.020)、pwMHs(r=0.201, p=0.044)、DwMHs(r=0.274, p=0.006)与老年T2DM伴抑郁均呈正相关, 性别(r=-0.225, p=0.024)、ALT(r=-0.208, p=0.037)、AST(r=-0.204, p=0.041)与老年T2DM伴抑郁均呈负相关;wMHs(r=0.213, p=0.033)、DwMHs(r=0.270, p=0.006)与老年T2DM伴焦虑均呈正相关。AST(r=-0.292, p=0.003)与老年T2DM伴焦虑呈负相关。二元Logistic回归分析显示, 性别(OR=0.359, 95%CI:0.130~0.990, p=0.048)、DwMHs(OR=4.373, 95%CI:1.290~14.828, p=0.018)均为老年T2DM伴抑郁的影响因素, DwMHs(OR=5.000, 95%CI:1.444~17.317, p=0.011)为老年T2DM伴焦虑的影响因素。结论 DwMHs与老年T2DM患者抑郁和焦虑发病密切相关, 提示CSVD可能参与了老年T2DM患者抑郁和焦虑发生发展。

关键词：糖尿病抑郁焦虑糖尿病血管病变脑小血管病

Sources for Heat-Stable Resistance to Southern Root-Knot Nematode (Meloidogyne incognita) in Solanum lycopersicum

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Agricultural Sciences in China 2009年第6期8卷 697-702页

作者： wU wen-wen SHEN Huo-lin YANG wen-cai Department of Vegetable Science College of Agronomy and Biotechnology China Agricultural University Beijing 100193 P.R.China

Southern root-knot nematode （Meloidogyne incognita） is a major problem in vegetable production in China due to the expansion of plastic tunnel and solar greenhouse. Using resistant cultivars is an effective approach to control the disease. Nine genes, Mi-1 to Mi-9, have been reported and only Mi-1 has been successfully used in tomato breeding. However, Mi-1 is inactive at a temperature above 28~C. In order to identify sources for heat-stable resistance to southern root-knot nematode, 53 genotypes of tomato （Solarium spp.） were inoculated with an isolate of M. incognita in the growth chamber at 28 or 32℃ for initial screening. 28 lines had less than 25 galls and were considered as resistant candidates. The top 60% （16 in total） of resistant candidates obtained from each temperature were subject to re-evaluation at 32~C using the same nematode isolate. Three lines zN17, zN 48, and LA0385 showed heat-stable resistance with an average of 10 galls or less per plant. LA0385 is a wild species, while zNI7 and zN48 are elite breeding lines. These lines were grown in a greenhouse for two seasons, and also showed high resistance with less than 10 galls per plant. Thus they were considered as good sources for breeding resistance to southern root-knot nematode in tomato.

关键词： heat-stable resistance Meloidogyne incognita tomato

Subjective cognitive decline domain improves accuracy of plasma Aβ_(42)/Aβ_(40)for preclinical Alzheimer’s disease diagnosis:The SILCODE study

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Chinese Medical Journal 2024年第9期137卷 1127-1129页

作者： Mingkai zhang Xiaoni wang weina zhao Yuxia Li Chao Ying Jiehui Jiang Yanning cai Jie Lu Ying Han Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing 100053China Department of Neurology Sir Run Run Shaw HospitalAffiliated with School of MedicineZhejiang UniversityHangzhouZhejiang 310016China Department of Neurology Hongqi Hospital Affiliated to Mudanjiang Medical UniversityMudanjiangHeilongjiang 157011China Heilongjiang Key Laboratory of Ischemic Stroke prevention and Treatment MudanjiangHeilongjiang 157011China Department of Neurology Tangshan Central HospitalTangshanHebei 063000China Department of Neurobiology Xuanwu Hospital of Capital Medical UniversityKey Laboratory for Neurodegenerative Diseases of the Ministry of EducationBeijing 100053China Institute for Advanced Communication and Data Science Shanghai UniversityShanghai 200444China Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics Beijing 100053China Key Laboratory of Neurodegenerative Diseases Ministry of EducationBeijing 100053China School of Biomedical Engineering Hainan UniversityHaikouHainan 570228China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing 100053China National Clinical Research Center for Geriatric Disorders Beijing 100053China Institute of Biomedical Engineering Shenzhen Bay LaboratoryShenzhenGuangdong 518132China

To the Editor:Accumulating evidence has shown that the preclinical stage of Alzheimer’s disease(AD)(i.e.,asymptomatic amyloidosis)lasts for decades before the onset of cognitive symptoms,providing a large window for early *** pathology,the earliest pathological change associated with AD,can be detected in vivo with cerebrospinal fluid(CSF)analysis or positron emission tomography(pET),and its presence is necessary for the diagnosis of preclinical AD(pre-AD).However,both pET scans and CSF analyses are expensive,hampering their use in large-scale ***,blood-based biomarkers are desirable alternatives,as they are cost-effective and not invasive.

关键词： diagnosis clinical Alzheimer

Measurement, modelling, and closed-loop control of crystal shape distribution： Literature review and future perspectives

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particuology 2016年第3期14卷 1-18页

作者： cai Y. Ma Jing J. Liu Xue z. wang Institute of particle Science and Engineering School of Chemical and Process Engineering University of Leeds Leeds 1.52 9JT United Kingdom School of Chemistry and Chemical Engineering South China University of Technology Guangzhou 510640 China

Crystal morphology is known to be of great importance to the end-use properties of crystal products, and to affect down-stream processing such as filtration and drying. However, it has been previously regarded as too challenging to achieve automatic closed-loop control. previous work has focused on controlling the crystal size distribution, where the size of a crystal is often defined as the diameter of a sphere that has the same volume as the crystal. This paper reviews the new advances in morphological population balance models for modelling and simulating the crystal shape distribution （CShD）, measuring and estimating crystal facet growth kinetics, and two- and three-dimensional imaging for on-line characterisation of the crystal morphology and CShD. A framework is presented that integrates the various components to achieve the ultimate objective of model-based closed-loop control of the CShD. The knowledge gaps and challenges that require further research are also identified.

关键词： Crystal morphology Crystal shape distribution Morphological population balance mode3D process imaging Closed-loop control of crystal shapeCrystal facet growth kinetics

Investigation of Nuclear Binding Energy and Charge Radius Based on Random Forest Algorithm

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原子能科学技术 2023年第4期57卷 704-712页

作者： cai Boshuai YU Tianjun lin Xuan zHANG Jilong wANG zhixuan YUAN Cenxi Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The random forest algorithm was applied to study the nuclear binding energy and charge *** regularized root-mean-square of error(RMSE)was proposed to avoid overfitting during the training of random *** for nuclides with z,N>7 is reduced to 0.816 MeV and 0.0200 fm compared with the six-term liquid drop model and a three-term nuclear charge radius formula,*** interest is in the possible(sub)shells among the superheavy region,which is important for searching for new elements and the island of *** significance of shell features estimated by the so-called shapely additive explanation method suggests(z,N)=(92,142)and(98,156)as possible subshells indicated by the binding *** the present observed data is far from the N=184 shell,which is suggested by mean-field investigations,its shell effect is not predicted based on present *** significance analysis of the nuclear charge radius suggests z=92 and N=136 as possible *** effect is verified by the shell-corrected nuclear charge radius model.

关键词： nuclear binding energy nuclear charge radius random forest algorithm