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Difference in the Hot Compressive Behavior and Processing Maps between the As-cast and Homogenized Al-Zn-Mg-Cu(7075) Alloys

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journal of Materials Science & Technology 2016年第7期32卷 660-670页

作者： S.Y. Park w.j. Kim Department of Materials Science and Engineering Hongik University 72-1 Sangsu-dong Mapo-gu Seoul 121-791 Republic of Korea Advanced Fusion Process R&D Group Korea Institute of Industrial Technology 994-32 Dongchun-dong Yeonsu-gu Incheon 406-130 Republic of Korea

The deformation mechanisms and processing maps of the as-cast Al-Zn-Mg-Cu （？0？5） aluminum （AI） alloy were studied and compared with those of the homogenized 7075 Al alloy in the temperature range of 573-723 K and in the strain rate range of 10 3-10 s-1 to explore a possibility for directly using the as- cast 7075 Al alloy as a billet for hot working. The as-cast and homogenized 7075 A1 alloys had similar grain sizes and showed similar high-temperature deformation behaviors. The as-cast 7075 Al alloy, however, exhibited higher power efficiencies and smaller unstable flow regions compared to the homogenized 7075 AI alloy because of the presence of secondary phases （MgZn2） segregated at the dendritic interfaces in the as-cast microstructure, which were formed during non-equilibrium solidification. These segregated phases provided nucleation sites for dynamic recovery or continuous dynamic recrystallization, and as a result a fine and more homogeneous （sub）grain structure could be obtained from the as-cast micro- structure compared to the homogenized microstructure. The current work suggested the possibility and advantage of using as-cast microstructures for hot working of aluminum alloys with high content of solutes.

关键词： Al-based alloysProcessing mapHot compressionAs-cast microstructureSegregationRecrystallization

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon C.Daeschler Katelyn j.w.So Konstantin Feinberg Marina Manoraj jenny Cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

CORROSION PROTECTION OF Al CATHODES IN ZINC ELECTROLYSIS

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Acta Metallurgica Sinica(English Letters) 1999年第3期12卷 221-228页

作者： Lu, F. Van Ooij, w.j. Beijing Inst of Aeronautical Materials Beijing China

A new pretreatment or a coating for Al was developed and tested to protect the Al effectively from corrosion when it was connected to pure zinc at electroplating potential and exposed to an acidic sulfate solution. It was found out that (1) Al alloy purity and electroplating potential have a large effect on galvanic corrosion between Zn-Al couples; (2) BTSE silane pretreatment and polyurethane coating have better performance in corrosion protection, which are evaluated by EIS, salt spray test and immersion test for Al cathodes in Zinc electrolyte; (3) BTSE treatment or BTSE plus polyurethane coating has the best anti-corrosion performance and can protect the Al cathode effectively in zinc electrolysis.

关键词： Aluminum Electrolysis

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse w.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew.j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Expression, Imprinting, and Evolution of Rice Homologs of the Polycomb Group Genes

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Molecular Plant 2009年第4期2卷 711-723页

作者： Ming Luo Damien Platten Abed Chaudhury w.j. Peacock Elizabeth S. Dennis CSIRO Plant Industry GPO BOX 1600 ACT 2601 Australia Present address: Vitagrain Uttara Model Town Dhaka Bangladesh Present address: IRRI Los Banos Laguna 4031 Philippines

Polycomb group proteins （PcG） play important roles in epigenetic regulation of gene expression. Some core PeG proteins, such as Enhancer of Zeste （E（z））, Suppressor of Zeste （12）（Su（z）12）, and Extra Sex Combs （ESC）, are conserved in plants. The rice genome contains two E（z）-Iike genes, OsiEZ1 and OsCLF, two homologs of Su（z）12, OsEMF2a and OsEMF2b, and two ESC-like genes, OsFIE1 and OsFIE2. OsFIE1 is expressed only in endosperm; the maternal copy is expressed while the paternal copy is not active. Other rice PcG genes are expressed in a wide range of tissues and are not imprinted in the endosperm. The two E（z）-Iike genes appear to have duplicated before the separation of the dicots and monocots; the two homologs of Su（z）12 possibly duplicated during the evolution of the Gramineae and the two ESC- like genes are likely to have duplicated in the ancestor of the grasses. No homologs of the Arabidopsis seed-expressed PcG genes MEA and FIS2 were identified in the rice genome. we have isolated T-DNA insertion lines in the rice homologs of three PcG genes. There is no autonomous endosperm development in these T-DNA insertion lines. One line with a T-DNA insertion in OsEMF2b displays pleiotropic phenotypes including altered flowering time and abnormal flower organs, suggesting important roles in rice development for this gene.

关键词： Polycomb group protein pseudograin imprinting development evolution panicle.

Experimental and Numerical Investigation on Impact Performance of Carbon Reinforced Aluminum Laminates

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journal of Materials Science & Technology 2010年第4期26卷 327-332页

作者： S.H. Song Y.S. Byun T.w. Ku w.j. Song j. Kim B.S. Kang National Core Research Center Pusan National University Busan 609-735 Korea Dept. of Aerospace Engineering Pusan National University Busan 609-735 Korea Industrial Liaison Innovation Cluster Pusan National University Busan 609-735 Korea

It is known that fiber metal laminates （FML） as one of hybrid materials with thin metal sheets and fiber/epoxy layers have the characteristics of the excellent damage tolerance, fatigue and impact properties with a relatively low density. Therefore, the mechanical components using FML can contribute the enhanced safety level of the sound construction toward the whole body. In this study, the impact performance of carbon reinforced aluminum laminates （CARAL） is investigated by experiments and numerical simulations. Drop weight tests are carried out with the weight of 4.7 kg at the speed of 1 and 2 m/s, respectively. Dynamic non-linear transient analyses are also accomplished using a finite element analysis software, ABAQUS. The experiment results and numerical results are compared with impact load-time histories. Also, energy-time histories are applied to investigate the impact performance of CARAL.

关键词： Fiber metal laminates (FML) Carbon reinforced aluminum laminates (CARAL) Numerical simulation Impact performance

Mechanosynthesis and mechanochemical treatment of bismuth-doped vanadium phosphorus oxide catalysts for the partial oxidation of n-butane to maleic anhydride

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journal of Natural Gas Chemistry 2008年第3期17卷 232-237页

作者： Y. H. Taufiq-Yap Y.C. wong Y. Kamiya w.j. Tang Putra Center for Catalysis Science and Technology Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang Selangor Darul Ehsan Malaysia Graduate School of Environmental Science Hokkaido Universit3 Sapporo 060-0810 Japan

Three Bi-doped vanadyl pyrophosphate catalysts were prepared via dihydrate route （VPD method）, which consisted of different preparation methods including mechanosynthesis, mechanochemical treatment, and the conventional reflux method. The catalysts produced by the above three methods were characterized by x-ray diffraction （XRD）, scanning electron microscopy （SEM）, and temperature programmed reduction （TPR）. Catalytic evaluation for the partial oxidation of n-butane to maleic anhydride （MA） was also carried out. The XRD patterns of all the Bi-doped catalysts showed the main peaks of pyrophosphate phase. Lower intensity peaks were observed for the mechanochemically treated Bi-doped catalyst （VPDBiMill） with two additional small peaks corresponding to the presence of a small amount of V5＋ phase. The TPR profiles showed that the highest amount of active oxygen species, i.e, V4＋–O- pair, responsible for n-butane activation, was removed from VPDBiMill. Furthermore, from the catalytic test results, the graph of selectivity to MA as a function of the conversion of n-butane demonstrated that VPDBiMill was the most selective catalyst. This suggests that the mechanochemical treatment of vanadium phosphate catalyst （VPDBiMill） is a potential method to improve the catalytic properties for the partial oxidation of n-butane to maleic anhydride.

关键词： mechanosynthesis mechanochemical treatment bismuth vanadyl pyrophosphate

The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction

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Neural Regeneration Research 2020年第7期15卷 1191-1198页

作者： Peter j.G. Cussell Margarita Gomez Escalada Nathaniel G.N. Milton Andrew w.j. Paterson Centre for Biomedical Science Research School of Clinical and Applied Sciences Leeds Beckett University

N-formyl peptide receptors(FPRs)were first identified upon phagocytic leukocytes,but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor *** are expressed within neuronal tissues and markedly in the central nervous system,where FPR interactions with endogenous ligands have been implicated in the pathophysiology of several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease,as well as neurological cancers such as *** the homeostatic function of FPRs in the nervous system is currently undefined,a variety of novel physiological roles for this receptor family in the neuronal context have been posited in both human and animal *** developments in recent years have implicated FPRs in the process of neurogenesis and neuronal differentiation which,upon greater characterisation,could represent a novel pharmacological target for neuronal regeneration therapies that may be used in the treatment of brain/spinal cord injury,stroke and *** review aims to summarize the recent progress made to determine the physiological role of FPRs in a neuronal setting,and to put forward a case for FPRs as a novel pharmacological target for conditions of the nervous system,and for their potential to open the door to novel neuronal regeneration therapies.

关键词： Alzheimer's disease formyl peptide receptor neural regeneration neuroblastoma neurodegeneration neuroinflammation neuronal differentiation stroke