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现代装饰（家居） 2016年第1期 130-137页

作者： vivek CHAUHAN Bureau de Change Alessandra Baldereschi Justyna Fabirkiewicz Clement Brazill Scholten&Baijings YOY Rasmus Warberg Patricia Urquiola Alexandre Boucher Alegre Design Monica Forster Design Studio 李薇

一直都很喜欢冬天,特别是冬天那素净的白雪。记得小时候因为想要留住冬天的雪,在下雪的时候便幼稚地把积雪装进玻璃瓶里储存起来,以为这样雪就不会消失了,奶奶看见后告诉我说＂雪还是会慢慢融化的＂,而我固执地不相信。存雪的第一天,雪... 详细信息

一直都很喜欢冬天,特别是冬天那素净的白雪。记得小时候因为想要留住冬天的雪,在下雪的时候便幼稚地把积雪装进玻璃瓶里储存起来,以为这样雪就不会消失了,奶奶看见后告诉我说＂雪还是会慢慢融化的＂,而我固执地不相信。存雪的第一天,雪并没有像奶奶说的那样融化掉,我庆幸地以为奶奶的话是骗我的,而在第二天,我却失望地发现储存在玻璃瓶中的白雪变成了清水,于是伤心了好一会儿。

关键词：告诉我颜色搭配木质结构柔软舒适木结构建筑金属框架 Forster 女性服装室内外空间管状结构

Does Chemo-Radiation Therapy Influence Outcomes in Unresectable Locally Advanced State IV Rectal Cancer?

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帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析

Surgical Science（外科学） 2012年第10期

作者： Joaquin J. Estrada vivek Chaudhry Jose R. Cintron Leela M. Prasad Herand Abcarian

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中华肿瘤防治杂志 2021年第24期28卷 1841-1850页

作者：陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh 山东省肿瘤防治研究院(山东省肿瘤医院) 山东第一医科大学(山东省医学科学院)山东济南250117 不详 Department of Radiation Oncology The University of Texas M D Anderson Cancer CenterHoustonTX 77030USA

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,... 详细信息

背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在***上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。

关键词：帕博利珠单抗非小细胞肺癌放疗汇总分析

印度Kaladgi盆地元古宙沉积的多尺度旋回

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海洋地质 2013年第1期29卷 40-40页

作者： vivek S. KALE Shilpa PATIL PILLAI

印度Kaladgi盆地元古宙沉积物沉积于塔尔瓦尔克拉通北部的克拉通边缘Kaladgi盆地的浅海、近滨环境。这一沉积序列在整个沉积过程中及其沉积前后，均受盆地基底构造的控制和影响。尽管如此，很显然在沉积物不断沉积期间，沉积供给和盆地... 详细信息

印度Kaladgi盆地元古宙沉积物沉积于塔尔瓦尔克拉通北部的克拉通边缘Kaladgi盆地的浅海、近滨环境。这一沉积序列在整个沉积过程中及其沉积前后，均受盆地基底构造的控制和影响。尽管如此，很显然在沉积物不断沉积期间，沉积供给和盆地基底的沉降是相互平衡的。因此，在潮汐周期体系中，盆地中发育近岸（包括海滩和河口）碎屑、潮坪泥岩和受潮汐影响的碳酸盐岩沉积。

关键词：盆地基底沉积物元古宙印度克拉通边缘旋回潮汐周期沉积过程

低成本电子系统印刷电子技术的开发与应用现状

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中国印刷与包装研究 2009年第3期1卷 77-78页

作者： vivek Subramanian Josephine B. Chang Alejandro de la Fuente Vornbrock Daniel C. Huang Lakshmi Jagannathan Frank Liao Brian Mattis Steven Molesa David R. Redinger Daniel Soltman Steven K. Volkman 张桂兰 Department of Electrical Engineering and Computer Sciences University of California

近年来,印刷电子技术作为一种可实现低成本、大面积电子系统的技术,已获得了可观的收益。印刷允许进行充分有效的处理,从而降低了过程的复杂性,减少了材料的使用种类。加上使用如塑料、金属箔等低成本基板,预计印刷电子技术能实现更多... 详细信息

近年来,印刷电子技术作为一种可实现低成本、大面积电子系统的技术,已获得了可观的收益。印刷允许进行充分有效的处理,从而降低了过程的复杂性,减少了材料的使用种类。加上使用如塑料、金属箔等低成本基板,预计印刷电子技术能实现更多领域电子系统的简单开发,包括显示器,传感器和RFID标签等。回顾印刷电子技术开发及应用工作,通过合成无机纳米粒子和有机材料的结合,可以制成一系列的印刷电子"油墨",并用于印刷无源元件、多层互联结构、二极管、晶体管、存储器、电池、不同类型的气体和生物传感器。通过拓展印刷能力,进一步降低将多种功能材料集成在相同基板上的成本。因此,开发出具有该优势的印刷系统是有可能的。

关键词：低成本电子系统印刷电子技术开发应用

Secure Cloud Data Storage System Using Hybrid Paillier–Blowsh Algorith

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Computers, Materials & Continua 2021年第4期 779-798页

作者： Bijeta Seth Surjeet Dalal Dac-Nhuong Le vivek Jaglan Neeraj Dahiya Akshat Agrawal Mayank Mohan Sharma Deo Prakash K.D.Verma SRM University Delhi-NCRSonipatHaryana131029India Institute of Research and Development Duy Tan UniversityDanang550000Vietnam Department of Information Technology Duy Tan UniversityDanang 550000Vietnam Graphic Era Hill University DehradunUttarakhand248171India Amity University Haryana122412India Principal Software Lead Zillow Inc.USA School of Computer Science&Engineering Faculty of EngineeringSMVD UniversityKakryalKatra182320India Material Science Research Laboratory Department of PhysicsS.V.CollegeAligarh202001India

Cloud computing utilizes enormous clusters of serviceable and manageable resources that can be virtually and dynamically recongured in order to deliver optimum resource utilization by exploiting the pay-per-use ***,concerns around security have been an impediment in the extensive adoption of the cloud computing *** this regard,advancements in cryptography,accelerated by the wide usage of the internet worldwide,has emerged as a key area in addressing some of these security *** this document,a hybrid cryptographic protocol deploying Blowsh and Paillier encryption algorithms has been presented and its strength compared with the existing hybrid Advanced Encryption Standard(AES)and Rivest Shamir Adleman(RSA)*** for secure data storage protocol in two phases have been *** proposed hybrid protocol endeavors to improve the power of cloud storage through a decrease in computation time and ciphertext *** have been carried out with Oracle Virtual Box and Fog server used on an Ubuntu 16.04 *** grouping of asymmetric and homomorphic procedures has demonstrated enhanced *** usage has helped in decreasing the storage space and computation *** analysis in terms of computation overhead and quality of service parameters like loads of parameters with and without attacks,throughput,and stream length for different modes of block cipher mode has been carried *** analysis has been carried out by utilizing the Hardening Index as an audit parameter using Lynis ***,for halting the aforementioned approaches and for regulating trafc,rewall protection has been generated in the chosen hybrid ***,enhancements in the performance of the Paillier and Blowsh hybrid scheme with and without compression compared to the existing schemes using RSA and AES procedures have been demonstrated.

关键词： Cryptography blowsh homomorphic paillier cloud computing

Limits on light WIMPs with a 1 kg-scale germanium detector at 160 eVee physics threshold at the China Jinping Underground Laboratory

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Chinese Physics C 2018年第2期42卷 12-21页

作者：杨丽桃李浩斌岳骞康克军程建平李元景王子敬 M.Agartioglu 安海鹏常建平陈景瀚陈云华邓智杜强宫辉何力胡津纬胡庆东黄瀚雄贾历平江灏李红李荐民李金李霞李学潜李玉兰林枫凯林兴德刘书魁刘仲智马豪马菁露潘辉任杰阮锡超 B.Sevda vivek Sharma 申满斌 Lakhwinder Singh Manoj Kumar Singh 唐昌建唐维优田阳王继敏王力王青王轶吴世勇吴玉成幸浩洋徐音薛涛杨松伟易难喻纯旭于海军岳剑峰曾雄辉曾鸣曾志张云华赵明刚赵伟周济芳周祖英朱敬军朱忠华 Key Laboratory of Particle and Radiation Imaging (Ministry of Education) and Department of Engineering Physics Tsinghua University Department of Physics Tsinghua University Institute of Physics Academia Sinica Key Laboratory of Particle and Radiation Imaging vand Department of Engineering Physics Tsinghua University NUCTECH Company YaLong River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Key Laboratory of Particle and Radiation Imaging and Department of Engineering Physics Tsinghua University

We report results of a search for light weakly interacting massive particle（WIMP） dark matter from the CDEX-1 experiment at the China Jinping Underground Laboratory（CJPL）. Constraints on WIMP-nucleon spin-independent（SI） and spin-dependent（SD） couplings are derived with a physics threshold of 160 eVee, from an exposure of 737.1 kg-days. The SI and SD limits extend the lower reach of light WIMPs to 2 GeV and improve over our earlier bounds at WIMP mass less than 6 GeV.

关键词： dark matter WIMPs CDEX pPCGe

Performances of a prototype point-contact germanium detector immersed in liquid nitrogen for light dark matter search

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Science China(Physics,Mechanics & Astronomy) 2019年第3期62卷 58-65页

作者： Hao Jiang LiTao Yang Qian Yue KeJun Kang JianPing Cheng YuanJing Li Henry Tsz-King Wong M.A?artio?lu HaiPeng An JianPing Chang JingHan Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He Jin Wei Hu QingDong Hu HanXiong Huang LiPing Jia HauBin Li Hong Li Jian Min Li Jin Li Xia Li XueQian Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu YuanYuan Liu ZhongZhi Liu Hao Ma JingLu Ma Hui Pan Jie Ren XiChao Ruan B.Sevda vivek Sharma ManBin Shen Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang JiMin Wang Li Wang Qing Wang Yi Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue SongWei Yang Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue XiongHui Zeng Ming Zeng Zhi Zeng FengShou Zhang YunHua Zhang MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu ZhongHua Zhu Key Laboratory of Particle and Radiation Imaging (Ministry of Education)and Department of Engineering Physics Tsinghua University College of Nuclear Science and Technology Beijing Normal University Institute of Physics Academia Sinica Department of Physics Dokuz Eylül University Department of Physics Tsinghua University NUCTECH Company Ya Long River Hydropower Development Company College of Physical Science and Technology Sichuan University Department of Nuclear Physics China Institute of Atomic Energy School of Physics Nankai University Department of Physics Banaras Hindu University Department of Physics Beijing Normal University

The CDEX-10 experiment searches for light weakly interacting massive particles, a form of dark matter, at the China Jinping Underground Laboratory, where approximately 10 kg of germanium detectors are arranged in an array and immersed in liquid nitrogen. Herein, we report on the experimental apparatus, detector characterization, and spectrum analysis of one prototype detector. Owing to the higher rise-time resolution of the CDEX-10 prototype detector as compared with CDEX-1 B, we identified the origin of an observed category of extremely fast events. For data analysis of the CDEX-10 prototype detector, we introduced and applied an improved bulk/surface event discrimination method. The results of the new method were compared to those of the CDEX-1 B spectrum. Both sets of results showed good consistency in the 0-12 ke Vee energy range, except for the 8.0 keV K-shell X-ray peak from the external copper.

关键词： WIMP pPCGe liquid nitrogen bulk/surface event discrimination extremely fast events

Nature:科学家鉴别出调节机体睡眠的两个关键基因

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现代生物医学进展 2017年第6期17卷 I0002-I0002页

作者： Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J. Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Shinichi Miyazaki, Linzi Connor, Yu Hayashi, Qinghua Liu, Joseph S. Takahashi Masashi Yanagisawa Hiromasa Funato Makito Sato Masashi Yanagisawa Shin Nakane, Jun Tomita Kazuhiko Kume Seiya Mizuno, Fumihiro Sugiyama Satoru Takahashi vivek Kumar Joseph S. Takahashi vivek Kumar Ikuo Miura, Tomohiro Suzuki Shigeharu Wakana Atsushi Watanabe Manabu Abe Kenji Sakimura Yu Hayashi Qinghua Liu Joseph S. Takahashi Masashi Yanagisawa Masashi Yanagisawa International Institute for Integrative Sleep Medicine (WPI-IIIS) University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Anatomy Faculty of Medicine Toho University Ota-ku Tokyo 143-8540 Japan Department of Molecular Genetics University of Texas Southwestern Medical Center Dallas Texas 75390 USA Department of Neuropharmacology Graduate School of Pharmaceutical Sciences Nagoya City University Nagoya Aichi 467-8603 Japan Laboratory Animal Resource Center University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Neuroscience University of Texas Southwestern Medical Center Dallas Texas 75390 USA The Jackson Laboratory Bar Harbor Maine 04609 USA Technology and Development Team for Mouse Phenotype Analysis RIKEN Bioresource Center Tsukuba Ibaraki 305-0074 Japan Laboratory of Research Advancement National Center for Geriatrics and Gerontology Obu Aichi 474-8511 Japan Department of Cellular Neurobiology Brain Research Institute Niigata University Niigata 951-8585 Japan PRESTO Japan Science and Technology Agency Kawaguchi Saitama 332-0012 Japan Department of Biochemistry University of Texas Southwestern Medical Center Dallas Texas 75390 USA Howard Hughes Medical Institute University of Texas Southwestern Medical Center Dallas Texas 75390 USA Life Science Center Tsukuba Advanced Research Alliance University of Tsukuba Tsukuba Ibaraki 305-8575 Japan

近日，刊登在国际杂志Nature上的一项研究报告中，来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因，这两个基因能够帮助调节机体深度睡眠和做梦的水平，相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。... 详细信息

近日，刊登在国际杂志Nature上的一项研究报告中，来自西南医学中心等机构的研究人员通过研究鉴别出了两个关键的核心基因，这两个基因能够帮助调节机体深度睡眠和做梦的水平，相关研究或为阐明相关的基因控制睡眠的网络提供新的线索。此前研究者通过对小鼠进行研究发现了能够控制机体快速眼动睡眠的基因，同时该基因还能够诱导深度睡眠。而第二个基因能够控制机体对快速眼动睡眠的需求量，相关研究为科学家们提供了一个关键的切入点来帮助解释睡眠工作的机制，同时研究者还鉴别出了治疗睡眠障碍的潜在靶点。

关键词：睡眠障碍核心基因科学家机体鉴别基因控制研究人员需求量