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The petroleum ether fraction of Celastrus paniculatus Willd. seeds demonstrates antiarthritic effect in adjuvant-induced arthritis in rats

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Journal of Traditional Chinese Medical Sciences 2015年第3期2卷 183-193页

作者： Pankaj S.Kothavade vipin d.bulani Padmini S.deshpande Amrita S.Chowdhury Archana R.Juvekar department of Pharmaceutical Sciences and Technology Institute of Chemical TechnologyMatungaMumbai400019India

Objective:Celastrus paniculatus(CP)*** a plant indigenous to India with medicinal *** is used in the ayurvedic treatment of inflammatory ailments such as rheumatoid *** present study was designed to investigate the therapeutic efficacy of the petroleum ether fraction(PCP)obtained from CP seeds on adjuvant-induced arthritis in ***:Arthritis was induced in Spragueedawley rats by immunization with Freund’s complete adjuvant(FCA).Arthritis severity was evaluated by arthritis score,paw volume,tibiotarsal joint thickness,body weight,dorsal flexion pain,motility test,stair climbing ability and index of thymus and ***,histopathology of knee joints supported by haematological analysis was used to assess the anti-arthritic action of *** levels of superoxide dismutase(SOd),glutathione(GSH),catalase(CAT),nitric oxide(NO)and malondialdehyde(MdA)in liver were also *** samples were collected for estimation of aspartate transaminase(AST),alanine transaminase(ALT)and alkaline phosphatase(ALP).In addition,cytokines such as tumour necrosis factor-alpha(TNF-a)and interleukin-6(IL-6)were estimated in ***:PCP significantly alleviated arthritic progression with regards to paw swelling,arthritic score,immune organ indices,hyperalgesic effect and body *** phenomenon was correlated with significant suppression of overproduction of inflammatory cytokines(TNFa and IL-6),oxidant stress markers(MdA and NO)and cellular enzyme(AST,ALT and ALP)levels versus arthritic rats without ***,PCP restored the decreased levels of SOd,CAT and ***:Our results suggest that the anti-arthritic properties of PCP may be due to immunosuppressive effects,cytokine regulation,antioxidant effects and bone-protective activities.

关键词： Celastrus paniculatus Rheumatoid arthritis Freund’s complete adjuvant Cytokine

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Controlling Tendons to Modulate Stiffness of a Planar-to-Spatial Tendon-driven Continuum Manipulator Under External Uncertain Forces

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Journal of Bionic Engineering 2024年第2期21卷 821-841页

作者： vipin Pachouri Pushparaj Mani Pathak Indian Institute of Technology Roorkee Roorkee247667India

Continuum manipulators(CM)are soft and flexible manipulators with large numbers of degrees of freedom and can perform complex tasks in an unstructured ***,their deformability and compliance can deviate distal tip under uncertain external *** address this challenge,a novel tension-based control scheme has been proposed to modulate the stiffness of a tendon-driven CM,reducing the tip position errors caused by uncertain external *** minimize the tip position error,a virtual spring is positioned between the deviated and the desired tip *** proposed algorithm corrects the manipulator deviated tip position,improving tension distribution and stiffness profile,resulting in higher stiffness and better *** corresponding task space stiffness and condition numbers are also computed under different cases,indicating the effectiveness of the tension control scheme in modulating the manipulator's *** validation conducted on an in-house developed prototype confirms the practical feasibility of the proposed approach.

关键词： Continuum arm Hyper-redundant robots Variable stiffness manipulator Tension-based control Mechatronic systems

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Fractal analysis of major faults and fractal dimension of lineaments in the Indo-Gangetic Plain on a regional scale

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Earthquake Science 2024年第2期37卷 107-121页

作者： vipin Chauhan Jagabandhu dixit disaster Management Laboratory Shiv Nadar UniversityDelhi NCRGautam Buddha NagarUttar Pradesh 201314India

The Indo-Gangetic Plain(IGP)is one of the most seismically vulnerable areas due to its proximity to the *** information system(GIS)-based seismic characterization of the IGP was performed based on the degree of deformation and fractal *** zone between the Main Boundary Thrust(MBT)and the Main Central Thrust(MCT)in the Himalayan Mountain Range(HMR)experienced large variations in earthquake magnitude,which were identified by Number-Size(NS)fractal *** central IGP zone experienced only moderate to low mainshock *** analysis of earthquake epicenters reveals a large scattering of earthquake epicenters in the HMR and central IGP ***,the fault fractal analysis identifies the HMR,central IGP,and south-western IGP zones as having more ***,the seismicity of the study region is strong in the central IGP,south-western IGP,and HMR zones,moderate in the western and southern IGP,and low in the northern,eastern,and south-eastern IGP zones.

关键词： geospatial analysis fractal modeling seismicity pattern fractal dimension

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Intraocular pressure and gonioscopic findings in primary angle-closure disease in India—a big data study

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1495-1500页

作者： Srikantaiah Ramyashri Anthony vipin das Sirisha Senthil VST Centre for Glaucoma Care Kallam Anji Reddy CampusL V Prasad Eye InstituteHyderabad 500034India drishti Eye Centre Hyderabad 500073India Kallam Anji Reddy Campus L V Prasad Eye InstituteHyderabad 500034India

AIM:To describe the gonioscopic profile and intraocular pressure(IOP)in primary angle-closure(PAC)disease in patients presenting to a tertiary eye care network in ***:A cross-sectional hospital-based study that included 31484 new patients presenting between 2011 and *** with a clinical diagnosis of PAC/suspect/glaucoma were *** data was collected from an electronic medical record ***:PAC glaucoma(PACG)(47.55%)was the most common diagnosis followed by PAC(39.49%)and PAC suspect(PACS;12.96%).Female preponderance(54.6%)was noted with higher mean age at presentation among males(Pd PAC showed the highest prevalence in 6th decade but PACG was higher at 7th *** probability of angle opening was 95.93%,90.32%and 63.36%in PACS,PAC and PACG eyes respectively post peripheral iridotomy(PI).Plateau iris syndrome(PIS)was noted in 252 eyes and all showed post dilated rise of IOP.A post dilated IOP rise was also noted with 8.86%,33.95%and 57.19%eyes with PACS,PAC and PACG respectively with IOP rise between 6-8 mm Hg across the disease ***:The superior quadrant is the narrowest angle and difficult to open with indentation and post *** probability of angle opening is less in PIS especially the complete variety along with post dilated IOP *** post dilated IOP rise in angle closure eyes warrants a careful dilatation,especially with PIS.

关键词： angle closure disease peripheral iridectomy gonioscopy post dilated intraocular pressure rise plateau iris syndrome

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HV Process Model of Software development

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Journal of Software Engineering and Applications 2024年第7期17卷 553-570页

作者： Hemant Kumar vipin Saxena department of Computer Science Babasaheb Bhimrao Ambedkar University Lucknow India

Software development Life Cycle (SdLC) is one of the major ingredients for the development of efficient software systems within a time frame and low-cost involvement. From the literature, it is evident that there are various kinds of process models that are used by the software industries for the development of small, medium and long-term software projects, but many of them do not cover risk management. It is quite obvious that the improper selection of the software development process model leads to failure of the software products as it is time bound activity. In the present work, a new software development process model is proposed which covers the risks at any stage of the development of the software product. The model is named a Hemant-vipin (HV) process model and may be helpful for the software industries for development of the efficient software products and timely delivery at the end of the client. The efficiency of the HV process model is observed by considering various kinds of factors like requirement clarity, user feedback, change agility, predictability, risk identification, practical implementation, customer satisfaction, incremental development, use of ready-made components, quick design, resource organization and many more and found through a case study that the presented approach covers many of parameters in comparison of the existing process models. .

关键词： Software Process Model Software development Software Engineering Software Risk Management and Software Quality

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On the Zeros of a Special Class of Polynomials

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Journal of Mathematical Research with Applications 2024年第4期44卷 470-474页

作者： Mahnaz Shafi CHISHTI vipin Kumar TYAGI Mohammad Ibrahim MIR School of Basic and Applied Sciences Shobhit Institute of Engineering and Technology (Deemed to be University) department of Mathematics University of KashmirSouth Campus

Let P be a complex polynomial of the form P （z）=（λz-a）mΠj=1n-m（z-zj）,where|zj|≥1,1≤j≤*** aim of this paper is to obtain generalisation of a result due to Zargar and Manzoor and a result due to Mir,Nazir and... 详细信息

关键词： bound coefficient polynomial zeros

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Software defect Prediction Using Hybrid Machine Learning Techniques: A Comparative Study

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Journal of Software Engineering and Applications 2024年第4期17卷 155-171页

作者： Hemant Kumar vipin Saxena department of Computer Science Babasaheb Bhimrao Ambedkar University Lucknow India

When a customer uses the software, then it is possible to occur defects that can be removed in the updated versions of the software. Hence, in the present work, a robust examination of cross-project software defect prediction is elaborated through an innovative hybrid machine learning framework. The proposed technique combines an advanced deep neural network architecture with ensemble models such as Support Vector Machine (SVM), Random Forest (RF), and XGBoost. The study evaluates the performance by considering multiple software projects like CM1, JM1, KC1, and PC1 using datasets from the PROMISE Software Engineering Repository. The three hybrid models that are compared are Hybrid Model-1 (SVM, RandomForest, XGBoost, Neural Network), Hybrid Model-2 (GradientBoosting, decisionTree, LogisticRegression, Neural Network), and Hybrid Model-3 (KNeighbors, GaussianNB, Support Vector Classification (SVC), Neural Network), and the Hybrid Model 3 surpasses the others in terms of recall, F1-score, accuracy, ROC AUC, and precision. The presented work offers valuable insights into the effectiveness of hybrid techniques for cross-project defect prediction, providing a comparative perspective on early defect identification and mitigation strategies. .

关键词： defect Prediction Hybrid Techniques Ensemble Models Machine Learning Neural Network

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Nested Levels of Hybrid Cryptographical Technique for Secure Information Exchange

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Journal of Computer and Communications 2024年第2期12卷 201-210页

作者： Pawan Kumar vipin Saxena department of Computer Science Babasaheb Bhimrao Ambedkar University Lucknow India

data security is a very important part of data transmission over insecure channels connected through high-speed networks. due to COVId-19, the use of data transmission over insecure channels has increased in an exponential manner. Hybrid cryptography provides a better solution than a single type of cryptographical technique. In this paper, nested levels of hybrid cryptographical techniques are investigated with the help of deoxyribonucleic Acid (dNA) and Paillier cryptographical techniques. In the first level, information will be encrypted by dNA and at the second level, the ciphertext of dNA will be encrypted by Paillier cryptography. At the decryption time, firstly Paillier cryptography will be processed, and then dAN cryptography will be processed to get the original text. The proposed algorithm follows the concept of Last Encryption First decryption (LEFd) at the time of decryption. The computed results are depicted in terms of tables and graphs.

关键词： Encryption decryption dNA Paillier Cryptography Nested Levels Hybrid Cryptography

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development of metal organic fromwork-199 immobilized zeolite foam for adsorption of common indoor VOCs

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Journal of Environmental Sciences 2017年第5期29卷 321-330页

作者： vipin K.Saini Joao Pires School of Environment and Natural Resources Doon UniversityDehradun 248001India department of Chemistry and Biochemistry Faculty of SciencesUniversity of LisbonLisbon 1749-016Portugal

Reticulated foam shaped adsorbents are more efficient for the removal of volatile organic compounds（VOCs）,particularly from low VOC-concentration indoor air streams. In this study composite structure of zeolite and metal organic frameworks（MOFs）,referred as ZMF,has been fabricated by immobilization of fine MOF-199 powder on foam shaped Zeolite Socony Mobil-5（ZSM-5）Zeolitic structure,referred as ZF. The ZMF possess a uniform and well-dispersed coating of MOF-199 on the porous framework of ZF. It shows higher surface area,pore volume,and VOCs adsorption capacity,as compared to ***-fabrication changes in selective adsorption properties of ZMF were studied with three common indoor VOCs（benzene,n-hexane,and cyclohexane）,using gravimetric adsorption technique. The adsorption capacity of ZMF with different VOCs follow the order of benzene 〉 n-hexane 〉 cyclohexane. In comparison with MOF-199 and ZF,the composite structure ZMF shows improvement in selectivity for benzene from other two VOCs. Further,improvement in efficiency and stability of prepared ZMF was found to be associated with its high MOF loading capacity and unique morphological and structural properties. The developed composite structure with improved VOCs removal and recyclability could be a promising material for small to limited scale air pollution treatment units.

关键词： VOCs Adsorption Composite materials Selectivity Zeolite foam MOFs HKUST-1

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Specific Control of Immunity by Regulatory Cd8 T Cells

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Cellular & Molecular Immunology 2005年第1期2卷 11-19页

作者： XiaOIeiTang TrevorRFSmitl vipin Kumar Laboratory of Autoimmunity Torrey Pines Institute for Molecular Studies San DiegoCA USA. Corresponding to:dr.vipin Kumar Torrey Pines Institute for Molecular Studies3550 General Atomics CourtSan DiegoCA 92121

T lymphocytes with dedicated suppressor function(Treg)play a crucial role in the homeostatic control of immunity in the *** Treg phenotypes have now been identified in the Cd4 and Cd8 T cell populations, suggesting their down-regulatory function in both human and animal models of autoimmunity,transplantation and tumor *** we will focus on the Cd8 Treg population and their ability to specifically inhibit a pathogenic autoimmune *** review will detail the current advances in the knowledge of Cd8 Treg in the context of antigen specificity,phenotype,MHC restriction,mechanism of action,and *** & Molecular Immunology.2005;2(1):11-19.

关键词： regulatory T cell Qa-1 TCR-peptides apoptosis immune deviation cross-priming EAE

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