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International Journal of Ophthalmology(English edition) 2020年第1期13卷 120-123页

作者： Peter W.macIntosh S.Vijay Kumar V.R.Saravanan virna m.shah Illinois Eye and Ear Infirmary University of Illinois at ChicagoChicagoIL 60612USA Neuro-Ophthalmology Service Aravind Eye HospitalCoimbatore 641014India

AIm:To elucidate the changes of different ganglion cell layer(GCL)thinning patterns between the optic neuritis(ON)and non-arteritic anterior ischemic optic neuropathy(NAION).mETHODS:A prospective,observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence ***:Thinning on optical coherence tomography in the NAION group occurs as early as 11 d after symptomatic onset of vision loss and follows an altitudinal *** mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7μm in the NAION cohort compared to controls of 0.8μm(P=0.032),but not significant in the ON group compared to controls with both groups measuring 1.1μ*** thinning was significant for the ON group compared to controls at 7.2μm(P=0.011)but not the NAION group compared to controls at 1.35μ***:These findings suggest that future treatments for NAION should be given early,and possibly before 11 d in order to prevent GCL and irreversible vision loss.

关键词： optic neuritis non-arteritic ischemic optic neuropathy optical coherence tomography ganglion cell layer

Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema

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World Journal of methodology 2017年第3期7卷 108-111页

作者： Ananth Bhosale virna m shah Parag K shah Department of Retina and Vitreous Aravind Eye Hospital and Postgraduate Institute of Ophthalmology Department of Neuro Ophthalmology Aravind Eye Hospital and Postgraduate Institute of Ophthalmology

AIm To study the usefulness of orbital ultrasonography in the diagnosis of *** Fifty patients who were referred to the neurophthalmology clinic and clinically suspected to have papilledema were selected. Thorough, clinical examination with slitlamp biomicroscopy and visual acuity assessment was done. These patients underwent ultrasonography to demonstrate the crescent sign. The patients were further evaluated with the neurologist and magnetic resonance imaging(mRI) thus confirming the diagnosis of papilledema. The results of our ultrasonographic evaluation were correlated with final diagnosis after thorough clinical evaluation, imaging and the neurologist's *** Out of 50 patients diagnosed having papilledema on mRI, 46(92%) showed crescent sign on B scan ultrasonography. Headache was most common presenting complaint in 47(94%) and idiopathic intracranial hypertension was most common underlying cause of papilledema in 30(60%) ***"Crescent sign" seen on ultrasonography is a sensitive tool for diagnosis of papilledema. It is cost effective, less cumbersome and effective tool to differentiatebetween papilledema and pseudo papilledema before subjecting the patients to costly investigations like mRI. A positive crescent sign should always be followed by mRI to find out the cause of papilledema.

关键词： Papilledema Orbital ultrasound Doughnut sign Crescent sign B scan

C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第7期14卷 279-287页

作者： Hritik Rathod Ritu m.Soni Jigna S.shah Department of Pharmacology Institute of Pharmacy Nirma UniversityAhmedabadGujaratIndia

Objective:To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s ***:C-phycocyanin(50 mg/kg,i.p.,daily)was administered to rotenone(30 mg/kg,p.o.,daily)treated mice for 28 *** studies(Y-maze,rotarod,round beam walk,and wire-hang tests)were carried out to assess neurobehavioral *** and malondialdehyde were determined in both serum and striatal *** proteins(AKT,AmPK,NF-κB,BDNF,and alpha-synuclein)in the striatum were estimated using *** analyses(hematoxylin and eosin stainning as well as Nissl staining)were carried out to assess structural abnormalities in the ***:C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein *** also slightly upregulated AmPK and AKT levels without significant difference compared with the rotenone ***,rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by ***:C-phycocyanin might have potential neuroprotective effects against Parkinson’s *** studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.

关键词： Parkinson’s disease C-phycocyanin Alphasynuclein BDNF Oxidative stress Rotenone

Twinning aspects and their efficient roles in wrought mg alloys:A comprehensive review

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Journal of magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： S.S.A.shah manping Liu Azim Khan Farooq Ahmad m.R.Abdullah Xingquan Zhang Shiwei Xu Zhen Peng School of materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of mechanical and Vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the microstructure and properties of wrought magnesium(mg)***,twins play a crucial role in initiating dynamic recrystallization(DRX),while twin regions experience rapid recrystallization during static recrystallization(SRX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by stress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs serve to stabilize them,restraining their *** such as segregation may also alter the twinning propensity in magnesium-rare earth(mg-RE)***{10–11}contraction twins(CT)and{10–11}-{10–12}double twins(DT)can promote dynamic recrystallization(DRX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.

关键词： mg alloys Twinning Recrystallization Texture mechanical properties

morphology-Tailored Dynamic State Transition in Active-Passive Colloidal Assemblies

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Research 2024年第3期2024卷 751-760页

作者： Nan Yu Zameer H.shah mingcheng Yang Yongxiang Gao Institute for Advanced Study Shenzhen University518060ShenzhenChina Key Laboratory of Optoelectronic Device and Systems of ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen University518060ShenzhenChina Beijing National Laboratory for Condensed matter Physics and Laboratory of Soft matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Songshan Lake materials Laboratory DongguanGuangdong 523808China.

mixtures of active self-propelled and passive colloidal particles promise rich assembly and dynamic states that are beyond reach via equilibrium ***,controllable transition between different dynamic states remains ***,we reveal a plethora of dynamic behaviors emerging in assemblies of chemically propelled snowman-like active colloids and passive spherical particles as the particle shape,size,and composition are *** example,assembles of one or more active colloids with one passive particle exhibit distinct translating or orbiting states while those composed of one active colloid with 2 passive particles display persistent“8”-like cyclic motion or hopping between circling states around one passive particle in the plane and around the waist of 2 passive ones out of the plane,controlled by the shape of the active colloid and the size of the passive particles,*** morphology-tailored dynamic transitions are in excellent agreement with state diagrams predicted by mesoscale dynamics *** work discloses new dynamic states and corresponding transition strategies,which promise new applications of active systems such as micromachines with functions that are otherwise impossible.

关键词： Transition otherwise transitions

Ir single atoms on NiFeZn-LDH matrix for exceptional oxygen evolution reaction

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Nano Research 2024年第8期17卷 7039-7044页

作者： muhammad Israr muhammad Humayun Jiaqi Zhang Khadim shah Xin Tan Chen Chen Yadong Li Department of Chemistry Tsinghua UniversityBeijing 100084China Energy Water and Environment LabCollege of Humanities and SciencePrince Sultan UniversityRiyadh11586Saudi Arabia

To address the sluggish kinetics of the oxygen evolution reaction(OER),a potential approach is to rationally design and fabricate extremely effective single atom catalysts(SACs).Using an appropriate matrix to stabilize single-atom active centers with optimal geometric and electronic structures is crucial for enhancing catalytic ***,we report the design and fabrication of Ir single atoms on NiFeZn layered double hydroxide(Ir-SAC/NiFeZn-LDH)electrocatalyst for highly efficient and stable *** is investigated that the NiFeZn support exhibits abundant defect sites and unsaturated coordination *** sites function to anchor and stabilize single Ir single atoms on the *** strong synergetic electronic interaction between the Ir single atoms and the NiFeZn matrix resulted in remarkable OER performance of the as-fabricated Ir-SAC/NiFeZn *** a loading Ir content of 1.09 wt.%,this catalyst demonstrates a highly stable OER activity,with an overpotential of 196 mV at 10 mA·cm^(−2) and a small Tafel slope of 35 mV·dec^(−1) for the OER in a 1 m KOH *** results significantly surpass the performance of the commercially available IrO_(2) catalyst.

关键词： Ir single atoms layered double hydroxides rational design geometric optimization oxygen evolution reaction

Al^(3+) doped CeO_(2) for proton conducting fuel cells

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International Journal of minerals,metallurgy and materials 2024年第10期31卷 2253-2262页

作者： Sarfraz shahzad Rasool muhammad Khalid mAKYousaf shah Bin Zhu Jung-Sik Kim muhammad Imran Asghar Nabeela Akbar Wenjing Dong Jiangsu Provincial Key Laboratory of Solar Energy Science and Technology/Energy Storage joint Research Center School of Energy and EnvironmentSoutheast UniversityNanjing 210096China School of microelectronics Hubei UniversityWuhan 430062China Sino-French Engineer School/School of General Engineering Beihang UniversityBeijing 100191China Renewable Energy Technologies Group Faculty of Engineering and Natural SciencesTampere UniversityFI-33014Finland

Developing high ionic conducting electrolytes is crucial for applying proton-conducting fuel cell(PCFCs)*** cur-rent study investigates the effect of alumina on the structural,morphological,electrical,and electrochemical properties of CeO_(2).Lattice oxygen vacancies are induced in CeO_(2) by a general doping concept that enables fast ionic conduction at low-temperature ranges(300-500℃)for *** refinement of the X-ray diffraction(XRD)patterns established the pure cubic fluorite structure of Al-doped CeO_(2)(ADC)samples and confirmed Al ions’fruitful integration in the CeO_(2) *** electronic structure of the alumina-doped ceria of the materials(10ADC,20ADC,and 30ADC)has been *** a result,it was found that the best composition of 30ADC-based electrolytes induced maximum lattice oxygen *** corresponding PCFC exhibited a maximum power output of 923 mW/cm^(2)at 500℃.moreover,the investigation proves the proton-conducting ability of alumina-doped ceria-based fuel cells by using an oxide ion-blocking layer.

关键词： proton ceramic fuel cells oxygen vacancies higher fuel cell performance doping fast ions transportation

Enhancing mild Cognitive Impairment Detection through Efficient magnetic Resonance Image Analysis

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Computers, materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif mehmood Zhonglong Zheng Rizwan Khan Ahmad Al Smadi Farah shahid shahid Iqbal mutasem K.Alsmadi Yazeed Yasin Ghadi Syed Aziz shah mostafa m.Ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).mild cognitive impairment(mCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify mCI,AD,and normal control(NC)*** paper focuses on using gray matter(Gm)scans obtained through magnetic resonance imaging(mRI)for the diagnosis of individuals with mCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and mCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose mCI,AD,and normal control individuals using Gm *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

An arrow in the quiver: evaluating the performance of Hyptis suaveolens(L.) Poit. in different light levels

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Antimicrobial stewardship and targeted therapies in the changing landscape of maternal sepsis

Ecological Processes 2024年第2期 130-147页

作者： Kanhaiya shah Gyan Prakash Sharma R.Sagar Department of Environmental Studies University of Delhi Department of Botany Banaras Hindu University

Background Hyptis suaveolens（L.） Poit.,native to the American tropics,is a pantropical annual plant and a major invasive species throughout *** was anticipated that the availability of sunlight,coupled with its superior reproductive potential,persistent propagule bank,and dispersal ability,could lead to an increase in the growth and spread of this invader,thus potentially impeding herbaceous growth and diversity in non-native *** its ecological fitness and competitive performance will be useful to manage the spread of *** in natural ecosystems that are facing a wide range of anthropogenic *** The present study is a three-tier *** the first tier,a field study was conducted to assess the patterns of *** abundance and herbaceous species diversity in response to light availability(sun,842-1072μmol m-2s-1and shade 253-341 μmol m-2S-1) in the tropical dry deciduous ecosystems in the Vindhyan highlands,***,the impact of *** abundance on the resident native and non-native species abundance and diversity was also *** the second tier,a randomized common garden experiment was conducted to understand the trait fitness of *** in sun(940 μmol m-2s-1) and shade(300 μmol m-2s-1) *** the third tier,a plant growth chamber experiment with high-light(940 μmol m-2s-1) and low-light(300 μmol m-2s-1)treatments was done to learn how *** partitions its biomass between aboveground and belowground plant *** The field study indicated that the sunlit areas had a higher abundance of *** and a lower diversity of resident herbaceous species than the shaded *** common garden experiment showed that sun-dwelling *** individuals performed better in germinative,vegetative,eco-physiological,and reproductive traits than the shade-dwelling *** growth chamber experiment exhibited that plants grown in high-light environment had greater seed germi

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Journal of Intensive medicine 2024年第1期4卷 46-61页

作者： Nishel m shah Esmita Charani Damien ming Fook-Choe Cheah mark R Johnson Department of metabolism Digestion and ReproductionImperial College LondonChelsea and Westminster HospitalLondonUK Health Protection Research Unit in Healthcare Associated Infection and Antimicrobial Resistance Imperial College LondonLondonUK Division of Infectious Diseases and HIV medicine Department of MedicineGroote Schuur HospitalUniversity of Cape TownCape TownSouth Africa Department of Infectious Diseases Imperial College LondonChelsea and Westminster HospitalLondonUK Department of Paediatrics Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia

Pregnant and postnatal women are a high-risk population particularly prone to rapid progression to sepsis with significant morbidity and mortality ***,severe maternal infections can have a serious detrimental impact on neonates with almost 1 million neonatal deaths annually attributed to maternal infection or *** this review we discuss the susceptibility of pregnant women and their specific physiological and immunological adaptations that contribute to their vulnerability to sepsis,the implications for the neonate,as well as the issues with antimicrobial stewardship and the challenges this poses when attempting to reach a balance between clinical care and urgent ***,we review advancements in the development of pregnancy-specific diagnostic and therapeutic approaches and how these can be used to optimize the care of pregnant women and neonates.

关键词： Sepsis Pregnancy Immunology Cardiovascular Personalised medicine Antibiotic stewardship