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Control of dislocation density maximizing precipitation strengthening effect

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journal of Materials Science & Technology 2022年第32期127卷 133-143页

作者： C.Xu w.j.dai Y.Chen Z.X.Qi G.Zheng Y.D.Cao j.P.Zhang C.C.Bu G.Chen MIIT Key Laboratory of Advanced Metallic and Internetallic Materials Technology Engineering Research Center of Materials Behavior and DesignMinistry of EducationNanjing University of Science and TechnologyNanjing 210094China

The strength-ductility trade-off has been the most challenging problem for structural metals for *** strengthening is an ideal approach to enhance the strength without significantly sacrificing the *** nanoprecipitates have been successfully acquired by nanostructural design,but the number density of nanoprecipitates cannot be further *** attempted to enhance number density by introducing highly potent nucleation sites(e.g.,dislocations).However,there remains controversy over the influence of dislocations on the nucleation and growth of coherent nanoprecipitates with minimized nucleation ***,Cu-rich nanoprecipitates in an HSLA steel,as a typical type of coherent nanoprecipitates,are *** combining analytical calculation and experiments,we show that dislocations are harmful for the formation of large numbered Cu-rich nanoprecipitates in a certain density *** dislocations deprive solute atoms which decrease homogenous precipitation that cannot be compensated by the increase in heterogeneous *** such circumstance,Cu-rich nanoprecipitates have smaller number density but larger size and higher fraction of incoherent structures due to rapid Ostwald *** a result,by controlling dislocation density,the yield strength is increased by 24%without obvious loss in ductility as compared with traditional solution-quench-age *** work would help to optimize composition and processing routes that fully exploit the nanoprecipitation strengthening effect.

关键词： Cu-rich nanoprecipitates Crystallographic defects Nucleation Structural transformation Ostwald ripening

Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen wu Xiaoxi dai Danni Li Haojie An Shiyi Zeng Chunyan wang Li Yang Cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

基于背景噪声研究东滩矿区地下介质波速变化特征

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大地测量与地球动力学 2025年第1期45卷 55-59页

作者：戴宗辉曲均浩山东省地震局济南市250014

基于地震背景噪声互相关方法,利用东滩煤矿CCH和BDS台2022-02-0802:00-2023-03-0807:00连续波形数据计算地下介质波速变化,并分析其与63上06工作面回采作业和矿震活动的相关性。研究结果表明,63上06工作面回采作业对地下介质波速影响明... 详细信息

基于地震背景噪声互相关方法,利用东滩煤矿CCH和BDS台2022-02-0802:00-2023-03-0807:00连续波形数据计算地下介质波速变化,并分析其与63上06工作面回采作业和矿震活动的相关性。研究结果表明,63上06工作面回采作业对地下介质波速影响明显;波速转折变化与矿震发生也具有较为明显的相关性,反映出地下应力水平变化与矿震发生的关系;矿震对地下应力的释放也可导致波速出现小幅度波动变化。

关键词：背景噪声波速变化东滩煤矿矿震

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

教育强国建设促进共同富裕的内在机理、现实困境与政策推进

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河北大学学报（哲学社会科学版） 2025年第1期50卷 32-43页

作者：戴岭华东师范大学教育学部上海200062

党的二十届三中全会强调,要通过深化教育强国战略改革,助力中国式现代化进程。教育强国建设作为国家对社会整体发展的长远规划和系统布局在推动全民共同富裕中占据基础性、引导性和战略性地位,依托提高国民素质、培养创新人才、优化社... 详细信息

党的二十届三中全会强调,要通过深化教育强国战略改革,助力中国式现代化进程。教育强国建设作为国家对社会整体发展的长远规划和系统布局在推动全民共同富裕中占据基础性、引导性和战略性地位,依托提高国民素质、培养创新人才、优化社会结构以及增强文化软实力等,赋能全民物质生活与精神生活协调统一的共同富裕,体现出造就共富格局、托举共富底线、赋能优质共富、涵养精神共富的作用机制。针对当前教育体系间不平衡不充分与研究范式单一分散制约整体效能、城乡发展异质与区域资源不均衡影响教育益贫式增长、数字鸿沟与算法风险加剧收入不平等阻碍教育技术赋能、公共文化服务建设与文化消费水平不足阻碍精神共富的现实困境,本文提出推进方略:构建融创教育新范式,推动人口红利向人才红利转变;发挥教育提低扩中效应,促进县域城乡融合发展;加速人工智能教育融合,优化劳动力市场战略布局;厚植立德树人精神根基,塑造中国式文化制度伦理。

关键词：教育强国建设共同富裕精神共富融创教育教育数字化转型

MANY-SERVER QUEUES wITH CUSTOMER ABANDONMENT:A SURVEY OF DIFFUSION AND FLUID APPROXIMATIONS

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journal of Systems Science and Systems Engineering 2012年第1期21卷 1-36页

作者： j. G. dai Shuangchi HE H. Milton Stewart School of Industrial and Systems Engineering Georgia Institute of Technology Atlanta GA 30332 USA. Department of Industrial and Systems Engineering National University of Singapore Singapore 11757

The performance of a call center is sensitive to customer abandonment. In this survey paper, we focus on G/GI/n ＋ GI parallel-server queues that serve as a building block to model call center operations. Such a queue has a general arrival process （the G ）, independent and identically distributed （iid） service times with a general distribution （the first G1 ）, and iid patience times with a general distribution （the ＋GI）. Following the square-root safety staffing rule, this queue can be operated in the quality- and efficiency-driven （QED） regime, which is characterized by large customer volume, the waiting times being a fraction of the service times, only a small fraction of customers abandoning the system, and high server utilization. Operational efficiency is the central target in a system whose staffing costs dominate other expenses. If a moderate fraction of customer abandonment is allowed, such a system should be operated in an overloaded regime known as the efficiency-driven （ED） regime. we survey recent results on the many-server queues that are operated in the QED and ED regimes. These results include the performance insensitivity to patience time distributions and diffusion and fluid approximate models as practical tools for performance analysis.

关键词： Heavy traffic square-root safety staffing quality- and efficiency-driven regime efficiency-driven regime piecewise OU process

Research of Neural Network Based on Improved PSO Algorithm for Carbonation Depth Prediction of Concrete

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武汉理工大学学报 2010年第17期32卷 170-175页

作者： dai w SHUI Z H School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China School of Economics and Management Huangshi Institution of TechnologyHuangshi 435003China

Firstly,neural network based on improved particle swarm optimization (PSO)algorithm is introduced in this paper. Based on the data collected from projects in typical areas,the concrete carbonation depth is assessed with consideration of various factors such as unit cement consumption (C),unit water consumption (w),binder material content (B),water binder ratio (w/B ),concrete strength (MPa),rapid carbonization days (D),fly ash consumption of unit volume concrete(FA),fly ash percentage of total cementitious materials (FA%),expansion agent consumption of unit volume concrete(EA),expansion agent percentage of total cementitious materials (FA%).Gaining the data from project-experiment,a model is presented to calculate and forecast carbonation depth using neural network based on improved PSO algorithm. The calculation results indicate that this algorithm accord with the prediction carbonation depth of concrete accuracy requirements and has a better convergence and generalization,worth being popularized.

关键词： PSO BP neural network concrete carbonation depth prediction

基于改进BP神经网络的烟草收获机械故障诊断研究

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农机化研究 2025年第4期47卷 70-76页

作者：戴欧阳胡洪林桂林信息科技学院广西桂林541000

烟草收获机械是烟草生产中的重要技术支撑,是提高收获效率的重要保证,但由于烟草收获机械内部结构较为复杂,在使用过程中极易造成机械运行故障。随着大数据及传感器技术的快速发展,基于人工神经网络模型实现机械故障的预测与诊断成为提... 详细信息

烟草收获机械是烟草生产中的重要技术支撑,是提高收获效率的重要保证,但由于烟草收获机械内部结构较为复杂,在使用过程中极易造成机械运行故障。随着大数据及传感器技术的快速发展,基于人工神经网络模型实现机械故障的预测与诊断成为提高烟草收获机械工作效率的重要技术。目前,主要以BP神经网络模型应用较为广泛,但在模型构建中预测效率低、鲁棒性强。针对以上问题,提出一种改进BP神经网络模型,以烟草收获机械中的齿轮故障诊断为研究对象,构建基于GA-BP神经网络模型的烟草收获机械齿轮故障诊断模型,并通过选取齿轮磨损、胶合、裂纹、断齿和正常齿轮的信号进行试验验证。结果表明:改进后的BP神经网络模型MAPE仅为0.87%,RMSE为1.12,MAE为0.92,MSE为1.19,满足烟草收获生产的实际需要,在模型算法与计算速度方面都得到了很大的提高。

关键词：烟草收获机械故障遗传算法 BP神经网络优化模型

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