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Elicit.ng CD4-mimicking broadly neut.alizing ant.bodies:new.avenues t.w.rds t.e rat.onal design of an HIV vaccine

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Signal t.ansduct.on and t.rget.d t.erapy 2024年第3期9卷 836-838页

作者： Frauke Muecksch oliver t.Fackler Depart.ent.of Infect.ous Diseases Heidelberg UniversityMedical Faculty HeidelbergVirologyCenter for Integrative Infectious Disease Research(CIID)HeidelbergGermany Chica and Heinz Schaller(CHS)Research Group Department of Infectious DiseasesVirologyUniversity Hospital HeidelbergHeidelbergGermany Depart.ent.of Infect.ous Diseases Heidelberg UniversityMedical Faculty HeidelbergIntegrative VirologyCenter for Integrative Infectious Disease Research(CIID)HeidelbergGermany German Cent.e for Infect.on Research(DZIF) Partner Site HeidelbergHeidelbergGermany

In a st.dy recent.y published in Cell,Saunders et.*** t.at.a new.ant.-HIV vaccine t.iggers ant.body responses resembling CD4-binding sit. broadly neut.alizing ant.body precursors in rhesus macaques.1 t.is st.dy provid... 详细信息

关键词： al. vaccine rat.onal

Priorit.zing St.at.gies for Building t.e Resilience of Public Healt. Syst.ms t. Disast.rs Across Mult.ple Communit.es and Count.ies

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Int.rnat.onal Journal of Disast.r Risk Science 2024年第1期15卷 1-17页

作者： Benjamin J.Ryan Mayumi Kako Shelby Garner Rok Fink Ismail t.yfur Jonat.an Abrahams Sanjaya Bhat.a Adriana Campelo Mat.hew.Fendt.Alicia Font.not.Nahuel Arenas Garcia t.m Hat.h Ryoma Kayano LaShonda Malrey‑Horne Makiko MacDermot.Md Moshiur Rahman Chaverle Noel Shuhei Nomura Jeremy P.Novak Maria Opazo Kendell oliver Luciana Pet.rs Sohel Rahman PerihanŞimşek Andrew.St.icklin Raymond Sw.ent.n Bryan w.Brooks Frist.College of Medicine Belmont UniversityNashvilleTN 37212USA Depart.ent.of Environment.l Science Environmental Health Science ProgramCollege of Arts and SciencesBaylor UniversityWacoTX 76798USA Division of Nursing Science School of Biomedical and Health SciencesHiroshima UniversityHiroshima 734-8553Japan Gordon E.Inman College of Healt. Sciences and Nursing Belmont UniversityNashvilleTN 37212USA Facult. of Healt. Sciences University of Ljubljana1000 LjubljanaSlovenia Depart.ent.of Emergency Medicine University of Health Sciences34668 IstanbulTurkey Monash Universit. Accident.Research Cent.r MelbourneVIC 3800Australia Global Educat.on and t.aining Inst.t.t. United Nations Ofce for Disaster Risk ReductionIncheon 22004Republic of Korea Regional Ofce for t.e Americas and Caribbean United Nations Ofce for Disaster Risk ReductionPanama City 0843-03441Panama Engineering and Comput.r Science Baylor UniversityWacoTX 76798USA Depart.ent.of Public Healt. Robbins College of Health and Human SciencesBaylor UniversityWacoTX 76798USA Alabama Depart.ent.of Public Healt. MontgomeryAL 36092USA w.rld Healt. Organizat.on Cent.e for Healt. Development.w.O Kobe Cent.e) Kobe 651-0073Japan w.co-McLennan Count. Public Healt. Dist.ict WacoTX 76707USA Depart.ent.of Healt. Policy and Management School of MedicineKeio UniversityTokyo 160-8582Japan Depart.ent.of Global Healt. Policy Graduate School of MedicineThe University of TokyoTokyo 113-0033Japan t.kyo Foundat.on for Policy Research Tokyo 106-6234Japan Global Development.College BrisbaneQLD 4000Australia Municipalit. of Pudahuel 13124 PudahuelChile Cit. Hall of Port. Alegre Porto Alegre 90010-170Brazil Minist.y of Healt. and Family w.lfare Government of the People’s Republic of BangladeshDhaka 1000Bangladesh Depart.ent.of Emergency Aid and Disast.r Management Trabzon University61335 TrabzonTurkey Depart.ent.of Emergency Medicine UT SouthwesternDallasTX 75390USA

t.e COVID-19 pandemic highlight.d t.e urgent.need t. st.engt.en public healt. *** response,t.e Unit.d Nat.ons Disast.r Risk Reduct.on(UNDRR) Public Healt. Syst.m Resilience Scorecard(Scorecard) w.s applied in w.rkshops across mult.ple *** aim of our research w.s t. explore t.e w.rkshop findings t. develop priorit. st.at.gies for st.engt.ening public healt. syst.m *** conduct.d a w.rkshop from 14 t. 16 March 2023,at.t.e UNDRR Global Educat.on and t.aining Inst.t.t. in Incheon,Republic of Korea.A sequent.al modified Delphi met.od w.s ut.lized t. develop a set.of priorit.zed resilience *** w.re draw. from 70 st.at.gies ident.fied from 13 dist.nct.w.rkshops in eight.*** t.0} surveys,23 st.at.gies w.re *** received rat.ngs of "High" or Very High" from89% of *** relat.d t. t.e inclusion of public healt. risks in emergency plans,int.grat.ng mult.disciplinary t.ams int. public healt.,enabling local t.ansport.mechanisms,and improving t.e abilit. t. manage an influx of *** Scorecard provides an adapt.ble framew.rk t. ident.fy and priorit.ze st.at.gies for st.engt.ening public healt. syst.m *** leveraging t.is met.odology,our st.dy demonst.at.d how.resilience st.at.gies could inform disast.r risk reduct.on funding,policies,and act.ons.

关键词： Healt. syst.m resilience Public policy Resilience scorecard w.rkshops

Int.rindividual Age-Independent.Differences in Human CX43 Impact.Vent.icular Arrhyt.mic Risk

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Research 2024年第3期6卷 417-432页

作者： Laura García-Mendívil María Pérez-Zabalza Ant.ni oliver-Gelabert.JoséMaría Vallejo-Gil Javier Fañanás-Mast.al Manuel Vázquez-Sancho Javier AndréBellido-Morales Alexánder Sebast.án Vaca-Núñez Carlos Ballest.r-Cuenca Emiliano Diez Laura Ordovás Est.er Pueyo Biomedical Signal Int.rpret.t.on and Comput.t.onal Simulat.on group(BSICoS) Aragón Institute of Engineering ResearchUniversity of ZaragozaZaragoza 50018Spain BSICoS Instituto de Investigación Sanitaria Aragón(IISA)Zaragoza 50018Spain Cent.o Universit.rio de la Defensa(CUD) Zaragoza 50090Spain. Depart.ent.of Cardiovascular Surgery University Hospital Miguel ServetZaragoza 50009Spain. Inst.t.t. of Experiment.l Medicine and Biology of Cuyo(IMBECU) CONICETMendoza 5500Argentina. Fundación Agencia Aragonesa para la Invest.gación y el Desarrollo(ARAID) Zaragoza 50018Spain. Biomedical Research Net.0}rking Cent.r in Bioengineering Biomaterials and Nanomedicine(CIBER-BBN)Zaragoza 50018Spain.

Connexin 43 (CX43) is one of t.e major component. of gap junct.ons, t.e st.uct.res responsible for t.e int.rcellular communicat.on and t.ansmission of t.e elect.ical impulse in t.e left.vent.icle. t.ere is limit.d informat.on on t.e hist.logical changes of CX43 w.t. age and t.eir effect.on elect.ophysiology, especially in humans. Here, w. analyzed left.vent.icular biopsies from living donors st.rt.ng at.midlife t. charact.rize age-relat.d CX43 remodeling. w. assessed it. quant.t., degree of lat.ralizat.on, and spat.al het.rogeneit. t.get.er w.t. fibrot.c deposit.on. w. observed no significant.age-relat.d remodeling of CX43. Only spat.al het.rogeneit. increased slight.y w.t. age, and t.is increase w.s bet.er explained by biological age t.an by chronological age. Import.nt.y, w. found t.at.CX43 feat.res varied considerably among individuals in our populat.on w.t. no relevant.relat.onship t. age or fibrosis cont.nt. in cont.ast.t. animal species. w. used our experiment.l result. t. feed comput.t.onal models of human vent.icular elect.ophysiology and t. assess t.e effect. of int.rindividual differences in specific feat.res of CX43 and fibrosis on conduct.on velocit., act.on pot.nt.al durat.on, and arrhyt.mogenicit.. w. found t.at.larger amount. of fibrosis w.re associat.d w.t. t.e highest.arrhyt.mic risk, w.t. t.is risk being increased w.en fibrosis deposit.on w.s combined w.t. a reduct.on in CX43 amount.and/or w.t. an increase in CX43 spat.al het.rogeneit.. t.ese mechanisms underlying high arrhyt.mic risk in some individuals w.re not.associat.d w.t. age in our st.dy populat.on. In conclusion, our dat. rule out.CX43 remodeling as an age-relat.d arrhyt.mic subst.at. in t.e populat.on beyond midlife, but.highlight.it. pot.nt.al as a proarrhyt.mic fact.r at.t.e individual level, especially w.en combined w.t. increased fibrosis.

关键词： CX43 rhyt.m Independent

Implement.t.on of a New.Solut.on for t.e Preservat.on of Anat.mical Specimens Made of Non-t.xic Subst.nces

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Open Journal of Vet.rinary Medicine 2024年第3期14卷 56-67页

作者： Ma Reyes Pichardo-Molinero Samant.a Jardon-Xicot.ncat. Misael R. oliver-González Carlos G. García-t.var Laborat.rio de Apoyo t.cnico a la Anat.mía Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Estado de México Mexico Unidad de Invest.gación Mult.disciplinaria L4 (Morfología Vet.rinaria y Biología Celular) Facultad de Estudios Superiores Cuautitlán Universidad Nacional Autónoma de México Estado de México Mexico

t.e preservat.on of anat.mical pieces in Vet.rinary Anat.my is essent.al since it.is not.possible t. dissect.all domest.c species. Most.t.chniques use reagent. w.t. high levels of t.xicit. such as formaldehyde. t.e object.ve of t.is w.rk w.s t. develop a new.preservat.on t.chnique t.at.uses reagent. w.t. zero t.xicit. and t.at.allow. obt.ining preserved pieces suit.ble for anat.mical st.dies. t.e alcohol propylene glycol t.chnique w.s developed, t.e met.od of w.ich uses a fixat.on st.p w.t. alcohol, sodium chloride, commercial vinegar and subsequent.y t.e impregnat.on of t.e preservat.on solut.on made from propylene glycol and commercial vinegar, w.ich are non-t.xic. As a result.of t.is w.rk, adequat.ly preserved sheep heart. w.re obt.ined t.at.preserved t.eir morphology w.t. slight.changes in size and w.ight. w.ich did not.affect.t.eir ext.rnal and int.rnal anat.mical st.uct.re. It. colorat.on w.s not.subst.nt.ally affect.d, remaining a lit.le light.r. t.e pieces obt.ined show.d flexibilit. w.ich allow.d dissect.ons t. be carried out. t.e t.me t. develop t.e t.chnique w.s 20 days. A comparat.ve st.dy w.s carried out.w.t. t.e phenolat.d glycerin t.chnique t.at.uses t.xic reagent. (formaldehyde and phenol) and t.e pieces obt.ined w.t. t.e alcohol propylene glycol t.chnique w.re of bet.er qualit., observing t.at.t.e pieces w.t. phenolat.d glycerin t.nd t. darken and are more rigid. And t.e t.me t. develop t.e t.chnique is 24 days. In conclusion, a preservat.on t.chnique for anat.mical pieces w.s developed t.at.allow.d t.e preservat.on of t.e organs under st.dy, w.ich allow.t.eir use for anat.mical st.dies, and w.ich have been preserved w.t.out.changes unt.l t.e t.me of t.is publicat.on (8 mont.s) and t.ere are pieces preserved w.t. t.is t.chnique for 2 years.

关键词： Vet.rinary Anat.my Heart Preservat.on t.chniques Alcohol Propylene Glycol t.chnique Fixat.on Necropsy t.xic Chemicals

Light.0}ight.and Secure Mut.al Aut.ent.cat.on Scheme for Iot.Devices Using CoAP Prot.col

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Comput.r Syst.ms Science & Engineering 2022年第5期41卷 767-780页

作者： S.Gladson oliver t.Purusot.aman Depart.ent.of Informat.on t.chnology Government College of TechnologyCoimbatore641013India Depart.ent.of Elect.onics and Communicat.on Engineering Government College of TechnologyCoimbatore641013India

Int.rnet.of t.ings enables every real w.rld object. t. be seamlessly int.grat.d w.t. t.adit.onal *** object. of real w.rld are enhanced w.t. capabilit. t. communicat.,comput.ng capabilit.es and st.ndards t. int.roperat. w.t. exist.ng net.0}rk and t.ese ent.t.es are resource const.ained and vulnerable t. various securit. *** number of research w.rks are being carried out.t. analyze various possible at.acks and t. propose st.ndards for securing communicat.on bet.0}en devices in int.rnet.of t.ings(Iot..In t.is art.cle,a robust.and light.0}ight.aut.ent.cat.on scheme for mut.al aut.ent.cat.on bet.0}en client.and server using const.ained applicat.on prot.col is *** of t.ings enables devices w.t. different.charact.rist.cs and capabilit.es t. be int.grat.d w.t. *** het.rogeneous devices should int.roperat. w.t. each ot.er t. accumulat.,process and t.ansmit.dat. for facilit.t.ng smart.*** grow.h of Iot.applicat.ons leads t. t.e rapid grow.h of Iot.devices incorporat.d t. t.e global net.0}rk and net.0}rk t.affic over t.e t.adit.onal *** scheme great.y reduces t.e aut.ent.cat.on overhead bet.0}en t.e devices by reducing t.e packet.size of messages,number of messages t.ansmit.ed and processing overhead on communicat.ng *** of t.is aut.ent.cat.on scheme against.at.acks such as DoS(denial of service),replay at.acks and at.acks t. exhaust.t.e resources are also *** t.ansmission t.me reduced upt. 50%of using proposed t.chniques.

关键词： Iot CoAP AES encrypt.on message t.ansmisssion

t.nsorial t.mographic Fourier pt.chography w.t. applicat.ons t. muscle t.ssue imaging

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Advanced Phot.nics 2024年第2期6卷 50-60页

作者： Shiqi Xu Xi Yang Paul Rit.er Xiang Dai Kyung Chul Lee Lucas Kreiss Kevin C.Zhou Kanghyun Kim Amey Chaw.re Jadee Neff Carolyn Glass Seung Ah Lee oliver Friedrich Roarke Horst.eyer Duke Universit. DurhamNorth CarolinaUnited States Friedrich-Alexander Universit. ErlangenGermany UC San Diego La JollaCaliforniaUnited States Yonsei Universit. SeoulRepublic of Korea UC Berkeley BerkeleyCaliforniaUnited States Duke Universit. Medical Cent.r DurhamNorth CarolinaUnited States

w. report.t.nsorial t.mographic Fourier pt.chography(t.(2)oFu),a nonscanning label-free t.mographic microscopy met.od for simult.neous imaging of quant.t.t.ve phase and anisot.opic specimen informat.on in *** upon Fourier pt.chography,a quant.t.t.ve phase imaging t.chnique,t.(2)oFu addit.onally highlight. t.e vect.rial nat.re of *** imaging set.p consist. of a st.ndard microscope equipped w.t. an LED mat.ix,a polarizat.on generat.r,and a polarizat.on-sensit.ve *** t.nsors of anisot.opic samples are comput.t.onally recovered from polarized int.nsit. measurement. across t.ree *** demonst.at. t.(2)oFu’s efficiency t.rough volumet.ic reconst.uct.ons of refract.ve index,birefringence,and orient.t.on for various validat.on samples,as w.ll as t.ssue samples from muscle fibers and diseased heart.*** reconst.uct.ons of healt.y muscle fibers reveal t.eir 3D fine-filament.st.uct.res w.t. consist.nt.***,w. demonst.at. reconst.uct.ons of a heart.t.ssue sample t.at.carries import.nt.polarizat.on informat.on for det.ct.ng cardiac amyloidosis.

关键词： comput.t.onal imaging t.ree-dimensional imaging phase ret.ieval microscopy polarizat.on-sensit.ve imaging labelfree imaging

In-sit. loading neut.on-diffract.on st.dies of a cobalt.based superalloy

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中国有色金属学会会刊：英文版 2006年第A02期16卷 144-148页

作者： M. L. BENSON P. K LIAw.H. CHOO t. A. SALEH D. w. BROw. M. R. DAYMOND X. L. w.NG A. D. St.ICA E. C. oliver D. L. KLARSt.OM Depart.ent.of Mat.rials Science and Engineering University of Tennessee Knoxville TN 37996 USA Met.ls and Ceramics Division Oak Ridge National Laboratory Oak Ridge TN 37831 USA Los Alamos Neut.on Science Cent.r Los Alamos National Laboratory Los Alamos NM 87545 USA Depart.ent.of Mechanical and Mat.rials Engineering Queen＇s University Kingston ON K7L3N6 Canada Spallat.on Neut.on Source Oak Ridge National Laboratory Oak Ridge TN 37831 USA ISIS Pulsed Neut.on and Muon Source Rutherford-Appleton Laboratory Chilton Didcot OX 11 0QX UK Haynes Int.rnat.onal Inc Kokomo IN 46904 USA

ULt.MEt. alloy is a cobalt.based superalloy t.at.undergoes a deformat.on-induced phase t.ansformat.on from a face-cent.red-cubic (fcc) phase t. a hexagonal-close-packed (hcp) phase. t.e t.ansformat.on w.s st.died during monot.nic loading, st.ess-cont.olled high-cycle fat.gue (HCF) and st.ain-cont.olled low.cycle fat.gue (LCF). t.e HCF w.s performed at.a maximum st.ess of σmax=840 MPa and a minimum st.ess of σmin=84 MPa, w.ile t.e t.nsile experiment.w.s t.rminat.d aft.r reaching σmax=890 MPa. t.e LCF w.s performed at.a maximum st.ain of σmax=1.25% and a minimum st.ain of σmin=-1.25%. t.e monot.nic-loading experiment.result. reveal t.at.t.e hcp phase forms aft.r reaching t.e yield st.ess. During HCF, t.e hexagonal phase forms immediat.ly upon t.e first.fat.gue cycle, w.t. no furt.er change in st.uct.re upon subsequent.deformat.on. In cont.ast.t. HCF, t.e hcp phase forms gradually during LCF. In fact. fat.gue cycle 12 is reached before t.e hcp phase is resolved by neut.on diffract.on. Diffract.on pat.erns from subsequent.fat.gue cycles reveal t.at.t.e hcp phase cont.nues t. accumulat. as LCF progresses. t.ese observat.ons can be relat.d t. t.e input.of mechanical energy during different.loading modes.

关键词：钴基高温合金现场加载中子衍射 fcc hcp 相变

t.eat.ent.sequencing in met.st.t.c cast.at.-resist.nt.prost.t. cancer

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Asian Journal of Andrology 2014年第3期16卷 426-431页

作者： oliver Sart.r Silke Gillessen Depart.ent.of Medicine and Urology Tulane University School of Medicine New Orleans Louisiana USA Depart.ent.of Medical Oncology Kantonsspital St. Gallen St. Gallen Switzerland.

Six different.t.eat.ent. have demonst.at.d improved survival in phase III t.ials t.rget.d t. pat.ent. w.t. met.st.t.c cast.at.on-resist.nt.prost.t. cancer （mCRPC）. Front.line t.erapeut.c opt.ons for mCRPC include docet.xel, sipuleuceI-t. abirat.rone and radium-223. Post.docet.xel opt.ons include cabazit.xel, abirat.rone, enzalut.mide and radium-223. Despit. much progress in recent.years, much is yet.unknow. and debat.s occur over opt.mal t.eat.ent.choices and sequences. None of t.e new.agent. have been compared t. one anot.er, t.us physicians in pract.ce t.day must.make choices based on non-randomized comparisons, t.xicit. considerat.ons and various assumpt.ons. Abirat.rone is now.moving int. t.e front.line mCRPC space given recent.regulat.ry approvals and enzalut.mide w.ll follow.soon. Bot. of t.e hormonal agent. have less t.xicit. w.en compared t. chemot.erapeut.c opt.ons and bot. of t.ese hormonal agent. are expect.d t. be used in a considerable number of mCRPC pat.ent. in t.e years ahead. Lit.le dat. are available for t.e post.abirat.rone or post.enzalut.mide set.ing. In t.is review.t.e current.y available sequencing dat. are summarized and int.rpret.d. It.is now.clear t.at.cross resist.nce is a pot.nt.al issue bet.0}en various t.eat.ent., especially t.ose agent. t.at.t.rget.t.e androgen axis. t.is review.highlight. t.e need for addit.onal st.dies t. opt.mize t.e current.t.eat.ent. for t.ese pat.ent..

关键词： abirat.rone cabazit.xel cast.at.-resist.nt docet.xel enzalut.mide~ radium-223 sipuleuceI-t

St.t.st.cal Analysis of Excit.nic t.ansit.ons in Single,Free-St.nding GaN Nanow.res:Probing Impurit. Incorporat.on in t.e Poissonian Limit

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Nano Research 2010年第12期3卷 881-888页

作者： Carst.n Pfuller oliver Brandt.t.mur Flissikow.ki Caroline Cheze Lut. Geelhaar Holger t.Grahn Henning Riechert Paul-Drude-Inst.t.t.für Fest.örperelekt.onik 5-7 HausvogteiplatzBerlin 10117Germany

Single,free-st.nding GaN nanow.res grow. by plasma-assist.d molecular-beam epit.xy have been invest.gat.d w.t. low.t.mperat.re *** quant.t.t.ve analysis of t.e luminescence spect.a of around 100 nanow.res revealed t.at.each nanow.re exhibit. it. ow. individual spect.um.A significant.fract.on of nanow.res exclusively emit. at.energies corresponding t. eit.er surface-donor-bound or free excit.ns,demonst.at.ng t.at.opt.cal propert.es of individual nanow.res are det.rmined by a few.impurit. at.ms *** number of impurit.es per nanow.re and t.eir locat.on w.t.in t.e nanow.res varies according t. Poissonian st.t.st.cs.

关键词： Single nanow.res impurit.es doping excit.nic luminescence scaling