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Unfoldomics of prostate cancer： on the abundance and roles of intrinsically disordered proteins in prostate cancer

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Asian Journal of Andrology 2016年第5期18卷 662-672页

作者： Kevin S Landau Insung na Ryan O Schenck vladimir n.uversky DepartmentofMolecularMedicine MorsaniCollegeofMedicineUniversityofSouthFloridaTampaFL33612USA USFHealthByrdAlzheimer'sResearchInstitute MorsaniCollegeofMedicineUniversityofSouthFloridaTampaFlorida33612USA LaboratoryofStructuralDynamics StabilityandFoldingofProteinsInstituteofCytologyRussianAcademyofSciencesStPetersburgRussia

Prostatic diseases such as prostate cancer and benign prostatic hyperplasia are highly prevalent among men. The number of studies focused on the abundance and roles of intrinsically disordered proteins in prostate cancer is rather limited. The goal of this study is to analyze the prevalence and degree of disorder in proteins that were previously associated with the prostate cancer pathogenesis and to compare these proteins to the entire human proteome. The analysis of these datasets provides means for drawing conclusions on the roles of disordered proteins in this common male disease. We also hope that the results of our analysis can potentially lead to future experimental studies of these proteins to find novel pathways associated with this disease.

关键词： intrinsical ly disordered proteins posttranslational mod ifications prostate cancer protein-protein interaction proteomics proteome unfoldome

High-level intrinsic disorder explains the universality of CLIP binding to diverse MHC class II variants

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Cellular & Molecular Immunology 2018年第1期15卷 76-78页

作者： vladimir n.uversky Yaping n Tu Onyekachi nwogu Shanitra n Butler Michael Ramsamooj George Blanck Department of Molecular Medicine Morsani College of MedicineUniversity of South Floridaand Immunology ProgramTampaFLUSA H.Lee Moffitt Cancer Center and Research Institute TampaFLUSA

MHC class I and II molecules bind peptides that are either recognized as self or as foreign to the immune system via interaction with T-cell *** T-cell receptor makes molecular contacts with the peptide and the MHC molecule in the region of the MHC peptide binding *** MHC class I and II molecules are highly polymorphic,which presumably allows for great diversity of antigen-binding sites over the population,leading to a species that is relatively fit to withstand foreign *** MHC class I molecules,this allelic variation predicts extensive variation in the sequence of peptides able to bind MHC class I molecules,and this is indeed the case.

关键词： explain class intrinsic

Study of asphaltene reaggregation in toluene/heptane mixture by dynamic and static light scattering

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Petroleum Research 2024年第1期9卷 48-54页

作者： vladimir n.Kuryakov Oil and Gas Research Institute of RAS(OGRI RAS) Gubkina Str.3119333MoscowRussian Federation

This paper presents the study of the effect of multiple ultrasonic impacts on submicron asphaltene aggregates in a toluene/heptane solution,conducted with dynamic light scattering *** objects of the study were four samples of asphaltenes obtained from four different *** all samples,the change in the average size of the asphaltene submicron aggregates with time was measured after the addition of a precipitant(heptane)to a solution of asphaltenes in toluene at an amount above the threshold *** aggregates formed in solution after the addition of the precipitant and were subjected to ultrasonic treatment,which led to the destruction of the asphaltene *** of destroyed asphaltenes was *** kinetics of this aggregation were similar to the kinetics of aggregation of asphaltenes after the addition of a *** iterations of asphaltene aggregate destruction in the sample led to a significant change in the kinetics of aggregation:the growth of aggregates slowed and stabilized at a size of approximately 200 nm and 30 nm for the different studied samples.

关键词： Asphaltenes Aggregation Sonication Dynamic light scattering Re-aggregation Colloidal stability Resins

A new Mantispid-Like Species of Rhachiberothinae (neuroptera:Berothidae) from Baltic Amber,with a Critical Review of the Fossil Record of the Subfamily

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 655-664页

作者： vladimir n.MAKARKIn Janusz KUPRYJAnOWICZ Institute of Biology and Soil Sciences Far Eastern Branch of the Russian Academy of SciencesVladivostokRussia Institute of Biology University of BialystokBialystokPoland Museum of the Earth the Polish Academy of SciencesWarsawPoland

Whalfera wiszniewskii sp. nov. is described from the Late Eocene Baltic amber. The genus Whalfera is considered as the only fossil genus confidently assigned to the Rhachiberothinae. Others previously placed in this subfamily belong to Paraberothinae （except perhaps for Oisea）. The Late Eocene/present Rhachiberothinae and the Cretaceous Paraberothinae are considered to be the subfamilies of Berothidae.

关键词： neuroptera Berothidae Rhachiberothinae Paraberothinae Mantispidae Symphrasinae

Image potential states mediated STM imaging of cobalt phthalocyanine on naCl/Cu(100)

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Chinese Physics B 2016年第3期25卷 314-318页

作者：郭秦敏秦志辉黄敏 vladimir n.Mantsevich 曹更玉 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of Sciences Faculty of Physics Moscow State University

The adsorption and electronic properties of isolated cobalt phthalocyanine （CoPc） molecule on an ultrathin layer of naC1 have been investigated. High-resolution STM images give a detailed picture of the lowest unoccupied molecular orbital （LUMO） of an isolated CoPc. It is shown that the naC1 ultrathin layer efficiently decouples the interaction of the molecules from the underneath metal substrate, which makes it an ideal substrate for studying the properties of single molecules. Moreover, strong dependence of the appearance of the molecules on the sample bias in the region of relatively high bias （〉 3.1 V） is ascribed to the image potential states （IPSs） of naCI/Cu（100）, which may provide us with a possible method to fabricate quantum storage devices.

关键词： image potential states naC1 ultrathin layer CoPc scanning tunneling microscopy

Role of the Rossiter-McLaughlin effect in the study of close binaries

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Research in Astronomy and Astrophysics 2019年第3期19卷 21-30页

作者： Galina n.Dryomova vladimir V.Dryomov Russian Federal nuclear Centre

This paper is devoted to binary stars belonging to the class of eclipsing-variable *** and spectroscopic analysis of eclipses allows us to determine geometric parameters of the orbit and physical characteristics of stellar components as well as inclinations of stellar equators to the orbital plane. Estimations of inclinations can be obtained from measurement of the Rossiter-McLaughlin effect, which is discussed using examples of some eccentric binaries with an anomalous apsidal effect. Our task is to find the complete spectrum of solutions of the equation of apsidal motion, depending on the inclinations of the polar axes of the components to the orbital one for these systems, based on their individual spectroscopic and photometric observational data. The matrix of solutions allows us to select those pairs of polar inclinations that provide agreement with the observational apsidal period.

关键词： Rossiter-McLaughlin effect: eclipsing-variable stars apsidal effect individual binaries: AI Hya,nY Cep,EW Ori,DI Her,AS Cam

Relaxation of Mechanical Stress in Poly(vinyl alcohol) Cryogels of Different Compositions

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Chinese Journal of Polymer Science 2023年第3期41卷 442-447,I0010页

作者： vladimir n.Manzhai Maria S.Fufaeva Ekaterina S.Kashlach Institute of Petroleum Chemistry of the Siberian Branch of the Russian Academy of Sciences Tomsk 634055Russia

The study presents the experimental results of measurements of the relaxation time of cryogels formed from various colloid-dispersed systems based on a poly(vinyl alcohol) aqueous *** is shown that the value of relaxation time,which characterizes the relationship between the viscosity and elasticity of real bodies,describes the rheological properties of materials more objectively than the traditional assessment of their physical and mechanical characteristics only by the elasticity modulus of the samples.

关键词： Cryogel Relaxation processes Viscoelasticity Rheological properties

Role of Electromagnetic Fluctuations in Organic Electronics

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Journal of Electronic Science and Technology 2020年第1期18卷 52-58页

作者： vladimir M.Mostepanenko Elena n.Velichko Maksim Aleksandrovich Baranov Institute of Physics Nanotechnology and TelecommunicationsPeter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 Central Astronomical Observatory at Pulkovo of Russian Academy of Sciences St.Petersburg 196140

Thin organic films find expanding applications in electronic and optoelectronic devices, biotechnology,food packing, and for many other purposes. Among other factors, the stability of films with a thickness below a micrometer is determined by the zero-point and thermal fluctuations of the electromagnetic field. These fluctuations result in the van der Waals and Casimir free energy and forces between a film and a substrate. The fluctuationinduced force may be both attractive and repulsive making the film either more or less stable, respectively. Here, we review recently obtained results for the Casimir free energy of both freestanding and deposited on the metallic and dielectric substrates peptide films. We also perform computations for the free energy of the peptide films deposited on a silica glass substrate in the region of parameters where this free energy vanishes. Possible applications of the obtained results are discussed.

关键词： Casimir free energy organic electronics peptide film

Analytical solution for a strong free-surface water vortex describing flow in a full-scale gravitational vortex hydropower system

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Water Science and Engineering 2021年第1期14卷 72-79页

作者： vladimir Joel Alzamora Guzman Julie Anne Glasscock Energy Research Group Kadagaya Research Centre for Appropriate TechnologyJunin 12866Peru

Strong free-surface water vortices are found throughout industrial hydraulic systems used for water treatment,flow regulation,and energy *** models using the volumetric flow rate as a model input have generally been semi-empirical,and have tended to have some limitations in terms of the design of practical hydropower *** this study,an analytical model of a strong free-surface water vortex was *** model only requires the water head and geometric parameters as its inputs and calculates the maximum volumetric flow rate,aircore diameter,and rotational *** experimental depthedischarge data from a full-scale gravitational vortex hydropower system,unavailable in the relevant literature,were obtained,and the simulated results showed excellent agreement with the experimental *** data could be used to verify similar models using laboratory-scale physical models in order to investigate the scaling *** contrast to previous models,this model does not assume a constant average velocity across the vortex radius and allows precise calculation of the resultant velocity ***,this model presents advantages in turbine design for energy generation systems.

关键词： Gravitational vortex Velocity measurements Scalability Analytical model Microhydropower