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Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma

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World journal of Gastroenterology 2009年第26期15卷 3269-3275页

作者： Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko j Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi vladimir B Obradovi Institute for Digestive Diseases Clinical Center of Serbia Institute for Nuclear Medicine Clinical Center of Serbia Gastroenterology Department Clinical Center Podgorica Gastroenterology Department Clinical Center Kragujevac

AIM： To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography （HRA） in secondary Hodgkin＇s hepatic lymphoma. METHODS： The research included patients with a diagnosis of Hodgkin＇s lymphoma with metastatic focal lesions in the liver and controls. Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal, hepatic and splenic veins were examined. Hepatic perfusion index （HPI） estimated by HRA was calculated. was observed. Lesions were mostly hypoechoic and mixed, solitary or multiple. Some of the patients presented with dilated splenic veins and hepatofugal blood flow. A pulse wave was registered in the centre and at the margins of lymphoma. The average velocity of the pulse wave was higher at the margins （P 〉 0.05）. A continuous venous wave was found only at the margins of lymphoma. There was no linear correlation between lymphoma size and velocity of pulse and continuous wave （r = 390, P 〈 0.01）. HPI was significantly lower in patients with lymphomas than in controls （P 〈 0.05）, pointing out increased arterial perfusion in comparison to portal perfusion. CONCLUSION： Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin＇s hepatic lymphoma and estimation of its intensity. Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions.

关键词： Color Doppler ultrasonography Hodgkin's disease Lymphoma Liver Radionuclide angiography Velocity Hepatic artery Portal vein Blood flow Splenomegaly

The Utility of Voided Urine Samples as a Proxy for the Vaginal Microbiome and for the Prediction of Bacterial Vaginosis

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Infectious Microbes & Diseases 2022年第4期4卷 149-156页

作者： Bin Zhu Christopher Diachok Laahirie Edupuganti David j.Edwards jeffrey R.Donowitz Katherine Tossas Andrey Matveyev Katherine M.Spaine vladimir Lee Myrna G.Serrano Gregory A.Buck Department of Microbiology and Immunology School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Center for Microbiome Engineering and Data Analysis Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Statistical Sciences and Operations Research College of Humanities and SciencesVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Pediatric Infectious Diseases Children's Hospital of Richmond at Virginia Commonwealth UniversityRichmondVirginiaUSA Department of Infectious Diseases and International Health University of VirginiaCharlottesvilleVirginiaUSA Department of Health Behavior and Policy School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Department of Family Medicine and Population Health School of MedicineVirginia Commonwealth UniversityRichmondVirginiaUSA Computer Science Department College of EngineeringVirginia Commonwealth UniversityRichmondVirginiaUSA Genomics Core Virginia Commonwealth UniversityRichmondVirginiaUSA

Recent work has shown that the vaginal microbiome exerts a strong impact on women's gynecological ***,collection of vaginal specimens is invasive and requires previous clinical training or the involvement of a trained *** contrast,urine sample collection is routine and noninvasive and does not require involvement of a *** sought to compare the vaginal and urogenital microbiomes to assess the utility of voided urine samples as a proxy for the vaginal *** urogenital and vaginal samples were collected from pregnant women and characterized by 16S rRNA taxonomic *** examined diversities and compositions of paired urogenital and vaginal microbiomes using five discrete strategies to explore the similarity between the vaginal and urogenital microbiomes.A strategy comparing the paired urogenital and vaginal microbiomes in which taxa were assigned using the STIRRUPS database and urine-specific taxa were removed showed no significant difference in diversity and composition between the paired urogenital and vaginal ***,the relative abundances of common vaginal taxa were linearly correlated with those in the paired *** similarities suggest that voided urine samples could represent a noninvasive protocol for accurate profiling of the vaginalmicrobiome with likely clinical ***,a machine learning model was established in which the voided urine microbiome was compared favorably to the vaginal microbiome in predicting bacterial vaginosis.

关键词： 16S rRNA vaginal microbiome urine microbiome bacterial vaginosis reproductive and gynecologic health

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中国角潜蝇属一新记录种

Entomotaxonomia 2005年第1期27卷 37-38页

作者：陈小琳 vladimir V. ZLOBIN 中国科学院动物研究所北京100080 俄罗斯科学院动物研究所圣彼得堡199034

记述采自中国新疆的潜蝇科 Agromyzidae 角潜蝇属 Cerondontha Rondani, 1861,1 新记录种:缝角潜蝇 Cerondontha (Dizygomyza) suturalis (Hendel, 1931),并附形态特征图。

关键词：双翅目潜蝇科角潜蝇属新记录中国

Photonic waveguide to free-space Gaussian beam extreme mode converter

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Light(Science & Applications) 2018年第1期7卷 346-358页

作者： Sangsik Kim Daron A.Westly Brian j.Roxworthy Qing Li Alexander Yulaev Kartik Srinivasan vladimir A.Aksyuk Center for Nanoscale Science and Technology National Institute of Standards and TechnologyGaithersburgMD 20899USA Maryland Nanocenter University of MarylandCollege ParkMD 20742USA Department of Electrical and Computer Engineering Texas Tech UniversityLubbockTX 79409USA

Integration of photonic chips with millimeter-scale atomic,micromechanical,chemical,and biological systems can advance science and enable new miniaturized hybrid devices and *** interaction via small evanescent volumes restricts performance in applications such as gas spectroscopy,and a general ability to photonically access optical fields in large free-space volumes is ***,conventional inverse tapers and grating couplers do not directly scale to create wide,high-quality collimated beams for low-loss diffraction-free propagation over many millimeters in free space,necessitating additional bulky collimating optics and expensive ***,we develop an extreme mode converter,which is a compact planar photonic structure that efficiently couples a 300 nm×250 nm silicon nitride high-index single-mode waveguide to a well-collimated near surface-normal Gaussian beam with an≈160μm waist,which corresponds to an increase in the modal area by a factor of>*** beam quality is thoroughly characterized,and propagation over 4mm in free space and coupling back into a single-mode photonic waveguide with low loss via a separate identical mode converter is *** achieve low phase error over a beam area that is>100×larger than that of a typical grating coupler,our approach separates the two-dimensional mode expansion into two sequential separately optimized stages,which create a fully expanded and well-collimated Gaussian slab mode before out-coupling it into free *** at 780 nm for integration with chip-scale atomic vapor cell cavities,our design can be adapted for visible,telecommunication,or other *** technique can be expanded to more arbitrary phase and intensity control of both large-diameter,free-space optical beams and wide photonic slab modes.

关键词： waveguide millimeter mode

Analysis of coupling of M2 muscarinic acetylcholine receptors to Gi/o,Gs and Gq heterotrimeric GTP-binding proteins

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Analysis of coupling of M2 muscarinic acetylcholine receptor...

第十五届国际药理学大会

作者： jakubik jan Dolezal vladimir Inst Physiology CAS Czech Republic Inst Physiology CAS Czech Republic

＜正＞ We have shown recently in our laboratory that activation of individual subtypes of muscarinic acetylcholine receptors leads to changes in several second messenger pathways via coupling to different G - protein subtypes （Michal et al. 2001 Br j Pharmacol 132: 1217 - 1228;Michal and Dolezal 2005 j Neurochem 94 （Suppi）:P. 520）. To study interaction between muscarinic M2 receptor and different G-proteins in detail we adopted scintillation proximity assay （DeLapp et al. 1999 j Pharmacol Exp Ther 289: 946 - 955）. We show that under identical conditions different agonists activate different sets of G - protein subtypes. The extent of activation of Gs and GqG - proteins does not correlate with the magnitude of stimulation of preferentially coupled Gi/o G - protein. On the other hand, it correlates with the magnitude of allosteric infraction between agonist and GDP on receptor - Gprotein complex. We conclude that conformations of M2 receptor induced by interaction with agonists are agonist specific and differ in interaction with G - proteins.

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来源： cnki会议评论

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对波黑医学院校的综合评估

复旦教育论坛 2007年第5期5卷 89-92页

作者： vladimir j Simunovic 温世浩第二军医大学医学教育教研室上海200433

按照国际标准对波黑的5所医学院进行了内部评估和外部评估,参与者包括医学院管理人员、教师、学生以及外部评估专家。评估内容包括10个项目:学校宗旨和目标、课程、管理、教师、学生、设施和技术、经费情况、国际关系、内部质量保证和... 详细信息

按照国际标准对波黑的5所医学院进行了内部评估和外部评估,参与者包括医学院管理人员、教师、学生以及外部评估专家。评估内容包括10个项目:学校宗旨和目标、课程、管理、教师、学生、设施和技术、经费情况、国际关系、内部质量保证和发展规划。结果表明,内部评估中有的学校高估了自己的总体表现,有的学校明显高估或低估自己在某些项目上的表现。评估工作表明,即使在复杂和不利的条件下,对医学教育进行建设性的、有组织的评估也是可能的。

关键词：医学教育本科评估波黑

Pathophysiology transforms to pathobiology:new technologies and interdisciplinary project-oriented learning

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中国病理生理杂志 2009年第11期25卷 2248-2248页

作者： Leonid P. Churilov Yury I. Stroev vladimir j. Utekhin Department ofPathology School ofMedicine State University off.113 bld821st line V.O. St.Petersburg199106 Russia

Integrative role of pathophysiology in medicine is analogous to that of systemic biology among non-medical life sciences. Pathology rooted in morphology,because autopsy and microscopy in early 19th century revealed some loci and elements of disease. However,this was not enough for comprehension of systemic disorders and relations between elements. This promoted the involvement of physiology and birth of pathophysiology. For a long time the methodological options for bedside studies were scarce,so generations of physicians percepted pathophysiology as a science of lab and vivarium only,unlike pathomorphology,had integrated in clinics earlier. This lead to fornication between two sister branches of pathology and teaching of pathology and clinical subjects separated. Methodological progress of 20th century created basis for less or non-invasive patient studies. Current advances of pathochemistry,medical genetics,immunopathology,bioinformatics-give the chance to pathophysiology and pathomorphology spread far beyond the constraint of their historical names and intermingle. Current Pathophysiology grew into clinics (via laboratory and functional diagnosis,which contains clinical experimenting). This promotes re-integration of pathology sister branches,not via absorption,but through mutual shift to clinical correlations. Holistic approach to patient,disease and education is traditional for Russian medicine. In our pathophysiology teaching,classical lab experiments are joint to early start of clinical pathology (6th term),case history analysis,lectures co-delivered by pathologist and clinician with demonstration of patients. Pathomorphologist and clinician are included in state board for pathophysiology exam. In teaching posters pathophysiological,clinical and pathomorphological data are fused. Local net of digital television microscopes gives instant video archive of experimental results added to student's protocols of lab studies. Teaching posters and course papers are co

关键词：病理生理学病原生物学跨学科学习导向项目技术病理生理作用

The Impact of the Block Freeze Concentration Process on Human Milk Properties Intended for Feeding Newborns

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Food and Nutrition Sciences 2017年第4期8卷 402-418页

作者： Ana Claudia Berenhauser Maria Helena Machado Canella Isabella de Bona Munoz Elane Schwinden Prudencio j.vladimir Oliveira jane Mara Block Maternity Ward of UFSC UFSCFlorianópolisBrazil Department of Food Science and Technology UFSCFlorianópolisBrazil Department of Chemical and Food Engineering UFSCFlorianópolisBrazil

Human milk is the ideal nutritional support for premature neonates. Considering the need for aggregating nutritional value to human milk provided to such vulnerable group of infants, human milk was concentrated by the block freeze concentration technique. The effects of freeze concentration on the physicochemical properties, the efficiency of the process, color parameters, and the density and dynamic viscosity of human milk were assessed. The freeze concentration technology was used to successfully concentrate human milk to a factor equal to 180.48% and 72% of total solid retention in the second stage of freeze concentration. The values observed in the concentrates for the biochemical properties showed that the fraction of concentrated fluid human milk of the second stage (C2) presented elevated amounts of carbohydrates, protein and energy. The elevated caloric value observed in the ice fraction of the first stage (I1) refers to the retention of lipids in it. When added to human milk, C2 and I1 may satisfy the special requisites of nutrients and energy to guarantee the growth and development of preterm neonates.

关键词： Freeze Concentration Human Milk Human Milk Fortifier Premature Neonate

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湿部优化：提高温强度性能效率（WSPE）

生活用纸 2014年第1期14卷 43-45页

作者： Clayton j. Campbell vladimir Grigoriev Lucyna Pawlowska 芬兰凯米拉(KEMIRA)化学品公司

介绍了利用阴离子功能促进剂和阳离子乙二醛聚丙烯酰胺干强剂，提高纸张湿强效率的应用案例。说明选择正确工艺化学品可为提高纸品质量和整体运行效率带来显著益处。

关键词：高温强度能效优化湿部聚丙烯酰胺运行效率纸品质量干强剂