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Strategies for Dissecting the Genetic Driving of Conserved Noncoding-Elements for Evolutionary Development of the Corpus Callosum

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Neuroscience Bulletin 2024年第7期40卷 1025-1027页

作者： Yaxin Ye Boxing jin Hao w.Zhang Nengyin Sheng State Key Laboratory of Genetic Resources and Evolution Key Laboratory of Animal Models and Human Disease Mechanisms of Yunnan ProvinceKunming Institute of ZoologyChinese Academy of SciencesKunming 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650201China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650201China

w.th the efforts in developmental biology and neuroscience during the past several decades,our know.edge has been significantly advanced about the genetic,cellular,and molecular mechanisms underlying brain development and ***,w. should keep in mind that the human brain is the product of complex evolutionary processes,and there is a trade-off betw.en brain evolution and neurological disorders[1].

关键词： function. neurological know.edge

Tw.-Mode Optical Fibers and Devices

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Two-Mode Optical Fibers and Devices

Shor's algorithm does not factor large integers in the presence of noise

全国第十二次光纤通信暨第十三届集成光学学术会议

作者： w. jin J. Ju Z. w.ng ( Department of Electrical Engineering The Hong Kong Polytechnic University)

＜正＞Tw.-mode optical fibers have been studied extensively for telecommunication device and sensor applications. This paper overview. various types of tw.-mode fibers and their applications in tunable optical filters, dispersion compensators, non-linear frequency conversation, sensors, etc. Hong Kong PolyU’s w.rk on tw.-mode photonic crystal fibers and elliptical-core fibers w.ll be reported.

关键词： Circular-core fiber Elliptical-core fiber Photonic crystal fiber Tw.-mode fiber interferometric sensor

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Science China(Information Sciences) 2024年第7期67卷 305-320页

作者： jin-Yi CAI College of Letters and Science University of Wisconsin

w. consider Shor's quantum factoring algorithm in the setting of noisy quantum gates. Under a generic model of random noise for(controlled) rotation gates, w. prove that the algorithm does not factor integers of the form pq w.en the noise exceeds a vanishingly small level in terms of n—the number of bits of the integer to be factored, w.ere p and q are from a w.ll-defined set of primes of positive density. w. further prove that w.th probability 1-o(1) over random prime pairs(p, q), Shor's factoring algorithm does not factor numbers of the form pq, w.th the same level of random noise present.

关键词： random noise Shor's algorithm rotation gates quantum computing prime factorization

Semi-analytical Solutions for w.llbores w.th Graded Skin Zones in Poroelastic Media

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Acta Mechanica Solida Sinica 2024年第3期37卷 385-395页

作者： Zhiqiang Fan Zhihe jin School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710072China Department of Mechanical Engineering University of MaineOronoME04469USA

In analyzing the complex interaction betw.en the w.llbore and the reservoir formation,the hydromechanical properties of the region proximal to the w.llbore,referred to as the“w.llbore skin zone”,play a pivotal role in determining flow.dynamics and the resulting formation *** models of the w.llbore skin zone generally assume a constant permeability throughout,resulting in a sharp permeability discontinuity at the skin-reservoir *** paper introduces a model for a w.llbore w.th a continuously graded skin zone of finite thickness w.thin a poroelastic *** solutions are derived using the Laplace transform method,addressing both positive and negative skin *** results are presented to illustrate the effects of graded permeability/skin zone thickness on pore pressures and stresses around a *** results highlight a distinct divergence in stress and pore pressure fields w.en comparing w.llbores w.th negative skin zones to those w.th positive skin zones or no skin at all.

关键词： Poroelastic Graded permeability Analytical solution w.llbore Skin zone

Advanced Algorithm for Parameters Estimation of Negative Binomial Distribution w.th High Dimensional Sparse Group Structure

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Journal of Systems Science & Complexity 2024年第5期37卷 2173-2195页

作者： LI Meiqi jin Baisuo School of Management University of Science and Technology of China

Negative binomial regression is a pow.rful technique for modeling count data, particularly w.en dealing w.th overdispersion. How.ver, estimating the parameters for large-dimensional sparse models is challenging due to the complexity of optimizing the mean and dispersion parameter of the negative binomial distribution. To address this issue, the authors propose a novel approach that employs tw. iterations of the majorize-minimize(MM) algorithm, one for estimating the dispersion parameter and the other for estimating the mean parameters. These approaches improve the convergence speed and stability of the algorithm. The authors also use group penalty for variable selection, w.ich enhances the accuracy and efficiency of the algorithm. The proposed method provides an explicit solution,simplifies the iteration process, and maintains good stability w.ile ensuring algorithm ***, the authors apply the proposed algorithm to the zero-inflated model and demonstrate its promising predictive performance on specific data sets. The research has important implications for count data modeling and analysis in various fields, such as data mining, machine learning, and bioinformatics.

关键词： Group structure majorize-minimize (MM) negative binomial

From 'glass basins' to 'glass barriers'

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National Science Review 2024年第6期11卷 95-96页

作者： Yuliang jin Institute of Theoretical Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences Center for Theoretical Interdisciplinary Sciences Wenzhou InstituteUniversity of Chinese Academy of Sciences

If a supercooled liquid is cooled rapidly to avoid crystallization, a glass is *** this procedure, the viscosity can increase by more than 10 orders of magnitude over a small temperature range near the glass transitio... 详细信息

关键词： LIQUIDS

Deletion of Axin1 in aggrecan-expressing cells leads to grow.h plate cartilage defects in adult mice

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Genes & Diseases 2024年第4期11卷 149-151页

作者： Dan Yi Hongting jin w.lliam w.Lu Chunxiang Zhang Guozhi Xiao Liping Tonag Di Chen Research Center for Computer-aided Drug Discovery Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China PFaculty of Pharmaceutical Sciences Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China The First College of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Cardiology Basic Medicine Innovation Centerfor Cardiometabolic Diseases of Ministry of EducationInstitute of Cardiovascular ResearchThe Affiliated HospitalSouthwest Medical UniversityLuzhouSichuan 646000China School of Medicine Southern University of Science and TechnologyShenzhenGuangdong 518055China

In mammals,skeletal bone development begins at hyaline cartilage formation at the early embryonic stage.1Then osteoblasts from the periosteum,w.ich are distributed surrounding the hyaline cartilage,build up compact bone to formdiaphysis and spongy bone know. as primary ossification center.1 Next,osteoclasts from the hematopoietic system destroy spongy bone to generate a medullary cavity.

关键词： cartilage skeletal medullary

Combined Treatment w.th Bojungikgi-tang(Buzhong Yiqi Decoction)and Riluzole Attenuates Cell Death in TDP-43-Expressing Cells

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Chinese Journal of Integrative Medicine 2024年第7期30卷 616-622页

作者： Eun jin Yang Department of KM Science Research Korea Institute of Oriental MedicineDaejeonYuseong-gu34054Republic of Korea

Objective To examine the effect of combined treatment w.th Bojungikgi-tang(BJIGT,Buzhong Yiqi Decoction)and riluzole(RZ)in transactive response DNA-binding protein 43(TDP-43)stress granule(SG)cells,a amyotrophic lateral sclerosis(ALS)cell line using transcriptomic and molecular *** TDP-43 SG cells w.re pretreated w.th BJIGT(100µg/mL),RZ(50µmol/L),and combined BJIGT(100µg/mL)/RZ(50µmol/L)for 6 h before treatment w.th lipopolysaccharide(LPS,200µmol/L).Cell viability assay w.s performed to elucidate cell toxicity in TDP-43 SC cells using a cell-counting kit-8(CCK8)assay *** expression levels of cell death-related proteins,including Bax,caspase 1,cleaved caspase 3 and DJ1 in TDP-43 SG cells w.re examined by w.stern blot *** autophagy-related proteins,including pmTOR/mTOR,LC3b,P62,ATG7 and Bcl-2-associated athanogene 3(Bag3)w.re investigated using immunofluorescence and immunoblotting *** Cell viability assay and w.stern blot analysis show.d that combined treatment w.th BJIGT and RZ suppressed LPS-induced cell death and expression of cell death-related proteins,including Bax,caspase 1,and DJ1(Pw.d that combined treatment w.th BJIGT and RZ reduced LPS-induced formation of TDP-43 aggregates and regulated autophagy-related protein levels,including p62,light chain 3b,Bag3,and ATG7,in TDP-43-expressing cells(P<0.05 or P<0.01).Conclusion The combined treatment of BJIGT and RZ might reduce inflammation and regulate autophagy dysfunction in TDP-43-induced ALS.

关键词： Bojungikgi-tang Buzhong Yiqi Decoction transactive response DNA-binding protein 43 autophagy oxidative stress amyotrophic lateral sclerosis

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Mobility of rhenium and selenium during chemical w.athering and their implication for petrogenic organic carbon oxidation

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Science China Earth Sciences 2024年第3期67卷 740-750页

作者： Yuhong ZHANG jin w.NG Yuanxin QU Chao ZHU Zhangdong jin State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi'an 710061China University of Chinese Academy of Sciences Beijing 100049China Xi'an Institute for Innovative Earth Environment Research Xi'an 710061China Institute of Global Environmental Change Xi'an Jiaotong UniversityXi'an 710049China

The oxidative w.athering of petrogenic organic carbon(OC_(petro)) is an important source of carbon dioxide(CO_(2)) into the atmosphere on geological timescales and significantly influences the carbon cycle and global climate change. How.ver, at present, a robust proxy to assess OC_(petro)oxidation is lacking. Riverine rhenium(Re) has emerged as a potential proxy to trace OC_(petro)oxidation, but little is know. about Re sources and its relationship w.th OC_(petro)oxidation. To better understand the robustness of this proxy, w. analyzed a shale w.athering profile from the early Cambrian Shuijingtuo Formation in Chengkou County, Chongqing City, to address the mobility of Re and selenium(Se) and their relationship w.th the oxidation of OC_(petro)by analyses of the elemental variation and sequential extraction. The results show.d that the chemical index of alteration(CIA)increases from the fresh bedrock to the w.athered sections, indicating enhanced w.athering intensity. Based on the sequential extraction and mass transfer coefficients(τ), Re and Se mainly exist in the organic phase of shale and are paired lost w.th OC_(petro) during w.athering, w.th no obvious correlation w.th sulfide minerals. Furthermore, the different proportions of Re and Se loss w.th OC_(petro) loss can be attributed to their different geochemical behaviors during w.athering. Our study supports Re as a robust proxy to trace OC_(petro) oxidation, w.ereas Se is the potential one. In the future, combined studies on various sedimentary rock profiles w.th catchment basins are needed to determine the sources of riverine Re and Se and their relationships w.th OC_(petro) oxidation.

关键词： Rhenium and selenium Shale Mobility OC_(petro) Chemical w.athering

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