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Amyloid-beta and tau protein beyond Alzheimer's disease

Neural Regeneration Research 2024年第6期19卷 1262-1276页

作者： Morteza Abyadeh Vivek gupta Joao A.Paulo Arezoo Gohari Mahmoudabad Sina Shadfar Shahab Mirshahvaladi Veer gupta Christine T.O.Nguyen David I.Finkelstein Yuyi You Paul A.Haynes Ghasem H.Salekdeh Stuart L.Graham Mehdi Mirzaei ProGene Technologies Pty Ltd. SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA School of Medicine Deakin UniversityGeelongVICAustralia Department of Optometry and Vision Sciences School of Health SciencesFaculty of Medicine Dentistry and Health SciencesUniversity of MelbourneParkvilleVICAustralia The Florey Institute of Neuroscience and Mental Health The University of MelbourneParkvilleVICAustralia School of Natural Sciences Macquarie UniversityMacquarie ParkNSWAustralia

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to play key roles in Alzheimer's disease pathogenesis and are considered the main pathological hallmarks of this devastating ***,these two proteins are produced and expressed within the normal human ***,under pathological conditions,abnormal expression,posttranslational modifications,conformational changes,and truncation can make these proteins prone to aggregation,triggering specific disease-related *** studies have indicated associations between aberrant behavior of amyloid-beta and tau proteins and various neurological diseases,such as Alzheimer's disease,Parkinson's disease,and amyotrophic lateral sclerosis,as well as retinal neurodegenerative diseases like Glaucoma and age-related macular ***,these proteins have been linked to cardiovascular disease,cancer,traumatic brain injury,and diabetes,which are all leading causes of morbidity and *** this comprehensive review,we provide an overview of the connections between amyloid-beta and tau proteins and a spectrum of disorders.

关键词： amyloid-beta cancer cardiovascular diseases diabetes neurodegeneration Tau traumatic brain injury

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Non-invasive assessment of esophageal varices:Status of today

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World Journal of Hepatology 2024年第2期16卷 123-125页

作者： Tarana gupta Department of Medicine Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

With increasing burden of compensated cirrhosis,we desperately need noninvasive methods for assessment of clinically significant portal *** use of liver and spleen stiffness measurement helps in deferring unnecessary endoscopies for low risk esophageal *** would reduce cost and patient ***,these special techniques may not be feasible at remote areas where still we need only biochemical *** prospective studies validating the non-invasive risk prediction models are definitely needed.

关键词： Compensated cirrhosis Spleen stiffness measurement Liver stiffness measurement High-risk esophageal varices Clinically significant portal hypertension

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A Workable Solution for Reducing the Large Number of Vehicle and Pedestrian Accidents Occurring on a Yellow Light

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Journal of Transportation Technologies 2024年第1期14卷 82-87页

作者： Pranav gupta Silki Arora Drive Safe Now Ottawa Canada

Traffic intersections are incredibly dangerous for drivers and pedestrians. Statistics from both Canada and the U.S. show a high number of fatalities and serious injuries related to crashes at intersections. In Canada, during 2019, the National Collision Database shows that 28% of traffic fatalities and 42% of serious injuries occurred at intersections. Likewise, the U.S. National Highway Traffic Administration (NHTSA) found that about 40% of the estimated 5,811,000 accidents in the U.S. during the year studied were intersection-related crashes. In fact, a major survey by the car insurance industry found that nearly 85% of drivers could not identify the correct action to take when approaching a yellow traffic light at an intersection. One major reason for these accidents is the “yellow light dilemma,” the ambiguous situation where a driver should stop or proceed forward when unexpectedly faced with a yellow light. This situation is even further exacerbated by the tendency of aggressive drivers to inappropriately speed up on the yellow just to get through the traffic light. A survey of Canadian drivers conducted by the Traffic Injury Research Foundation found that 9% of drivers admitted to speeding up to get through a traffic light. Another reason for these accidents is the increased danger of making a left-hand turn on yellow. According to the National Highway Traffic Safety Association (NHTSA), left turns occur in approximately 22.2% of collisions—as opposed to just 1.2% for right turns. Moreover, a study by CNN found left turns are three times as likely to kill pedestrians than right turns. The reason left turns are so much more likely to cause an accident is because they take a driver against traffic and in the path of oncoming cars. Additionally, most of these left turns occur at the driver’s discretion—as opposed to the distressingly brief left-hand arrow at busy intersections. Drive Safe Now proposes a workable solution for reducing the number of accidents occ

关键词： Traffic Accidents Yellow Light Traffic Light Signals Intersection Crashes Collision Traffic Fatalities Traffic Injuries Vehicles Safety Speed Limit Driving Pedestrians Bicyclists Motorcyclists Caution Line Yellow Light Dilemma Left Hand Turn on Yellow Distance Smart Road Technology Signs Signage Autonomous Vehicles AVs Road Safety IoT Internet of Things Infrastructure Accident Reduction Driving Habits Stop Line Red Light Jumping Pedestrian Safety Caution Light Stopping at Intersection Safety at Intersections

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Minimum 10-year follow-up outcomes of arthroscopic Bankart’s repair with metallic anchors:Reliable results with low redislocation rates

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World Journal of Methodology 2024年第2期14卷 88-96页

作者： Prateek Kumar gupta Vishesh Khanna Nikunj Agrawal Pratyaksh gupta Department of Sports Medicine Sir Ganga Ram HospitalNew Delhi 110060India Department of Trauma and Orthopdaedics Wirral University Teaching Hospital NHS Foundation TrustWirral CH495PEUnited Kingdom Sports Medicine Sir Ganga Ram HospitalSir Ganga Ram Hospital MargRajinder NagarNew Delhi 110060India Department of Orthopaedics Sir Ganga Ram HospitalNew Delhi 110060India

BACKGROUND With stiff competition from alternative albeit more expensive counterparts,it has become important to establish the applicability of metallic anchors for shoulder instability in the modern *** can be accomplished,in part,by analysing long-term *** To analyse minimum 10-year outcomes from 30 patients following arthroscopic anterior stabilisation using metallic *** Prospectively collected data from arthroscopic Bankart repairs performed using metal anchors during 2007P-2010 were retrospectively analysed in this singlesurgeon *** data collection included historical and clinical findings,dislocation details,operative specifics,and follow-up radiological and clinical findings including shoulder *** primary outcomes were patientreported scores(Constant,American Shoulder and Elbow Surgeons[ASES],and Rowe scores)and pain and instability on a visual analogue scale(VAS).RESULTS A 3% recurrence rate of dislocation was noted at the final *** constant scores at 10 years postoperatively measured between 76 and 100(mean 89)were significantly better than preoperative scores(mean 62.7).Congruous improvements were also noted in the Rowe and ASES scores and VAS at the 10-year *** Reliable long-term outcomes with metallic anchors in surgery for shoulder instability can be *** results provide additional evidence of their continued,cost-effective presence in the modern scenario.

关键词： Long-term outcomes Arthroscopic Bankart repair Metallic anchors Low failure rates

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Microstructural, wettability, and corrosion behaviour of TiO_(2) thin film sputtered on aluminium

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Journal of Central South University 2024年第7期31卷 2210-2224页

作者： Rajeev VERMA Vijay KUMAR Saurabh KANGO Amindra KHILLA Rajeev gupta Department of Industrial and Production Engineering Dr B R Ambedkar National Institute of Technology JalandharJalandhar-144008PunjabIndia Department of Mechanical Engineering Dr B R Ambedkar National Institute of Technology JalandharJalandhar-144008PunjabIndia Department of Physics School of EngineeringUniversity of Petroleum&Energy StudiesDehradun 248007UttarakhandIndia

The study investigated the application of radiofrequency(RF)-sputtered TiO2 coatings at various temperatures to enhance the hydrophobicity and corrosion resistance of Al6061 *** research aimed to establish a correlation between the coating process and the resulting surface *** roughness and wettability were quantified with a surface profilometer and ***,chemical boiling and salt spray corrosion tests were conducted to evaluate any topographical changes during these *** analysis further involved the use of field-emission scanning electron microscopy(FESEM),energy-dispersive spectroscopy(EDS),and X-ray diffraction(XRD)techniques to characterize the deposited *** findings indicated that the TiO2 coating applied at 500℃exhibited the highest water contact angle and superior corrosion resistance compared to other *** characterization confirmed that this specific TiO_(2) coating at 500℃ effectively delays corrosion due to its hydrophobic behavior,making it durable for industrial applications.

关键词： aluminium TiO_(2) coating radiofrequency-sputtering hydrophobic corrosion

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CuO–TiO_(2) based self-powered broad band photodetector

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Nano Materials Science 2024年第3期6卷 345-354页

作者： Chiranjib Ghosh Arka Dey Iman Biswas Rajeev Kumar gupta Vikram Singh Yadav Ashish Yadav Neha Yadav Hongyu Zheng Mohamed Henini Aniruddha Mondal Department of Physics National Institute of Technology DurgapurWest BengalIndia Department of Physics University of Petroleum&Energy Studies DehradunUttarakhandIndia Babasaheb Bhimrao Ambedkar University Lucknow226031India Center for Advanced Laser Manufacturing(CALM) Shandong University of TechnologyZibo255000PR China School of Physics and Astronomy University of NottinghamNottinghamNG72RDUnited Kingdom

An efficient room-temperature self-powered,broadband(300 nm–1100 nm)photodetector based on a CuO–TiO_(2)/TiO_(2)/p-Si(100)heterostructure is *** CuO–TiO_(2)nanocomposites were grown in a two-zone horizontal tube furnace on a 40 nm TiO_(2)thin film deposited on a p-type Si(100)*** CuO–TiO_(2)/TiO_(2)/p-Si(100)devices exhibited excellent rectification characteristics under dark and individual photoillumination *** devices showed remarkable photo-response under broadband(300–1100 nm)light illumination at zero bias voltage,indicating the achievement of highly sensitive self-powered photodetectors at visible and near-infrared light *** maximum response of the devices is observed at 300 nm for an illumination power of 10 *** response and recovery times were calculated as 86 ms and 78 ms,***,under a small bias,the devices showed a prompt binary response by altering the current from positive to negative under illumination *** main reason behind this binary response is the low turn-on voltage and photovoltaic characteristics of the *** illumination conditions,the generation of photocurrent is due to the separation of photogenerated electron-hole pairs within the built-in electric field at the CuO–TiO_(2)/TiO_(2)*** characteristics make the CuO–TiO_(2)/TiO_(2)broadband photodetectors suitable for applications that require high response speeds and self-sufficient functionality.

关键词： Self-powered CuO–TiO_(2) nanocomposite Broadband photodetector Two-zone horizontal tube furnace Responsivity

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Can we predict the incidence of high-grade Clavien-Dindo complications in patients with forgotten encrusted stents undergoing endourologic management?

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Asian Journal of Urology 2024年第1期11卷 99-104页

作者： Praanjal gupta Ramanitharan Manikandan Lalgudi Narayanan Dorairajan Kodakattil Sreenivasan Sreerag Sidhartha Kalra Swapnil Singh Kushwaha Department of Urology Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherryIndia

Objective:Ureteral stents are customarily inserted to facilitate urinary drainage,but they come with their own glitches of being forgotten and/or encrusted leading to serious *** present study aimed to report the complications in patients with forgotten and encrusted stents according to the Clavien-Dindo system specific to urological procedures and identify the factors leading to high-grade(Clavien-Dindo Grade 4A or above)***:The hospital records of patients with forgotten encrusted double-J stents over a period of 8 years were *** parameters recorded included patient demographics,indwelling time,need for percutaneous nephrostomy,hemodialysis,urine culture,blood culture,total blood counts,serum creatinine,radiologic findings,management techniques,number of surgical interventions,modified Clavien-Dindo complications,follow-up,and mortality,if ***:Forty patients were included in the *** median age was 52(range 6-85)*** the total,25(62.5%)patients had a“significant”stent load;31(77.5%)had renal failure or acute kidney injury on presentation;19(47.5%)patients had sepsis at *** the patients presented with sepsis,11(57.9%)patients demonstrated a positive urine culture;and 7/11(63.6%)patients exhibited pan-resistant *** out of 40(30.0%)patients in our series developed high-grade Clavien-Dindo *** univariate analysis,sepsis at presentation(p=0.007),stent load(p=0.031),diabetes(p=0.023),positive urine culture(p=0.007),and stent indwelling time of more than 1 year(p=0.031)were found to be *** multivariate logistic regression analysis,sepsis at presentation(p=0.017)and positive urine culture(p=0.016)were significant predictors for high-grade ***:It is prudent to identify specific risk factors,namely sepsis at presentation and positive urine culture to triage and optimize these patients before surgical management.

关键词： Forgotten Encrusted stent Outcome Predictor Clavien-Dindo complication

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Estimating Optimal Location of STATCOM and Minimization of Congestion Cost by Locational Marginal Price Using Flower Pollination， and Particle Swarm Optimization Techniques

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Journal of Harbin Institute of Technology(New series) 2024年

作者： Gagandeep Kaur Akhil gupta Electrical Engineering Department， M.R.Singh Punjab Technical University Electrical Engineering Department， I.K.Gujral Punjab Technical University Main Campus

Restructuring of power market not only introduces competition， but also brings complexity which increases overloading of Transmission Lines (TL). To obliviate this complexity， this paper aims to mitigate the overloading and estimate the optimal location of Static Synchronous Compensator (STATCOM) by reducing congestion for a deregulated power system. The proposed method is based on the use of Locational Marginal Price (LMP) difference technique and congestion cost. LMPs are obtained as a by-product of Optimal Power Flow (OPF)， whereas Congestion Cost (CC) is a function of difference in LMP and power flows. An endeavor is justified by reducing the CCand solution space which can identify the TLs more suitable for placement of STATCOM. Importantly， total real power loss， reactive power loss and total CCare the three main objective functions in this optimization process. The process is implemented by developing an IEEE-69 bus test system which verifies and validates the effectiveness of proposed optimization technique. Additionally， a comparative analysis is enumerated by implementing two optimization techniques: Flower Pollination Algorithm (FPA) and Particle Swarm Optimization (PSO). The comparative analysis is sufficient to demonstrate the superiority of FPA technique over PSO technique in estimating an optimal placement of a STATCOM. The results from the load-flow analysis illustrate the reduction in CC， total real and reactive power loss using FPA technique over PSO technique. Overall， satisfactory results are obtained without using complex calculations which verify the effectiveness of optimization techniques.

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Development and validation of multicentre study on novel Artificial Intelligence-based Cardiovascular Risk Score(AICVD)

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Family Medicine and Community Health 2024年第S1期12卷 20-33页

作者： Shiv Kumar Jalepalli Prashant gupta Andre L A J Dekker Inigo Bermejo Sujoy Kar Apollo Hospitals HyderabadTelanganaIndia Azure Microsoft Research IndiaBengaluruIndia Department of Radiation Oncology(Maastro) Maastricht UniversityMaastrichtNetherlands

Objective Cardiovascular diseases(CVD)are one of the most prevalent diseases in India amounting for nearly 30%of total deaths.A dearth of research on CVD risk scores in Indian population,limited performance of conventional risk scores and inability to reproduce the initial accuracies in randomised clinical trials has led to this study on large-scale patient *** objective is to develop an Artificial Intelligence-based Risk Score(AICVD)to predict CVD event(eg,acute myocardial infarction/acute coronary syndrome)in the next 10 years and compare the model with the Framingham Heart Risk Score(FHRS)and *** Our study included 31599 participants aged 18–91 years from 2009 to 2018 in six Apollo Hospitals in India.A multistep risk factors selection process using Spearman correlation coefficient and propensity score matching yielded 21 risk factors.A deep learning hazards model was built on risk factors to predict event occurrence(classification)and time to event(hazards model)using multilayered neural ***,the model was validated with independent retrospective cohorts of participants from India and the Netherlands and compared with FHRS and *** The deep learning hazards model had a good performance(area under the curve(AUC)0.853).Validation and comparative results showed AUCs between 0.84 and 0.92 with better positive likelihood ratio(AICVD−6.16 to FHRS−2.24 and QRisk3−1.16)and accuracy(AICVD−80.15%to FHRS 59.71%and QRisk351.57%).In the Netherlands cohort,AICVD also outperformed the Framingham Heart Risk Model(AUC−0.737 vs 0.707).Conclusions This study concludes that the novel AI-based CVD Risk Score has a higher predictive performance for cardiac events than conventional risk scores in Indian population.

关键词： AICVD Cardiovascular acute

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Boron neutron capture therapy of cancer:where do we stand now?

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Cancer Communications 2024年第8期44卷 889-892页

作者： Rolf F.Barth Gong Wu Maria da Graca H.Vicente John C Grecula Nilendu gupta Department of Pathology The Ohio State UniversityColumbusOhioUSA Mass Spectrometry and Proteomics Facility The Ohio State UniversityColumbusOhioUSA Department of Chemistry Louisiana State UniversityBaton RougeLouisianaUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA

1 INTRODUCTION,This is the third Editorial/Commentary that one of us(***)has written relating to boron neutron capture therapy(BNCT)[1,2].For those readers who are unfamiliar with BNCT we would refer them to several recent comprehensive reviews[3–5].The second Editorial ended on a hopeful note that with the introduction of acceleratorbased neutron sources(ABNSs),BNCT would enter into the mainstream of radiation therapy[2].

关键词： boron 1,2 neutron

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