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Headaches and Erectile Dysfunction Medications at UTH-k.ra (Togo)

World Journal of Neuroscience 2023年第4期13卷 228-235页

作者： Léhleng Agba Nyinèvi k. Anayo Hola k. Sik.a Mensah k. Guinhouya Tchilabalo M. k.atcha vinyo k. kumako Damelan k.mbate k.mi Assogba Agnon A. Balogou Neurology Department University Teaching Hospital of Kara University of Kara Kara Togo Neurology Department University Teaching Hospital of Campus University of Lomé Lomé Togo Urology-Andrology Department University Teaching Hospital of Kara University of Kara Kara Togo Neurology Department University Teaching Hospital of Sylvanus Olympio University of Lomé Lomé Togo Neurology Department Regional Hospital of Kara University of Kara Kara Togo

Introduction: Headaches are a common symptom affecting individuals worldwide, including in the tropical zone, and have been extensively studied in Togo. Phosphodiesterase-5 inhibitors, commonly prescribed for erectile dysfunction, are k.own to induce headaches, yet there is a lack.of research on this topic in sub-Saharan Africa and Togo. Methods: A cross-sectional study conducted from February 1st to June 30th, 2023, including adult patients seek.ng erectile dysfunction treatment and prescribed PDE-5 inhibitors. Results: A total of 28 patients were included in the study, with an average age of 34.46 ± 7.5 years. The age group of 30 - 39 years was the most represented (53.57%). Among the participants, 67.86% had a history of chronic headaches. During the intak. of PDE-5 inhibitors, 71.43% reported the onset of headaches. Among the 19 patients with chronic headaches, 68.42% developed headaches following PDE-5 inhibitor use (RR = 0.88, 95% CI: 0.55 - 1.40, p = 0.484). The characteristics of the induced headaches were similar to the patients’ pre-existing headaches in 78.95% of cases. Additional symptoms included nasal congestion (36.84%) and an urge to have a bowel movement (26.32%). Sildenafil (75.00%) and Tadalafil (25.00%) were the primarily prescribed PDE-5 inhibitors. The incidence of headaches did not significantly differ between the two groups (RR = 1.33, 95% CI: 0.67 - 2.64, p = 0.306). Treatment for the induced headaches involved self-medication with paracetamol (65.00%) and nonsteroidal anti-inflammatory drugs (NSAIDs) (35.00%). Conclusion: Headaches induced by PDE-5 inhibitors are a well-established reality, emphasizing the need for caution and warning in patients with pre-existing headache conditions, while individualized approaches are necessary to address the potential interplay between migraine medications and erectile dysfunction treatments.

关键词： Headache Phosphodiesterase-5 Inhibitors Erectile Dysfunction Togo Sub-Saharan Africa

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