检索结果-南通市图书馆

Disease modifying treatment of spinal cord injury with directly reprogrammed neural precursor cells in non-human primates

引用

World Journal of Stem Cells 2021年第5期13卷 452-469页

作者： vladimir p Baklaushev Oleg V Durov vladimir A Kalsin Eugene V Gulaev Sergey V Kim Ilya L Gubskiy Veronika A Revkova Ekaterina M Samoilova pavel A Melnikov Dzhina D Karal-Ogly Sergey V Orlov Alexander V Troitskiy vladimir p chekhonin Alexander V Averyanov Jan-Eric Ahlfors Biomedical Research Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Neurosurgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBAMoscow 115682MoskvaRussia Department of Anesthesiology N.N.Blokhin Russian Cancer Research CentreMoscow 115478MoskvaRussia Radiology and Clinical physiology Scientific Research Center Federal center of brain research and neurotechnologies of the Federal Medical Biological AgencyMoscow 117997Russia Department of Neurobiology Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119992MoskvaRussia Department of primatology Russian Acad Med SciResearch Institute of Medical PrimatologySochi 119992SochiRussia Department of Vascular Surgery Federal Research and Clinical Center of Specialized Medical Care and Medical TechnologiesFMBA of RussiaMoscow 115682MoskvaRussia Department of Basic and Applied Neurobiology V.P.Serbsky Federal Medical Research Center for Psychiatry and NarcologyRussia Department of Medical Nanobiotechnology Pirogov Russian National Research Medical University(RNRMU)Moscow 115682MoskvaRussia New World Laboratories Laval H7V 4A7QuebecCanada

BACKGROUND The development of regenerative therapy for human spinal cord injury(SCI)is dramatically restricted by two main challenges:the need for a safe source of functionally active and reproducible neural stem cells and the need of adequate animal models for preclinical *** reprogramming of somatic cells into neuronal and glial precursors might be a promising solution to the first *** use of non-human primates for preclinical studies exploring new treatment paradigms in SCI results in data with more translational relevance to human *** To investigate the safety and efficacy of intraspinal transplantation of directly reprogrammed neural precursor cells(drNpCs).METHODS Seven non-human primates with verified complete thoracic SCI were divided into two groups:drNpC group(n=4)was subjected to intraspinal transplantation of 5 million drNpCs rostral and caudal to the lesion site 2 wk post injury,and lesion control(n=3)was injected identically with the equivalent volume of *** Follow-up for 12 wk revealed that animals in the drNpC group demonstrated a significant recovery of the paralyzed hindlimb as well as recovery of somatosensory evoked potential and motor evoked potential of injured *** resonance diffusion tensor imaging data confirmed the intraspinal transplantation of drNpCs did not adversely affect the morphology of the central nervous system or cerebrospinal fluid *** immunohistochemical analysis showed that drNpCs maintained SOX2 expression characteristic of multipotency in the transplanted spinal cord for at least 12 wk,migrating to areas of axon growth *** Our data demonstrated that drNpC transplantation was safe and contributed to improvement of spinal cord function after acute SCI,based on neurological status assessment and neurophysiological recovery within 12 wk after *** functional improvement described was not associated with neuronal differentiation of th

关键词： Direct cell reprogramming Neural precursor cells Directly reprogrammed neural precursor cells Spinal cord injury Nonhuman primates Regenerative therapy,Evoked potentials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

prospects for the use of olfactory mucosa cells in bioprinting for the treatment of spinal cord injuries

引用

World Journal of Clinical Cases 2023年第2期11卷 322-331页

作者： Olga Vladislavovna Stepanova Grigorii Andreevich Fursa Svetlana Sergeevna Andretsova Valentina Sergeevna Shishkina Anastasia Denisovna Voronova Andrey Viktorovich Chadin Ekaterina Konstantinovna Karsuntseva Igor vladimirovich Reshetov vladimir p.vlovich chekhonin Department of Basic and Applied Neurobiology V.P.Serbsky National Medical Research Center for Psychiatry and NarcologyMoscow 119034Russia Department of Neurohumoral and Immunological Research National Medical Research Center of CardiologyMoscow 121552Russia Department of Biology Moscow State UniversityMoscow 119991Russia Department of plastic Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119435Russia Department of Medical Nanobiotechnologу N.I.Pirogov Russian National Research Medical UniversityMoscow 117997Russia

The review focuses on the most important areas of cell therapy for spinal cord *** mucosa cells are promising for *** these cells is safe for *** use of olfactory mucosa cells is effective in restoring motor function due to the remyelination and regeneration of axons after spinal cord *** cells express neurotrophic factors that play an important role in the functional recovery of nerve tissue after spinal cord *** addition,it is possible to increase the content of neurotrophic factors,at the site of injury,exogenously by the direct injection of neurotrophic factors or their delivery using gene *** advantages of olfactory mucosa cells,in combination with neurotrophic factors,open up wide possibilities for their application in threedimensional and four-dimensional bioprinting technology treating spinal cord injuries.

关键词： Olfactory mucosa cells Neurotrophic factors Cell therapy Injury of spinal cord Three-dimensional bioprinting Four-dimensional bioprinting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

应用磁共振扩散张量成像技术诊断大鼠创伤后脊髓空洞症

引用

中华实验外科杂志 2018年第7期35卷 1303-1303页

作者：陈凯张超李之珺付嘉园圆 vladimir p. chekhonin 天津市第四中心医院肿瘤介入科 300140 天津医科大学肿瘤医院骨与软组织肿瘤科 300060 天津医科大学肿瘤医院放射科 300060 天津医科大学临床医学院 300270 Moscow Pirogov Russian National Research Medical University117997

创伤后脊髓空洞症（pTS）是脊髓损伤（SCI）后髓内囊性退变。pTS可加剧SCI后症状。传统磁共振扫描（MRI）难以对pTS进行早期诊断。磁共振弥散张量成像（DTI）已应用于SCI研究。我们基于7．0TMRI通过DTI分析大鼠SCI模型，评估DTI早期诊断... 详细信息

创伤后脊髓空洞症（pTS）是脊髓损伤（SCI）后髓内囊性退变。pTS可加剧SCI后症状。传统磁共振扫描（MRI）难以对pTS进行早期诊断。磁共振弥散张量成像（DTI）已应用于SCI研究。我们基于7．0TMRI通过DTI分析大鼠SCI模型，评估DTI早期诊断pTS可行性。

关键词：磁共振扩散张量成像脊髓空洞症创伤后技术诊断大鼠应用磁共振弥散张量成像 SCI模型

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：