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Atherosclerotic Descending Aortic Aneurysms. Pros and Cons of Surgery

World Journal of Cardiovascular Surgery 2015年第9期5卷 91-101页

作者： vladimir petrovich krylov Leonid petrovich Titov Valentina Nikolaevna Gaiduk Leonid Ivanovich Reut Аleksey Leonidovich Smaliakou Nadezhda vladimirovna Mankevich Republican Scientific and Practical Centre “Cardiology” Ministry of Health of Belarus Minsk Belarus Republican Scientific and Practical Centre “Epidemiology and Microbiology” Ministry of Health of Belarus Minsk Belarus

Within the last few years, there has been a strong trend to rethink the issue of management of atherosclerotic descending thoracic and abdominal aortic aneurysms (AAAs). When etiopathogenetic associations among changes observed during the progression of the disease were not fully described, surgeons had successfully applied, although traumatic, but a rather radical method to rescue from the rupture threat. As we gained experience and knowledge about long-term outcomes, mostly concerned mortality, we realized that surgery could not be the main tactical approach to AAAs treatment due to its frequent inefficiency and failure to guarantee that the disease would be suppressed including co-morbidities, polymorphic processes and clinical manifestations. It all required more sparing treatment strategies. The situation gave rise to a more argumentative and sparing medical-and-surgical approach to treatment based on a more in-depth understanding of the etiopathogenesis of the disease whereas surgery would remain of prime importance when appropriate. The following has been developed to improve treatment outcomes for AAA: 1) Multifactorial determination of indications for surgical correction with outlining the area of relative and absolute risk of aneurysm rupture;2) Method of conservative treatment aimed to attain and maintain optimal blood pressure, target levels of cholesterol and low-density lipoproteins, as well as reduce oxidative and inflammatory processes in aorta, strengthen its wall, stabilize the disease and control co-morbidities. A four-year follow-up of patients using this developed technology has yielded more preferred results suggesting the need for narrowing indications for surgery to treat AAAs. Another advantage of the sparing approach to treat AAA is economic, due to fewer operations and implantations of stent-grafts, considering the fact that medical treatment should be used in operated subjects, too.

关键词： Aneurysms Descending Thoracic and Abdominal Aorta Indications for Surgery Surgical Conservative Treatment

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Can We Change a Look at Atherosclerotic Aortic Aneurism Treatment?

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Health 2014年第12期6卷 1345-1351页

作者： vladimir petrovich krylov Аlexander Gennadyevich Mrochek Leonid petrovich Titov Valentina Nikolaevna Gaiduk Leonid Ivanovich Reut Аleksey Leonidovich Smaliakou Republican Scientific and Practical Centre “Cardiology” Ministry of Health of Belarus Minsk Belarus Republican Scientific and Practical Centre “Cardiology” Ministry of Health of Belarus Minsk Belarus Republican Scientific and Practical Centre “Epidemiology and Microbiology” Ministry of Health of Belarus Minsk Belarus

In recent years, the increasing number of cardiologists and cardiac surgeons tend to think that surgical treatment of patients with atherosclerotic aneurisms does not fully comply with contemporary ideas of what the disease is. Some data show that early operations in the presence of this pathology are associated with an unreasonably high mortality. Additionally, the use of intra-aortic stents and grafts cannot principally affect the therapeutic efficacy. Therefore, more attention is paid to the development of conservative therapeutic approaches leaving surgery defeated without surgical treatment. Two groups of patients with similar descending thoracic aortic atherosclerotic aneurisms (DTAAA) and abdominal aortic aneurisms (AAA) were retro- and prospectively studied over a 2-year period. Control group (Comparison group), (63 patients) received common surgical treatment from 2009 to 2010 whereas Main group (121 subjects) received multifaceted medical treatment to remove inflammatory reactions, strengthen aortic wall and control its dilation from 2011 to 2012. Operative treatment was used only in case of potential aneurism rupture. The comparison of the two groups of subjects showed that 2-year all-cause mortality in control group was 20.6% while in the main group it amounted to 9.1% due to the similar incidence of aneurism ruptures and deaths associated with concomitant diseases. It suggests that the odds ratio (OR) of survival when using attenuated therapeutic approach to treating atherosclerotic aneurisms is 2.6-fold higher compared to conventional surgical approach. One of the principal factors contributing to a higher mortality when using traditional surgical approach was the presence of polyorgan pathology that required constant medical correction irrespective of therapeutic option (surgical or medical) used. Another important factor is aortic aneurism wall frailty. The development of mechanisms that would allow its strengthening is considered a principal challen

关键词： Atherosclerotic Aortic Aneurisms Surgical and Conservative Treatment

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A Five-Year Experience of Sparing Treatment of Descending Aortic Atherosclerotic Aneurysms

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World Journal of Cardiovascular Surgery 2016年第4期6卷 47-54页

作者： vladimir petrovich krylov Alexander Gennadyevich Mrochek Valentina Nukolaevna Gayduk Leonid Ivanovich Reut Aleksey Leonidovich Smaliakou Nadezhda vladimirovna Mankevich Roman Nikolaevich Pizhik Republican Research and Practical Centre “Cardiology” Ministry of Health of the Republic of Belarus Minsk Belarus

A growing number of specialists are now beginning to ascertain that treatment of individuals with descending aortic atherosclerotic aneurysms must be provided by cardiologists on a scheduled basis. Surgery is feasible when there is a risk of aneurysm rupture. It requires for the development of conservative treatments and elaboration of indications for surgery. A total of 97 patients with thoracic aortic atherosclerotic aneurysms (TAAA) and abdominal aortic aneurysms (AAA) have been examined over a 5-year period. They received multifaceted anti-inflammatory medical treatment to strengthen the aortic wall and control its possible expansion. Operative treatment was offered only if there was a risk of aneurysm rupture. One of the principal factors adversely affecting mortality is the presence of co-morbidities requiring permanent medical corrective treatment irrespective of surgical or medical treatment provided. It is also important to outline the indications for surgery based on multifactorial pathogenetic manifestations. Treatment aiming at the reversal of ethiopathogenic mechanisms of disease progression contributes to a significant longer survival in DAA patients.

关键词： Aortic Atherosclerotic Aneurysms Surgical Treatment Conservative Treatment Outcomes

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Long-Term Results (Seven and More Years) of Sparing Treatment of Subjects with Descending Aortic Aneurysms

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Health 2019年第6期11卷 661-670页

作者： vladimir petrovich krylov Dmitry Evgeniyevich Shevtsov Gennadiy Adolfovich Popel Valentina Nikolaevna Gayduk Leonid Ivanovich Reut Aleksey Leonidovich Smaliakou Nadezhda vladimirovna Mankevich Republican Research and Practical Centre of Cardiology Minsk Belarus Belarusian Association of Physicians Ministry of Health of Belarus Minsk Belarus

Descending aortic aneurysms (DAAs), including dissecting aneurysms (DA) have a multifactorial etiology and pathogenesis, therefore raising questions about the leading role of operative treatment to repair the lesion. Objective: To investigate remote (7 and more years) results of treatment in patients with DAAs in operative treatment only if there is a danger of aneurysm rupture. A total of 82 patients with atherosclerotic DAA identified between 2008 and 2011, and 22 patients with type 1 or 3 DeBakey dissecting aneurysms (DA) who had not been operated in the acute period due to a number of reasons were examined. The follow-up period of these groups was 7 or more years. When using a sparing treatment to treat DAA, we saw survival of 90.1 at 2 years, 76.8% at 4 years, 59.4% at 6 years, and 57.5% at 7 years with the uniform increase in mortality rate, mainly due to a comorbidity. Survival in DA group (77.3%) was better due to a younger age and was 68.4% in operated and 54% in non-operated patients at 7 years. It is symptomatic that the aneurysm rupture rate was not always affected by operative treatment. Therefore, it seems like medical treatment is more consistent with etiopathogenesis of the disease compared to surgery during the stabilization period.

关键词： Descending Aortic Aneurysms Medical and Surgical Treatment 7-Year Treatment Results Survival

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The Role of Atherosclerosis and Inflammation in the Development of Descending Aortic Aneurysms: Special Aspects of Medical Correction

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Health 2016年第13期8卷 1335-1348页

作者： vladimir petrovich krylov Nikolay Andreevich Mana Leonid petrovich Titov Valentina Nikolaevna Gayduk Leonid Ivanovich Reut Nadezhda vladimirovna Mankevich Alexander Stanislavovich Zhigalcovitch Aleksey Leonidovich Smolyakou Gennady Adolfovich Popel Roman Nikolaevich Pyzhyk Republican Scientific and Practical Centre “Cardiology” Ministry of Health of Belarus Minsk Belarus Republican Scientific and Practical Centre “Epidemiology and Microbiology” Ministry of Health of Belarus Minsk Belarus Belarusian Medical Academy of Post-Graduate Education Minsk Belarus

Modern medicine has achieved much progress in the field of medical and surgical repair of a variety of disorders. It is especially true for the early stages of treatments. In long-term period, however, instead of recovery, we frequently observe progressive regression, which completely annuls all our efforts. Moreover, the algorithm used to correct acute process may sometimes be detrimental to organs and tissues. Such situation is also frequent in the treatment of atherosclerotic descending aortic aneurysms (DAA). This is because the successful medical and even surgical repair to prevent aneurysm rupture in long-term period may trigger some detrimental processes in other regions thus producing negative results of the treatment. The present article doesn’t aim to prove some provisions in DAA clinical picture, atherosclerosis and inflammatory states. But we have faced some systematicity at these clinical implications which are absolutely not specified in literature. We have managed to find an explanation for this thing making a scrupulous analysis of nonsurgical sources. Comparing them with our observations, we have found out that aseptic and septic inflammation of connective tissue, probably, is a key component in the formation of DAA disregarding of which correction of dyslipidemia may lead to negative results. We are looking for in-depth research and discussion.

关键词： Aneurism Formation Atherosclerosis and Inflammation Aortic Aneurisms

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Physico−mathematical model of the voltage−current characteristics of light-emitting diodes with quantum wells based on the Sah−Noyce−Shockley recombination mechanism

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Journal of Semiconductors 2024年第8期45卷 25-33页

作者： Fedor I.Manyakhin Dmitry O.Varlamov vladimir P.krylov Lyudmila O.Morketsova Arkady A.Skvortsov vladimir K.Nikolaev Dinamics Strength of Machines and Resisance of MaterialsMoscow Polytechnic UniversityRussia Biomedical and Electronic Means and Technologies Vladimir State UniversityRussia Computer-Aided Design and Engineering National University of Science and Technology"MISiS"Russia

Herein,a physical and mathematical model of the voltage−current characteristics of a p−n heterostructure with quantum wells(QWs)is prepared using the Sah−Noyce−Shockley(SNS)recombination mechanism to show the SNS recombination rate of the correction function of the distribution of QWs in the space charge region of diode configuration.A comparison of the model voltage−current characteristics(VCCs)with the experimental ones reveals their *** technological parameters of the structure of the VCC model are determined experimentally using a nondestructive capacitive approach for determining the impurity distribution profile in the active region of the diode structure with a profile depth resolution of up to 10Å.The correction function in the expression of the recombination rate shows the possibility of determining the derivative of the VCCs of structures with QWs with a nonideality factor of up to 4.

关键词： light-emitting diodes with quantum wells voltage−current relation nonideality factor recombination mechanism Sah−Noyce−Shockley model

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Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev vladimir A.Chernyshev Aleksandr S.Aleksandrovsky Alexander S.krylov Svetlana N.krylova Nikolai P.Shestakov Dmitriy A.Velikanov Alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

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Prediction and Optimization of System Quality and Risks on the Base of Modelling Processes

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American Journal of Operations Research 2013年第1期3卷 217-244页

作者： Andrey Kostogryzov Leonid Grigoriev George Nistratov Andrey Nistratov vladimir krylov Gubkin Russian State University of Oil and Gas Moscow Russia Institute of Informatic Problems of the Russian Academy of Sciences Moscow Russia Research Institute of Applied Mathematics and Certification Moscow Russia Scientific&Technical Center “NAOPRO” Moscow Russia

The paper is concerned with the development and application of the original probability models and supporting them software tools to predict and optimize quality and risks for complex systems. The examples demonstrate possibilities to use modeling results from different application spheres and to go in making decision “from a pragmatical filtration of information to generation of the proved ideas and effective decisions”.

关键词： Analysis Model Quality Prediction Reliability Risk Safety Software Tools System Engineering

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Are There Differences in the Response of Natural Stand and Plantation Biomass to Changes in Temperature and Precipitation?A Case for Two-needled Pines in Eurasia

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Journal of Resources and Ecology 2020年第4期11卷 331-341页

作者： USOLTSEV vladimir Andreevich SHOBAIRI Seyed Omid Reza TSEPORDEY Ivan Stepanovich AHRARI Amirhossein ZHANG Meng SHOAIB Ahmad Anees CHASOVSKIKH Viktor petrovich Ural State Forest Engineering University Yekaterinburg 620100Russia Botanical Garden Russian Academy of SciencesUral BranchYekaterinburg 620144Russia Department of Remote Sensing and GIS Faculty of GeographyUniversity of TehranTehran 14155-6619Iran Research Center of Forestry Remote Sensing and Information Engineering Central South University of Forestry and TechnologyChangsha 410004China Beijing Key Laboratory of Precision Forestry Forestry CollegeBeijing Forestry UniversityBeijing 100083China

A comparative discussion of the advantages and disadvantages of natural stands and plantations,including in terms of their productivity and stability,began from the moment of the first forest plantings and continues to this *** the context of the progressive replacement of natural forests by plantations due to deforestation,the question of how will change the carbon storage capacity of forest cover when replacing natural forests with artificial ones in a changing climate becomes extremely *** article presents the first attempt to answer this question at the transcontinental level on a special case for two-needled pine trees(subgenus Pinus L.).The research was carried out using the database compiled by the authors on the single-tree biomass structure of forest-forming species of Eurasia,in particular,data of 1880 and 1967 of natural and plantation trees,***-factor regression models are calculated after combining the matrix of initial data on the structure of tree biomass with the mean January temperature and mean annual precipitation,and their adequacy indices allow us to consider them *** is found that the aboveground and stem biomass of equal-sized and equal-aged natural and plantation trees increases as the January temperature and precipitation *** pattern is only partially valid for the branches biomass,and it has a specific character for the foliage *** biomass of all components of plantation trees is higher than that of natural trees,but the percent of this excess varies among different components and depends on the level of January temperatures,but does not depend at all on the level of annual precipitation.A number of uncertainties that arose during the modeling process,as well as the preliminary nature of the obtained regularities,are noted.

关键词： two-needled pine trees natural stands and plantations regression models biomass equations mean January temperature annual precipitation

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Principles of Network Security Protocols Based on Dynamic Address Space Randomization

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通讯和计算机（中英文版） 2016年第2期13卷 77-89页

作者： vladimir krylov Kirill Kravtsov Institute of Radio Electronics and Information Technologies Nizhny Novgorod State Technical University n.a. R.E. Alekseev NizhnyNovgorod 603950 Russia

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