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Protective effects of D-002 on experimentally induced gastroesophageal reflux in rats

World Journal of Gastroenterology 2014年第8期20卷 2085-2090页

作者： Zullyt Zamora vivian molina Rosa Mas Yazmin Ravelo Yohany Perez Ambar Oyarzabal Department of Pharmacology Centre of Natural ProductsNational Centre for Scientific ResearchHavana 10600Cuba

AIM: To investigate the effects of beeswax alcohols (D-002) on the esophageal damage induced by gastroesophageal reflux (GER) in rats.

关键词： D-002 Beeswax alcohols Esophagitis Gastroesophageal reflux Oxidative stress

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Ex vivo antioxidant effects of D-004, a lipid extract from Roystonea regia fruits, on rat prostate tissue

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Asian Journal of Andrology 2008年第4期10卷 659-666页

作者： Yohani Perez vivian molina Rosa Mas Roberto Menendez Rosa M. Gonzailez Ambar Oyarzabal Sonia Jimenez Laboratory of Biochemistry Center of Natural Products National Center for Scientific Research Havana City 6990 Cuba

Aim： To investigate whether oral treatment with D-004, a lipid extract of the Cuban royal palm fruit, produces antioxidant effects in the prostate tissue of normal and testosterone （T）-treated rats. Methods： In our first experiment, normal rats were distributed into five groups： one group treated with the vehicle and four groups treated with D-004 （100, 200, 400 or 800 mg/kg）. In our second experiment, rats were randomized into five groups： a negative control group and four T-injected groups. The latter were comprised of a positive control group treated with the vehicle, and three groups treated with D-004 （200, 400 or 800 mg/kg）. Results： In normal rats, D-004 （100-800 mg/kg） inhibited significantly and dose-dependently iron-initiated malondialdehyde （MDA） accumulation in prostate homogenates （35.7%-80.0%） vs. the controls. D-004 （200-800 mg/kg） significantly reduced baseline MDA and carbonyl groups in prostate homogenates of normal rats to approximately 80% and 50%, respectively, and totally （100%） in T-treated rats. Conclusion： Oral treatment with D-004 reduced MDA and carbonyl groups dose-dependently and markedly in normal and T-injected rats. These findings show that D-004 given at doses effective to prevent prostate hyperplasia also produces antioxidant effects in the prostate tissue.

关键词： D-004 Roystonea regia Cuban royal palm prostate hyperplasia lipid peroxidation antioxidant

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Antioxidant effects of D-004, a lipid extract from the Roystonea regia fruit, on the plasma of healthy men

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Asian Journal of Andrology 2009年第3期11卷 385-392页

作者： Emesto Lopez vivian molina Jose Illnait Ambar Oyarzfibal Lilia C. Femandez Rosa Mas Rafael Gamez Julio C. Fernandez Sonia Jimenez Meilis Mesa Ivon Hollands Sarahi Mendoza Medical Surgical Research Centre Havana 6990 Cuba Centre of Natural Products from the National Centre for Scientific Research Havana 6880 Cuba

The aim of thisstudy was to conduct a randomized, double-blind and placebo-controlled study to investigate the effects of D-004, a lipid extract of the Roystonea regia fruit that prevents testosterone- and phenylepinephrine- induced prostate hyperplasia in rodents, on plasma oxidative markers in healthy men. We enrolled male volunteers （20-55 years） in good health and without lower urinary tract symptoms. Thirty-four eligible participants were randomized to placebo or D-004 （320 mg） capsules administered daily for 6 weeks. An interim check-up and a final visit were conducted after 3 and 6 weeks of therapy, respectively. Physical examinations were performed at each visit, and laboratory tests were performed at baseline and at treatment completion. Oxidative variables included plasma malondialdehyde （MDA）, total hydroxyperoxides （TOH）, sulphydryl （SH） groups and total antioxidant status （TAS）. We assessed treatment compliance and addressed adverse experiences （AEs） at weeks 3 and 6. At week 6, with D-004, the mean reductions of plasma MDA （26.7%）, TOH （18.8%） and SH groups （31.6%）, and the mean increase of TAS （35.3%） were significantly different from those of placebo （P 〈 0.001 for plasma TAS, P 〈 0.0001 for all other comparisons）. D-004 did not differ from the placebo in safety indicators. There were two withdrawals （both in the D-004 group）, with one due to dyspepsia （the only AE during the trial）. In conclusion, D-004 displayed antioxidant effects on plasma oxidative markers in healthy men, which was consistent with findings from laboratory experimental studies.

关键词： antioxidant benign prostate hyperplasia D-004 lipid peroxidation Roystonea regia

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