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Pathophysiology transforms to pathobiology:new technologies and interdisciplinary proj.ct-oriented learning

中国病理生理杂志 2009年第11期25卷 2248-2248页

作者： Leonid P. Churilov Yury I. Stroev vladimir j. utekhin Department ofPathology School ofMedicine State University off.113 bld821st line V.O. St.Petersburg199106 Russia

Integrative role of pathophysiology in medicine is analogous to that of systemic biology among non-medical life sciences. Pathology rooted in morphology,because autopsy and microscopy in early 19th century revealed some loci and elements of disease. However,this was not enough for comprehension of systemic disorders and relations between elements. This promoted the involvement of physiology and birth of pathophysiology. For a long time the methodological options for bedside studies were scarce,so generations of physicians percepted pathophysiology as a science of lab and vivarium only,unlike pathomorphology,had integrated in clinics earlier. This lead to fornication between two sister branches of pathology and teaching of pathology and clinical subj.cts separated. Methodological progress of 20th century created basis for less or non-invasive patient studies. Current advances of pathochemistry,medical genetics,immunopathology,bioinformatics-give the chance to pathophysiology and pathomorphology spread far beyond the constraint of their historical names and intermingle. Current Pathophysiology grew into clinics (via laboratory and functional diagnosis,which contains clinical experimenting). This promotes re-integration of pathology sister branches,not via absorption,but through mutual shift to clinical correlations. Holistic approach to patient,disease and education is traditional for Russian medicine. In our pathophysiology teaching,classical lab experiments are j.int to early start of clinical pathology (6th term),case history analysis,lectures co-delivered by pathologist and clinician with demonstration of patients. Pathomorphologist and clinician are included in state board for pathophysiology exam. In teaching posters pathophysiological,clinical and pathomorphological data are fused. Local net of digital television microscopes gives instant video archive of experimental results added to student's protocols of lab studies. Teaching posters and course papers are co

关键词：病理生理学病原生物学跨学科学习导向项目技术病理生理作用

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Overcoming thermo-optical dynamics in broadband nanophotonic sensing

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Microsystems & Nanoengineering 2021年第4期7卷 47-57页

作者： Mingkang Wang Diego j.Perez-Morelo vladimir Aksyuk Microsystems and Nanotechnology Division National Institute of Standards and TechnologyGaithersburgMD 20899USA Institute for Research in Electronics and Applied Physics University of MarylandCollege ParkMD 20742USA

Advances in integrated photonics open up exciting opportunities for batch-fabricated optical sensors using high-quality-factor nanophotonic cavities to achieve ultrahigh sensitivities and *** sensitivity improves with increasing optical power;however,localized absorption and heating within a micrometer-scale mode volume prominently distorts the cavity resonances and strongly couples the sensor response to thermal dynamics,limiting the sensitivity and hindering the measurement of broadband time-dependent ***,we derive a frequency-dependent photonic sensor transfer function that accounts for thermo-optical dynamics and quantitatively describes the measured broadband optomechanical signal from an integrated photonic atomic force microscopy nanomechanical *** this transfer function,the probe can be operated in the high optical power,strongly thermo-optically nonlinear regime,accurately measuring low-and intermediate-frequency components of a dynamic signal while reaching a sensitivity of 0.7fm/Hz^(1/2) at high frequencies,an improvement of=10x relative to the best performance in the linear ***,we discover that a higher transduction gain and sensitivity are achieved with lower quality-factor optical modes for low signal *** limited to optomechanical transducers,the derived transfer function is generally valid for describing the small-signal dynamic responses of a broad range of technologically important photonic sensors subj.ct to the thermo-optical effect.

关键词： dynamics regime hinder

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Self-assembled formation of long, thin, and uncoalesced GaN nanowires on crystalline TiN films

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Nano Research 2018年第1期11卷 565-576页

作者： David van Treeck Gabriele Calabrese j.lle j. W. Goertz vladimir M. Kaganer Oliver Brandt Sergio Fernandez-Garrido, Lutz Geelhaar PauI-Drude-lnstitut f~r Festk6rperelektronik Leibniz-lnstitut im Forschungsverbund Berlin e.V. Hausvogteiplatz 5-7 I 0117 Berlin Germany

We investigate in detail the self-assembled nucleation and growth of vertically oriented GaN nanowires by molecular beam epitaxy on crystalline TiN films. We demonstrate that this type of substrate allows for the growth of long and thin GaN nanowires that do not suffer from coalescence, a problem common to the growth on Si and other substrates. Only beyond a certain nanowire length that depends on the nanowire density and exceeds here 1.5 bun, coalescence takes place by bundling, i.e. the same process as on Si. By analyzing the nearest neighbor distance distribution, we identify the diffusion-induced repulsion of neighboring nanowires as the main mechanism limiting nanowire density during nucleation on TiN. Since on Si the final density is determined by shadowing of the impinging molecular beams by existing nanowires, it is the difference in adatom surface diffusion that enables the formation of nanowire ensembles with reduced density on TiN. These nanowire ensembles combine properties that make them a promising basis for the growth of core-shell heterostructures.

关键词： nanocolumn gallium nitride nucleation metal substrate coalescence core-shell

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Thermoelectric and electrical characteristics of SmS ceramic samples after exposure to a pulsed magnetic field

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j.urnal of Rare Earths 2022年第11期40卷 1778-1784,I0004页

作者： Ivan Volchkov Evgeniy Baskakov vladimir Strelov vladimir Kanevskii FSRC"Crystallography and Photonics"RAS Leninskiy Prospekt 59119333MoscowRussia

Samarium monosulfide(SmS)is a promising material for creating thermoelectric generators(TEG),gas sensors and strain *** the high values of the generated thermo electromotive force(TEMF)(α≈170-350μV/K),methods for increasing the efficiency of TEGs based on SmS are of considerable *** of these methods can be short-term effects of magnetic fields,including pulsed ones,on these *** action of a pulsed magnetic field(PMF)leading to an increase in TEMF(U)of SmS ceramic samples is *** that are not subj.cted to high frequency currents(HFC)annealing show an increase in UT of 44.54%-62.18%(from 11.9 to 17.2-19.3 mV).The conductivity(σ)of the samples is~22 Q/cm and is insensitive to short-term exposure to a *** that undergo HFC annealing show an increase in Uof 23.47%-41.31%(from 21.3 to 26.3-30.1 mV)after exposure to a *** conductivity of the samples is~15Ω^(-1)/cm and after a short exposure to the PMF is changing nonmo notonically,with an increase in the overall *** difference in the values of Uand a can be explained by presence of an ordered grain structure and a significant amount of the Sm_(2)O_(2)S phase in the samples subj.cted to HFC *** mechanisms of the observed changes are discussed.

关键词： Rare earths Thermoelectric Electric properties Magnetically induced changes Samarium monosulfide

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Effect of Y_2O_3 and Total Oxide Addition on Mechanical Properties of Pressureless Sintered β-SiC

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j.urnal of Materials Science & Technology 2003年第3期19卷 193-196页

作者： vladimir D.Krstic Centre for Manufacturing of Advanced Ceramics and Nanomaterials Queen’s UniversityNicol HallKingstonOntarioCanada K7L 3N6

The effect of Y203 and the total oxide volume fraction (Y203+AI203) on density and mechanical properties of low temperature (1770-1940℃) pressureless sintered β-SiC ceramics were presented. The optimum temperature for pressureless sintering of β-SiC was found to be -1850℃ and the optimum content of Y203 in the oxides was found to be between 40 and 57 wt pct. The highest sintered density was achieved by adding oxides at 14 vol. pct. Both of the highest strength and fracture toughness were achieved at -14 vol. pct oxide addition and yttria concentrations between 40 and 57 wt pct in the oxides. Hardness, on the other hand, was found to be the highest for samples with 14 vol. pct oxide addition and -64 wt pct Y2O3 in oxides.

关键词： Y_2O_3 SiC Mechanical properties Sintering

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Elaboration of a conceptual solution for the development of the Arctic shelf from seasonally flooded coastal areas

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International j.urnal of Mining Science and Technology 2022年第1期32卷 113-119页

作者： vladimir S.Litvinenko Mikhail V.Dvoynikov vladimir L.Trushko Saint-Petersburg Mining University Saint-Petersburg 199106Russia

Currently,construction of facilities in the Arctic is carried out on sand islands,but there are limitations for remote coastal *** restrictions are associated with the lack of quarries with construction sand in the immediate vicinity of the work site,as well as the risk of seasonal flooding of the *** article includes conceptual solutions for construction of modular piling in Arctic nearshore conditions,upon which drilling rigs and auxiliary equipment can be placed for the purpose of subsequent wildcatting,development and exploratory extended reach drilling wells(with measured depth about 15000 m).During the construction of the modular piling foundations,a mathematical simulation of the thermodynamic condition of the frozen ground was conducted,and the bearing capacity of the foundations was *** proposed solutions will solve these problems by constructing modular pile foundations and placing the necessary infrastructure on them,taking into account the distribution of loads during operation in seasonally flooded areas.

关键词： Drilling&drillholes Stress analysis Offshore engineering Infrastructure planning Geotechnical engineering Extended reach drilling

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Impact of normal stress-induced closure on laboratory-scale solute transport in a natural rock fracture

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j.urnal of Rock Mechanics and Geotechnical Engineering 2020年第4期12卷 732-741页

作者： Liangchao Zou vladimir Cvetkovic Division of Resources Energy and InfrastructureDepartment of Sustainable DevelopmentEnvironmental Science and EngineeringRoyal Institute of TechnologyStockholm10044Sweden Department of Physical Geography Stockholm UniversityStockholm10691Sweden

The impact of normal stress-induced closure on fluid flow and solute transport in a single rock fracture is demonstrated in this *** fracture is created from a measured surface of a granite rock *** Bandis model is used to calculate the fracture closure due to normal stress,and the fluid flow is simulated by solving the Reynold *** Lagrangian particle tracking method is applied to modeling the advective transport in the *** results show that the normal stress significantly affects fluid flow and solute transport in rock *** causes fracture closure and creates asperity contact areas,which significantly reduces the effective hydraulic aperture and enhances flow ***,the reduced aperture and enhanced channeling affect travel time *** particular,the enhanced channeling results in enhanced first arriving and tailing behaviors for solute *** fracture normal stiffness correlates linearly with the 5th and 95th percentiles of the normalized travel *** finding from this study may help to better understand the stress-dependent solute transport processes in natural rock fractures.

关键词： Normal stress Fluid flow Solute transport Stiffness Particle tracking

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Biological Dose Estimation Model for Proton Beam Therapy

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International j.urnal of Medical Physics, Clinical Engineering and Radiation Oncology 2015年第2期4卷 149-161页

作者： vladimir Anferov Indra j. Das Pronova Solutions LLC Knoxville USA Indiana University School of Medicine Indianapolis USA IU Health Proton Therapy Center Bloomington USA

Purpose: The recommended value for the relative biological effectiveness (RBE) of proton beams is currently assumed to be 1.1. However, there is increasing evidence that RBE increases towards the end of proton beam range that may increase the biological effect of proton beam in the distal regions of the dose deposition. Methods: A computational approach is presented for estimating the biological effect of the proton beam. It includes a method for calculating the dose averaged linear energy transfer (LET) along the measured Bragg peak and published LET to RBE conversion routine. To validate the proposed method, we have performed Monte Carlo simulations of the pristine Bragg peak at various beam energies and compared the analysis with the simulated results. A good agreement within 5% is observed between the LET analysis of the modeled Bragg peaks and Monte Carlo simulations. Results: Applying the method to the set of Bragg peaks measured at a proton therapy facility we have estimated LET and RBE values along each Bragg peak. Combining the individual RBE-weighted Bragg peaks with known energy modulation weights we have calculated the RBE-weighted dose in the modulated proton beam. The proposed computational method provides a tool for calculating dose averaged LET along the measured Bragg peak. Conclusions: Combined with a model to convert LET into RBE, this method enables calculation of RBE-weighted dose both in pristine Bragg peak and in modulated beam in proton therapy.

关键词： Proton Beam Therapy Relative Biological Effectiveness Linear Energy Transfer

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Improved theory of proj.ctile traj.ctory reference heights as characteristics of meteo-ballistic sensitivity functions

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Defence Technology（防务技术） 2017年第3期13卷 177-187页

作者： vladimir Cech j.ri j.vicky Department of Weapons and Ammunition University of Defence Oprox Inc. Department of Mathematics and Physics University of Defence

Proj.ctile traj.ctories calculated under non-standard conditions are considered to be perturbed. The tools utilized for the analysis of perturbed traj.ctories are weighting factor functions(WFFs) which are a special kind of sensitivity functions. WFFs are used for calculation of meteo ballistic elements mB(ballistic wind wB, virtual temperature tB, pressure pB, density rB, speed of sound a) as well. An effect of weapon system parameters can be incorporated into calculations through the reference height of *** are also calculated from WFFs. Methods based on RHT are far more effective than traditional methods that use weighting factors *** have found that the existing theory of RHT has several shortcomings due to we created an improved theory of generalized RHT which represent a special sensitivity parameters of dynamical systems. Using this theory will improve methods for designing firing tables, fire control systems algorithms, and meteo message generation algorithms.

关键词：灵敏度函数气象要素弹道风特征动力系统理论消防控制系统加权因子生成算法

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Improved theory of generalized meteo-ballistic weighting factor functions and their use

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Defence Technology（防务技术） 2016年第3期12卷 242-254页

作者： vladimir CECH j.ri j.VICKY Department of Weapons and Ammunition University of Defence Oprox Inc. Department of Mathematics and Physics University of Defence

It follows from the analysis of artillery fire errors that approximately two-thirds of the inaccuracy of indirect artillery fire is caused by inaccuracies in the determination of the meteo parameters included in fire error budget *** calculated under non-standard conditions are considered to be *** tools utilized for the analysis of perturbed traj.ctories are weighting factor functions(WFFs)which are a special kind of sensitivity *** are used for calculation of meteo ballistic elements B(ballistic wind w B,densityρB,virtual temperatureτB,pressure p B)as *** have found that the existing theory of WFF calculation has several significant *** aim of the article is to present a new,improved theory of generalized WFFs that eliminates the deficiencies *** this theory will improve methods for designing firing tables,fire control systems algorithms,and meteo message generation algorithms.

关键词： Exterior ballistic Non-standard proj.ctile traj.ctory Perturbation Meteoconditions Sensitivity function (Generalized) weighting (factor) function(curve) (Generalized) effect function Norm effect

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