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大剂量阿糖胞苷治疗高危急性髓细胞白血病优于中剂量阿糖胞苷:一项不同年龄组的前瞻性随机对比结果

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德国医学 2000年第1期17卷 13-15页

作者： w.kern C.Aul G.Maschmeyer R.Schnrock-Nabulsi wDLudwig A.Bartholomus P.Bettelheim B.wrmann T.Büchner w.Hiddemann 曾慧兰 Georg-August-University Department of Hematology and OncologyRobert-Koch-Strasse 40 D-37075 Gttingen Germany 广州暨南大学医学院第一附属医院

阿糖胞苷(AraC)是白血病治疗中最古老的药物之一,至今成人急性髓细胞白血病(AML)大部分治疗方案仍以其为基本组成。大剂量阿糖胞苷(HD-AraC)对难治、复发 AML 有明显的抗白血病活性,增加 AraC 剂量的联合方案已被作为一线治疗。前瞻性... 详细信息

阿糖胞苷(AraC)是白血病治疗中最古老的药物之一,至今成人急性髓细胞白血病(AML)大部分治疗方案仍以其为基本组成。大剂量阿糖胞苷(HD-AraC)对难治、复发 AML 有明显的抗白血病活性,增加 AraC 剂量的联合方案已被作为一线治疗。前瞻性随机研究已证实诱导期或强化巩固期使用 HD-AraC 远期疗效佳,但相对于传统剂量(如100～200mg/m^2.次)AraC 最佳剂量多少为宜,目前仍未明了。

关键词：急性白血病髓细胞药物疗法阿糖胞苷

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老年急性髓性白血病的治疗

德国医学 2000年第4期17卷 222-222页

作者： w.kern C.Schoch C.Fonatsch A.Heinecke B.wrmann T.Büchner w.Hiddemann 唐锦治 Ludwig-Maximilians-Universitt Klinikum Groβhadern Medizinische Klinik ⅢD-81366 MnchenGermany 同济医科大学附属同济医院

急性髓性白血病(AML)是一成年人的疾病,其发病率随年龄的增加而增加,其中数年龄为65～70岁。由于患者的治疗禁忌证以及医生和患者对化疗及其毒性所持保守态度,临床报道的中数发病年龄比上述要低15～20岁。绝大多数的临床观察显示老年AM... 详细信息

急性髓性白血病(AML)是一成年人的疾病,其发病率随年龄的增加而增加,其中数年龄为65～70岁。由于患者的治疗禁忌证以及医生和患者对化疗及其毒性所持保守态度,临床报道的中数发病年龄比上述要低15～20岁。绝大多数的临床观察显示老年AML的治疗效果差,生存期较年轻组为短,因此有必要探讨其原因并制定适合于老年AML的治疗方针。

关键词：老年人急性髓性白血病 AML 治疗

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy