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Neural Regeneration Research 2018年第12期13卷 2160-2163页

作者： viviane rostirola elsner Laura Reck Cechinel Louisiana Carolina Ferreira de Meireles Karine Bertoldi Ionara Rodrigues Siqueira Programa de Pós-Graduacao em Ciências Biológicas:Fisiologia Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul Programa de Pós-Graduacao em Biociências e Reabilitacao Centro Universitário Metodista-IPA Curso de Fisioterapia Centro Universitário Metodista-IPA

Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation marks has been demonstrated in young adult and aged rats; however, there are no studies reporting epigenetic changes in the adolescent period. Therefore, this study aimed to investigate the effects of gender on hippocampal DNA methyltransferase 1 content and histone deacetylase（HDAC） activity of adolescent rats at different time points, specifically early morning and afternoon. Both epigenetic markers increased significantly in the hippocampi of female rats compared to the male group, an indicator of reduced transcriptional activity. In addition, HDAC activity during the early morning was higher compared to afternoon groups in both male and female rats, while DNA methyltransferase 1 content was not altered by the time of day. Our findings demonstrate that hippocampal DNA methylation and histone acetylation status can be influenced by gender during the adolescent period, while the time of the day impacts HDAC activity.

关键词： adolescent rats DNA methyltransferase 1 histone deacetylase hippocampus time of the day gender epigenetic marks

Therapeutic effectiveness of a single exercise session combined with WalkAide functional electrical stimulation in post-stroke patients:a crossover design study

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Neural Regeneration Research 2021年第5期16卷 805-812页

作者： viviane rostirola elsner Lucieli Trevizol Isadora de Leon Marcos da Silva ThaynáWeiss Milena Braga Daniela Pochmann Amanda Stolzenberg Blembeel Caroline Dani Elenice Boggio Curso de Fisioterapia do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil

A growing body of evidence has suggested that the imbalance of epigenetic markers and oxidative stress appears to be involved in the pathophysiology and progression of ***,strategies that modulate these biomarkers might be considered targets for neuroprotection and novel therapeutic opportunities for these *** exercise has been reported to induce changes in these epigenetic markers and improve clinical outcomes in different ***,little is reported on this in post-stroke *** purpose of this study was to investigate the effect of a single exercise session with WalkAide functional electrical stimulation(FES)on cognitive performance,clinical functional parameters,oxidative stress and epigenetic modulation in post-stroke *** this crossover design study,12 post-stroke individuals aged 54–72 years of either sexes were included and subjected to a single session of exercise(45 minutes)without WalkAide functional electrical stimulation(EXE alone group),followed by another single session of exercise(45 minutes)with WalkAide functional electrical stimulation(EXE+FES group).The clinical functional outcome measures,cognitive performance and blood collections for biomarker measurements were assessed pre-and *** intervention,higher Berg Balance Scale scores were obtained in the EXE+FES group than in the EXE alone *** was no significant difference in the Timed Up and Go test results post-intervention between EXE alone and EXE+FES *** intervention,a better cognitive performance was found in both groups compared with before the *** intervention,the Timed Up and Go test scores were higher in the EXE+FES group than in the EXE alone *** addition,the intervention induced lower levels of lipid *** intervention,carbonyl level was lower,superoxide dismutase activity and superoxide dismutase/catalase activity ratio were higher in the EXE+FES group,compared with the

关键词： cognition epigenetic exercise functional electrical stimulation functional mobility oxidative stress stroke WalkAide

Aquatic exercise program-modulated oxidative stress markers in patients with Parkinson's disease

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Neural Regeneration Research 2020年第11期15卷 2067-2072页

作者： Caroline Dani Isabel Teixeira Proenca Jessica Marinho Pamela Peccin Ivy Reichert Vital da Silva Simone Nique Vera Striebel Daniela Pochmann viviane rostirola elsner Programa de Pos Graduacao em Biociencias e Reabilitacao do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Curso de Fisioterapia do Centro Universitario Metodista-IPA Porto AlegreRSBrazil Programa de Pos Graduacao em Ciencias Biologicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil Programa de Pos Graduacao em Farmacologia e Terapeutica Universidade Federal do Rio Grande do SulPorto AlegreRSBrazil

Parkinson's disease is a neurodegenerative *** stress,i.e.,the imbalance between the generation of reactive oxygen species and the antioxidant defense capacity of the body,plays an important role in the pathogenesis of this *** exercise can regulate oxidative *** purpose of this study was to analyze the short-and long-term effects of an aquatic exercise program on oxidative stress levels in patients with Parkinson's *** aquatic exercise program was carried out during 1 month with two sessions per week(1 hour/session).Blood samples were collected at four different time points:pre-intervention,immediately,48 hours,and 30 days after the first session of aquatic exercise *** results revealed that water-based programs modulated antioxidant enzyme activity,increased superoxide dismutase activity,reduced catalase activity,and increased the ratio of superoxide dismutase activity to catalase activity in patients with Parkinson's *** with pre-intervention and 48 hours after the first session of aquatic exercise program,superoxide dismutase activity was higher and catalase activity was lower immediately and 30 days after the first *** results demonstrated that aquatic exercise program could modulate oxidative stress,mainly by the effect of antioxidant enzyme *** results could better help understand the target of oxidative stress in Parkinson's *** study was approved by the Ethics Committee of Centro Universitário Metodista IPA(approval No.1.373.911)on August 9,2019 and registered with REBEC(registration number:RBR-6 NJ4 MK).

关键词： antioxidant enzyme antioxidants aquatic exercise exercise therapies neurodegenerative disease oxidative stress Parkinson's disease

Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring

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Neural Regeneration Research 2019年第3期14卷 491-500页

作者： Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval viviane rostirola elsner Simone Marcuzzo Programa de Pos-Graduacao em Neurociencias Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Laboratorio de Histofisiologia Comparada Departamento de Ciencias Morfologicas Instituto de Ciencias Basicas da Saude Universidade Federal do Rio Grande do Sul Programa de Pos-Graduacao em Biociências e Reabilitacao Centro Universitario Metodista-IPA

It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear.

关键词： epigenetics preconception methylation learning treadmill running fetal programming inheritance sperm nerve regeneration

Effects of a multimodal exercise protocol on functional outcomes,epigenetic modulation and brain-derived neurotrophic factor levels in institutionalized older adults:a quasi-experimental pilot study

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Neural Regeneration Research 2021年第12期16卷 2479-2485页

作者： Iasmin Fraga Camila Weber Wériton Baldo Galiano Lucio Iraci Mariana Wohlgemuth Gabriela Morales Camila Cercato Juliana Rodriguez Daniela Pochmann Caroline Dani Pérsia Menz Adriane Dal Bosco viviane rostirola elsner Programa de Pós-Graduação em Ciências Biológicas:Fisiologia Universidade Federal do Rio Grande do SulPorto AlegreRSBrasil Curso de Fisioterapia do Centro Universitário Metodista-IPA Porto AlegreRSBrasil Programa de Pós-Graduação em Biociências e Reabilitação Centro Universitário Metodista-IPAPorto AlegreRSBrasil Physiotherapist working in Long-Term InstitutionsPorto AlegreRSBrasil

Epigenetic changes have been shown to be associated with both aging process and aging-related *** is evidence regarding the benefits of physical activity on the functionality,cognition,and quality of life of institutionalized older adults,however,the molecular mechanisms involved are not *** purpose of this pilot study was to investigate the effects of a multimodal exercise intervention on functional outcomes,cognitive performance,quality of life(QOL),epigenetic markers and brain-derived neurotrophic factor(BDNF)levels among institutionalized older adult ***(n=8)without dementia who were aged 73.38±11.28 years and predominantly female(87.5%)were included in this quasi-experimental pilot study.A multimodal exercise protocol(cardiovascular capacity,strength,balance/agility andﬂexibility,perception and cognition)consisted of twice weekly sessions(60 minutes each)over 8 ***(Berg Scale),mobility(Timed Up and Go test),functional capacity(Six-Minute Walk test),cognitive function(Mini-Mental State Examination)and QOL(the World Health Organization Quality of Life-BREF Scale questionnaire)were evaluated before and after the *** sample(15 mL)was also collected before and after intervention for analysis of biomarkers global histone H3 acetylation and brain-derived neurotrophic factor *** improvements were observed in cognitive function,balance,mobility,functional capacity and QOL after the *** addition,a tendency toward an increase in global histone H3 acetylation levels was observed,while brain-derived neurotrophic factor level remained *** study provided evidence that an 8-week multimodal exercise protocol has a significant effect on ameliorating functional outcomes and QOL in institutionalized older adult *** addition,it was also able to promote cognitive improvement,which seems to be partially related to histone hyperacetylation *** Ethics Research Com

关键词： aging balance brain-derived neurotrophic factor cognition epigenetics physical exercise quality of life risk of falling