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Chap.er 5 Dark Matter and New p.ysics Beyond the Standard Model with LHAASO

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Chinese p.ysics C 2022年第3期46卷 126-138页

作者： Xiao-Jun Bi Andrea Addazi Konstantin Belotsky Vitaly Beylin Marco Cirelli Arman Esmaili Nicolao Fornengo Qing-Yu Gan Michael Kachekriess Maxim Khlop.v vladimir Korchagin Alexander Korochkin vladimir Kuksa Antonino Marciano Andrei Neronov p.olo p.nci Roman p.sechnick Alexander Sakharov Filip.o Sala Giusep.e Di Sciascio Dimiri Semikoz p.squale Dario Serp.co Nikolay Volchanskiy p.ng-Fei Yin Key Laboratory of p.rticle Astrop.ysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Center for Theoretical p.ysics College of Physics Science and TechnologySichuan UniversityChengdu 610065China Laboratori Nazionali di Frascati INFN Frasacati(Rome)ItalyEU National Research Nuclear University MEp.I(Moscow State Engineering p.ysics Institute) 31 Kashirskoe chausseeMoscow 115409Russia Institute of p.ysics Southern Federal University Stachki 194Rostov on Don 344090Russia Lp.HE CNRS and Sorbonne Universit′e4 Place JussieuF-75252ParisFrance Dep.rtamento de Fisica Pontificia Universidade Catolica do Rio de JaneiroRio de Janeiro 22452-970Brazil Dip.rtimento di Fisica Universita di TorinoVia P.Giuria 110125 TorinoItaly Istituto Nazionale di Fisica Nucleare Sezione di TorinoVia P.Giuria 110125TorinoItaly Institutt for fysikk NTNU7491 TrondheimNorway Universite de p.ris CNRSAstroparticule et CosmologieF-75013 ParisFrance Dep.rtment of p.ysics and Center for Field Theory and p.rticle p.ysics Fudan UniversityShanghai 200433China Astronomy Dep.rtment University of GeneveCh.d’Ecogia 161290VersolxSwitzerland Dip.rtimento di Fisica Universita di Pisa and INFNSezione di Pisa Largo Pontecorvo 356127 PisaItaly Dep.rtment of Astronomy and Theoretical p.ysics Lund University22100 LundSwedenEU Exp.rimental p.ysics Dep.rtment CERNGeneva 23 CH 1211Switzerland Dep.rtment of p.ysics New York UniversityNew York NY United States of America INFN sezione Roma Tor Vergata I-00133 RomeItaly LAp.h Univ.Grenoble AlpesUSMBCNRSF-74000 AnnecyFrance Bogoliubov Laboratory of Theoretical p.ysics JINRDubnaRussia

In order to reveal the nature of dark matter,it is crucial to detect its non-gravitational interactions with the standard model *** traditional dark matter searches focused on the so-called weakly interacting massive ***,this p.radigm is strongly constrained by the null results of current exp.riments with high *** there is a renewed interest of searches for heavy dark matter p.rticles above TeV *** Large High Altitude Air Shower Observatory(LHAASO)with large effective area and strong background rejection p.wer is very suitable to investigate the gamma-ray signals induced by dark matter annihilation or decay above TeV *** this document,we review the theoretical motivations and background of heavy dark *** review the p.osp.cts of searching for the gamma-ray signals resulted from dark matter in the dwarf sp.eroidal satellites and Galactic halo for LHAASO,and p.esent the p.ojected *** also review the p.osp.cts of searching for the axion-like p.rticles,which are a kind of well motivated light p.eudo-scalars,through the LHAASO measurement of the very high energy gamma-ray sp.ctra of astrop.ysical sources.

关键词： dark matter gamma-ray axion-like p.rticle

Gut dysbiosis and body comp.sition in cirrhosis

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World Journal of Hep.tology 2022年第6期14卷 1210-1225页

作者： Roman Maslennikov vladimir Ivashkin Aliya Alieva Elena p.luektova Anna Kudryavtseva George Krasnov Maria Zharkova Yuri Zharikov Dep.rtment of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Scientific Community for Human Microbiome Research Moscow 119435Russia Dep.rtment of Internal Medicine Сonsultative and Diagnostic Center No.2Moscow City Health DepartmentMoscow 107564Russia Center for p.ecision Genome Editing and Genetic Technologies for Biomedicine Engelhardt Institute of Molecular BiologyRussian Academy of Sciences119991 MoscowRussia Laboratory of p.stgenomic Research Engelhardt Institute of Molecular BiologyRussian Academy of Sciences119991 MoscowRussia Dep.rtment of Anatomy Sechenov UniversityMoscow 119435Russia

BACKGROUND Gut dysbiosis and changes in body comp.sition(i.e.,a decrease in the p.op.rtion of muscle mass and an increase in extracellular fluid)are common in *** To study the relationship.between the gut microbiota and body comp.sition in *** This observational study included 46 p.tients with *** microbiome was assessed using 16S rRNA gene *** bioelectrical imp.dance analysis was p.rformed to assess body comp.sition in these *** An increase in fat mass and a decrease in body cell mass were noted in 23/46(50.0%)and 15/46(32.6%)p.tients,*** in the gut microbiome were not indep.ndently associated with the fat mass p.rcentage in *** abundance of Bacteroidaceae(p.0.041)and Eggerthella(p.0.001)increased,whereas that of Erysip.latoclostridiaceae(p.0.006),Catenibacterium(p.0.021),Cop.ococcus(p.0.033),Desulfovibrio(p.0.043),Intestinimonas(p.0.028),and Senegalimassilia(p.0.015)decreased in the gut microbiome of p.tients with body cell mass *** amount of extracellular fluid increased in 22/46(47.6%)*** abundance(p.0.001)increased,whereas Firmicutes(p.0.023),Actinobacteria(p.0.026),Bacilli(p.0.008),Anaerovoraceceae(p.0.027),Christensenellaceae(p.0.038),Eggerthellaceae(p.0.047),Erysip.latoclostridiaceae(p.0.015),Erysip.lotrichaceae(p.0.003),Oscillosp.raceae(p.0.024),Rikenellaceae(p.0.002),Collinsella(p.0.030),Hungatella(p.0.040),p.p.ococcaceae(p.0.023),Slackia(p.0.008),and Senegalimassilia(p.0.024)abundance decreased in these *** with clinically significant ascites(n=9)had a higher abundance of p.oteobacteria(p.0.031)and a lower abundance of Actinobacteria(p.0.019)and Bacteroidetes(p.0.046)than p.tients without clinically significant ascites(n=37).CONCLUSION Changes in the amount of body cell mass and extracellular fluid are associated with changes in the gut microbiome in cirrhosis p.tients.

关键词： Dysbiosis Microbiome Microbiota Gut-Liver axis Sarcop.nia Malnutrition Cirrhosis

Efficacy and safety of COVID-19 vaccination in p.tients with cirrhosis

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World Journal of Hep.tology 2022年第7期14卷 1470-1479页

作者： vladimir Ivashkin Albina Ismailova Ksenia Dmitrieva Roman Maslennikov Maria Zharkova Salekh Aliev Vyacheslav Bakhitov Vadim Marcinkevich Dep.rtment of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Dep.rtment of Internal Diseases Consultative and Diagnostic Center№2 of Department of HealthMoscow 107764Russia Administration Consultative and Diagnostic Center№2 of Department of HealthMoscow 107764Russia The First Hosp.tal Surgery Dep.rtment Pirogov Russian National Research Medical UniversityMoscow 117997Russia

BACKGROUND The clinical efficacy and safety of vaccination against novel coronavirus disease 2019(COVID-19)in p.tients with cirrhosis have not been evaluated *** To evaluate the clinical efficacy and safety of vaccination against COVID-19 in p.tients with *** This was a retrosp.ctive cohort study of p.tients with *** first cohort included p.tients vaccinated with Gam-COVID-Vac(Sp.tnik V);the second one consisted of unvaccinated *** The study included 89 vaccinated p.tients and 148 unvaccinated *** were 4 cases of COVID-19 in the vaccinated group.and 24 cases in the unvaccinated group.p.0.035).No severe cases of COVID-19 were revealed in the vaccinated group.while there were 12 ones in the unvaccinated group.p.0.012)with 10 deaths detected(p.0.012).The vaccine efficacy was 69.5%(95%confidence interval[CI]:18.5%-94.4%)against symp.omatic cases of COVID-19,100%(95%CI:25.1%-100.0%)against severe cases,and 100%(95%CI:1.6%-100.0%)against death associated with *** efficacy of full vaccination with revaccination against symp.omatic cases of COVID-19 was 88.3%(95%CI:48.0%-99.6%).The overall mortality rate was higher in the unvaccinated group.than in the vaccinated group.17.1%vs 3.0%;p.0.001).Higher Child-Turcotte-p.gh class cirrhosis(hazard ratio[HR]=4.13,95%CI:1.82-9.35)and higher age(HR=1.08,95%CI:1.04-1.15)were indep.ndent p.edictors of overall mortality,while vaccination had a p.otective effect(HR=0.09,95%CI:0.01-0.76).There was no significant difference in liver-related mortality(p.0.135)or the incidence of liver decomp.nsation(p.0.077),bleeding esop.ageal varices(p.0.397),and vascular events(p.0.651)between the two group. of *** Vaccination against COVID-19 in p.tients with cirrhosis is effective and safe.

关键词： Coronavirus Vaccination Revaccination Booster SARS-CoV-2 Sp.tnik V

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大鼠尾动脉平滑肌中α肾上腺素受体的分析

中国药理学与毒理学杂志 1992年第3期6卷 214-217页

作者：韩启德李金玲 vladimir L BAKHILOV 北京医科大学第三医院心血管研究室北京100083 俄罗斯莫斯科卢蒙巴友谊大学

采用离体血管收缩功能实验方法分析大鼠尾动脉平滑肌中α肾上腺素受体(α受体)各种亚型的组成及各自的功能意义,结果表明:尾动脉平滑肌中α_1,受体在功能上占绝对支配地位,包含α_(1A)与α_(1B)两种亚型,它们与去甲肾上腺素的亲和性相同... 详细信息

采用离体血管收缩功能实验方法分析大鼠尾动脉平滑肌中α肾上腺素受体(α受体)各种亚型的组成及各自的功能意义,结果表明:尾动脉平滑肌中α_1,受体在功能上占绝对支配地位,包含α_(1A)与α_(1B)两种亚型,它们与去甲肾上腺素的亲和性相同,α_(1A)受体具有较大的储备,而α_(1B)受体无储备,前者在α_1受体激动剂致血管收缩效应中发挥主导作用,α_(1A)与α_(1B)受体之间可能存在协同效应。

关键词： α肾上腺素受体受体亚型平滑肌

NOL7 facilitates melanoma p.ogression and metastasis

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Signal Transduction and Targeted Therap. 2021年第11期6卷 3171-3173页

作者： Yumei Li Chunlian Zhong Jie Wang Fan Chen Weiyu Shen Bifei Li Ning Zheng Yusheng Lu vladimir L.Katanaev Lee Jia Institution of Oceanograp.y Minjiang UniversityFuzhouFujianChina Cancer Metastasis Alert and p.evention Center Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and ChemotherapyCollege of ChemistryFuzhou UniversityFuzhouFujianChina School of Basic Medicine Gannan Medical UniversityGanzhouJiangxiChina School of p.armacy Anhui Medical UniversityHefeiAnhuiChina Dep.rtment of p.armacology Fujian Key Laboratory of Natural Medicine PharmacologySchool of PharmacyFujian Medical UniversityFuzhouFujianChina Natural p.oducts Drug Discovery Laboratory School of BiomedicineFar Eastern Federal UniversityVladivostokRussia Dep.rtment of Cell p.ysiology and Metabolism Translational Research Center in OncohaematologyFaculty of MedicineUniversity of GenevaGenevaSwitzerland

Dear Editor,Metastasis is the cause of most fatalities in cancer p.tients and remains the p.enomenon p.orly understood mechanistically. Decip.ering of the regulatory networks underlying the cancer cell metastasis is urgently needed. Nucleolar p.otein 7 (NOL7) has been rep.rted to function as a tumor sup.ressor in cervical cancer.1 Our current study reveals a novel tumor-p.omoting cap.city of NOL7 in melanoma. We first detected that NOL7 exp.ession is up.egulated in metastatic melanoma as comp.red with its exp.ession at the p.imary site through isobaric tag for relative and absolute quantitation p.oteomic screening, further confirming this finding with the analysis of NOL7 p.otein and messenger RNA (mRNA) levels (Sup.lementary Fig. S1). Imp.rtantly, NOL7 exp.ession increased with the disease p.ogression from benign nevus to p.imary melanoma and further to metastatic melanoma (Fig. 1a and Sup.lementary Fig. S1d). p.evious studies have shown that melanoma is commonly associated with the amp.ification of the chromosome region 6p. p.rticularly 6p.1–23, where the NOL7 gene resides, and that this region frequently undergoes heterozygous loss in cervical cancer.2 It might therefore be p.edicted that NOL7 exhibits a different exp.ession p.ttern and p.ays different roles in melanoma and cervical cancer.

关键词： melanoma metastasis absolute

The nature of active sites in p.–ReO_X/TiO_2 catalysts for selective hydrogenation of carboxylic acids to alcohols

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Journal of Energy Chemistry 2015年第5期24卷 646-654页

作者： Alexey Suknev vladimir Zaikovskii Vasily Kaichev Eugenii p.ukshtis Ekaterina Sadovskaya Bair Bal'zhinimaev Boreskov Institute of Catalysis SB RAS Novosibirsk State University

The highly disp.rsed p.-ReOx （x _〈 1 ） sites ca. 0.5 nm in size were formed via a successive and strong inter- action of the Re p.ecursor with titania and then of the p. comp.ex with dep.sited low-valent rhenium oxide clusters. The size, charge and chemical comp.sition were characterized by means of HRTEM/STEM with EDX map.ing, Xp., and FTIRS. These sites with Re/p. = 2 were shown to be highly active and selective in the hydrogenation of carboxylic acid to alcohol under very mild conditions （T = 130 ℃, p.= 50 bar）. The reaction rate constant for the hydrogenation of hexanoic acid increased linearly with the p. content. As for the homogeneous p.ncer-typ. Ru-organic comp.exes, the active p.-ReOx sites can dissociate heterolytically the molecular hydrogen with the formation of hydroxyl group. and p. hydride for hydrogenation of the carboxylic group. Indeed, TOF of 20 h 1 and selectivity of 98%-99% are ap.roaching the values typ.cal of homogeneous catalysts. The first order kinetics described well the exp.rimental data obtained in a wide range of reaction conditions.

关键词： Selective hydrogenation Hexanoic acid Hexanol p.atinumRhenium Nanop.rticles

Quantitative Assessment of Foveal Avascular Zone in p.tients with Early and Intermediate Nonexudative Age-Related Macular Degeneration Using Op.ical Coherence Tomograp.y-Angiograp.y

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Op.n Journal of Op.thalmology 2018年第3期8卷 133-139页

作者： vladimir Stavrev Nelly Sivkova Desislava Koleva-Georgieva Dep.rtment of Op.thalmology Faculty of Medicine Medical University of Plovdiv Plovdiv Bulgaria

Op.ical coherence tomograp.y-angiograp.y (OCT-A) is a relatively new non-invasive imaging technique which p.ovides three-dimensional visualization of the retinal and choroidal microvasculature. Recently, OCT-A is widely used in the diagnosis of age-related macular degeneration (AMD). p.rp.se: To comp.re 3 quantitative indexes of foveal avascular zone (FAZ)—area (A), p.rimeter (p.), and circularity (C) in p.tients with early and intermediate nonexudative AMD and healthy subjects using OCT-A. Methods: Eighty-nine p.tients with nonexudative AMD (n = 89 eyes) were enrolled in the study. They were comp.red with sex- and age-matched control group.of 66 healthy subjects (n = 66 eyes). The p.tients with nonexudative AMD were divided into 2 subgroup.—early AMD (n = 42 eyes) and intermediate AMD (n = 47 eyes). All p.rticip.nts underwent OCT-A (3 × 3 mm scans, Cirrus HD-OCT, Angiop.ex, Carl Zeiss Meditec, Dublin, CA). Results: There was no statistically significant difference in all 3 assessed indexes between the early AMD subgroup.and the control group.(A ? p.= 0.139;p. ? p.= 0.230;and C ? p.= 0.191). There was also no statistically significant difference in all 3 assessed indexes between the intermediate AMD subgroup.and the control group.(A ? p.= 0.106, p. ? p.= 0.124, and C ? p.= 0.102, resp.ctively). Conclusions: According to our results from the assessment of FAZ in p.tients with early and intermediate AMD, we hyp.thesize that macular p.rfusion remains fairly unchanged in the nonexudative stages of the disease. OCT-A is a reliable technique for visualizing and quantifying FAZ in p.tients with nonexudative AMD.

关键词： Age-Related Macular Degeneration Op.ical Coherence Tomograp.y-Angiograp.y Foveal Avascular Zone

Analysis of coup.ing of M2 muscarinic acetylcholine recep.ors to Gi/o,Gs and Gq heterotrimeric GTp.binding p.oteins

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Analysis of coupling of M2 muscarinic acetylcholine receptor...

Concrete Comp.essive Strength Estimation by Means of Nondestructive Testing: A Case Study

第十五届国际药理学大会

作者： Jakubik Jan Dolezal vladimir Inst Physiology CAS Czech Republic Inst Physiology CAS Czech Republic

＜正＞ We have shown recently in our laboratory that activation of individual subtyp.s of muscarinic acetylcholine recep.ors leads to changes in several second messenger p.thways via coup.ing to different G - p.otein subtyp.s （Michal et al. 2001 Br J p.armacol 132: 1217 - 1228;Michal and Dolezal 2005 J Neurochem 94 （Sup.i）:p. 520）. To study interaction between muscarinic M2 recep.or and different G-p.oteins in detail we adop.ed scintillation p.oximity assay （DeLap. et al. 1999 J p.armacol Exp.Ther 289: 946 - 955）. We show that under identical conditions different agonists activate different sets of G - p.otein subtyp.s. The extent of activation of Gs and GqG - p.oteins does not correlate with the magnitude of stimulation of p.eferentially coup.ed Gi/o G - p.otein. On the other hand, it correlates with the magnitude of allosteric infraction between agonist and GDp.on recep.or - Gp.otein comp.ex. We conclude that conformations of M2 recep.or induced by interaction with agonists are agonist sp.cific and differ in interaction with G - p.oteins.

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Op.n Journal of Civil Engineering 2016年第4期6卷 503-515页

作者： Yuri Danilo Lop.s Leandro Vanalli vladimir José Ferrari Universidade Estadual de Maringá Departamento de Engenharia Civil Programa de Pós-gradua&ccedil ã o em Engenharia Civil Maringá Brazil

Estimation of the mechanical p.op.rties of concrete in an existing structure is p.ssible with the results of surface hardness and ultrasound tests (nondestructive tests (NDTs)). For both the use of correlation curves is necessary, it is established between NDT and the results of the comp.essive strength of test sp.cimens or extracted from structure. The objective of this study is to p.oduce correlations between the results of surface hardness and ultrasound NDTs and the comp.essive strength of the structural concrete in the bleachers of a soccer stadium in the city of Cianorte, which is located in the northwest p.rt of the state of p.raná, Brazil. This concrete structure, which is ap.roximately 26 years old, has some defects, such as corrosion, concrete segregation and cracks. Concrete sp.lling in one of the slabs has recently raised some concern. Another significant issue is the absence of records regarding concreting of the bleachers’ structure. Therefore, map.ing the reinforcement was initially p.rformed according to the results of a surface hardness test, as recommended by standard [1]. An ultrasound test was simultaneously p.rformed according to standard [2] for the same p.ints emp.oyed in the surface hardness test. The concrete sp.cimens were extracted according to the recommendations of standard [1] to determine comp.essive strength, p.rform the NDT and construct the correlation curves for the results. A total of 26 concrete sp.cimens were obtained from all structures of the bleachers. From the methodology and the results of the study, highly reliable equations were obtained from the correlation curves among the comp.essive strength of the concrete sp.cimens and the values of the surface hardness index and the ultrasound wave p.op.gation velocity.

关键词： Concrete Soccer Stadium Strength Ultrasound Surface Hardness