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Acute changes in ganglion cell layer thickness in ischemic optic neuropathy compared to optic neuritis using optical coherence tomography

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International Journal of Ophthalmology(English edition) 2020年第1期13卷 120-123页

作者： Peter W.MacIntosh S.Vijay Kumar V.R.Saravanan virna M.Shah Illinois Eye and Ear Infirmary University of Illinois at ChicagoChicagoIL 60612USA Neuro-Ophthalmology Service Aravind Eye HospitalCoimbatore 641014India

AIM:To elucidate the changes of different ganglion cell layer(GCL)thinning patterns between the optic neuritis(ON)and non-arteritic anterior ischemic optic neuropathy(NAION).METHODS:A prospective,observational study was conducted to evaluate the timing of GCL changes between acute ON and NAION using optical coherence ***:Thinning on optical coherence tomography in the NAION group occurs as early as 11 d after symptomatic onset of vision loss and follows an altitudinal *** mean superior-inferior GCL thickness difference in the NAION cohort was clinically significant at 5.7μm in the NAION cohort compared to controls of 0.8μm(P=0.032),but not significant in the ON group compared to controls with both groups measuring 1.1μ*** thinning was significant for the ON group compared to controls at 7.2μm(P=0.011)but not the NAION group compared to controls at 1.35μ***:These findings suggest that future treatments for NAION should be given early,and possibly before 11 d in order to prevent GCL and irreversible vision loss.

关键词： optic neuritis non-arteritic ischemic optic neuropathy optical coherence tomography ganglion cell layer

Accuracy of crescent sign on ocular ultrasound in diagnosing papilledema

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World Journal of Methodology 2017年第3期7卷 108-111页

作者： Ananth Bhosale virna M Shah Parag K Shah Department of Retina and Vitreous Aravind Eye Hospital and Postgraduate Institute of Ophthalmology Department of Neuro Ophthalmology Aravind Eye Hospital and Postgraduate Institute of Ophthalmology

AIM To study the usefulness of orbital ultrasonography in the diagnosis of *** Fifty patients who were referred to the neurophthalmology clinic and clinically suspected to have papilledema were selected. Thorough, clinical examination with slitlamp biomicroscopy and visual acuity assessment was done. These patients underwent ultrasonography to demonstrate the crescent sign. The patients were further evaluated with the neurologist and magnetic resonance imaging(MRI) thus confirming the diagnosis of papilledema. The results of our ultrasonographic evaluation were correlated with final diagnosis after thorough clinical evaluation, imaging and the neurologist's *** Out of 50 patients diagnosed having papilledema on MRI, 46(92%) showed crescent sign on B scan ultrasonography. Headache was most common presenting complaint in 47(94%) and idiopathic intracranial hypertension was most common underlying cause of papilledema in 30(60%) ***"Crescent sign" seen on ultrasonography is a sensitive tool for diagnosis of papilledema. It is cost effective, less cumbersome and effective tool to differentiatebetween papilledema and pseudo papilledema before subjecting the patients to costly investigations like MRI. A positive crescent sign should always be followed by MRI to find out the cause of papilledema.

关键词： Papilledema Orbital ultrasound Doughnut sign Crescent sign B scan

Modelling the interaction of the Astro Bio Cube Sat with the Van Allen's Belt radiative field using Monte Carlo transport codes

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Radiation Detection Technology and Methods 2022年第2期6卷 262-279页

作者： N.Burgio L.Cretara M.Corcione M.Frullini L.lannascoli A.Nascetti A.Santagata G.Palmerini A.Quintino J.R.brucato A.Meneghin D.Paglialunga ENEA FSN-FISS-RNRC.R.CasacciaRomeItaly DIAEE Sapienza UniversitàDi RomaVia Eudossiana 1800184 RomeItaly School of Aerospace Engineering Sapienza University of RomeVia Salaria 85100138 RomeItaly INAF-Astrophysical Observatory of Arcetri L.go E.Fermi 550125 FlorenceItaly

Purpose The AstroBio Cube Satellite(ABCS)will deploy within the inner Van Allen belt on the Vega C Maiden Flight launch opportunity of the European Space *** this altitude,ABCS will experience radiation doses orders of magnitude greater than in low earth orbit,where CubeSats usually *** paper aims to estimate the irradiation effect on the ABCS payload in the orbital condition,their possible mitigation designing shielding solutions and performs a preliminary representativity simulation study on the ABCS irradiation with fission neutron at the TAPIRO(TAratura Pila Rapida Potenza 0)nuclear research reactor facility at *** We quantify the contributions of geomagnetically trapped particles(electron and proton),Galactic Cosmic Rays(GCR ions),Solar energetic particle within the ABCS orbit using the ESA's SPace ENVironment information ***(Fluktuierende Kaskade-Fluctuating Cascade)code models the ABCS interaction with the orbital *** We found a shielding solution of the weight of 300 g constituted by subsequent layers of tungsten,resins,and aluminium that decreases on average the 20%overall dose rate relative to the shielding offered by the only satellite's ***,simulations of neutron irradiation of the whole ABCS structure within the TAPIRO's thermal column cavity show that a relatively short irradiation time is requested to reach the same level of 1 MeV neutron Silicon equivalent damage of the orbital *** The finding deserves the planning of a future experimental approach to confirm the TAPIRO's performance and establish an irradiation protocol for testing aerospatial electronic components.

关键词： Galactic cosmic rays and solar energetic particles Spacecraft shielding Dosimetry Monte Carlo methods MCNP and FLUKA

CXCR4+ and SDF-1+ Bone Marrow Cells Are Mobilized into the Blood Stream in Acute Myocardial Infarction and Acute Ischemia

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World Journal of Cardiovascular Diseases 2014年第7期4卷 361-367页

作者： Jose Luis Aceves Rafael Vilchis Maria Antonieta Medina Monserrat Borja Silvia Cortes Guillermo Diaz Armando Castro Alexis Gomez Jose JParra Martha Alvarado Manuel Lopez Hernandez virna Poveda Felipe Masso Luis FMontano Division de Cardiocirugia Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Departamento de Hematologia Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Laboratorio de Hormonas Centro Medico Nacional 20 de Noviembre ISSSTEMexico DFMexico Departamento de Inmunobiologia Biologia Celular y Tisular Facultad de Medicina UNAMMexico DFMexico

Cell therapy has shown beneficial effects on ventricular function and tissue regeneration in patients with acute and chronic myocardial infarction, although with diverse grades of variability in the results, possibly by proportion, subtype and cell cycle status. Objective: Identify and phenotypically characterize, via CXCR4 and SDF-1 expression, the bone marrow cell subpopulations that are mobilized into the bloodstream in patients with Acute Myocardial Infarction (AMI) and Acute Ischemia (AI) such as acute angina and Chronic Ischemia (CI) such as chronic stable angina, and also determine the cell cycle status of these cells. Method: Patients with AMI and AI were recruited in the ICCU, and patients with CI in the departments of cardiology and cardiovascular surgery. The quantification of cellular subpopulations was made by cytofluorometry with a FACS caliburcyto fluorometry (Becton Dickinson) with specific FITC-labeled anti human monoclonal antibodies against CD34, CD133, CD117, CD48, CXCR4, SDF-1 and Ki67 (Becton Dickinson). Serum concentration of IL-6 and IL-8 were determined by a sequential solid phase chemiluminescent assay performed in a SIEMENS IMMULITE 1000 Analyzer. Statistical analysis was made with the SPSS version 20.0 for Windows. A p value 3/ml) than that in AI (9.2 ± 1.3 × 103/ml) and CI (6.6 ± 1.1 × 103/ml) patients (p p = 0.22 to 0.39), but interestingly in AMI and AI patients, cells were CXCR4+ in almost half of these mobilized cells, although the proportion was significantly higher in AMI patients (46.8% ± 7.1% to 55.7% ± 6.3% vs 23% ± 1.6% to 28.4% ± 2.1%, p = 0.03 to 0.05). A similar behavior was observed with the Ki67 antibody (29.9% ± 2.1% to 36.1% ± 6.3% vs 10% ± 1.2% to 24% ± 1.1%, p = 0.001 to 0.05). Bivariate analysis of the results showed a significant correlation of the cell proportion in AMI but not in AI and CI patients (p = 0.001 to 0.05;0.12 to 0.87 and 0.17 to 0.92 respectively). The amount of myocardial tissue infarcted did not show

关键词： Stem Cells CXCR4:SDF-1 Axis Cardiac Repair Acute and Chronic Ischemia

Family Organization in the Care of Pediatric Heart Transplant Patients:The Genogram as an Investigative Tool

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Health 2015年第11期7卷 1409-1418页

作者： Silvania Braga Ribeiro Angela Maria Alves e Souza Ana Ruth Macedo Monteiro Kiarelle Lourenco Penaforte Sarah Maria de Sousa Feitoza virna Ribeiro Feitosa Cestari Flávia Paula Magalhaes Monteiro Maria Gyslane Vasconcelos Sobral Samila Torquato Araújo Máguida Gomes da Silva Mona Lisa Menezes Bruno Islene Victor Barbosa Isabelle Barbosa Pontes Department of Nursing Universidade de FortalezaFortalezaBrazil

This study aimed to describe structure, functionality and development of pediatric heart transplant families, from the understanding of the experienced chronic condition. A descriptive, exploratory study using a qualitative approach was developed in a hospital situated in a city of Northeast Brazil, in 2012. The study was conducted with three families, using the Calgary Family Assessment Model (CFAM). In addition to the genogram, an analysis of the children’s/adolescents’ family members was conducted at the time of interview. Two families were binuclear families and one was mononuclear. From the evaluation, it was possible to determine the care and support network of children and adolescents with heart transplants, as well as some difficulties faced by the investigated families. Nurses are important in this family context since the visualization of the family genogram can generate a change in the nursing care to each family.

关键词： Chronic Disease Heart Transplant Child Family Nursing Assessment