检索结果-南通市图书馆

Anti-donor immunoglobulin G subclass in liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第2期8卷 125-128页

作者： vivian C.mcalister Department of Surgery University of Western OntarioLondonONCanada

Immunoglobulin G(IgG)subclasses in human health and immunity have only be sporadically studied in the half century since their *** patterns of IgG subclass production are seen if the immune response is deviated towards type 1 versus type *** current state of our knowledge of IgG subclasses in liver transplantation is reviewed *** several studies have been conducted in liver disease,only four relatively small studies have been undertaken in liver transplant *** IgG4 elevation in serum is related to sclerosing pancreatico-cholangiopathy that is sensitive to treatment with *** immunosuppressive regimes,especially with a combination of tacrolimus and sirolimus,reduce the production of all IgG subclasses after transplantation but it is not known if they deviate the immune *** of anti-donor IgG3 before transplantation,or its expansion after transplantation,has been associated with rejection and liver graft ***-GSTT1 IgG4 production after transplantation is associated with de-novo immune *** knowledge of anti-donor IgG subclass responses after transplantation will allow us tailor novel treatments for greater effect.

关键词： Anti-donor immunoglobulin G subclass liver transplantation

Fatal graft versus host hemolytic reaction from Rhesus compatible mismatched liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第2期8卷 186-188页

作者： Hemant Sharma vivian mcalister Department of Multiorgan Transplant Surgery Ochsner Medical CenterNew OrleansLAUSA Department of Surgery University of Western OntarioLondonONCanada

Matching for Rhesus(Rh)blood group is not part of organ allocation *** principle concern expressed in the literature is that Rh-negative recipients might become sensitized and produce anti-D antibody which would have consequences for them if transfusion with Rh-positive blood or a pregnancy were to occur *** Rh allosensitization is thought to occur in over 80%of Rh-negative recipients of Rh-positive blood,Starzl reported that it is less much less common in organ(liver,heart,lung)recipients even if they received Rh-positive blood during the operation(1).A more recent review of pediatric liver transplantation confirms the very low rate of allosensitization of Rh recipients of grafts from Rh-positive donors(2).In theory,there should be no risk of rejection if the combination is reversed—Rh-negative donor to a Rh-positive ***,it does not appear to be necessary to consider Rh status when allocating organs for transplantation.

关键词： organs transfusion liver

Long term follow-up after liver transplantation from a JAK2 mutation positive donor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第2期8卷 189-191页

作者： Alejandro Lazo-Langner Peter Ainsworth vivian mcalister Department of Medicine Division of HematologyWestern UniversityLondonONCanada Department of Epidemiology and Biostatistics Western UniversityLondonONCanada Department of Oncology Western UniversityLondonONCanada Department of Pathology and Laboratory Medicine Western UniversityLondonONCanada Department of Surgery Western UniversityLondonONCanada

Introduction Philadelphia-negative myeloproliferative neoplasms(MPN),including polycythemia vera(PV),essential thrombocythemia(ET),and primary myelofibrosis(PMF),are characterized by the presence of mutations involving the Janus Kinase 2(JAK2),calreticulin(CALR)or myeloproliferative leukemia virus oncogene(MPL)genes(1).Of these,the JAK2 V617F gain-of-function mutation is the most frequently found and is present in>95%of patients with PV and in about 60%of those with ET or PMF whereas JAK2 exon 12 mutations are found in the remaining PV patients(2).JAK2 V617F somatic mutations have been detected in granulocytes and platelets and therefore they could potentially be transmitted to recipients of solid organ transplants(3)and in fact the presence of the JAK2 V617F mutation has been detected in otherwise healthy blood donors(4,5).

关键词： JAK2 neoplasms patients

Bidirectional graft-host hematological traffic in liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第3期8卷 253-257页

作者： Hemant Sharma Mauro E.Tun-Abraham vivian mcalister Department of Multiorgan Transplant Surgery Ochsner Medical CenterNew OrleansLAUSA Department of Surgery University of Western OntarioLondonONCanada

The highly complex immuno-hematological system of the recipient has to rebalance itself when the liver is replaced with a graft that has its own *** gives us an opportunity for *** we consider the graft-to-recipient direction with passenger lymphocyte syndrome(PLS)as well as the recipient-to-graft direction with Factor VIII(FVIII)inhibitors,paroxysmal nocturnal hemoglobinuria(PNH)and graft endothelial replacement with liver *** extends beyond the ABO blood groups to any situation where the donor has been sensitized to a recipient *** directed against ABO or minor blood group antigens is usually self limiting whereas Rhesus(Rh)PLS persists with life threatening immune *** platelet antigen(HPA)1A PLS results in life threatening immune *** of severe PLS may include reduction in immunosuppression,anti-B-cell therapy,plasmapheresis and *** transplantation into recipients with FVIII inhibitors has been *** with acquired hemophilia may transmit the capacity to make FVIII inhibitors by PLS and should be *** with PNH have been transplanted successfully but a considerable cost in the continued use of high dose *** speculate that combined bone marrow and liver transplantation would be a better option for recipients with FVIII inhibitors or *** of liver graft endothelium with recipient cells is common and may explain relative transplant tolerance that is believed to occur with liver transplantation.

关键词： Liver transplantation passenger lymphocyte syndrome(PLS) human platelet antigen(HPA) paroxysmal nocturnal hemoglobinuria(PNH) endothelium

The impact of alloantibodies directed against the second donor on long-term outcomes of repeat liver transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary Surgery and Nutrition 2019年第3期8卷 246-252页

作者： Qingyong Xu Brad Shrum Steve Leckie Anton Skaro vivian C.mcalister Department of Pathology and Lab Medicine University of Western OntarioLondonONCanada Department of Surgery University of Western OntarioLondonONCanada

Background:Despite reports that associate donor specific antibody(DSA)with rejection after liver transplantation,grafts are still allocated according to blood group(ABO)but not human leukocyte antigen(HLA)compatibility,possibly due to the absence of an easily discernible clinical association between adverse recipient outcome and ***-transplantation provides a test environment where the presence of preformed DSA is prevalent and its effect on outcome should be ***:All patients undergoing a second liver transplantation with available pre-operative serum were included with the exception of ABO incompatible or multiple organ *** sera were tested for anti-HLA antibodies with Luminex-based solid phase ***-HLA antibodies to the second donor(D2SA)were determined using antibodies specificity and HLA typing of 2nd liver ***:Preformed HLA antibodies directed to second liver transplantation(D2SA)were found in 31(39%)of the 79 patients that were included in the *** and re-transplantation characteristics were similar in both subgroups except first graft survival which was significantly shorter in recipients who are negative for *** survival of the second graft was similar in D2SA+and D2SA?cohorts[8.55(range,0.01–24.74)vs.7.56(range,0–23.53)years respectively,P=0.574].Mean patient survival after 2nd liver transplantation was similar in D2SA+and D2SA?cohorts[9.11(range,0.01–24.74)vs.8.10(range,0–23.53)years respectively,P=0.504].Subgroup univariate analysis demonstrated no detrimental effect of class,locus,or strength of D2SA on survival of the second liver *** multivariate cox regression model,neither class I D2DSA(HR=1.101,P=0.92)nor class II D2SA(HR=1.74,P=0.359)were significant risks of graft ***:Presence of D2SA was not found to be associated with inferior outcomes in this retrospective cohort study of liver re-transplantation suggesting that changes to the allocation system are not requ

关键词： Donor-specific antibodies(DSA) human leucocytes antigen(HLA) liver transplantation

Evaluation of the updated definition of early allograft dysfunction in donation after brain death and donation after cardiac death liver allografts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 372-376页

作者： Kris P Croome William Wall Douglas Quan Sai Vangala vivian mcalister Paul Marotta Roberto Hernandez-Alejandro Multi-Organ Transplant Program London Health Sciences CentreThe University of Western OntarioLondonCanada Department of Surgery Division of General SurgeryThe University of Western OntarioLondonCanada Division of Gastroenterology The University of Western OntarioLondonCanada

BACKGROUND:An updated definition of early allograft dysfunction(EAD) was recently validated in a multicenter study of 300 deceased donor liver transplant *** analysis did not differentiate between donation after brain death(DBD) and donation after cardiac death(DCD) allograft ***:We reviewed our prospectively entered database for all DBD(n=377) and DCD(n=38) liver transplantations between January 1,2006 and October 30,*** incidence of EAD as well as its ability to predict graft failure and survival was compared between DBD and DCD ***:EAD was a valid predictor of both graft and patient survival at six months in DBD allograft recipients,but in DCD allograft recipients there was no significant difference in the rate of graft failure in those with EAD(11.5%) compared with those without EAD(16.7%)(P=0.664) or in the rate of death in recipients with EAD(3.8%) compared with those without EAD(8.3%)(P=0.565).The graft failure rate in the first 6 months in those with international normalized ratio ≥1.6 on day 7 who received a DCD allograft was 37.5% compared with 6.7% for those with international normalized ratio <1.6 on day 7(P=0.022).CONCLUSIONS:The recently validated definition of EAD is a valid predictor of patient and graft survival in recipients of DBD *** initial assessment,it does not appear to be a useful predictor of patient and graft survival in recipients of DCD allografts,however a study with a larger sample size of DCD allografts is needed to confirm these *** high ALT/AST levels in most recipients of DCD livers as well as the predisposition to biliary complications and early cholestasis make these parameters as poor predictors of graft *** alternative definition of EAD that gives greater weight to the INR on day 7 may be more relevant in this population.

关键词： donor risk index model for end-stage liver disease early allograft dysfunction donation after brain death

Reuse of liver grafts following the brain death of the initial recipient

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2014年第6期6卷 443-447页

作者： Hideaki Tanaka vivian C mcalister Mark A Levstik Cameron N Ghent Paul J Marotta Douglas Quan William J Wall Multi-Organ Transplant Program London Health Sciences CentreLondonOntario N6A 5A5Canada Department of Pediatric Surgery Faculty of MedicineUniversity of TsukubaTsukuba CityIbaraki 305-8575Japan Canadian Armed Forces Health Service OttawaOntario K1A 0K2Canada

AIM: To determine if there is a reasonable prospect of success of a re-use liver ***: We systematically searched for reports of liver graft re-use using electronic searches of PubMed and Web of Knowledge. We performed hand searches of references lists of articles reporting re-use of ***: A systematic review of the literature reveals 28 liver transplantations using previously transplanted grafts. First and second recipients ranged in age from 4 to 72 years and 29 to 62 years respectively. Liver disease in the first recipient was varied including 5(18%) patients with fulminant liver failure who died subsequently of cerebral edema. The second transplanta-tion was performed after a median interval of 5 d(one day-13 years). Viral hepatitis was present in 3(11%) of the initial recipients and in 8(29%) of final recipients. Hepatocellular carcinoma was present in 6(21%) of the final recipients. Early survival after the final transplantation was 93%, whereas long-term survival was 78% with a mean follow-up of 23.3(3-120) ***: Outcomes of transplantation using previously transplanted grafts in this select population are similar to those seen with conventional grafts.

关键词： Reuse Liver graft Brain death Liver transplantation

scLink:Inferring Sparse Gene Co-expression Networks fromSingle-cell Expression Data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2021年第3期19卷 475-492页

作者： Wei vivian Li Yanzeng Li Department of Biostatistics and Epidemiology Rutgers School of Public HealthRutgersThe State University of New JerseyPiscatawayNJ 08854USA

A system-level understanding of the regulation and coordination mechanisms of gene expression is essential for studying the complexity of biological processes in health and *** the rapid development of single-cell RNA sequencing technologies,it is now possible to investigate gene interactions in a cell type-specific *** we propose the scLink method,which uses statistical network modeling to understand the co-expression relationships among genes and construct sparse gene co-expression networks from single-cell gene expression *** use both simulation and real data studies to demonstrate the advantages of scLink and its ability to improve single-cell gene network *** scLink R package is available at https://***/vivianstats/scLink.

关键词： Gene co-expression network Single-cell RNA sequencing Network modeling Robust correlation

On Eccentric Connectivity Index and Connectivity

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2019年第7期35卷 1205-1216页

作者： vivian MUKUNGUNUGWA Simon MUKWEMBI Department of Mathematics University of Zimbabwe

Let G be a finite connected graph. The eccentric connectivity index ξ^c(G) of G is defined as ξ^c(G)=∑v∈V(G)ec(υ)deg(υ), where ec(v) and deg(υ) denote the eccentricity and degree of a vertex v in G, respectively. In this paper, we give an asymptotically sharp upper bound on the eccentric connectivity index in terms of order and vertex-connectivity and in terms of order and edge-connectivity. We also improve the bounds for triangle-free graphs.

关键词： Extremal graph order diameter vertex-connectivity edge-connectivity