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Exogenous testosterone therapy on choroid in androgen deficiency

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1489-1494页

作者： volkan yeter Nurullah Koçak Merve Kalyoncu Ramazan Aşçi Nurşen Aritürk Department of Ophthalmology Ondokuz Mayıs UniversitySamsun 55139Turkey Department of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

AIM:To investigate the effects of exogenous testosterone treatment on the choroidal parameters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFCT),choroidal vascularity index(CVI),choroidstromal area(C-SA),choroid-luminal area(C-LA),choroidstromal to luminal area ratio(CSLR),and the choroidal parameters within central 1500μm of the macula(CVI1500,C-LA1500,C-SA1500,and CSLR1500)by enhanced-depth imaging optical coherence tomography(EDI-OCT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The mean SFCT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm(P=0.8).However,CVI,C-SA,CSLR,CVI1500,C-LA1500,and CSLR1500 were significantly different between the groups(all P0.05).However,CVI1500 and LA1500 significantly increased at the end of the follow-up period(P<0.001).CONCLUSION:CVI is lower in androgen-deficient patients than in healthy *** alterations in the choroid during the testosterone peak are transient in the treatment of patients with androgen ***,the increase in CVI within the central 1500μm of the macula persists even after 4mo.

关键词： testosterone androgen deficiency choroid vascularity index

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Atherogenic indices in non-arteritic ischemic optic neuropathy

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International Journal of Ophthalmology(English edition) 2021年第7期14卷 1041-1046页

作者： Nurullah Kocak volkan yeter Mustafa Turunc Merve Bayrambas Bilge Eraydın inci Gungor Department of Ophthalmology Ondokuzmayıs University HospitalAtakum 55200SamsunTurkey Department of Ophthalmology CankırıState HospitalCankırı18100Turkey Department of Ophthalmology Erbaa State HospitalTokat 60500Turkey

AIM:To evaluate the atherogenic indices and the relationship with visual acuity and bilateral sequential involvement in patients with non-arteritic ischemic optic neuropathy(NAION).METHODS:A total of 65 patients with NAION and 48 age-sex matched healthy individuals were included in this retrospective *** demographic characteristics and laboratory findings of the patients and control subjects were obtained from the electronic medical *** atherogenic indices were calculated using the lipid *** association between visual acuity,bilateral sequential involvement,and atherogenic indices was ***:The mean age was 63.8±12.5 y in the NAION group and 64.7±10.1 y in control group(P=0.707).Although there were no significant differences in terms of total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-c)between two groups(P=0.089,0.091),all the nontraditional serum lipid ratios were significantly higher in NAION group(P20/200(P=0.032,0.025,0.032,respectively).The values for the atherogenic indices were higher in NAION patients with bilateral sequential involvement in comparison to those with unilateral involvement(P=0.271,0.127,0.197,0.128,0.127,respectively).CONCLUSION:The study reveals a relationship between NAION and the non-traditional lipid *** indices may predict the visual loss severity and second eye involvement in patients with NAION.

关键词： atherosclerosis atherogenic index lipid profile non-arteritic ischemic optic neuropathy second eye involvement

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