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A case of Sjogren's syndrome evolving into multicentric reticulohistiocytosis

Rheumatology & Autoimmunity 2023年第3期3卷 179-184页

作者： Daniel Gonzalez vinh lu Madeline Bonnet Rachelle Gietzen Anthony Linfante Enrique Medina Vijaya Murthy Division of Rheumatology University of Texas Medical BranchGalvestonTexasUSA Department of Internal Medicine University of Texas Medical BranchGalvestonTexasUSA University of Texas Medical Branch(UTMB)John Sealy School of Medicine GalvestonTexasUSA Department of Pathology University of Texas Medical BranchGalvestonTexasUSA Department of Dermatology University of Texas Medical BranchGalvestonTexasUSA

Introduction:Multicentric reticulohistiocytosis(MRH)is a rare disease that is known to affect the skin and joints,*** is considered a rare form of non-Langerhans cell histiocytosis(Group C)that can cause destructive inflammatory arthritis involving both the small and large *** eruptions of periungual,“coral beads”and nodules appearing over the distal fingers are considered pathognomonic clues for identifying this *** evaluation of the cutaneous papules typically shows infiltrative histiocytes and multinucleated giant *** no well-established therapies exist to date,a variety of immunosuppressants have been used with varying degrees of *** Description:A 53-year-old Caucasian female patient with a family history of rheumatoid arthritis and a personal history of Sjogren's syndrome presented to the rheumatology clinic complaining of pain in her bilateral hands and *** were several small,papulo-nodular lesions ranging from 1 to 2mm in size noted at the base of her nails.A 4mm punch biopsy of one of the papules from the neck showed dermal infiltration of eosinophilic mononucleated and multinucleated giant cells with“ground glass”appearing cytoplasm consistent with MRH.X-ray of her hands showed periarticular demineralization and erosions surrounding several bilateral proximal and distal interphalangeal joints,and thus tofacitinib in addition to methotrexate,hydroxychloroquine,and dexamethasone(dosed weekly)was started to help control any further articular ***:Our aim is to further support the relation of MRH with autoimmune diseases,including Sjogren's *** diseases have been reported in association with MRH,although a clear association has yet to be made.

关键词： erosive arthritis multicentric reticulohistiocytosis Sjogren's syndrome

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Predicting 3D Radiotherapy Dose-Volume Based on Deep Learning

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Intelligent Automation & Soft Computing 2024年第2期39卷 319-335页

作者： Do Nang Toan Lam Thanh Hien Ha Manh Toan Nguyen Trong vinh Pham Trung Hieu Institute of Information Technology Vietnam Academy of Science and TechnologyHanoi10072Vietnam Faculty of Information Technology Lac Hong UniversityBien HoaDong Nai76120Vietnam

Cancer is one of the most dangerous diseaseswith *** of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and *** our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer *** image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction *** proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and *** strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the *** output of the network is added with a rectified linear unit(Re-lu)function for each pixel to ensure there are no negative values,which are absurd with radiation *** experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation *** results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is *** addition,we also conducted a comparison with the results of another study in the same context of using the loss function.

关键词： CT image 3D dose prediction data preprocessing augmentation

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越南永河水电站水轮发电机组启动试运行试验

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红水河 2017年第5期36卷 20-23,38页

作者：李天仲逯鹏甘磊中国能源建设集团广西电力设计研究院有限公司广西南宁530007

以越南永河水电站水轮发电机组启动试运行试验的主要技术工作为主要内容,介绍了总承包商依靠设计院的技术力量在机组安装、调试和启动试验期间的技术和技术管理工作;介绍了现场解决的部分调试和试运行的问题;现场的经验对设计院技术人... 详细信息

以越南永河水电站水轮发电机组启动试运行试验的主要技术工作为主要内容,介绍了总承包商依靠设计院的技术力量在机组安装、调试和启动试验期间的技术和技术管理工作;介绍了现场解决的部分调试和试运行的问题;现场的经验对设计院技术人员的思路有一定启发。

关键词：水轮发电机组启动试运行试验

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