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Preclinical and clinical evidence of the association of colibactinproducing Escherichia coli with anxiety and depression in colon cancer

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World Journal of Gastroenterology 2024年第21期30卷 2817-2826页

作者： Fabien Rondepierre Maëva Meynier Johan Gagniere vincent Deneuvy Anissa Deneuvy Gwenaelle Roche Elodie Baudu Bruno Pereira Richard Bonnet Nicolas Barnich Frédéric Antonio Carvalho Denis Pezet Mathilde Bonnet Isabelle Jalenques Service de Psychiatrie de l’Adulte A et Psychologie Médicale CHU Clermont-FerrandClermont-Ferrand 63000France M2iSH UMR 1071INSERMUniversity of Clermont AuvergneINRAE USC 1382Clermont-Ferrand 63001France NeuroDol UMR 1107INSERMUniversity of Clermont AuvergneClermont-Ferrand 63001France Department of Digestive Surgery CHU de Clermont-FerrandClermont-Ferrand 63001France Biostatistics Unit Department of Clinical Research and InnovationCHU Clermont-FerrandClermont-Ferrand 63000France Department of Bacteriology CHU de Clermont-FerrandClermont-Ferrand 63001France UniversitéClermont Auvergne INPCNRSClermont Auvergne Institut PascalClermont-Ferrand 63000France

BACKGROUND The association between the intestinal microbiota and psychiatric disorders is becoming increasingly *** gut microbiota contributes to colorectal carcinogenesis(CRC),as demonstrated with colibactin-producing Escherichia coli(CoPEC).AIM To evaluate the association between CoPEC prevalence and anxiety-and depressive-like behaviors with both preclinical and clinical *** Patients followed after a CRC surgery and for whom the prevalence of CoPEC has been investigated underwent a psychiatric *** were compared according to the CoPEC *** parallel C57BL6/J wild type mice and mice with a CRC susceptibility were chronically infected with a CoPEC *** behavior was assessed using the Elevated Plus Maze test,the Forced Swimming Test and the Behavior recognition system PhenoTyper®.RESULTS In a limited cohort,all patients with CoPEC colonization presented with psychiatric disorders several years before cancer diagnosis,whereas only one patient(17%)without CoPEC *** result was confirmed in C57BL6/J wildtype mice and in a CRC susceptibility mouse model(adenomatous polyposis colimultiple intestinal neoplasia/+).Mice exhibited a significant increase in anxiety-and depressive-like behaviors after chronic infection with a CoPEC *** This finding provides the first evidence that CoPEC infection can induce microbiota-gut-brain axis disturbances in addition to its procarcinogenic properties.

关键词： Colorectal cancer Colibactin Escherichia coli Colibactin-producing Escherichia coli Inflammation Anxiety Depression Behavior

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晏紫东随心而动

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中国服饰 2024年第5期 12-17页

作者：杨睿婷 vincent

见到晏紫东之前,记者先从他分享在社交平台上的日常记录中认识了他。交通堵塞的时候,他写下:“堵车的时候可以看看沿途的风景,换个角度,换个思路,心情也许就会不一样。”在给角色舒一南配音的日常分享中,晏紫东配图自己当天吃到的美食,... 详细信息

见到晏紫东之前,记者先从他分享在社交平台上的日常记录中认识了他。交通堵塞的时候,他写下:“堵车的时候可以看看沿途的风景,换个角度,换个思路,心情也许就会不一样。”在给角色舒一南配音的日常分享中,晏紫东配图自己当天吃到的美食,并说道:“除了工作,还有很多美好瞬间值得记录!”晏紫东的小红书笔记中,最常带的话题是“这才是生活啊”,他在这里记录着自己工作之外的鲜活日常……

关键词：社交平台交通堵塞日常记录晏紫小红书分享换个角度

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杨蓉：角色背后

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中国服饰 2024年第1期 20-25页

作者：杨睿婷 vincent

时隔四年，再一次做客《中国服饰》，杨蓉对第一次参与#我为国潮发声#项目的拍摄依然记忆犹新，“那次拍摄也是在冬天，我印象很深刻，还记得穿了白色的羽绒服和抹胸裙。”作为#我为国潮发声#项目启动时邀请的第一位明星，四年来，看着...

时隔四年，再一次做客《中国服饰》，杨蓉对第一次参与#我为国潮发声#项目的拍摄依然记忆犹新，“那次拍摄也是在冬天，我印象很深刻，还记得穿了白色的羽绒服和抹胸裙。”作为#我为国潮发声#项目启动时邀请的第一位明星，四年来，看着这个项目集结了越来越多的明星、达人，从平面拍摄到落地产业集群持续为中国服饰品牌提供亮相、发声的平台，杨蓉感到很荣幸。

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Evaluation of Phytochemical Contents and Antimicrobial Activities of Pandiaka heudelotii

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Advances in Biological Chemistry 2024年第2期14卷 55-63页

作者： Ikenna Obiora Alaekwe Uche Eunice Ekpunobi vincent Ishmel Egbulefu Ajiwe Chinedu Chris Aguoma Jamilu Ahmad Department of Chemistry Federal University Gusau Gusau Nigeria Department of Pure and Industrial Chemistry Nnamdi Azikiwe University Awka Awka Nigeria

The work investigated the secondary metabolites present in different parts of the Pandiaka heudelotii plant harvested from Ezira, Orumba south local government area of Anambra state, southeastern Nigeria as well as their antimicrobial activity. The objectives were to extract, determine the phytochemicals present, evaluate the antimicrobial potential and determine the zones of inhibition of the root, stem and leaf extracts of the plant. The emergence of antibiotics has decreased the spread and severity of a wide range of diseases. Plant extracts were tested for antibacterial and antifungal activities against Staphylococcus aureus, Escherichia coli, Proteus vulgaris, Streptococcus pyogenes, Bacillus subtelis, Pseudomonas aerogenes, Salmonella typhi, Aspergillus flavus, Aspergillus niger and Candida albicans. The zone of inhibition of extracts was compared with that of standard drugs like Erythromycin, Ciprofloxacin, Fulcin and Fluconazole. The result revealed the inhibition of bacterial and fungal growth with some test organisms. The microbial activity of the plant parts may be due to the presence of various secondary metabolites. The ethyl acetate extracts of Pandiaka heudelotii stood out with a minimum inhibitory concentration (MIC) range of 5 - 10 mg/mL and a minimum bactericidal concentration (MBC)/minimum fungicidal concentration (MFC) of 10 - 20 mg/ml against some test organisms. The plant can thus be worked upon to discover biologically active natural products that may serve as a prelude to the development of new pharmaceutical research undertakings.

关键词： Pharmaceuticals Secondary Metabolites Antibiotics Pandiaka heudelotii Bacteria

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Development of a Web-Based GIS of Flood Zones in the Municipality of Ouagadougou in Burkina Faso

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Journal of Geographic Information System 2024年第1期16卷 32-43页

作者： Halidou Kafando Blaise Ouedraogo vincent Nduka Ojeh Andreas Rienow Aliou Gadiaga Ibrahim Elh Maman Garba WASCAL Graduate Research Programme on Climate Change and Education Department of Agriculture and Environment Science University of The Gambia Kanifing The Gambia Institute of Environment and Agricultural Research Ouagadougou Burkina Faso Department of Geography Faculty of Social Sciences Taraba State University Jalingo Nigeria Interdisciplinary Geographic Information Science Institute of Geography Ruhr-University Bochum Bochum Germany WASCAL Graduate Research Programme on Climate Change and Human Habitat University of Mina Mina Nigeria

This document describes the creation of an informative Web GIS aimed at mitigating the impacts of flooding in the municipality of Ouagadougou, in Burkina Faso, a region that is highly sensitive to climate change. Burkina Faso, which is undergoing rapid urbanization, faces major natural threats, particularly flooding, as demonstrated by the severe floods of 2009 that caused loss of life, injury, structural damage and economic losses in Ouagadougou. The aim of this research is to develop a web map highlighting the municipality’s flood-prone areas, with a view to informing and raising awareness of flood risk reduction. Using the Leaflet JavaScript mapping library, the study uses HTML, CSS and JavaScript to implement web mapping technology. Data on Ouagadougou’s flood zones is generated by a multi-criteria analysis combining Saaty’s AHP method and GIS in QGIS, integrating seven (7) parameters including hydrography, altitude, slope, rainfall, soil types, land use and soil moisture index. QGIS processes and maps the themes, PostgreSQL with PostGIS serves as the DBMS and GeoServer functions as the map server. The Web GIS platform allows users to visualize the different flood risks, from very low to very high, or the high-risk areas specific to Ouagadougou. The AHP calculations classify the municipality into five flood vulnerability zones: very low (24.48%), low (27.93%), medium (23.01%), high (17.11%) and very high (7.47%). Effective risk management requires communication and awareness-raising. This online mapping application serves as a tool for communication, management and flood prevention in Ouagadougou, helping to mitigate flood-related natural disasters.

关键词： Web GIS Flood Mapping Leaflet JavaScript Mapping Library Analysis Hierarchical Processes (AHP) Climate Change Adaptation Ouagadougou Municipality

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贾青轻舟已过万重山

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中国服饰 2024年第4期 16-21页

作者：杨睿婷 vincent(摄影) 不详

“大千世界里,到底什么是我们应该去在意和有所为的呢?”在《成为波伏娃》这本书中,波伏瓦对于这个问题的答案是:我们的行动。因为只有行动是唯一属于你,且仅属于你一个人的,这是你成为你自己的方式。在采访正式开始之前,记者和贾青探... 详细信息

“大千世界里,到底什么是我们应该去在意和有所为的呢?”在《成为波伏娃》这本书中,波伏瓦对于这个问题的答案是:我们的行动。因为只有行动是唯一属于你,且仅属于你一个人的,这是你成为你自己的方式。在采访正式开始之前,记者和贾青探讨了这个问题,她没有直接回答,而是通过以下的讲述给出了自己的答案……。

关键词：轻舟已过万重山波伏瓦贾青波伏娃有所为大千世界采访记者

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Prevalence and risk factors for impaired renal function among Asian patients with nonalcoholic fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 241-248页

作者： Chao Sun George Boon-Bee Goh Wan-Cheng Chow Wah-Kheong Chan Grace Lai-Hung Wong Wai-Kay Seto Yi-Hsiang Huang Han-Chieh Lin I-Cheng Lee Hye Won Lee Seung Up Kim vincent Wai-Sun Wong Jian-Gao Fan Center for Fatty Liver Disease Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghai 200092China Department of Gastroenterology&Hepatology Singapore General HospitalSingaporeSingapore Gastroenterology and Hepatology Unit Department of MedicineFaculty of MedicineUniversity of MalayaKuala LumpurMalaysia Department of Medicine and Therapeutics and State Key Laboratory of Digestive Disease The Chinese University of Hong KongHong KongChina Department of Medicine The University of Hong KongHong KongChina Institute of Clinical Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Division of Gastroenterology and Hepatology Taipei Veterans General HospitalTaipeiTaiwanChina Faculty of Medicine National Yang Ming Chiao Tung University School of MedicineTaipeiTaiwanChina Department of Internal Medicine Yonsei University College of MedicineSeoulKorea

Background:Nonalcoholic fatty liver disease(NAFLD)is associated with impaired renal function,and both diseases often occur alongside other metabolic ***,the prevalence and risk factors for impaired renal function in patients with NAFLD remain *** objective of this study was to identify the prevalence and risk factors for renal impairment in NAFLD ***:All adults aged 18-70 years with ultrasound-diagnosed NAFLD and transient elastography examination from eight Asian centers were enrolled in this prospective *** fibrosis and cirrhosis were assessed by FibroScan-aspartate aminotransferase(FAST),Agile 3+and Agile 4 *** renal function and chronic kidney disease(CKD)were defined by an estimated glomerular filtration rate(eGFR)with value of<90 mL/min/1.73 m^(2) and<60 mL/min/1.73 m^(2),respectively,as estimated by the CKD-Epidemiology Collaboration(CKD-EPI)***:Among 529 included NAFLD patients,the prevalence rates of impaired renal function and CKD were 37.4%and 4.9%,*** multivariate analysis,a moderate-high risk of advanced liver fibrosis and cirrhosis according to Agile 3+and Agile 4 scores were independent risk factors for CKD(P<0.05).Furthermore,increased fasting plasma glucose(FPG)and blood pressure were significantly associated with impaired renal function after controlling for the other components of metabolic syndrome(P<0.05).Compared with patients with normoglycemia,those with prediabetes[FPG≥5.6 mmol/L or hemoglobin A1c(HbA1c)≥5.7%]were more likely to have impaired renal function(P<0.05).Conclusions:Agile 3+and Agile 4 are reliable for identifying NAFLD patients with high risk of *** glycemic control in the prediabetic stage might have a potential renoprotective role in these patients.

关键词： Nonalcoholic fatty liver disease Impaired renal function Agile 3+ Agile 4 Metabolic syndrome

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Frequency of the C677T Polymorphism of MTHFR, G20210A of Prothrombin and R506Q of Factor V Leiden in Type 2 Diabetics in Abidjan

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Open Journal of Genetics 2024年第1期14卷 13-25页

作者： N’Guessan-Blao Rebecca Yapo vincent Yayo-Ayé Mireille Adjambri Eusèbe Koné-Koné Fatoumata Sawadogo Duni Hematology and General Biology Unit Faculty of Pharmaceutical and Biological Sciences Department of Biological Sciences Felix Houphouet-Boigny University Abidjan Ivory Coast Laboratory of Biology and Medical Research National Institute of Public Health (INSP) Abidjan Ivory Coast Molecular Biology Unit Center for Diagnosis and Research on AIDS and Other Infectious Diseases (CeDReS) Treichville University Hospital (CHU) Abidjan Ivory Coast

In Africa, the prevalence of diabetes is escalating and remains a concern due to the numerous complications it causes. Vascular damage associated with diabetes leads to a prothrombotic state observed in diabetic individuals. Diabetes is a complex and multifactorial disease involving genetic components. With the aim of preventing complications and contributing to an efficient management of diabetes, we investigated genes likely to lead to a risk of thrombosis, in particular the C677T of MTHFR, G20210A of prothrombin, and R506Q of factor V Leiden in type 2 diabetics in Abidjan receiving ambulatory care. A descriptive cross-sectional study was carried out on consenting type 2 diabetic patients. Mutation detection was carried out using the PCR-RFLP method employing restriction enzymes. Hemostasis tests (fibrinogen, D-dimers, fibrin monomers, and von Willebrand factor) were performed using citrate tubes on the Stage? Star Max automated system. Plasminogen activator inhibitor was assayed by ELISA method, and biochemical parameters were determined using the COBAS C311. The study population consisted of 45 diabetic patients, 51.1% of whom presented vascular complications, mainly neuropathy. Disturbances in hemostasis parameters were observed, with 15.5% of patients showing an increase in fibrin monomers. Mutation analysis revealed an absence of factor V mutation (factor V Leiden) and of G20210A mutation of the prothrombin gene. However, 15.6% of subjects had a heterozygous C677T mutation of MTHFR, with 57% of them being anemic. The exploration of biological and genetic factors associated with thrombotic risk is of significant interest in the optimal management of African type 2 diabetics.

关键词： Type 2 Diabetes C677T of MTHFR G20210A Factor V Leiden Thrombosis

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陈子由:跃入人生的旷野

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中国服饰 2024年第3期 16-21页

作者：杨睿婷(采访/撰文) vincent(摄影) 不详

2月底的北京春寒料峭,前几日的积雪融成了冰,贪婪地吸收着空气中的热量。户外拍摄中,陈子由穿着单薄的牛仔西服外套,露在外面的两只手冻得通红,身体也不自觉地发抖,但一旦面对镜头,他立刻就进入了状态,动作干净利索,展现出专业的一面。... 详细信息

2月底的北京春寒料峭,前几日的积雪融成了冰,贪婪地吸收着空气中的热量。户外拍摄中,陈子由穿着单薄的牛仔西服外套,露在外面的两只手冻得通红,身体也不自觉地发抖,但一旦面对镜头,他立刻就进入了状态,动作干净利索,展现出专业的一面。镜头之外,陈子由哈着气搓了搓手,笑着安慰工作人员:“没关系,这点冷不算什么。”在团队中,陈子由很多时候都充当着那个调节气氛的角色,“朋友们都喜欢叫我出去玩,觉得有我就不会冷场”。他总是能敏锐地捕捉到大家的情绪变化,然后活跃现场氛围。

关键词：现场氛围干净利索调节气氛陈子情绪变化镜头

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Cervical Myelopathy: Diagnostic Aspects, Surgical Treatment and Evolution of Patients Operated upon in Yaounde

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Open Journal of Modern Neurosurgery 2024年第1期14卷 72-82页

作者： Bello Figuim Djoubairou Ben Ousmanou Oumarou Haman Nassourou Ndome Toto Orlande Amadou Tidjani Djientcheu vincent de Paul Yaounde Central Hospital Faculty of Medicine and Biomedical Sciences of the University of Yaounde 1 Yaounde Cameroon Yaounde Military Hospital Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon Douala General Hospital Faculty of Medicine and Pharmaceutical Sciences of the University of Douala Douala Cameroon Higher Institute of Health Sciences Université des Montagnes Bangangté Cameroon

Introduction: Although cervical myelopathy is the most common degenerative cervical spine pathology in adults, the indications and approaches of surgical treatment have not yet been clearly defined in the literature. Very few studies exist regarding these aspects in our setting, and they are mostly outdated. This study aimed to describe the diagnostic aspects, current surgical treatment with technical improvements, and progression in patients. Patients and Methods: We conducted a multicentre retrospective descriptive study over a 10-year period between January 2011 and January 2020 in three referral centres in Yaoundé. All patients who underwent surgery for cervical myelopathy were included. Results: Fifty-two patients were recruited. The rate of operated cervical myelopathies among all degenerative spinal pathologies was 14.05%. The M/F sex ratio was 3/1, and the average age was 52 ± 10 years. All included patients had gait problems, 90.38% demonstrated motor deficiency, and 67.30% experienced at least three levels of compression. Surgery was decided based on the Nurick grade;a posterior approach was applied to 86.54% of patients. Postoperative progression showed a neurological improvement of 82% with an average follow-up of 4 years. Conclusion: In this study, the patients who underwent surgery were relatively young, their clinical presentations were mostly advanced, and surgical management showed good results in well-selected cases.

关键词： Cervical Myelopathy Diagnosis Treatment Evolution Cameroon

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