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Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening

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World Journal of Gastroenterology 2007年第2期13卷 192-218页

作者： Ekaterina I Galanzha valery v Tuchin vladimir P Zharov Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Department of Optics and Biomedical Physics Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov Russia Philips Classic Laser Laboratories University of Arkansas for Medical Sciences (UAMS) Little Rock AR United States

Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed.

关键词： Lymph microcirculation Transmission digital microscopy Rat mesentery Flow cytometry Photothermal technique

The Cauchy Problem for Coupled Nonlinear Schrdinger Equations with Linear Damping： Local and Global Existence and Blowup of Solutions

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Chinese Annals of Mathematics,Series B 2016年第5期37卷 665-682页

作者： Joao-Paulo DIAS Mario FIGUEIRA vladimir v. KONOTOP LCMAF-CIO Faculdade de Ciencias Universidade de Lisboa Av. Prof. Gama Pinto 2 1649-003 Lisboa Portugal. Centro de Fisica Teorica e Computacional and Departamento de Fisica Faculdade de Ciencias Universidade de Lisboa Campo Grande Ed.C8 1749-016 Lisboa Portugal.

The authors study, by applying and extending the methods developed by Cazenave(2003), Dias and Figueira(2014), Dias et al.(2014), Glassey(1994–1997), Kato(1987), Ohta and Todorova(2009) and Tsutsumi(1984), the Cauchy problem for a damped coupled system of nonlinear Schrdinger equations and they obtain new results on the local and global existence of H^1-strong solutions and on their possible blowup in the supercritical case and in a special situation, in the critical or supercritical cases.

关键词： supercritical Cauchy applying estimates proof admissible constants uniqueness nonlinearity inequality

Hidden symmetry operators for asymmetric generalized quantum Rabi models

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Chinese Physics B 2022年第1期31卷 320-323页

作者： Xilin Lu Zi-Min Li vladimir v Mangazeev Murray T Batchelor Department of Theoretical Physics Research School of PhysicsAustralian National UniversityCanberra ACT 2601Australia Mathematical Sciences Institute Australian National UniversityCanberra ACT 2601Australia Centre for Modern Physics Chongqing UniversityChongqing 40444China

The hidden Z2 symmetry of the asymmetric quantum Rabi model(AQRM)has recently been revealed via a systematic construction of the underlying symmetry *** on the AQRM result,we propose an ansatz for the general form of the symmetry operators for AQRM-related *** this ansatz we obtain the symmetry operator for three models:the anisotropic AQRM,the asymmetric Rabi–Stark model(ARSM),and the anisotropic ARSM.

关键词： light-matter interaction hidden symmetry asymmetric quantum Rabi model asymmetric Rabi-Stark model

Dynamic failure of dry and fully saturated limestone samples based on incubation time concept

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 125-134页

作者： Yuri v. Petrov Ivan v. Smirnov Grigory A. volkov Andrei K. Abramian Anatoliy M. Bragov Stanislav N. verichev Saint Petersburg University Universitetskaya nab. 7-9 Saint Petersburg 199034 Russia Institute of Problems of Mechanical Engineering Russian Academy of Sciences Bolshoj pr. 61 V.O. Saint Petersburg 199178 Russia Lobachevsky State University of Nizhni Novgorod Prospekt Gagarina 23 Nizhny Novgorod 603950 Russia Allseas Engineering B.v. Poortweg 12 Delft 2612 PA The Netherlands

This paper outlines the results of experimental study of the dynamic rock failure based on the comparison of dry and saturated limestone samples obtained during the dynamic compression and split tests. The tests were performed using the Kolsky method and its modifications for dynamic splitting. The mechanical data(e.g. strength, time and energy characteristics) of this material at high strain rates are obtained. It is shown that these characteristics are sensitive to the strain rate. A unified interpretation of these rate effects, based on the structuraletemporal approach, is hereby presented. It is demonstrated that the temporal dependence of the dynamic compressive and split tensile strengths of dry and saturated limestone samples can be predicted by the incubation time criterion. Previously discovered possibilities to optimize(minimize) the energy input for the failure process is discussed in connection with industrial rock failure processes. It is shown that the optimal energy input value associated with critical load, which is required to initialize failure in the rock media, strongly depends on the incubation time and the impact duration. The optimal load shapes, which minimize the momentum for a single failure impact, are demonstrated. Through this investigation, a possible approach to reduce the specific energy required for rock cutting by means of high-frequency vibrations is also discussed.

关键词： Dynamic strength Incubation time criterion Split Hopkinson pressure bar(SHPB) test Tensile strength Compressive strength Water-saturated limestone vibration-assisted rock cutting

Siberian silkmoth outbreaks surpassed geoclimatic barrier in Siberian Mountains

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Journal of Mountain Science 2020年第8期17卷 1891-1900页

作者： KHARUK viacheslav I. IM Sergei T. SOLDATOv vladimir v. Sukachev Institute of Forest Federal Scientific CenterRussian Academy of ScienceSiberian BranchAcademgorodok 50/28Krasnoyarsk660036 Russia Siberian Federal University Svobodny str.79Krasnoyarsk660041 Russia Reshetnev Siberian State University of Science and Technology Krasnoyarsky rabochy str.31Krasnoyarsk660014 Russia Russian Center of Forest Protection Academgorodok 50A/2Krasnoyarsk660036 Russia

Siberian silkmoth(SSM,Dendrolimus sibiricus Tschetv.)is the most important defoliator of Siberian pine(Pinus sibirica Du Tour)and fir(Abies sibirica Ledeb.)***-induced SSM outbreaks are one of the major driving factors of successions within the taiga *** is suggested that climate change impacted the SSM range and life *** analyzed the migration of alpine and northerly SSM outbreak boundaries in Siberia and the impact of the climate variables and topography on the outbreak *** used time-series scenes(multispectral data,and vegetation indexes EvI and NDII)in combination with field studies,climate variables,and GIS *** found that SSM outbreaks in the area of alpine boundary shifted about 370 m uphill since the mid of *** outbreak onset was promoted by increased dryness and active temperatures and decreased root zone moisture content in the spring-early summer *** terrain topography strongly affected SSM outbreak onset and ***,the outbreak was located at the middle elevations on the gentle concave southeastern slopes,which are the favorable insect habitats between *** the outbreak expanded uphill and downhill,to steeper slopes,and both concave and convex *** with elevation range expansion,SSM surpassed its northern historical outbreak boundary:the potential outbreaks’boundary moved about 300 km *** warming contributes to SSM migration into former outbreak free conifer stands located in highlands and at northern latitudes.

关键词： Insect outbreaks Remote sensing monitoring Insect ranges expansion Siberian silkmoth Forest health Conifer mortality

Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

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World Journal of Stem Cells 2021年第5期13卷 452-469页

作者： vladimir P Baklaushev Oleg v Durov vladimir A Kalsin Eugene v Gulaev Sergey v Kim Ilya L Gubskiy veronika A Revkova Ekaterina M Samoilova Pavel A Melnikov Dzhina D Karal-Ogly Sergey v Orlov Alexander v Troitskiy vladimir P Chekhonin Alexander v Averyanov Jan-Eric Ahlfors Biomedical Research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia Department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia Radiology and Clinical Physiology Scientific Research Center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia Department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia Department of Primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia Department of vascular Surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia Department of Medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNPCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNPC group(n=4)was subjected to intraspinal transplantation of 5 million drNPCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** Follow-up for 12 wk revealed that animals in the drNPC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNPCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNPCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNPC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： Direct cell reprogramming Neural precursor cells Directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates Regenerative therapy,Evoked potentials

Incubation time fracture criterion for FEM simulations

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Acta Mechanica Sinica 2011年第4期27卷 541-549页

作者： vladimir Bratov Institute for Problem in Mechanical Engineering of the Russian Academy of Sciences Bolshoj pr.V.O.61199178St.-PetersburgRussia

The paper is discussing problems connected with embedment of the incubation time criterion for brittle fracture into finite element computational schemes. Incubation time fracture criterion is reviewed; practical questions of its numerical implementation are extensively discussed. Several examples of how the incubation time fracture criterion can be used as fracture condition in finite element computations are given. The examples include simulations of dynamic crack propagation and arrest, impact crater formation （i.e. fracture in initially intact media）, spall fracture in plates, propagation of cracks in pipelines. Applicability of the approach to model initiation, development and arrest of dynamic fracture is claimed.

关键词： Fracture dynamics Incubation time Crack dy-namics Finite element method Fracture arrest

Low-altitude geophysical magnetic prospecting based on multirotor UAv as a promising replacement for traditional ground survey

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Geo-Spatial Information Science 2018年第1期21卷 67-74页

作者： Alexander v.Parshin vladimir A.Morozov Anton v.Blinov Alexey N.Kosterev Alexander E.Budyak Ore Geology Lab Vinogradov Institute of Geochemistry SB RASIrkutskRussia SibGISTech LLC MarkovaRussia Geoinformatics Lab Irkutsk National Research Technical UniversityIrkutskRussia

The prospects for expanding the mineral resource base in many countries are linked with the exploration of stranded sites localized at unexplored areas with complex natural and landscape conditions that make any ground survey,including magnetic prospecting,difficult and *** current level of geology requires high-precision and large-scale data at the first stages of geological *** 2012,technologies of aeromagnetic surveying with unmanned aircraft vehicles(UAv)enter the market,but most of them are based on big fixed-wing UAv and do not allow to substantially increase the level of survey granularity compared with traditional aerial *** increase the scale of survey,it is necessary to reduce the altitude and speed of flight,for which the authors develop the methodical and technical solutions described in this *** obtain data at altitudes of 5 m above the terrain even in a rugged relief,we created heavy multirotor UAvs that are stable in flight and may be used in a wide range of environmental conditions(even a moderate snowfall),and develop a special software to generate flight missions on the basis of digital elevation models.A UAv has special design to reduce magnetic interference of the flight platform;the magnetic sensor is hung below the *** technology was conducted in a considerable amount of magnetic surveys in the mountainous regions of East Siberia between 2014 and *** results of the comparison between airborne and ground surveys are presented,which show that the sensitivity of the developed system in conjunction with low-altitude measurements can cover any geologically significant anomalies of the magnetic *** unmanned survey is cheaper and more productive;the multirotor-based technologies may largely replace traditional ground magnetic exploration in scales of 1:10,000−1:1000.

关键词： Unmanned aircraft vehicles(UAv) magnetic survey geophysical prospecting airborne geophysics unmanned aerial system(UAS)

Methane oxidative carbonylation catalyzed by rhodium chalcogen halides over carbon supports

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Journal of Natural Gas Chemistry 2008年第1期17卷 1-7页

作者： G.R.Kosmambetoval P.E.Strizhak v.I.Gritsenko S.v.volkov L.B.Kharkova O.G.Yanko O.M.Korduban L.v Pisarzhevsky Institute of Physical Chemistry of National Academy of Sciences of Ukraine pr.Nauki 31Kiev03039Ukraine v.I.vernadsky Institute of General and Inorganic Chemistry of National Academy of Sciences of Ukraine pr.PaUadina 32/34Kiev03680Ukraine v.I.vernadsky Institute of General and Inorganic Chemistry of National Academy of Sciences of Ukraine pr.Palladina 32/34Kiev03680Ukraine G.v.Kurdyumov Institute of Metal Physics of National Academy of Sciences of Ukraine 36Vernadskij avKyiv03680Ukraine

Gas phase carbonylation of methane is studied in the presence of molecular oxygen over pure carbon carriers and carbon supported rhodium chalcogen halides. Activated carbons and fullerene blacks have been used as carbon supports. XPS and IR-spectroscopy data show the formation of rhodium chalcogen halides in solids prepared by different methods. We have found that the productivity of acetic acid by carbon supported rhodium chalcogen halides depends strongly on the carbon carrier and the method of the catalyst preparation. Namely, the catalyst with highest productivity for the acetic acid is prepared by synthesizing the rhodium chalcogen halide over the carbon support followed by thermal destruction. We have also found that rhodium chalcogen halides over activated carbons are more active compared with fullerene supported catalysts.

关键词： catalysts methane oxidative carbonylation rhodium chalcogen halides carbon supports