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废空气烟羽γ剂量估算

核物理动态 1993年第1期10卷 29-33页

作者：朱连芳 E.Pomplum K.heinemann 中国科学院近代物理研究所兰州730000 德国尤利希核子中心辐射防护与安全部

本文叙述了高架点源非连续排放的废空气烟羽的γ剂量估算方法,并给出了部分估计算结果,讨论了该方法的应用前景。

关键词：废气烟羽 γ辐射剂量估算

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Youth Physical Activity and Enjoyment during Semi-Structured versus Unstructured School Recess

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Open Journal of Preventive Medicine 2014年第8期4卷 631-639页

作者： Jessyka N. Larson Timothy A. Brusseau Benjamin Chase Angela heinemann James C. Hannon Department of Exercise and Sport Science University of Utah Salt Lake City UT USA

Background: Physical activity throughout the school day may help reduce the risk of childhood obesity. Semi-structured recess is a unique approach to create more physical activity. Therefore, the purpose of this study was to compare the physical activity and enjoyment of urban school children during traditional unstructured recess and semi-structured recess. Method: Children from the Southwestern US (N = 165) wore a NL-1000 piezoelectric accelerometer during their 15-minute lunch recess. Children participated in both their traditional unstructured (no structure and no equipment) recess and semi-structured (organized games and equipment) recess. An enjoyment scale was completed after both types of recess formats. Results: During unstructured recess, children accumulated 1028 ± 356 steps and 4.59 ± 2.2 minutes of MVPA compared to 1156 ± 434 steps and 5.44 ± 2.76 minutes of moderate to vigorous physical activity (MVPA) during semi-structured recess. Paired sample t-tests revealed that children took significantly more steps (t = 𕒸.98;p < 0.001) and MVPA (t = 𕒹.940;p < 0.001) during semi-structured recess. No significant differences were found for enjoyment (p = 0.847) between recesses. Conclusions: It is important for schools to consider creative, semi-structured recess opportunities to increase step counts and time in MVPA (while maintaining enjoyment) and reinforce recess as an important component of a comprehensive school physical activity program.

关键词： Moderate-to-Vigorous Physical Activity (MVPA) Step Counts Physical Education

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先进的航天器热防护系统的性能分析

导弹与航天运载技术(中英文) 1988年第9期 45-50页

作者： K.heinemann 陈小金

本文采用模型分析,对用作航天器热防护系统的两种绝缘体的性能作了比较,最后提出应设计一种复合材料作为航天器的热防护系统。

关键词：航天材料陶瓷复合材料热防护系统

Improving photosynthetic efficiency toward food security:Strategies,advances,and perspectives

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Molecular Plant 2023年第10期16卷 1547-1563页

作者： Edward N.Smith Marvin van Aalst Tiina Tosens Ülo Niinemets Benjamin Stich Tomas Morosinotto Alessandro Alboresi Tobias J.Erb Paul AGómez-Coronado Dimitri Tolleter Giovanni Finazzi Gilles Curien Matthias heinemann Oliver Ebenhöh Julian M.Hibberd Urte Schlüter Tianshu Sun Andreas P.M.Weber Faculty of Science and Engineering Molecular Systems Biology–Groningen Biomolecular Sciences and BiotechnologyNijenborgh 49747 AG Groningenthe Netherlands Institute of Quantitative and Theoretical Biology Cluster of Excellence on Plant Science(CEPLAS)Heinrich Heine UniversityUniversitätsstrasse 140225 DüsseldorfGermany Institute of Agricultural and Environmental Sciences Estonian University of Life Sciences51006 TartuEstonia Institute of Quantitative Genetics and Genomics of Plants Cluster of Excellence on Plant Science(CEPLAS)Heinrich Heine UniversityUniversitätsstrasse 140225 DüsseldorfGermany Department of Biology University of Padova35131 PadovaItaly Max Planck Institute for Terrestrial Microbiology Department of Biochemistry&Synthetic Metabolism35043 MarburgGermany Interdisciplinary Research Institute of Grenoble IRIG-LPCVGrenoble Alpes UniversityCNRSCEAINRAE38000 GrenobleFrance Molecular Physiology Department of Plant SciencesUniversity of CambridgeCambridge CB23EAUK Institute for Plant Biochemistry Cluster of Excellence on Plant Science(CEPLAS)Heinrich Heine UniversityUniversitätsstrasse 140225 DüsseldorfGermany Institute for Breeding Research on Agricultural Crops Federal Research Center for Cultivated Plants18190 SanitzGermany

Photosynthesis in crops and natural vegetation allows light energy to be converted into chemical energy and thus forms the foundation for almost all terrestrial trophic networks on *** efficiency of photosynthetic energy conversion plays a crucial role in determining the portion of incident solar radiation that can be used to generate plant biomass throughout a growth ***,alongside the factors such as resource availability,crop management,crop selection,maintenance costs,and intrinsic yield potential,photosynthetic energy use efficiency significantly influences crop *** efficiency is relevant to sustainability and food security because it affects water use efficiency,nutrient use efficiency,and land use *** review focuses specifically on the potential for improvements in photosynthetic efficiency to drive a sustainable increase in crop *** discuss bypassing photorespiration,enhancing light use efficiency,harnessing natural variation in photosynthetic parameters for breeding purposes,and adopting new-to-nature approaches that show promise for achieving unprecedented gains in photosynthetic efficiency.

关键词： photosynthesis photorespiration photorespiratory bypass natural variation synthetic biology plant metabolic engineering

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高绝缘能力的高效冷却大功率高频变压器

变流技术与电力牵引 2003年第3期 22-25,35页

作者： L.heinemann 曾小娟德

讨论了一种用于大功率多级变流器的高绝缘能力的高效冷却大功率高频变压器。该变压器是按350kW的功率级设计的,并且用无定形铁心材料和同轴绕组制成。为了保证装置有较长的寿命,详细研究了介电损耗和具有陡沿的电压波形的影响,为此特别... 详细信息

讨论了一种用于大功率多级变流器的高绝缘能力的高效冷却大功率高频变压器。该变压器是按350kW的功率级设计的,并且用无定形铁心材料和同轴绕组制成。为了保证装置有较长的寿命,详细研究了介电损耗和具有陡沿的电压波形的影响,为此特别注重绝缘问题。

关键词：变压器大功率绝缘冷却

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人脑的分子生物学

医学分子生物学杂志 1988年第1期 41-42页

作者： heinemann SF Jones EG 谭景莹

由于分子生物学技术的渗透以及在分子生物学方面训练有素人材的流入使人脑和其疾病的研究发生了变革。1987年4月在美国克罗拉多州召开了一次人脑分子生物学讨论会,会上分子生物学的奠基人之一 Gilbert 主张对人及小鼠的基因组进行序列分... 详细信息

由于分子生物学技术的渗透以及在分子生物学方面训练有素人材的流入使人脑和其疾病的研究发生了变革。1987年4月在美国克罗拉多州召开了一次人脑分子生物学讨论会,会上分子生物学的奠基人之一 Gilbert 主张对人及小鼠的基因组进行序列分析,其目的之一是探讨是什么使人成为人,要回答这个问题就必须对人脑及控制脑装配及功能的基

关键词：人脑分子生物学神经递质受体淀粉样基因定位神经元神经组织蛋白激酶丙酮酸激酶家族家系离子通道神经系统磷酸化

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations

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Human EAG channels are directly modulated by PIP2 as reveale...

FOLFIRI联合西妥昔单抗或贝伐珠单抗治疗晚期结直肠癌:随机临床试验FIRE-3的最终生存及符合方案分析

第十一届全国钙信号和细胞功能研讨会

作者： Bo Han Kunyan He Chunlin Cai Yin Tang Linli Yang Stefan H.heinemann Toshinori Hoshi Shangwei Hou Key Laboratory of Systems Biomedicine(Ministry of Education) Institute of Systems Biomedicine Shanghai Jiao Tong University Center for Molecular Biomedicine Department of Biophysics Friedrich Schiller University Jena & Jena University Hospital Department of Physiology University of Pennsylvania Key Laboratory of Systems Biomedicine(inistry of Education) Institute of Systems Biomedicine Shanghai Jiao Tong University State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Renji Hospital School of MedicineShanghai Jiao Tong University

Voltage-gated ether à go-go(EAG) K channels are expressed in various types of cancer cells and also in the central nervous system. Aberrant overactivation of human EAG1(h EAG1) channels is associated with cancer and neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes. Although h EAG1 channels are recognized as potential therapeutic targets, regulation of their functional properties is only poorly understood. Here, we show that the membrane lipid phosphatidylinositol 4,5-bisphosphate(PIP) is a potent inhibitory gating modifier of hE AG1 channels. PIP inhibits the channel activity by directly binding to a short Nterminal segment of the channel important for Ca/calmodulin(CaM) binding as evidenced by biolayer interferometry measurements. Conversely, depletion of endogenous PIP either by serotonininduced phospholipase C(PLC) activation or by a rapamycin-induced translocation system enhances the channel activity at physiological membrane potentials, suggesting that PIP exerts a tonic inhibitory influence. Our study, combining electrophysiological and direct binding assays, demonstrates that hE AG1 channels are subject to potent inhibitory modulation by multiple phospholipids and suggests that manipulations of the PIP signaling pathway may represent a strategy to treat hE AG1 channel-associated diseases.

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结直肠肛门外科 2021年第1期27卷 77-79页

作者：何婉 heinemann V VON WEIKERSTHAL L F DECKER T 深圳市人民医院肿瘤科广东深圳510028 不详

背景:在FIRE-3研究中,与贝伐珠单抗+FOLFIRI相比,西妥昔单抗+FOLFIRI可提高KRAS野生型转移性结直肠癌(mCRC)的总生存率,但是未发现相应的无进展生存获益。本研究目的在于分析RAS野生型结直肠癌接受一线FOLFIRI治疗的可评价疗效患者中,... 详细信息

背景:在FIRE-3研究中,与贝伐珠单抗+FOLFIRI相比,西妥昔单抗+FOLFIRI可提高KRAS野生型转移性结直肠癌(mCRC)的总生存率,但是未发现相应的无进展生存获益。本研究目的在于分析RAS野生型结直肠癌接受一线FOLFIRI治疗的可评价疗效患者中,与贝伐珠单抗相比,西妥昔单抗是否可改善治疗反应和生存情况,同时分析原发肿瘤部位对预后的影响。方法:意向治疗人群包括593例KRAS第2外显子野生型mCRC患者。进一步检测确认400名患者为全RAS野生型肠癌,其中352名(88%)患者接受了至少3个周期的治疗和至少1次基线后的影像检查以评估疗效,并纳入符合方案的患者(西妥昔单抗组169名,贝伐珠单抗组183名)。

关键词：贝伐珠单抗西妥昔单抗随机临床试验 FOLFIRI 影像检查晚期结直肠癌总生存率治疗反应

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蜘蛛丝蛋白的生物技术生产及其纤维的成形

国外纺织技术（纺织针织服装化纤染整） 2000年第9期 7-10页

作者： K.heinemann 时淑芝张胜兰