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Outcomes of long-acting injectable antipsychotics use in pregnancy:A literature review

World Journal of Psychiatry 2024年第4期14卷 582-599页

作者： Ana V Pejčić srdjan M stefanović MilošN Milosavljević vladimir s Janjić Marko M Folić Nevena D Folić Jovana Z Milosavljević Department of Pharmacology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pharmacy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Clinical Pharmacology University Clinical Center KragujevacKragujevac 34000Serbia Department of Psychiatry Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for Psychiatry University Clinical Center KragujevacKragujevac 34000Serbia Center for Pharmaceutical and Pharmacological Research Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Department of Pediatrics Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatric Clinic University Clinical Center KragujevacKragujevac 34000Serbia Department of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGROUND Women with a history of serious psychotic disorders are at increased risk of disease relapse during ***-acting injectable(LAI)antipsychotics have been widely used to improve adherence and prevent relapse in patients with various severe psychotic disorders,but there is a lack of high-quality data from previous research on the safety of LAI antipsychotics during *** To summarize relevant data on maternal,pregnancy,neonatal,and developmental outcomes from published cases of LAI antipsychotic use in *** A literature search was performed through November 11,2023,using three online databases:PubMed/MEDLINE,scopus,and Web of *** reports or case series that reported information about the outcomes of pregnancy in women who used LAI antipsychotics at any point in pregnancy,with available full texts,were *** statistics,narrative summation,and tabulation of the extracted data were *** A total of 19 publications satisfied the inclusion criteria:3 case series,15 case reports,and 1 conference *** reported the outcomes of LAI antipsychotic use in 74 women and 77 *** use of secondgeneration LAI antipsychotics was reported in the majority(n=47;61.0%)of ***-generation LAI antipsychotics were administered during 30 pregnancies(39.0%).Most of the women(approximately 64%)had either satisfactory control of symptoms or no information about relapse,while approximately 12%of them had developed gestational diabetes mellitus.A minority of cases reported adverse outcomes such as stillbirth,spontaneous abortion,preterm birth,low birth weight,congenital anomalies,and neurological manifestations in ***,there were no reports of negative long-term developmental *** Currently available data seem reassuring,but further well-designed studies are required to properly evaluate the risks and benefits of LAI antipsychotic use during pregnancy.

关键词： Antipsychotic agents Long-acting injectable Pregnancy Outcome Review

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Elucidating elusive quaternary selenide EuCeCuse3:synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim s.Molokeev vladimir A.Chernyshev Aleksandr s.Aleksandrovsky Alexander s.Krylov svetlana N.Krylova Nikolai P.shestakov Dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas schleid Damir A.safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuse3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuse3with excellent yield(96.7%)accompanied with a minor fraction of Cese2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCus3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuse3(RE=La,Pr,Nd,sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCus3structural *** distortion of the Cuse4polyhedron was compared for the whole series of EuRECuse3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides srCeCus3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuse3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuse3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuse3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide synthesis Crystal structure Ab initio calculations Magnetic measurements spectroscopy

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selection of shaped charges parameters for producing aluminum particles with velocities in the range of 2.5-16 km/s

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Defence Technology（防务技术） 2024年第8期38卷 126-135页

作者： vladimir I.Kolpakov sergey V.Fedorov Ekaterina P.Vinogradova Irina A.Bolotina Bauman Moscow state Technical University Moscow 105005Russia

Testing rocket and space technology objects in ground conditions for resistance to the impact of meteoroids and fragments of space debris can be carried out using shaped charges. To substantiate the design parameters of shaped charges that ensure the formation of aluminum particles in a wide velocity range(from 2.5 to 16 km/s), numerical modeling of the formation process was carried out within the framework of a two-dimensional axisymmetric problem of continuum mechanics using three different computing codes to increase the reliability of the results. The calculations consider shaped charges with a diameter of 20-100 mm with aluminum liners of various shapes. It is shown that the formation of particles with velocities close to the lower limit of the considered range is ensured by gently sloping segmental liners of degressive thickness. To form higher-velocity particles with velocities over 5 km/s, it is proposed to use combined liners, the jet-forming part of which has the shape of a hemisphere of constant thickness or the shape of a semi-ellipsoid or semi-superellipsoid of rotation of degressive thickness.

关键词： space debris Meteoric impact Explosion shaped charge High-velocity aluminum element segmental liner Combined liner Numerical simulation

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Moderate Fields, Maximum Potential: Achieving High Records with Temperature‑stable Energy storage in Lead‑Free BNT‑Based Ceramics

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Nano-Micro Letters 2024年第5期16卷 184-200页

作者： Wenjing shi Leiyang Zhang Ruiyi Jing Yunyao Huang Fukang Chen vladimir shur Xiaoyong Wei Gang Liu Hongliang Du Li Jin Electronic Materials Research Laboratory Key Laboratory of the Ministry of EducationSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China school of Materials and Energy Southwest UniversityChongqing 400715People’s Republic of China school of Natural sciences and Mathematics Ural Federal UniversityEkaterinburg 620000Russia Multifunctional Electronic Ceramics Laboratory College of EngineeringXi’an International UniversityXi’an 710077People’s Republic of China

The increasing awareness of environmental concerns has prompted a surge in the exploration of leadfree,high-power ceramic *** efforts to develop leadfree dielectric ceramics with exceptional energystorage performance(EsP)have predominantly relied on multicomponent composite strategies,often accomplished under ultrahigh electric ***,this approach poses challenges in insulation and system downsizing due to the necessary working voltage under such *** extensive study,bulk ceramics of(Bi_(0.5)Na_(0.5))TiO_(3)(BNT),a prominent lead-free dielectric ceramic family,have seldom achieved a recoverable energy-storage(Es)density(Wrec)exceeding 7 J cm^(−3).This study introduces a novel approach to attain ceramic capacitors with high EsP under moderate electric fields by regulating permittivity based on a linear dielectric model,enhancing insulation quality,and engineering domain structures through chemical formula *** incorporation of srTiO_(3)(sT)into the BNT matrix is revealed to reduce the dielectric constant,while the addition of Bi(Mg_(2/3)Nb_(1/3))O_(3)(BMN)aids in maintaining ***,the study elucidates the methodology to achieve high EsP at moderate electric fields ranging from 300 to 500 kV cm^(−1).In our optimized composition,0.5(Bi_(0.5)Na_(0.4)K_(0.1))TiO_(3)–0.5(2/3sT-1/3BMN)(B-0.5sB)ceramics,we achieved a Wrec of 7.19 J cm^(−3) with an efficiency of 93.8%at 460 kV cm^(−1).Impressively,the B-0.5sB ceramics exhibit remarkable thermal stability between 30 and 140℃ under 365 kV cm^(−1),maintaining a Wrec exceeding 5 J cm^(−3).This study not only establishes the B-0.5sB ceramics as promising candidates for Es materials but also demonstrates the feasibility of optimizing EsP by modifying the dielectric constant under specific electric field ***,it provides valuable insights for the future design of ceramic capacitors with high EsP under constraints of limited electric field.

关键词： BNT Energy storage Lead-free Relaxor ferroelectrics Capacitors

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Determination of Thermal Properties of Unsmooth si Nanowires

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Chinese Physics Letters 2024年第1期41卷 51-56页

作者：刘世贤 Alexander A.Barinov 訚菲 vladimir I.Khvesyuk Department of Thermophysics Bauman Moscow State Technical UniversityMoscow 105005Russian Federation

We estimate the thermal properties of unsmooth si nanowires,considering key factors such as size(diameter),surface texture(roughness)and quantum size effects(phonon states)at different *** nanowires with a diameter of less than 20 nm,we highlight the importance of quantum size effects in heat capacity calculations,using dispersion relations derived from the modified frequency equation for the elasticity of a *** thermal conductivities of nanowires with diameters of 37,56,and 115nm are predicted using the Fuchs–sondheimer model and soffer’s specular ***,the roughness parameters are chosen to reflect the technological characteristics of the real *** findings reveal that surface texture plays a significant role in thermal conductivity,particularly in the realm of ballistic heat transfer within *** study provides practical recommendations for developing new thermal management materials.

关键词： nanowires roughness size

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An Integrated Bipolar Picture Fuzzy Decision Driven system to scrutinize Food Waste Treatment Technology through Assorted Factor Analysis

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Computer Modeling in Engineering & sciences 2024年第9期140卷 2665-2687页

作者： Navaneethakrishnan suganthi Keerthana Devi samayan Narayanamoorthy Thirumalai Nallasivan Parthasarathy Chakkarapani sumathi Thilagasree Dragan Pamucar vladimir simic Hasan Dinçer serhat Yüksel Department of Mathematics Bharathiar UniversityCoimbatore641046India Department of Mathematics Sri Ramakrishna Mission Vidyalaya College of Arts and ScienceCoimbatore641020India Department of Operations Research and statistics Faculty of Organizational SciencesUniversity of BelgradeBelgrade11000Serbia College of Engineering Department of Industrial Engineering and ManagementYuan Ze UniversityTaoyuan City320315TaiwanChina Faculty of Transport and Traffic Engineering University of BelgradeVojvode Stepe 305Belgrade11000Serbia Department of Computer science and Engineering College of InformaticsKorea UniversitySeoul02841Republic of Korea school of Business Istanbul Medipol UniversityIstanbul34083Turkey Department of Economics and Management Khazar UniversityBakuAzerbaijan

Food Waste(FW)is a pressing environmental concern that affects every country *** one-third of the food that is produced ends up as waste,contributing to the carbon ***,the FW must be properly treated to reduce environmental *** study evaluates a few available Food Waste Treatment(FWT)technologies,such as anaerobic digestion,composting,landfill,and incineration,which are widely used.A Bipolar Picture Fuzzy set(BPFs)is proposed to deal with the ambiguity and uncertainty that arise when converting a real-world problem to a mathematical model.A novel Criteria Importance Through Intercriteria Correlation-stable Preference Ordering Towards Ideal solution(CRITIC-sPOTIs)approach is developed to objectively analyze FWT selection based on thirteen criteria covering the industry’s technical,environmental,and entrepreneurial *** CRITIC method is used for the objective analysis of the importance of each criterion in FWT *** sPOTIs method is adopted to rank the alternative hassle-free,following the *** proposed model offers a rank reversal-free model,i.e.,the rank of the alternatives remains unaffected even after the addition or removal of an *** addition,comparative and sensitivity analyses are performed to ensure the reliability and robustness of the proposed model and to validate the proposed result.

关键词： Fuzzy food waste treatment selection bipolar picture fuzzy set and decision-making

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A review of solid-state lithium metal batteries through in-situ solidification

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science China Chemistry 2024年第1期67卷 67-86页

作者： Pan Xu Zong-Yao shuang Chen-Zi Zhao Xue Li Li-Zhen Fan Aibing Chen Haoting Chen Elena Kuzmina Elena Karaseva vladimir Kolosnitsyn Xiaoyuan Zeng Peng Dong Yingjie Zhang Mingpei Wang Qiang Zhang Beijing Key Laboratory of Green Chemical Reaction Engineering and Technology Department of Chemical EngineeringTsinghua UniversityBeijing 100084China National and Local Joint Engineering Laboratory for Lithium-ion Batteries and Materials Preparation Technology Key Laboratory of Advanced Battery Materials of Yunnan ProvinceFaculty of Metallurgical and Energy EngineeringKunming University of Science and TechnologyKunming 650093China Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China College of Chemical and Pharmaceutical Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Ordos Carbon Neutral Research and Application Co. Ltd.Ordos City 017010China Ufa Institute of Chemistry UFRC RAs Ufa 450054Russia Institute for Carbon Neutrality Tsinghua UniversityBeijing 100084China shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan 030032China

High-energy-density lithium metal batteries are the next-generation battery systems of choice,and replacing the flammable liquid electrolyte with a polymer solid-state electrolyte is a prominent conduct towards realizing the goal of high-safety and high-specific-energy ***,the inherent intractable problems of poor solid-solid contacts between the electrode/electrolyte and the growth of Li dendrites hinder their practical *** in-situ solidification has demonstrated a variety of advantages in the application of polymer electrolytes and artificial interphase,including the design of integrated polymer electrolytes and asymmetric polymer electrolytes to enhance the compatibility of solid–solid contact and compatibility between various electrolytes,and the construction of artificial interphase between the Li anode and cathode to suppress the formation of Li dendrites and to enhance the high-voltage stability of polymer *** review firstly elaborates the history of in-situ solidification for solid-state batteries,and then focuses on the synthetic methods of solidified ***,the recent progress of in-situ solidification technology from both the design of polymer electrolytes and the construction of artificial interphase is summarized,and the importance of in-situ solidification technology in enhancing safety is ***,prospects,emerging challenges,and practical applications of in-situ solidification are envisioned.

关键词： in-situ solidification polymer electrolyte artificial solid electrolyte interphase rechargeable lithium metal batteries dendrite-free lithium metal anode

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Contribution to the Characterization of Laterites Developed on Granitic Rock in Mbanga (Littoral-Cameroon): significance in the sustainable Pavements Design

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Journal of Geoscience and Environment Protection 2024年第3期12卷 181-191页

作者： Willy Chance Guimezap Kenou vladimir Willianov Keubou Tatapzia Bertile Ilalie Manefouet Institut Universitaire de la cô te P&#244le de Recherche de l&#8217Inovation et de l&#8217Entreprenariat (PRIE) Douala Cameroun Faculty of sciences University of Dschang Dschang Cameroon

The materials studied were lateritic soils from souza-Mbanga-Cameroon, with a view to their better use in road geotechnics. In order to achieve the set objective, the work was carried out in two phases, firstly in the field, to provide a morpho-structural description of the soil profiles, followed by a laboratory phase to analyse the samples collected in the field. The results of the physical characterisation of the soil samples show that, for average values, the water content is 9.87%, the percentage of fines 48%, the plasticity index 21.6%, the liquidity limit 50.91%, and the consistency index 1.97. These soils are classified as silty sands in the LCPC classification and as fine soils in the GTR classification. The average value of the maximum dry density is 1.81 g/cmsup>3sup> and that of the water content at the modified Proctor optimum is 16.24%. The CBR index is between 1.8% and 17.8%, showing that these soils belong to classes s1, s2, s3, s4 and s5. souza-Mbanga lateritic soils can be used in their natural state as subgrades.

关键词： soils souza-Mbanga Characterisation CBR

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Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

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World Journal of Hepatology 2024年第5期16卷 822-831页

作者： Irina Efremova Roman Maslennikov Elena Poluektova Oleg Medvedev Anna Kudryavtseva George Krasnov Maria Fedorova Filipp Romanikhin Maria Zharkova Oxana Zolnikova Gyunay Bagieva vladimir Ivashkin Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Department of scientific Scientific Community for the Promotion of the Clinical Study of the Human MicrobiomeMoscow 119435Russia Department of Pharmacology Lomonosov Moscow State UniversityMoscow 119192Russia Department of Post-Genomic Research Laboratory Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

BACKGROUND The gut–liver axis and bacterial translocation are important in cirrhosis,but there is no available universal biomarker of cellular bacterial translocation,for which presepsin may be a *** To evaluate the relationship of the blood presepsin levels with the state of the gut microbiota in cirrhosis in the absence of obvious *** This study included 48 patients with Child–Pugh cirrhosis classes B and C and 15 healthy *** fecal microbiome was assessed using 16s rRNA gene *** levels of presepsin were measured.A total of 22 patients received a probiotic(saccharomyces boulardii)for 3 *** Presepsin levels were higher in patients with cirrhosis than in healthy individuals[342(91-2875)vs 120(102-141)pg/mL;P=0.048].Patients with elevated presepsin levels accounted for 56.3%of all included *** had lower levels of serum albumin and higher levels of serum total bilirubin and overall severity of cirrhosis as assessed using the Child–Pugh *** with elevated presepsin levels had an increased abundance of the main taxa responsible for bacterial translocation,namely Bacilli and Proteobacteria(including the main class Gammaproteobacteria and the minor taxa Xanthobacteraceae and stenotrophomonas),and a low abundance of bacteria from the family Lachnospiraceae(including the minor genus Fusicatenibacter),which produce short-chain fatty acids that have a positive effect on intestinal barrier *** presepsin level directly correlated with the relative abundance of Bacilli,Proteobacteria,and inversely correlated with the abundance of Lachnospiraceae and *** 3 months of taking the probiotic,the severity of cirrhosis on the Child–Pugh scale decreased significantly only in the group with elevated presepsin levels[from 9(8-11)to 7(6-9);P=0.004],while there were no significant changes in the group with normal presepsin levels[from 8(7-8)to 7(6-8);P=0.123].A high level of presepsin

关键词： Dysbiosis Gut Intestinal permeability Leaky gut Gut-liver axis Liver Microbiota

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Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

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Acta Pharmaceutica sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay s.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.s.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products sesterterpenoids synthetic biology Terpene synthases Variecolin

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