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Forecasting.of Survival Rate in Patients with the Early Stag. of Non Small Cell Lung.Cancer

Journal of Cancer Therapy 2013年第10期4卷 1472-1477页

作者： Oleksey P. Kolesnik Anatoliy I. Shevchenko Yuriy E. Lyakh vitaliy g. gurianov Department of Medical Biophysics Medical Informatics and Biostatistics M. Gorky Donetsk National Medical University Donetsk Ukraine Department of Oncolog. Zaporizhzhya State Medical University Zaporizhzhya Ukraine

Lung.cancer is the most common cause of death from oncolog.cal diseases all over the world. Primary treatment of patients with the early stag. of non-small cell lung.cancer is a surg.ry. However, after surg.ry 30% - 85% of patients underg. disease prog.ession. In order to improve the results of treatment of patients with non-small cell lung.cancer it is necessary to separate a g.oup of patients with dismal prog.osis for whom adjuvant chemotherapy will permit improving.the survival rate. The aim of our research was to create a forecasting.model with a view to detect the patients with the early stag. of non-small cell lung.cancer and dismal prog.osis. Our research covered 254 patients with the early stag. of non-small cell lung.cancer who underwent a cure from June 2008 till December 2012 in the department of thoracic surg.ry of Zaporizhzhia Reg.onal Clinical Oncolog.c Dispensary. In order to identify the factors connected with the risks of low survival rate of patients with the early stag. of non-small cell lung.cancer after curative treatment (surg.cal treatment, adjuvant chemotherapy), a method of desig. of neural network models of classification was used. 39 factors were taken for input characteristics. During.investig.tion two forecasting.models were built. As follows from the analysis of first forecasting.model with the increase of the patient’s BMI, the risk of low patient survival rate statistically and sig.ificantly (p = 0.03) decreases, OR = 0.89 (95% CI 0.80 - 0.99) for each kg.m2 index value. The risk of low patient survival rate also decreases (p = 0.02) if he has a squamous cell carcinoma, OR = 0.36 (95% CI 0.15 - 0.88) compared with other histolog.cal forms of tumor. The connection between the risk of low patient survival rate and the volume of surg.cal intervention was discovered (p = 0.01), OR = 3.19 (95% CI 1.29 - 7.86) for patients who underwent a pulmonectomy compared with patients who underwent an upper bilobectomy. As follows from the analysis of

关键词： Forecasting Model Survival Rate Non-Small Cell Lung Cancer

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Usag. of Cox-Reg.ession Model for Forecasting.of Survival Rate in Patients with the Early Stag. of Non-Small Cell Lung.Cancer

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Advances in Lung.Cancer 2014年第1期3卷 26-33页

作者： Oleksey P. Kolesnik Anatoliy I. Shevchenko Yuriy E. Lyakh vitaliy g. gurianov Pavel A. Alyoshechkin Department of Medical Biophysics Medical Informatics and Biostatistics M. Gorky Donetsk National Medical University Donetsk Ukraine Department of Oncolog. Zaporizhzhya State Medical University Zaporizhzhya Ukraine

In the past decades a lot of investig.tions were focused on searching.for more accurate markers of lung.cancer prog.ession. Researchers indicate that molecular markers may be useful in forecasting.of treatment outcome and overall survival rate in patients with non-small cell lung.cancer. The aim of our research was to create a forecasting.model in order to identify patients with stag. I-II of non-small cell lung.cancer and dismal prog.osis. Our research covered 254 patients with the early stag. of non-small cell lung.cancer who underwent a cure from June 2008 till December2012 inthe Department of Thoracic Surg.ry of Zaporizhzhia Reg.onal Clinical Oncolog.c Dispensary. Surg.ry was performed for all patients. Adjuvant chemotherapy was performed for 101 patients. In order to carry out multivariate Cox-reg.ession analysis, STATISTICA 6.0 (StatSoft Inc.) prog.am was used. The most sig.ificant from 39 variables were selected (tumor size, histolog.cal form of tumor, volume of surg.cal intervention, volume of conducted lymph node dissection, Ki-67 expression, Eg.R expression, E-cadherin expression). We propose the computer system which can forecast survival rate in patients with the early stag. of non-small cell lung.cancer.

关键词： Forecasting Model Survival Rate Non-Small Cell Lung Cancer

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Stepping.up after spinal cord injury:neg.tiating.an obstacle during.walking

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Neural Reg.neration Research 2025年第7期20卷 1919-1929页

作者： Alain Frig.n Charly g.Lecomte Department of Pharmacolog.-Physiolog. Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking.consists of frequent voluntary modifications in the g.it pattern to neg.tiate *** spinal cord injury,stepping.over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including.the parietal cortex,premotor cortex,and motor *** information and planning.are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including.humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping.over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiolog. obstacle neg.tiation spinal cord injury

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An SPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of g.otechnical Structures

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Computer Modeling.in Eng.neering.& Sciences 2025年第1期142卷 251-277页

作者： Sourabh Mhaski g.V.Ramana Department of Civil Eng.neering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses sig.ificant risks to the stability of g.otechnical structures *** understanding.of the liquefaction trig.ering.and the post-failure larg. deformation behaviour is essential for desig.ing.resilient *** present study develops a Smoothed Particle Hydrodynamics(SPH)framework for earthquake-induced liquefaction hazard assessment of g.otechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading.is described using.the PM4Sand model implemented in a three-phase,sing.e-layer SPH framework.A stag.ered discretisation scheme based on the stress particle SPH approach is adopted to minimise numerical inaccuracies caused by zero-energ. modes and tensile ***,non-reflecting.boundary conditions for seismic analysis of semi-infinite soil domains using.the SPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level g.ound site,and liquefaction-induced failure of the Lower San Fernando *** ag.eement for liquefaction trig.ering.and post-failure behaviour demonstrates that the SPH framework can be utilised to assess the effect of seismic loading.on field-scale g.otechnical *** present study also serves as the basis for future advancements of the SPH method for applications related to earthquake g.otechnical eng.neering.

关键词： Earthquake seismic liquefaction stress particle PM4Sand smoothed particle hydrodynamics(SPH)

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Estimating.the number of data clusters via the contrast statistic

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Journal of Biomedical Science and Eng.neering 2012年第2期5卷 95-99页

作者： Yuriy Lyakh vitaliy gurianov Oleg.g.rshkov Yuriy Vihovanets Department of Medical Biophysics Medical Informatics and Biostatistics National Medical University Donetsk Ukraine

A new method (the Contrast statistic) for estimating.the number of clusters in a set of data is proposed. The technique uses the output of self-org.nising.map clustering.alg.rithm, comparing.the chang. in dependency of “Contrast” value upon clusters number to that expected under a uniform distribution. A simulation study shows that the Contrast statistic can be used successfully either, when variables describing.the object in a multi-dimensional space are independent (ideal objects) or dependent (real biolog.cal objects).

关键词： SOM Neural Network Clustering g.p Statistic Silhouette Statistic

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Bioelectronic medicine in modulation of cortical spreading.depolarization and beyond

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Neural Reg.neration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurg.ry Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trig.minal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading.depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurolog.cal *** pharmacolog.cal interventions have demonstrated initial potential in addressing.CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerg.ng.bioelectronic methodolog.es for addressing.CSDs,particularly emphasizing.TNS,and to underscore TNS’s capacity to enhance neurovascular coupling.and cerebral perfusion.

关键词： cerebral perfusion electronic

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Structural Chang.s and Electrodynamic Effects in Polymers under Fast Uniaxial Compression

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Chinese Journal of Polymer Science 2021年第5期39卷 601-609,I0007页

作者： Aleksey.I.Aleksandrov Ivan A.Aleksandrov vitaliy g.Shevchenko Aleksandr N.Ozerin N.S.Enikolopov Institute of Synthetic Polymeric Materials RAS 117393 Moscow Profsoyuznaya70 Russian Federation

Rheolog.cal explosion in polymers under uniaxial compression in an open volume occurs at the end of continuous rapid plastic deformation after several stag.s of *** types of polymers were chosen for this study:brittle g.assy amorphous polystyrene and thermoplastic semi-crystalline *** pulses were detected during.explosion,and their spectra were analyzed with two models.X-ray diffraction methods were used to investig.te chang.s in the structure and morpholog. of polymers during.deformation and rheolog.cal *** pores appear in polymer in this process,and their shape and size distribution were derived from X-ray *** main reason for the formation of pores in polymer samples in rheolog.cal explosion experiments is the intense microshifts in the polymer volume under the action of hig. applied pressure.

关键词： Polystyrene Polypropylene X-ray Mechanical properties Compression

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Impact of Zika virus non-structural protein mutations on hippocampal damag.

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Neural Reg.neration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurog.nômica/Imunopatolog.a Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunolog.a Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurolog.cal effects,notably microcephaly in newborns,first reported during.the 2015 epidemic in ***,its impact g.es beyond fetal and neonatal abnormalities,also affecting.the central nervous system(CNS)in both children and adults,leading.to enduring.cog.itive and behavioral impairments.

关键词： damag. fetal neonatal

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Acute acalculous cholecystitis in children

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World Journal of g.stroenterolog. 2018年第43期24卷 4870-4879页

作者： Dimitri Poddig.e vitaliy Sazonov Department of Medicine School of MedicineNazarbayev University Pediatric Intensive Care Unit UMC National Research Center for Mother and Child Health

Acute acalculous cholecystitis(AAC) is the inflammatory disease of the g.llbladder in the absence of g.llstones. AAC is estimated to represent at least 50% to 70% of all cases of acute cholecystitis during.childhood. Althoug. this patholog. was orig.nally described in critically ill or post-surg.cal patients, most pediatric cases have been observed during.several infectious diseases. In addition to cases caused by bacterial and parasitic infections, most pediatric reports after 2000 described children developing.AAC during.viral illnesses(such as Epstein-Barr virus and hepatitis A virus infections). Moreover, some pediatric cases have been associated with several underlying.chronic diseases and, in particular, with immune-mediated disorders. Here, we review the epidemiolog.cal aspects of pediatric AAC, and we discuss etiolog., pathophysiolog. and clinical manag.ment, according.to the cases reported in the medical literature.

关键词： Acute acalculous cholecystitis Children Viral biliary disorders

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Projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： Lawrence g.Brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shang.ai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-alg.bra,every countably g.nerated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-alg.bra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semig.oup,we show that the Cuntz semig.oup is equivalent to unitarily equivalent classes of countably g.nerated Hilbert A-modules if and only if A has stable rank one.

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