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Zingiber officinale extends Drosophila melanogaster life span in xenobiotic-induced oxidative stress conditions

Frontiers in Biology 2018年第2期13卷 130-136页

作者： volodymyr padalko Viktoriya Dzyuba Olena Kozlova Hanna Sheremet Olena Protsenko School of Medicine V.N. Karazin Kharkiv National University 4 Svobody Sq. Kharkiv 61022 Ukraine Department of Membrane Biophysics Research Institute of Biology V.N. Karazin Kharkiv National University 4 Svobody Sq. Kharkiv61022 Ukraine

BACKGROUND： The possibility of dietary ginger to enhance oxidative stress resistance and to extend life span was studied on Drosophila melanogaster. METHODS： Oxidative stress was induced by a reducing agent dithiothreitol. Experimental groups of male D. melanogaster were cultured on media containing： 1） no additive; 2） dithiothreitol, added into the nutritional mixture to the final concentration of 10 mM; 3） 25 mg of ginger powder g^-1 of the nutritional mixture; and 4） 10 mM ofdithiothreitol and 25 mg of ginger powder g l of the nutritional mixture. The number of alive fruit flies was inspected daily, and mean life span was determined for each experimental group. RESULTS： The addition of dithiothreitol to D. melanogaster nutritional mixture was established to result in an increase in concentration of two markers of oxidative stress conditions （thiobarbituric acid reactive substances as products of lipid peroxidation and carbonylated proteins as products of protein oxidation） in fly tissues. It was followed by significant reduction of mean life span and maximum life span of the last 10% of flies. Plant preparation, being added simultaneously with dithiothreitol, significantly diminished the negative effects of this xenobiotic. In conditions of additional stress load induced by hydrogen peroxide or high temperature, survival of insects treated with dithiothreitol on the background of ginger powder was the highest. CONCLUSIONS： Thus, the presented data give the evidence that ginger preparations can reduce oxidative stress outcomes and significantly increase the life expectancy of fruit flies in stress conditions.

关键词： ginger oxidative stress Drosophila melanogaster

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Modeling of the effect of hydrogen injection on blast furnace operation and carbon dioxide emissions

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International Journal of Minerals,Metallurgy and Materials 2022年第10期29卷 1851-1861页

作者： volodymyr Shatokha National Metallurgical Academy of Ukraine Dnipro 49005Ukraine

The effect of hydrogen injection on blast furnace operation and carbon dioxide emissions was simulated using a 1D steady-state zonal *** maximum hydrogen injection rate was evaluated on the basis of the simulation of the vertical temperature pattern in the blast furnace with a focus on the thermal reserve *** effects of blast temperature and oxygen enrichment were also examined to estimate coke replacement ratio,productivity,hydrogen utilization efficiency,and carbon dioxide emission *** blast temperature of 1200℃,the maximum hydrogen injection rate was 19.0 and 28.3 kg of H_(2)/t of hot metal(HM)for oxygen enrichment of 2vol%and 12vol%,*** showed a coke replacement ratio of 3-4 kg of coke/kg of H_(2),direct CO_(2) emission reduction of 10.2%-17.8%,and increased productivity by up to 13.7%depending on oxygen enrichment *** blast temperature further reduced the direct CO_(2) *** utilization degree reached the maximum of 0.52-0.54 H_(2)O/(H_(2)O+H_(2)).The decarbonization potential of hydrogen injection was estimated in the range from 9.4 t of CO_(2)/t of H_(2) to 9.7 t of CO_(2)/t of H_(2).For economic feasibility,hydrogen injection requires revolutionary progress in terms of low-cost H_(2) generation unless the technological change is motivated by the carbon emission *** injection may unfavorably affect the radial temperature pattern of the raceway,which could be addressed by adopting appropriate injection techniques.

关键词： hydrogen injection blast furnace zonal model carbon dioxide emissions

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226Ra irradiation to produce 225Ac and 213Bi in an accelerator-driven system reactor

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Nuclear Science and Techniques 2020年第5期31卷 12-17页

作者： Amer A.Al Qaaod volodymyr Gulik International Centre for Theoretical Physics(ICTP) TriesteItaly Institute for Safety Problems of NPPs KyivUkraine

This study aims to produce 229Th using an innovative nuclear reactor concept,i.e.,accelerator-driven system(ADS)***,we investigated the feasibility of producing 229Th from neutron transmutation of 226Ra to expand the availability of 225Ac and 213Bi in a simple model of ADS *** reactor comprises two zones,i.e.,an inner zone with a fast neutron spectrum and outer zone with thermal neutron spectrum,which is a subcritical core coupled with an external neutron *** behavior,activity,and mass ratio of the obtained isotopes were investigated using the Monte-Carlo *** addition with offering the capability,flexibility,and safety of radioactive waste transmutation,the proposed ADS model provides high 229Th yield and requires less time than a critical reactor with the same neutron flux and irradiated quantity of 226Ra.

关键词： 229Th production 226Ra irradiation Targeted alpha therapy ADS reactor Monte Carlo

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A novel image fusion algorithm based on 2D scale-mixing complex wavelet transform and Bayesian MAP estimation for multimodal medical images

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Journal of Innovative Optical Health Sciences 2017年第3期10卷 52-68页

作者： Abdallah Bengueddoudj Zoubeida Messali volodymyr Mosorov Department of Electrical Engineering University of Bordj Bou Arreridj34030 El AnasserAlgeria Institute of Applied Computer Science Lodz University of Technology Stefanowskiego 18/2290-924 LodzPoland

In this paper,we propose a new image fusion algorithm based on two-dimensional Scale-Mixing Complex Wavelet Transform(2D-SMCWT).The fusion of the detail 2D-SMCWT cofficients is performed via a Bayesian Maximum a Posteriori(MAP)approach by considering a trivariate statistical model for the local neighboring of 2D-SMCWT *** the approx imation coefficients,a new fusion rule based on the Principal Component Analysis(PCA)is *** conduct several experiments using three different groups of multimodal medical images to evaluate the performance of the proposed *** obt ained results prove the superiority of the proposed method over the state of the art fusion methods in terms of visual quality and several commonly used *** of the proposed method is further tested against different types of *** plots of fusion met rics establish the accuracy of the proposed fusion method.

关键词： Medical imaging multimodal medical image fusion scale mixing complex wavelet transform MAP Bayes estimation principal component analysis.

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Analysis of EX5del4232ins268 and EX5del955 PAH gene mutations in Ukrainian patients with phenylketonuria

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Genes & Diseases 2017年第2期4卷 108-110页

作者： volodymyr Pampukha Maryna Nechyporenko Ludmila Livshyts Institute of Molecular Biology and Genetics of the National Academy of Sciences of Ukraine Department of Human Genomics150Zabolotnogo str.03680 KyivUkraine

Phenylketonuria(PKU)is an autosomal recessive metabolic disorder caused by deficiency of phenylalanine hydroxylase(PAH).The major molecular defects causing PKU are missense mutations of PAH *** deletions of exon 5(EX5del955 and EX5del4232ins)were first reported by the Czech study and were later found also in the Polish,Slovak,Slovenian and Italian *** observations demonstrate the existence of a common subset of this mutation predominantly among Central European populations of Slavic *** is why we suggest that EX5del1955 and EX5del4232ins268 mutations might be frequent causes of PKU in Ukrainian ***5del955 and EX5del4232ins268 mutations were analyzed in 106 unrelated PKU patients negative for PAH gene mutations on one or both alleles from our previous *** simultaneous detection of EX5del4232ins268 and EX5del955 mutations was performed by PCR amplification of mutant ***5del955 mutation was not detected in the Ukrainian *** relative alleles frequency of EX5del4232ins268 mutation in the Ukrainian PKU population was determined as 1,66%.Our findings can be the one more evidence of Central European Slavic origin of EX5del4232ins268 mutation,suggested *** finding is important for the improvement of DNA diagnosis necessary for the management of PKU patients from Ukraine.

关键词： Large deletions Mutation analysis Phenylalanine hydroxylase Phenylketonuria

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Cluster Representation of the Structural Description of Images for Effective Classification

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Computers, Materials & Continua 2022年第12期73卷 6069-6084页

作者： Yousef Ibrahim Daradkeh volodymyr Gorokhovatskyi Iryna Tvoroshenko Medien Zeghid Department of Computer Engineering and Networks College of Engineering at Wadi AddawasirPrince Sattam Bin Abdulaziz UniversityWadi Addawasir11991Saudi Arabia Department of Informatics Kharkiv National University of Radio ElectronicsKharkiv61166Ukraine Electrical Engineering Department College of Engineering at Wadi AddawasirPrince Sattam Bin Abdulaziz UniversityWadi Addawasir11991Saudi Arabia Electronics and Micro-Electronics Laboratory Faculty of SciencesUniversity of MonastirMonastir5000Tunisia

The problem of image recognition in the computer vision systems is being *** results of the development of efficient classification methods,given the figure of processing speed,based on the analysis of the segment representation of the structural description in the form of a set of descriptors are *** propose three versions of the classifier according to the following principles:“object-etalon”,“object descriptor-etalon”and“vector description of the object-etalon”,which are not similar in level of integration of researched data *** options for constructing clusters over the whole set of descriptions of the etalon database,separately for each of the etalons,as well as the optimal method to compare sets of segment centers for the etalons and object,are *** experimental rating of the efficiency of the created classifiers in terms of productivity,processing time,and classification quality has been realized of the *** proposed methods classify the set of etalons without *** have formed the inference about the efficiency of classification approaches based on segment *** time of image processing according to the developedmethods is hundreds of times less than according to the traditional one,without reducing the accuracy.

关键词： Cluster representation computer vision description relevance descriptor image classification keypoint processing speed vector space

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Pharmacological induced target temperature management after cardiac arrest： the capsaicinoids

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Neural Regeneration Research 2017年第10期12卷 1623-1624页

作者： J.Marc Simard Xiaofeng Jia volodymyr Gerzanich Department of Neurosurgery University of Maryland School of MedicineBaltimoreMDUSA Department of Orthopedics University of Maryland School of MedicineBaltimoreMDUSA Department of Anatomy and Neurobiology University of Maryland School of MedicineBaltimoreMDUSA Department of Biomedical Engineering Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA

Cardiac or respiratory arrest lasting only a few minutes can inflict grave harm on numerous bodily organs, not least of all, the brain. Neurocognitive deficits, which are often severe and profoundly life altering, rem... 详细信息

关键词： Pharmacological induced target temperature management after cardiac arrest:the capsaicinoids

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Improving the Effectiveness of Image Classification Structural Methods by Compressing the Description According to the Information Content Criterion

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Computers, Materials & Continua 2024年第8期80卷 3085-3106页

作者： Yousef Ibrahim Daradkeh volodymyr Gorokhovatskyi Iryna Tvoroshenko Medien Zeghid Department of Computer Engineering and Information College of Engineering inWadi AlddawasirPrince Sattam bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia Department of Informatics Kharkiv National University of Radio ElectronicsKharkiv61166Ukraine Electronics and Micro-Electronics Laboratory Faculty of SciencesUniversity of MonastirMonastir5000Tunisia

The research aims to improve the performance of image recognition methods based on a description in the form of a set of keypoint *** main focus is on increasing the speed of establishing the relevance of object and etalon descriptions while maintaining the required level of classification *** class to be recognized is represented by an infinite set of images obtained from the etalon by applying arbitrary geometric *** is proposed to reduce the descriptions for the etalon database by selecting the most significant descriptor components according to the information content *** informativeness of an etalon descriptor is estimated by the difference of the closest distances to its own and other *** developed method determines the relevance of the full description of the recognized object with the reduced description of the *** practical models of the classifier with different options for establishing the correspondence between object descriptors and etalons are *** results of the experimental modeling of the proposed methods for a database including images of museum jewelry are *** test sample is formed as a set of images from the etalon database and out of the database with the application of geometric transformations of scale and rotation in the field of *** practical problems of determining the threshold for the number of votes,based on which a classification decision is made,have been *** has revealed the practical possibility of tenfold reducing descriptions with full preservation of classification *** the descriptions by twenty times in the experiment leads to slightly decreased *** speed of the analysis increases in proportion to the degree of *** use of reduction by the informativeness criterion confirmed the possibility of obtaining the most significant subset of features for classification,which guarantees a decent

关键词： Description reduction description relevance descriptor image classification information content keypoint processing speed

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Lignite oxidative desulphurization Notice *** condition selection

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International Journal of Coal Science & Technology 2014年第1期1卷 62-69页

作者： volodymyr Gunka Serhiy Pyshyev Institute of Chemistry and Chemical Technologies Lviv Polytecnic National University12 Bandery Str.Lviv 79013Ukraine

The process of lignite desulphurization via its treatment by an oxidant(air or air–steam mixture)has been *** research objective was useful determination of steam application in oxidative lignite *** has been proved that the water steam should be included in the oxidant composition to increase the hydrogen sulphide and combustible constituent content in the gases obtained during the processes under *** impact of factors which affect the reactions between solid(in our case–lignite)and gaseous reagent(oxidant,*** and or air–steam mixture)upon the research process has been investigated,if these reactions occur in the kinetic *** factors are linear rate of oxidant movement and coal grain *** values of oxidant movement linear rate and coal grain size,which the reaction transfer from pyrite sulphur and organic content of lignite from diffusion into kinetic area occurs by,have been *** these‘‘transfer’’conditions,the values of coefficients of oxidant mass transfer(β,m/s)as well as Sherwood criteria and boiling layer differences have been calculated.

关键词： Lignite Oxidative desulphurization Pyrite Sulphur Hydrogen sulphide

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Lignite oxidative desulphurization. Notice 2： effects of process parameters

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International Journal of Coal Science & Technology 2015年第3期2卷 196-201页

作者： volodymyr Gunka Serhiy Pyshyevt Institute of Chemistry and Chemical Technologies LvivPolytecnic National University 12 Bandery Str. Lviv 79013Ukraine

The influence of main characteristics upon conversion directions of the lignite organic part during its oxidation desulphurization was studied. The optimum temperature values, the ratio oxidant ： raw material, and time of coal stay in the reaction zone, which provide the maximum degree of sulphur conversion and hydrogen sulphide content in desulphur- ization gases, were calculated. The process implemented under these conditions will decrease environment pollution by sulphur dioxide during further lignite burning at least to 55 %-60 % and utilize sulphur in coal in the form of desul- phurization gases with hydrogen sulphide content of 7 %. Such obtaining sulphur. The effect of the above three factors on the depth was studied. gases can be reprocessed by the known methods of and character of the coal organic matter transformation

关键词： Lignite Oxidative desulphurization Pyrite Sulphur in coal Hydrogen sulphide

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