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Sub-chronic effects of a Phthirusa pyrifolia aqueous extract on reproductive function and comparative hormone levels in male rats

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 202-210页

作者： Romero Marcos Pedrosa Brandao-Costa vivianne ferreira araujo Elizabeth Neves Maria Tereza Santos Correia Ana Lucia Figueiredo Porto Maria das Gracas Carneiro-da-Cunha Department of Biochemistry Center of Biological Sciences Federal University of Pernambuco Keizo Asami Laboratory of Imunopathology LIKA/UFPE Department of Anatomy Federal University of Pernambuco Department of Animal Morphology and Physiology Federal Rural University of Pernambuco Keizo Asami Laboratory of Imunopathology LIKA/UFPE

Objective: To explore the effects of aqueous extract from Phthirusa pyrifolia leaves(67 mg/kg body weight for 12 days) on the reproductive function of male Wistar rats through oral ***: Animals(n = 30), aged 13 weeks and weighing(378.5 ± 5.0) g, were housed in a vivarium under controlled environmental conditions [photoperiod of 12 h light/dark,temperature of(23 ± 1)C] and were fed standard rations ad libitum. The experiment ran for 12 days, wherein animals were divided into three groups: negative control(n = 6)received water, positive control(n = 12) with finasteride at a concentration of 1.0 mg/kg;and a test group(n = 12) submitted to aqueous extract. At the end of the experiment, the animals were sacrificed and submitted to ***: The morphological results of the testes showed that the aqueous extract induced significant changes in the diameter and cross-sectional area of the seminiferous tubules as well as the thickness of the seminiferous epithelium. Furthermore, the extract was able to abruptly decrease testosterone concentrations by about 81.88% in the treated group when compared with the negative control,(47.0 ± 4.8) ng/d L and(255.0 ± 2.0) ng/d L,respectively, and 76.8%,(211.0 ± 8.7) ng/d L, when compared with finasteride. However,the extract causes neither liver damage nor impairment of renal ***: These results suggest that the high amounts of flavonoids shown to be in the extract may be responsible for its hepato-protective effects and suggest a possible decrease in the libido and reproduction of rats.

关键词： Reproductive function Phytochemical Testosterone Finasteride Phthirusa pyrifolia

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