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Azithromycin in a triple therapy for *** eradication in active duodenal ulcer

World Journal of Gastroenterology 2002年第5期8卷 879-882页

作者： vladimir T.Ivashkin Tatiana L.Lapina Oksana Yu.Bondarenko Olga A. Sklanskaya petr Va.Grigoriev Yuri V.Vasiliev Emilia p.Yakovenko pavel V.Gulyaev Valeri I.Fedchenko V.Vasilenko Clinic of internal diseases gastroenterology and hepatology of the Moscow Sechenov Medical Academy119881 Pogodinskaya 5MoscowRussia pathology Department of the Moscow Sechenov Medical Academy 119881Trubetskaya 8MoscowRussia Gastroenterological Center of the Health Ministry of Russia 105203N.Pervomayskaya ul.70MoscowRussia Central Institution of Gastroenterology 111123Sh.Entusiastov 86MoscowRussia

AIM:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole, which is still widely used in Russia,and B)azithromycin, amoxicillin and omeprazole in healing active duodenal ulcer and *** eradication. METHODS:100 patients with active duodenal ulcer were included in the open,multicentre,randomized study with comparative *** were randomly assigned to one of the following one-week triple regimes:A) metronidazole 500 mg bid,amoxicillin I g bid and omeprazole 20 mg bid(OAM,n=50)and B)azithromycin 1 god for the first 3 days(total dose 3 g),amoxicillin 1 g bid and omeprazole 20 mg bid(OAA,n=50).Omeprazole 20 mg od was given after the eradication course as a monotherapy for three *** control endoscopy was performed 8 weeks after the *** was determined in the entry of the study and four weeks after the cessation of treatment by means of histology and CLO-test. RESULTS:97 patients completed the study according to the protocol(1 patient of the OAM group did not come to the control endoscopy,2 patients of the OAA group stopped the treatment because of mild allergic urticaria).Duodenal ulcers were healed in 48 patients of the OAM group(96 %, C190.5-100 %)and in 46 patients of the OAA group(92 %, CI 89.5-94.5 %)(p=ns).*** was eradicated in 15 out of 50 patients with OAM(30 %,CI 17-43 %)and in 36 out of 50 patients treated with OAA(72 %;CI 59-85 %) (pple therapy with omeprazole, amoxicillin and metronidazole failed to eradicate ***'vc\ the majority of patients, which is an essential argument to withdraw this regimen out of the national recommendations. Macrolide with amoxicillin are preferable to achieve higher eradication rates. Azithromycin (1 g od for the first 3 days) can be considered as a successful component of the triple ppI-based regimen.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-Ulcer Agents Azithromycin Comparative Study Drug Therapy, Combination Duodenal Ulcer Female Helicobacter Infections Humans Male Metronidazole Middle Aged Omeprazole penicillins Research Support, Non-U.S. Gov't Treatment Outcome

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Stabilization versus decomposition in alpine ecosystems of the Northwestern Caucasus:The results of a tea bag burial experiment

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Journal of Mountain Science 2018年第8期15卷 1633-1641页

作者： Tatiana G.ELUMEEVA vladimir G.ONIpCHENKO Asem A.AKHMETZHANOVA Mikhail I.MAKAROV Joost A.KEUSKAMp Department of Geobotany Biological FacultyLomonosov Moscow State University119234 Leninskie Gory 1/12MoscowRussia Department of General Soil Science Faculty of Soil ScienceLomonosov Moscow State University119234 Leninskqe Gory 1/12MoscowRussia Ecology 8:Biodiversity Group Utrecht UniversityP.O.Box 80.0563508 TB UtrechtThe Netherlands Netherlands Institute of Ecology(NIOO-KNA W) P.O.Box 596700 AB WageningenThe Netherlands

Mountainous areas exhibit highly variable decomposition rates as a result of strong local differences in climate and vegetation type. This paper describes the effect of these factors on two major determinants of the local carbon cycle: litter decomposition and carbon stabilization. In order to adequately reflect local heterogeneity, we have sampled 12 typical plant communities of the Russian Caucasus. In order to minimize confounding effects and encourage comparative studies, we have adapted the widely used tea bag index(TBI) that is typically used in areas with low decomposition. By incubating standardized tea litter for a year, we investigated whether(1) initial litter decomposition rate(k) is negatively correlated with litter stabilization(S) and(2) whether k or S exhibit correlations with altitude and other environmental conditions. Our results show that S and k are not correlated. Altitude, p H, and water content significantly influenced the stabilization factor S, while soil-freezing had no influence. In contrast, none of these factors predicted the decomposition rate k. Based on our data, we argue that collection of decomposition rates alone, as is now common practice, is not sufficient to understand carbon input to soils and can potentially lead to misleading results. Our data on community-specific decomposition and stabilization rates further constrain estimates of litter accumulation in subalpine communities and the potential effects of climate change.

关键词： Litter decomposition Alpine communities Tea bag index Carbon cycle

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previous hepatitis B viral infection–an underestimated cause of pancreatic cancer

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World Journal of Gastroenterology 2022年第33期28卷 4812-4822页

作者： Sergey Batskikh Sergey Morozov Alexey Dorofeev Zanna Borunova Dmitry Kostyushev Sergey Brezgin Anastasiya Kostyusheva vladimir Chulanov Department of Hepatology Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Scientific and Clinical Laboratory Research Moscow Clinical Scientific Center N.A.A.S.LoginovMoscow 111123Russia Laboratory of Genetic Technologies Sechenov UniversityMoscow 119435Russia Division of Biotechnology Scientific Center for Genetics and Life SciencesSirius University of Science and TechnologySochi 354340Russia Laboratory of Genetic Technologies and Translational Research National Medical Research Center for Tuberculosis and Infectious Diseases of Ministry of Health of RussiaMoscow 127994Russia

BACKGROUND The etiology of pancreatic cancer remains unclear. This limits the possibility of prevention and effective treatment. Hepatitis B virus(HBV) is responsible for the development of different types of cancer, but its role in pancreatic cancer is still being *** To assess the prevalence of previous HBV infection and to identify viral biomarkers in patients with pancreatic ductal adenocarcinoma(pDAC) to support the role of the virus in etiology of this *** The data of 130 hepatitis B surface antigen-negative subjects were available for the final analysis,including 60 patients with pDAC confirmed by cytology or histology and 70 sex-and age-matched controls. All the participants were tested for HBV biomarkers in blood [antibody to hepatitis B core antigen(anti-HBc), antibody to hepatitis B surface antigen(anti-HBs) and HBV DNA], and for those with pDAC, biomarkers in resected pancreatic tissues were tested(HBV DNA, HBV pregenomic RNA and covalently closed circular DNA). We performed immunohistochemistry staining of pancreatic tissues for hepatitis B virus X antigen and Ki-67 protein. Non-parametric statistics were used for the *** Anti-HBc was detected in 18/60(30%) patients with pDAC and in 9/70(13%) participants in the control group(p = 0.029). Accordingly, the odds of pDAC in anti-HBc-positive subjects were higher compared to those with no previous HBV infection(odds ratio: 2.905, 95% confidence interval: 1.191-7.084, standard error 0.455). HBV DNA was detected in 8 cases of pDAC and in 6 of them in the pancreatic tumor tissue samples only(all patients were anti-HBc positive). Blood HBV DNA was negative in all subjects of the control group with positive results of the serum anti-HBc test. Among 9 patients with pDAC, 5 revealed signs of replicative competence of the virus(covalently closed circular DNA with or without pregenomic RNA) in the pancreatic tumor tissue samples. Hepatitis B virus X antigen expression and active cell

关键词： Hepatitis B virus previous hepatitis B Occult hepatitis B virus infection pancreatic cancer pancreatic ductal adenocarcinoma

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Dissociation behavior of “dry water” C_3H_8 hydrate below ice point:Effect of phase state of unreacted residual water on a mechanism of gas hydrates dissociation

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Journal of Energy Chemistry 2015年第3期24卷 309-314页

作者： Andrey O Drachuk vladimir p Melnikov Nadezhda S Molokitina Anatoliy N Nesterov Lev S podenko Aleksey M Reshetnikov Andrey Yu Manakov Institute of Earth Cryosphere SB RAS625026Malygin str.86TyumenRussian Federation Tyumen State Oil and Gas University 625000Volodarsky str.38TyumenRussian Federation Nikolaev Institute of Inorganic Chemistry SB RAS630090Lavrentiev av.3NovosibirskRussian Federation

The results on a dissociation behavior of propane hydrates prepared from ＂dry water＂ and contained unreacted residual water in the form of ice inclusions or supercooled liquid water（water solution of gas） were presented for temperatures below 273 *** temperature ramping or pressure release method was used for the dissociation of propane hydrate *** was found that the mechanism of gas hydrate dissociation at temperatures below 273 K depended on the phase state of unreacted water in the hydrate *** hydrates dissociated into ice and gas if the ice inclusions were in the hydrate *** samples of propane hydrates with inclusions of unreacted supercooled water only（without ice inclusions） dissociated into supercooled water and gas below the pressure of the supercooled water-hydrate-gas metastable equilibrium.

关键词： gas hydrates dry water supercooled liquid water ice hydrate dissociation

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马加丹冻土特征和基础类型选择(英文)

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黑龙江大学工程学报 2014年第3期5卷 247-256,261页

作者： vladimir p.Vlasov 俄罗斯科学院西伯利亚分院麦尔尼科夫冻土研究所东北冻土站俄罗斯东北州立大学

马加丹州地区拥有季节性深层冻结和不稳定冻结等冻土特征。该地区的基础依据建筑和结构的使用寿命内允许冻土最退化程度的原则设计。在马加丹州使用的桩基础采用共同的基础类型。通过井底驱动结合现浇和制浆,使桩基础穿过永久性冻土嵌... 详细信息

马加丹州地区拥有季节性深层冻结和不稳定冻结等冻土特征。该地区的基础依据建筑和结构的使用寿命内允许冻土最退化程度的原则设计。在马加丹州使用的桩基础采用共同的基础类型。通过井底驱动结合现浇和制浆,使桩基础穿过永久性冻土嵌入底层解冻地面。在马加丹州地区,这种布桩方法提高了建筑物的稳定性。论述了在该地区冻土条件下,基础类型的选择并概述桩布置方法。

关键词：不稳定冻土解冻解冻土壤基础桩布置方法工程结构稳定性

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Luminescent-plasmonic core-shell microspheres,doped with Nd3+ and modified with gold nanoparticles,exhibiting whispering gallery modes and SERS activity

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Journal of Rare Earths 2019年第11期37卷 1152-1156页

作者： Marcin Runowski Inocencio R.Martin vladimir N.Sigaev Vitaliy I.Savinkov Georgiy Yu.Shakhgildyan Stefan Lis Faculty of Chemistry Adam Mickiewicz UniversityUniwersytetu Poznanskiego 861-614 PoznanPoland Departamento de Fisica Instituto de Materiales y Nanotecnologia(IMN)Universidad de La LagunaApdo.456E-38200 San Cristobal de La LagunaSanta Cruz de TenerifeSpain D.Mendeleev University of Chemical Technology Miusskaya Sq.9125047 MoscowRussia

Multifunctional core/shell type,luminescent-plasmonic material composed of lanthanide doped microspheres(≈50μm)and gold nanoparticles(Au Nps;≈10-20 nm)deposited onto their surface,were successfully prepared(Nd^3+:YAS@Au).The material was synthesized to combine the luminescence properties of the Nd^3+-doped microspheres,*** resonance with plasmonic activity of the surface Au Nps,*** enhanced Raman scattering(SERS)effect,within a single,micro-sized *** luminescent-plasmonic microspheres were used as the active SERS substrate for detection of the organic probe,and for generation of Whispering Gallery Modes(WGM),which red-shift together with increasing laser power(temperature elevation).The products obtained were analysed with optical,scanning and transmission electron microscopy(SEM and TEM),as well as by Raman,absorption and photoluminescence spectroscopies.

关键词： Luminescence Gold Nps-SpR Surface enhanced Raman scattering Microsphere resonators-WGM Lanthanide ions Optical sensors

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Hypersphere World-Universe Model

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Journal of High Energy physics, Gravitation and Cosmology 2021年第2期7卷 915-941页

作者： vladimir S. Netchitailo Biolase Inc. Irvine CA USA

Dirac’s themes were the unity and beauty of Nature. He identified three revolutions in modern physics: Relativity, Quantum Mechanics and Cosmology. In his opinion: “The new cosmology will probably turn out to be philosophically even more revolutionary than relativity or the quantum theory, perhaps looking forward to the current bonanza in cosmology, where precise observations on some of the most distant objects in the universe are shedding light on the nature of reality, on the nature of matter and on the most advanced quantum theories” [Farmelo, G. (2009) The Strangest Man. The Hidden Life of paul Dirac, Mystic of the Atom. Basic Books, Britain, 661 p]. In 1937, paul Dirac proposed the Large Number Hypothesis and the Hypothesis of the variable gravitational “constant”;and later added the notion of continuous creation of Matter in the World. The developed Hypersphere World-Universe Model (WUM) follows these ideas, albeit introducing a different mechanism of matter creation. In this paper, we show that WUM is a natural continuation of Classical physics and it can already serve as a basis for a New Cosmology proposed by paul Dirac.

关键词： Hypersphere World-Universe Model Law of Conservation of Angular Momentum Dark Epoch Rotational Fission Luminous Epoch Dark Matter particles Macroobject Shell Model Dark Matter Core Medium of the World Dark Matter Fermi Bubbles Galactic Wind Solar Wind Gravitational Bursts Intergalactic plasma Macroobjects Supremacy of Matter Gravitomagnetic parameter Impedance Energy Density Gravitational parameter Hubble’s parameter Temperature of Microwave Background Radiation Inter-Connectivity of primary Cosmological parameters Dark Matter Reactor

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Decisive Role of Gravitational parameter G in Cosmology

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Journal of High Energy physics, Gravitation and Cosmology 2023年第3期9卷 611-625页

作者： vladimir S. Netchitailo Freelancer Livermore USA

In 1937, p. Dirac proposed the Large Number Hypothesis and the Hypothesis of the variable gravitational “constant”, and later added the notion of continuous creation of Matter in the World. The Hypersphere World-Universe Model (WUM) follows these ideas, albeit introducing a different mechanism of Matter creation. In this paper, we show that Gravitational parameter G that can be measured directly makes measurable all Cosmological parameters, which cannot be measured directly.

关键词： World-Universe Model Fundamental physical Constants primary Cosmological parameters Dirac Large Number Intergalactic plasma Medium of the World Age of Universe Maxwell’s Equations

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JWST Discoveries—Confirmation of World-Universe Model predictions

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Journal of High Energy physics, Gravitation and Cosmology 2022年第4期8卷 1134-1154页

作者： vladimir S. Netchitailo Biolase Inc. Cromwell CA USA

In 1937, p. Dirac proposed the Large Number Hypothesis and Hypothesis of Variable Gravitational Constant [1], and later added notion of Continuous Creation of Matter in the World [2]. Developed Hypersphere World-Universe Model (WUM) follows these ideas, albeit introducing different mechanism of Matter creation. Most direct observational evidence of validity of WUM are: 1) Microwave Background Radiation and Intergalactic plasma speak in favor of existence of Medium;2) Laniakea Supercluster with binding mass ~10p>17p>M⊙ is home to Milky Way (MW) galaxy and ~10p>5p> other nearby galaxies, which did not start their movement from Initial Singularity (see Figure 1);3) MW is gravitationally bounded with Virgo Supercluster (VSC) and has Orbital Angular Momentum calculated based on distance of 65 Mly from VSC and orbital speed of ~400 km·sp>-1p>, which far exceeds rotational angular momentum of MW;4) Mass-to-light ratio of VSC is ~300 times larger than that of Solar ratio. Similar ratios are obtained for other superclusters (see Figure 2). These ratios are main arguments in favor of the presence of tremendous amounts of Dark Matter (DM) in the World. JWST discoveries confirm the most important predictions of WUM in 2018: 1) Absolute Age of World is 14.22 Gyr;2) Dark Epoch (spanning for Laniakea Supercluster (LSC) from the Beginning of World for 0.45 Gyr) when only DM Macroobjects (MOs) form and evolve;3) Luminous Epoch (ever since, 13.77 Gyr for LSC) when Luminous MOs (superclusters, galaxies, extrasolar systems, etc.) emerge;4) Transition from Dark Epoch to Luminous Epoch is due to Explosive Rotational Fission of Overspinning (surface speed at equator exceeding escape velocity) DM Supercluster’s Cores and self-annihilation of DM particles (DMps);5) MOs of World form from top (Superclusters) down to Galaxies and Extrasolar systems in parallel around different Cores made up of different DMps;6) 3D Finite Boundless World presents a patchwor

关键词： James Webb Space Telescope World-Universe Model Medium Angular Momentum Dark Matter Dark Epoch Luminous Epoch Rotational Fission patchwork Quilt Early-Galaxies Inter-Connectivity of primary Cosmological parameters

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基于现场试井数据和岩心驱替试验的采油初期渗透率演化规律

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岩土力学 2023年第3期44卷 834-842页

作者： KOZHEVNIKOV V.Evgenii TURBAKOV S.Mikhail RIABOKON p.Evgenii GLADKIKH A.Evgeniy pOpLYGIN V.vladimir GUZEV A.Mikhail 戚承志彼尔姆国立科研理工大学石油和天然气技术系俄罗斯彼尔姆614990 俄罗斯科学院远东分院应用数学研究所俄罗斯符拉迪沃斯托克690041 北京建筑大学土木与交通工程学院中国北京100044

油气开采过程中渗透率预测是一个非常重要的问题。由于油气储量衰竭导致渗透率降低,储层压力下降(有效压力增加),导致油气生产时间增加。对有效压力导致渗透率降低的问题进行了大量研究,主要是通过各种方法建立渗透率模型,如岩心驱替试... 详细信息

油气开采过程中渗透率预测是一个非常重要的问题。由于油气储量衰竭导致渗透率降低,储层压力下降(有效压力增加),导致油气生产时间增加。对有效压力导致渗透率降低的问题进行了大量研究,主要是通过各种方法建立渗透率模型,如岩心驱替试验和现场试井。前期研究结果表明,渗透率对有效压力具有幂律或指数依赖性,然而,预测渗透率的困难在于滞后现象,其原因尚不完全清楚。一些学者利用储层力学模型模拟渗透率以及解释滞后的原因,但该模型在油气生产初期有效压力波动较小时并不适用。在这项工作中,分析perm地区北部一个油田的试井数据得出:生产初期的储层渗透率很大程度上取决于流体产出量。基于陆相储层的试井数据,得到一个描述采油初期渗透率变化的模型。为验证该模型,根据专门开发的程序对陆相储层样品进行岩心驱替试验。岩心驱替结果表明,从试井数据中获得的模型具有高收敛性。利用计算机断层扫描(computed tomography,简称CT)和扫描电镜(scanning electron microscope,简称SEM)研究岩心孔隙的属性和结构,发现天然胶体的迁移是生产初期低黏土岩石渗透率下降的主要原因。

关键词：渗透率渗透率滞后胶体迁移岩心驱替多孔介质

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